cytokine-mediated signaling pathway Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. (Gene Ontology, GO_0019221)
External Link http://amigo.geneontology.org/amigo/term/GO:0019221
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Genes

377 genes participating in the cytokine-mediated signaling pathway biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ACKR2 atypical chemokine receptor 2
ACKR3 atypical chemokine receptor 3
ACKR4 atypical chemokine receptor 4
ACSL1 acyl-CoA synthetase long-chain family member 1
ADAR adenosine deaminase, RNA-specific
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADIPOR2 adiponectin receptor 2
AIM2 absent in melanoma 2
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
B2M beta-2-microglobulin
BAD BCL2-associated agonist of cell death
BBS2 Bardet-Biedl syndrome 2
BBS4 Bardet-Biedl syndrome 4
BST2 bone marrow stromal cell antigen 2
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CARD14 caspase recruitment domain family, member 14
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CCR1 chemokine (C-C motif) receptor 1
CCR10 chemokine (C-C motif) receptor 10
CCR2 chemokine (C-C motif) receptor 2
CCR3 chemokine (C-C motif) receptor 3
CCR4 chemokine (C-C motif) receptor 4
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR6 chemokine (C-C motif) receptor 6
CCR7 chemokine (C-C motif) receptor 7
CCR8 chemokine (C-C motif) receptor 8
CCR9 chemokine (C-C motif) receptor 9
CCRL2 chemokine (C-C motif) receptor-like 2
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDIP1 cell death-inducing p53 target 1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CIB1 calcium and integrin binding 1 (calmyrin)
CIITA class II, major histocompatibility complex, transactivator
CISH cytokine inducible SH2-containing protein
CLCF1 cardiotrophin-like cytokine factor 1
CMKLR1 chemerin chemokine-like receptor 1
CNTF ciliary neurotrophic factor
CNTFR ciliary neurotrophic factor receptor
COMMD7 COMM domain containing 7
CSF1R colony stimulating factor 1 receptor
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CSF3 colony stimulating factor 3 (granulocyte)
CSF3R colony stimulating factor 3 receptor (granulocyte)
CSNK2B casein kinase 2, beta polypeptide
CTR9 CTR9, Paf1/RNA polymerase II complex component
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR1 chemokine (C-X-C motif) receptor 1
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR3 chemokine (C-X-C motif) receptor 3
CXCR4 chemokine (C-X-C motif) receptor 4
CXCR5 chemokine (C-X-C motif) receptor 5
CXCR6 chemokine (C-X-C motif) receptor 6
DUOX1 dual oxidase 1
DUOX2 dual oxidase 2
EBI3 Epstein-Barr virus induced 3
EDA2R ectodysplasin A2 receptor
EDN2 endothelin 2
EGR1 early growth response 1
EIF4A1 eukaryotic translation initiation factor 4A1
EIF4A2 eukaryotic translation initiation factor 4A2
EIF4A3 eukaryotic translation initiation factor 4A3
EIF4E eukaryotic translation initiation factor 4E
EIF4E2 eukaryotic translation initiation factor 4E family member 2
EIF4E3 eukaryotic translation initiation factor 4E family member 3
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3
EPOR erythropoietin receptor
EREG epiregulin
F3 coagulation factor III (thromboplastin, tissue factor)
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FER fer (fps/fes related) tyrosine kinase
FKBP1A FK506 binding protein 1A, 12kDa
FLNB filamin B, beta
FLT3 fms-related tyrosine kinase 3
GAB1 GRB2-associated binding protein 1
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GHR growth hormone receptor
GPR17 G protein-coupled receptor 17
GPR75 G protein-coupled receptor 75
GREM2 gremlin 2, DAN family BMP antagonist
HCK HCK proto-oncogene, Src family tyrosine kinase
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB3 major histocompatibility complex, class II, DR beta 3
HLA-DRB4 major histocompatibility complex, class II, DR beta 4
HLA-DRB5 major histocompatibility complex, class II, DR beta 5
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
ICAM1 intercellular adhesion molecule 1
IFI27 interferon, alpha-inducible protein 27
IFI30 interferon, gamma-inducible protein 30
IFI35 interferon-induced protein 35
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IFNA10 interferon, alpha 10
IFNA14 interferon, alpha 14
IFNA16 interferon, alpha 16
IFNA17 interferon, alpha 17
IFNA2 interferon, alpha 2
IFNA21 interferon, alpha 21
IFNA4 interferon, alpha 4
IFNA5 interferon, alpha 5
IFNA6 interferon, alpha 6
IFNA7 interferon, alpha 7
IFNA8 interferon, alpha 8
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNB1 interferon, beta 1, fibroblast
IFNE interferon, epsilon
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IFNK interferon, kappa
IFNLR1 interferon, lambda receptor 1
IFNW1 interferon, omega 1
IL10RA interleukin 10 receptor, alpha
IL10RB interleukin 10 receptor, beta
IL11RA interleukin 11 receptor, alpha
IL12B interleukin 12B
IL12RB1 interleukin 12 receptor, beta 1
IL12RB2 interleukin 12 receptor, beta 2
IL13RA1 interleukin 13 receptor, alpha 1
IL13RA2 interleukin 13 receptor, alpha 2
IL15RA interleukin 15 receptor, alpha
IL17RA interleukin 17 receptor A
IL17RB interleukin 17 receptor B
IL17RC interleukin 17 receptor C
IL17RD interleukin 17 receptor D
IL17RE interleukin 17 receptor E
IL18R1 interleukin 18 receptor 1
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1F10 interleukin 1 family, member 10 (theta)
IL1R1 interleukin 1 receptor, type I
IL1R2 interleukin 1 receptor, type II
IL1RAP interleukin 1 receptor accessory protein
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IL1RL1 interleukin 1 receptor-like 1
IL1RL2 interleukin 1 receptor-like 2
IL20RA interleukin 20 receptor, alpha
IL20RB interleukin 20 receptor beta
IL21R interleukin 21 receptor
IL22RA1 interleukin 22 receptor, alpha 1
IL22RA2 interleukin 22 receptor, alpha 2
IL23R interleukin 23 receptor
IL27RA interleukin 27 receptor, alpha
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
IL3 interleukin 3
IL31RA interleukin 31 receptor A
IL36A interleukin 36, alpha
IL36B interleukin 36, beta
IL36G interleukin 36, gamma
IL36RN interleukin 36 receptor antagonist
IL37 interleukin 37
IL3RA interleukin 3 receptor, alpha (low affinity)
IL4R interleukin 4 receptor
IL5 interleukin 5
IL5RA interleukin 5 receptor, alpha
IL6 interleukin 6
IL6R interleukin 6 receptor
IL6ST interleukin 6 signal transducer
IL7R interleukin 7 receptor
IL9R interleukin 9 receptor
IP6K2 inositol hexakisphosphate kinase 2
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK2 interleukin-1 receptor-associated kinase 2
IRAK3 interleukin-1 receptor-associated kinase 3
IRAK4 interleukin-1 receptor-associated kinase 4
IRF1 interferon regulatory factor 1
IRF2 interferon regulatory factor 2
IRF3 interferon regulatory factor 3
IRF4 interferon regulatory factor 4
IRF5 interferon regulatory factor 5
IRF6 interferon regulatory factor 6
IRF7 interferon regulatory factor 7
IRF8 interferon regulatory factor 8
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
JAGN1 jagunal homolog 1 (Drosophila)
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JAK3 Janus kinase 3
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF6 Kruppel-like factor 6
KPNA1 karyopherin alpha 1 (importin alpha 5)
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KPNA3 karyopherin alpha 3 (importin alpha 4)
KPNA4 karyopherin alpha 4 (importin alpha 3)
KPNA5 karyopherin alpha 5 (importin alpha 6)
KPNA7 karyopherin alpha 7 (importin alpha 8)
KPNB1 karyopherin (importin) beta 1
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT18 keratin 18, type I
KRT8 keratin 8, type II
LEP leptin
LEPR leptin receptor
LIFR leukemia inhibitory factor receptor alpha
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MAPK3 mitogen-activated protein kinase 3
MID1 midline 1
MKKS McKusick-Kaufman syndrome
MPL MPL proto-oncogene, thrombopoietin receptor
MST1R macrophage stimulating 1 receptor
MT2A metallothionein 2A
MT3 metallothionein 3
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
NCAM1 neural cell adhesion molecule 1
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NUMBL numb homolog (Drosophila)-like
NUP107 nucleoporin 107kDa
NUP133 nucleoporin 133kDa
NUP153 nucleoporin 153kDa
NUP155 nucleoporin 155kDa
NUP160 nucleoporin 160kDa
NUP188 nucleoporin 188kDa
NUP205 nucleoporin 205kDa
NUP210 nucleoporin 210kDa
NUP214 nucleoporin 214kDa
NUP35 nucleoporin 35kDa
NUP37 nucleoporin 37kDa
NUP43 nucleoporin 43kDa
NUP50 nucleoporin 50kDa
NUP54 nucleoporin 54kDa
NUP62 nucleoporin 62kDa
NUP85 nucleoporin 85kDa
NUP88 nucleoporin 88kDa
NUP93 nucleoporin 93kDa
NUP98 nucleoporin 98kDa
NUPL1 nucleoporin like 1
NUPL2 nucleoporin like 2
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OASL 2'-5'-oligoadenylate synthetase-like
OSM oncostatin M
OSMR oncostatin M receptor
PF4 platelet factor 4
PF4V1 platelet factor 4 variant 1
PIAS1 protein inhibitor of activated STAT, 1
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCG1 phospholipase C, gamma 1
PLP2 proteolipid protein 2 (colonic epithelium-enriched)
PLVAP plasmalemma vesicle associated protein
PML promyelocytic leukemia
POM121 POM121 transmembrane nucleoporin
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PRKCD protein kinase C, delta
PRLR prolactin receptor
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTAFR platelet-activating factor receptor
PTK2B protein tyrosine kinase 2 beta
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRN protein tyrosine phosphatase, receptor type, N
PYCARD PYD and CARD domain containing
PYDC1 PYD (pyrin domain) containing 1
RAE1 ribonucleic acid export 1
RANBP2 RAN binding protein 2
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RGR retinal G protein coupled receptor
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RPS27A ribosomal protein S27a
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RQCD1 RCD1 required for cell differentiation1 homolog (S. pombe)
RSAD2 radical S-adenosyl methionine domain containing 2
SAMHD1 SAM domain and HD domain 1
SEH1L SEH1-like (S. cerevisiae)
SH2B2 SH2B adaptor protein 2
SLC27A1 solute carrier family 27 (fatty acid transporter), member 1
SOCS1 suppressor of cytokine signaling 1
SOCS2 suppressor of cytokine signaling 2
SOCS3 suppressor of cytokine signaling 3
SOCS4 suppressor of cytokine signaling 4
SOCS5 suppressor of cytokine signaling 5
SOCS6 suppressor of cytokine signaling 6
SOCS7 suppressor of cytokine signaling 7
SP100 SP100 nuclear antigen
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT2 signal transducer and activator of transcription 2, 113kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SUMO1 small ubiquitin-like modifier 1
TFF2 trefoil factor 2
THPO thrombopoietin
TNF tumor necrosis factor
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFRSF18 tumor necrosis factor receptor superfamily, member 18
TNFRSF19 tumor necrosis factor receptor superfamily, member 19
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TNIP2 TNFAIP3 interacting protein 2
TPR translocated promoter region, nuclear basket protein
TRADD TNFRSF1A-associated via death domain
TRAF2 TNF receptor-associated factor 2
TRAF3 TNF receptor-associated factor 3
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIM21 tripartite motif containing 21
TRIM22 tripartite motif containing 22
TRIM25 tripartite motif containing 25
TRIM26 tripartite motif containing 26
TRIM31 tripartite motif containing 31
TRIM34 tripartite motif containing 34
TRIM38 tripartite motif containing 38
TRIM5 tripartite motif containing 5
TRIM62 tripartite motif containing 62
TRIM68 tripartite motif containing 68
TRIM8 tripartite motif containing 8
TXNDC17 thioredoxin domain containing 17
TYK2 tyrosine kinase 2
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBA7 ubiquitin-like modifier activating enzyme 7
UBB ubiquitin B
UBC ubiquitin C
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UBE2N ubiquitin-conjugating enzyme E2N
USP18 ubiquitin specific peptidase 18
VCAM1 vascular cell adhesion molecule 1
XAF1 XIAP associated factor 1
XCR1 chemokine (C motif) receptor 1
ZC3H15 zinc finger CCCH-type containing 15
ZCCHC11 zinc finger, CCHC domain containing 11
ZNF675 zinc finger protein 675