dacarbazine-2754 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the dacarbazine-2754 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ADAM5 ADAM metallopeptidase domain 5 (pseudogene)
AGXT alanine-glyoxylate aminotransferase
AIF1 allograft inflammatory factor 1
AIM2 absent in melanoma 2
ANG angiogenin, ribonuclease, RNase A family, 5
ANXA2P1 annexin A2 pseudogene 1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
C11ORF1 chromosome 11 open reading frame 1
C1ORF56 chromosome 1 open reading frame 56
CDH10 cadherin 10, type 2 (T2-cadherin)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CNTD2 cyclin N-terminal domain containing 2
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12
DBP D site of albumin promoter (albumin D-box) binding protein
DOK4 docking protein 4
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
EHD1 EH-domain containing 1
EHD2 EH-domain containing 2
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
ELOVL2 ELOVL fatty acid elongase 2
EPHA5 EPH receptor A5
ETV5 ets variant 5
EXOSC2 exosome component 2
FBXO41 F-box protein 41
FRMD4A FERM domain containing 4A
GLIPR1 GLI pathogenesis-related 1
GLRA3 glycine receptor, alpha 3
GPR15 G protein-coupled receptor 15
GRB10 growth factor receptor-bound protein 10
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HOXB2 homeobox B2
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
HYAL1 hyaluronoglucosaminidase 1
IL2RB interleukin 2 receptor, beta
IL6R interleukin 6 receptor
IPW imprinted in Prader-Willi syndrome (non-protein coding)
KAZN kazrin, periplakin interacting protein
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LHX2 LIM homeobox 2
LTC4S leukotriene C4 synthase
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K
MAP4 microtubule-associated protein 4
MAU2 MAU2 sister chromatid cohesion factor
MST1 macrophage stimulating 1
MTA2 metastasis associated 1 family, member 2
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NDRG2 NDRG family member 2
NOV nephroblastoma overexpressed
NR4A1 nuclear receptor subfamily 4, group A, member 1
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OAZ3 ornithine decarboxylase antizyme 3
OR1D2 olfactory receptor, family 1, subfamily D, member 2
ORAI2 ORAI calcium release-activated calcium modulator 2
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PHF14 PHD finger protein 14
PHOX2B paired-like homeobox 2b
PKNOX2 PBX/knotted 1 homeobox 2
PLLP plasmolipin
PLXNC1 plexin C1
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PSG1 pregnancy specific beta-1-glycoprotein 1
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
PTPRM protein tyrosine phosphatase, receptor type, M
PTRF polymerase I and transcript release factor
RAB6B RAB6B, member RAS oncogene family
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RNF122 ring finger protein 122
RNF216 ring finger protein 216
RNF39 ring finger protein 39
RPL35A ribosomal protein L35a
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SH2D3A SH2 domain containing 3A
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SLN sarcolipin
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
TBL1Y transducin (beta)-like 1, Y-linked
TMEM176A transmembrane protein 176A
TMOD2 tropomodulin 2 (neuronal)
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VIM vimentin
VN1R1 vomeronasal 1 receptor 1
WNT16 wingless-type MMTV integration site family, member 16
ZC3H7B zinc finger CCCH-type containing 7B
ZCCHC14 zinc finger, CCHC domain containing 14
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF175 zinc finger protein 175
ZNF37BP zinc finger protein 37B, pseudogene
ZNF518A zinc finger protein 518A

decreased expression

Symbol Name
ADAM15 ADAM metallopeptidase domain 15
ADCY6 adenylate cyclase 6
ALS2CL ALS2 C-terminal like
APH1B APH1B gamma secretase subunit
ARL15 ADP-ribosylation factor-like 15
ARMC6 armadillo repeat containing 6
ARSB arylsulfatase B
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCORL1 BCL6 corepressor-like 1
BMP4 bone morphogenetic protein 4
C11ORF80 chromosome 11 open reading frame 80
C17ORF70 chromosome 17 open reading frame 70
C5AR2 complement component 5a receptor 2
C5ORF45 chromosome 5 open reading frame 45
C7ORF43 chromosome 7 open reading frame 43
C9ORF40 chromosome 9 open reading frame 40
CCDC121 coiled-coil domain containing 121
CCDC85C coiled-coil domain containing 85C
CDK3 cyclin-dependent kinase 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHKB choline kinase beta
CISH cytokine inducible SH2-containing protein
COL9A2 collagen, type IX, alpha 2
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DLEU2 deleted in lymphocytic leukemia 2 (non-protein coding)
DSCAM Down syndrome cell adhesion molecule
ENO2 enolase 2 (gamma, neuronal)
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM189A2 family with sequence similarity 189, member A2
FAM63A family with sequence similarity 63, member A
FBXO46 F-box protein 46
FLCN folliculin
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GDAP2 ganglioside induced differentiation associated protein 2
GFOD1 glucose-fructose oxidoreductase domain containing 1
GLTSCR1 glioma tumor suppressor candidate region gene 1
GSTCD glutathione S-transferase, C-terminal domain containing
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HP1BP3 heterochromatin protein 1, binding protein 3
IDI2-AS1 IDI2 antisense RNA 1
INCENP inner centromere protein antigens 135/155kDa
ITPKB inositol-trisphosphate 3-kinase B
LIG4 ligase IV, DNA, ATP-dependent
LMNB1 lamin B1
LNPEP leucyl/cystinyl aminopeptidase
MBTD1 mbt domain containing 1
MEX3C mex-3 RNA binding family member C
MKLN1 muskelin 1, intracellular mediator containing kelch motifs
MMP9 matrix metallopeptidase 9
MTCP1 mature T-cell proliferation 1
MTERF1 mitochondrial transcription termination factor 1
MXD3 MAX dimerization protein 3
NDRG1 N-myc downstream regulated 1
NIPAL2 NIPA-like domain containing 2
NOL12 nucleolar protein 12
NPFFR1 neuropeptide FF receptor 1
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PARPBP PARP1 binding protein
PC pyruvate carboxylase
PCDHA6 protocadherin alpha 6
PEX26 peroxisomal biogenesis factor 26
PLA2G10 phospholipase A2, group X
PLA2G15 phospholipase A2, group XV
PODXL podocalyxin-like
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2
PPT2 palmitoyl-protein thioesterase 2
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
RNF170 ring finger protein 170
SAYSD1 SAYSVFN motif domain containing 1
SETD1A SET domain containing 1A
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC35F5 solute carrier family 35, member F5
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SOX9 SRY (sex determining region Y)-box 9
SPIDR scaffolding protein involved in DNA repair
TCP10 t-complex 10
TMCO3 transmembrane and coiled-coil domains 3
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAPPC2 trafficking protein particle complex 2
TSPAN5 tetraspanin 5
TUBA3D tubulin, alpha 3d
ULK1 unc-51 like autophagy activating kinase 1
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
ZBTB6 zinc finger and BTB domain containing 6
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZDHHC24 zinc finger, DHHC-type containing 24
ZNF205 zinc finger protein 205
ZNF212 zinc finger protein 212
ZNF350 zinc finger protein 350