cyproterone-4470 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the cyproterone-4470 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOX3 acyl-CoA oxidase 3, pristanoyl
AEN apoptosis enhancing nuclease
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ANKH ANKH inorganic pyrophosphate transport regulator
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARSD arylsulfatase D
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ASCL1 achaete-scute family bHLH transcription factor 1
BAHCC1 BAH domain and coiled-coil containing 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BMP8B bone morphogenetic protein 8b
C22ORF46 chromosome 22 open reading frame 46
C3AR1 complement component 3a receptor 1
CD300C CD300c molecule
CELF2 CUGBP, Elav-like family member 2
CHN2 chimerin 2
COL5A1 collagen, type V, alpha 1
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa
CRAT carnitine O-acetyltransferase
DCTN1 dynactin 1
DNASE1L3 deoxyribonuclease I-like 3
ECE1 endothelin converting enzyme 1
EGFL7 EGF-like-domain, multiple 7
ERAP1 endoplasmic reticulum aminopeptidase 1
ESR1 estrogen receptor 1
FAS Fas cell surface death receptor
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GAS7 growth arrest-specific 7
GRIP2 glutamate receptor interacting protein 2
HCRP1 hepatocellular carcinoma-related HCRP1
HKDC1 hexokinase domain containing 1
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
INPP5J inositol polyphosphate-5-phosphatase J
IRX4 iroquois homeobox 4
KHSRP KH-type splicing regulatory protein
KIF25-AS1 KIF25 antisense RNA 1
LAMA2 laminin, alpha 2
LATS1 large tumor suppressor kinase 1
LMTK2 lemur tyrosine kinase 2
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LTB4R leukotriene B4 receptor
MBD2 methyl-CpG binding domain protein 2
MCF2L MCF.2 cell line derived transforming sequence-like
MED16 mediator complex subunit 16
MMP3 matrix metallopeptidase 3
MYT1 myelin transcription factor 1
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NCAPH2 non-SMC condensin II complex, subunit H2
NPY2R neuropeptide Y receptor Y2
NRP2 neuropilin 2
NTF3 neurotrophin 3
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
OR7A10 olfactory receptor, family 7, subfamily A, member 10
OSGIN2 oxidative stress induced growth inhibitor family member 2
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PCDHA5 protocadherin alpha 5
PCDHGA10 protocadherin gamma subfamily A, 10
PGAP3 post-GPI attachment to proteins 3
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PISD phosphatidylserine decarboxylase
PLXND1 plexin D1
POU6F1 POU class 6 homeobox 1
PRKCE protein kinase C, epsilon
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
PRSS50 protease, serine, 50
PURG purine-rich element binding protein G
RAP1GAP RAP1 GTPase activating protein
RFX2 regulatory factor X, 2 (influences HLA class II expression)
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RNF5 ring finger protein 5, E3 ubiquitin protein ligase
RPLP2 ribosomal protein, large, P2
SAP30 Sin3A-associated protein, 30kDa
SFRP4 secreted frizzled-related protein 4
SLC17A2 solute carrier family 17, member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SP110 SP110 nuclear body protein
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
TAS2R1 taste receptor, type 2, member 1
TBX2 T-box 2
TCP11L1 t-complex 11, testis-specific-like 1
THSD7A thrombospondin, type I, domain containing 7A
TLR2 toll-like receptor 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
TOM1L2 target of myb1-like 2 (chicken)
TOP3B topoisomerase (DNA) III beta
TRIM29 tripartite motif containing 29
UNC93B1 unc-93 homolog B1 (C. elegans)
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
VAV2 vav 2 guanine nucleotide exchange factor
VPS9D1 VPS9 domain containing 1
WDR62 WD repeat domain 62
WNT16 wingless-type MMTV integration site family, member 16
WNT3 wingless-type MMTV integration site family, member 3
YIPF4 Yip1 domain family, member 4
YY1 YY1 transcription factor
ZHX3 zinc fingers and homeoboxes 3
ZNF334 zinc finger protein 334

decreased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
AGMAT agmatine ureohydrolase (agmatinase)
AK5 adenylate kinase 5
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ARL14 ADP-ribosylation factor-like 14
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BEX1 brain expressed, X-linked 1
BEX4 brain expressed, X-linked 4
C4ORF29 chromosome 4 open reading frame 29
C8ORF60 chromosome 8 open reading frame 60
CBX8 chromobox homolog 8
CCDC9 coiled-coil domain containing 9
CDADC1 cytidine and dCMP deaminase domain containing 1
CDK3 cyclin-dependent kinase 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEP295 centrosomal protein 295kDa
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CINP cyclin-dependent kinase 2 interacting protein
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CPNE7 copine VII
DBF4B DBF4 zinc finger B
DCAF13 DDB1 and CUL4 associated factor 13
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DZANK1 double zinc ribbon and ankyrin repeat domains 1
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM50B family with sequence similarity 50, member B
FKBPL FK506 binding protein like
GAS8 growth arrest-specific 8
GCA grancalcin, EF-hand calcium binding protein
GINS4 GINS complex subunit 4 (Sld5 homolog)
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GPR19 G protein-coupled receptor 19
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GUSBP3 glucuronidase, beta pseudogene 3
HIRA histone cell cycle regulator
HIST1H1D histone cluster 1, H1d
HIST1H2AM histone cluster 1, H2am
HIST1H3C histone cluster 1, H3c
IFI6 interferon, alpha-inducible protein 6
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IL6 interleukin 6
ING4 inhibitor of growth family, member 4
MFSD11 major facilitator superfamily domain containing 11
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MX1 MX dynamin-like GTPase 1
MXRA8 matrix-remodelling associated 8
NABP1 nucleic acid binding protein 1
NAT6 N-acetyltransferase 6 (GCN5-related)
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NOTCH1 notch 1
NPFFR1 neuropeptide FF receptor 1
ODF2 outer dense fiber of sperm tails 2
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDE12 phosphodiesterase 12
PID1 phosphotyrosine interaction domain containing 1
POLH polymerase (DNA directed), eta
POM121 POM121 transmembrane nucleoporin
PRF1 perforin 1 (pore forming protein)
PRSS22 protease, serine, 22
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RFWD3 ring finger and WD repeat domain 3
SETBP1 SET binding protein 1
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SYNPO synaptopodin
TAOK1 TAO kinase 1
THRAP3 thyroid hormone receptor associated protein 3
TMEM156 transmembrane protein 156
TNRC6B trinucleotide repeat containing 6B
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
URM1 ubiquitin related modifier 1
VEZT vezatin, adherens junctions transmembrane protein
WDR76 WD repeat domain 76
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
YOD1 YOD1 deubiquitinase
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZBTB6 zinc finger and BTB domain containing 6
ZNF254 zinc finger protein 254
ZNF286A zinc finger protein 286A
ZNF426 zinc finger protein 426
ZNF562 zinc finger protein 562
ZNF571 zinc finger protein 571
ZNF652 zinc finger protein 652
ZNF667 zinc finger protein 667
ZNF675 zinc finger protein 675
ZSCAN16 zinc finger and SCAN domain containing 16
ZXDC ZXD family zinc finger C