cyproheptadine-6740 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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194 genes differentially expressed following the cyproheptadine-6740 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADGRB2 adhesion G protein-coupled receptor B2
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
AGXT alanine-glyoxylate aminotransferase
AMOT angiomotin
ARHGAP44 Rho GTPase activating protein 44
ATP10B ATPase, class V, type 10B
BAAT bile acid CoA:amino acid N-acyltransferase
BTG2 BTG family, member 2
C14ORF105 chromosome 14 open reading frame 105
C8A complement component 8, alpha polypeptide
CABP1 calcium binding protein 1
CCL2 chemokine (C-C motif) ligand 2
CD244 CD244 molecule, natural killer cell receptor 2B4
CD79B CD79b molecule, immunoglobulin-associated beta
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CSF1 colony stimulating factor 1 (macrophage)
CXCL8 chemokine (C-X-C motif) ligand 8
CYSLTR1 cysteinyl leukotriene receptor 1
ELOVL5 ELOVL fatty acid elongase 5
EPB41L1 erythrocyte membrane protein band 4.1-like 1
EPO erythropoietin
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
FGFR2 fibroblast growth factor receptor 2
FOXP3 forkhead box P3
FPR1 formyl peptide receptor 1
FRMD4B FERM domain containing 4B
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GPR85 G protein-coupled receptor 85
HNF4A hepatocyte nuclear factor 4, alpha
HPCA hippocalcin
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
IFNA8 interferon, alpha 8
IGFALS insulin-like growth factor binding protein, acid labile subunit
IGLJ3 immunoglobulin lambda joining 3
IL1RN interleukin 1 receptor antagonist
IQSEC2 IQ motif and Sec7 domain 2
ITGB8 integrin, beta 8
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KIAA1467 KIAA1467
KIF25 kinesin family member 25
KLHL25 kelch-like family member 25
LDLR low density lipoprotein receptor
LIPG lipase, endothelial
LOXL3 lysyl oxidase-like 3
MEP1B meprin A, beta
MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
MPPE1 metallophosphoesterase 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUC4 mucin 4, cell surface associated
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NME8 NME/NM23 family member 8
NRG1 neuregulin 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
ONECUT2 one cut homeobox 2
OR7C1 olfactory receptor, family 7, subfamily C, member 1
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PAX2 paired box 2
PAX8 paired box 8
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PEX5L peroxisomal biogenesis factor 5-like
PML promyelocytic leukemia
PODXL2 podocalyxin-like 2
POU1F1 POU class 1 homeobox 1
POU6F2 POU class 6 homeobox 2
PRB1 proline-rich protein BstNI subfamily 1
PRELP proline/arginine-rich end leucine-rich repeat protein
PTCRA pre T-cell antigen receptor alpha
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RBM12B-AS1 RBM12B antisense RNA 1
RGS16 regulator of G-protein signaling 16
RIMS2 regulating synaptic membrane exocytosis 2
RUNX1 runt-related transcription factor 1
SASH3 SAM and SH3 domain containing 3
SH3D21 SH3 domain containing 21
SLCO2A1 solute carrier organic anion transporter family, member 2A1
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STMN2 stathmin 2
TAC3 tachykinin 3
TACR1 tachykinin receptor 1
TMPRSS4 transmembrane protease, serine 4
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TSPY1 testis specific protein, Y-linked 1
TTC9 tetratricopeptide repeat domain 9
VNN1 vanin 1
ZCCHC14 zinc finger, CCHC domain containing 14
ZFAND5 zinc finger, AN1-type domain 5
ZFP30 ZFP30 zinc finger protein
ZNF407 zinc finger protein 407
ZNF76 zinc finger protein 76
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ADAM23 ADAM metallopeptidase domain 23
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ASB7 ankyrin repeat and SOCS box containing 7
ATAD5 ATPase family, AAA domain containing 5
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
BAK1 BCL2-antagonist/killer 1
BGLAP bone gamma-carboxyglutamate (gla) protein
C10ORF88 chromosome 10 open reading frame 88
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CAND2 cullin-associated and neddylation-dissociated 2 (putative)
CBX8 chromobox homolog 8
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CEP112 centrosomal protein 112kDa
CLASRP CLK4-associating serine/arginine rich protein
CLCN5 chloride channel, voltage-sensitive 5
CNTLN centlein, centrosomal protein
COG4 component of oligomeric golgi complex 4
CTSO cathepsin O
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DENND4A DENN/MADD domain containing 4A
DNAL4 dynein, axonemal, light chain 4
DPY19L2P2 DPY19L2 pseudogene 2
E2F8 E2F transcription factor 8
EPHX2 epoxide hydrolase 2, cytoplasmic
FAM172A family with sequence similarity 172, member A
FAM50B family with sequence similarity 50, member B
FANCE Fanconi anemia, complementation group E
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GLDC glycine dehydrogenase (decarboxylating)
GTF2H2B general transcription factor IIH, polypeptide 2B (pseudogene)
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HIST1H4E histone cluster 1, H4e
INF2 inverted formin, FH2 and WH2 domain containing
IPO8 importin 8
KATNBL1 katanin p80 subunit B-like 1
KIAA0319L KIAA0319-like
LINC00341 long intergenic non-protein coding RNA 341
MANSC1 MANSC domain containing 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MFSD11 major facilitator superfamily domain containing 11
MRPL44 mitochondrial ribosomal protein L44
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MXD3 MAX dimerization protein 3
NABP1 nucleic acid binding protein 1
NDP Norrie disease (pseudoglioma)
NLK nemo-like kinase
NUP62CL nucleoporin 62kDa C-terminal like
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PALMD palmdelphin
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
POLR1B polymerase (RNA) I polypeptide B, 128kDa
PPT2 palmitoyl-protein thioesterase 2
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRPH peripherin
PRR7 proline rich 7 (synaptic)
PTK7 protein tyrosine kinase 7 (inactive)
RABL6 RAB, member RAS oncogene family-like 6
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RBL1 retinoblastoma-like 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RETSAT retinol saturase (all-trans-retinol 13,14-reductase)
RHOBTB2 Rho-related BTB domain containing 2
RNF121 ring finger protein 121
RNF2 ring finger protein 2
RPAIN RPA interacting protein
RPL23AP32 ribosomal protein L23a pseudogene 32
RRAGB Ras-related GTP binding B
SCG5 secretogranin V
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SHROOM2 shroom family member 2
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLITRK5 SLIT and NTRK-like family, member 5
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SPRYD7 SPRY domain containing 7
STARD3 StAR-related lipid transfer (START) domain containing 3
TENM4 teneurin transmembrane protein 4
TMEM186 transmembrane protein 186
TMEM53 transmembrane protein 53
TOR3A torsin family 3, member A
USP18 ubiquitin specific peptidase 18
WDR76 WD repeat domain 76
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF137P zinc finger protein 137, pseudogene
ZNF189 zinc finger protein 189
ZNF205 zinc finger protein 205
ZNF264 zinc finger protein 264
ZNF385D zinc finger protein 385D
ZNF408 zinc finger protein 408
ZNF702P zinc finger protein 702, pseudogene
ZNF767P zinc finger family member 767, pseudogene