cycloserine-6139 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the cycloserine-6139 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADARB1 adenosine deaminase, RNA-specific, B1
AHSG alpha-2-HS-glycoprotein
ANGPTL4 angiopoietin-like 4
APOE apolipoprotein E
B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BEGAIN brain-enriched guanylate kinase-associated
BIN1 bridging integrator 1
C17ORF59 chromosome 17 open reading frame 59
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CDC14B cell division cycle 14B
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDCP1 CUB domain containing protein 1
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFAP70 cilia and flagella associated protein 70
CHRM4 cholinergic receptor, muscarinic 4
CLEC10A C-type lectin domain family 10, member A
COL10A1 collagen, type X, alpha 1
CORO2B coronin, actin binding protein, 2B
CTAG2 cancer/testis antigen 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DCAF4 DDB1 and CUL4 associated factor 4
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DOCK9 dedicator of cytokinesis 9
DRD5 dopamine receptor D5
EFNA3 ephrin-A3
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EPN2 epsin 2
FCAR Fc fragment of IgA receptor
FDXR ferredoxin reductase
FERMT1 fermitin family member 1
FOXD1 forkhead box D1
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GPR153 G protein-coupled receptor 153
GRM6 glutamate receptor, metabotropic 6
GSK3A glycogen synthase kinase 3 alpha
GSPT1 G1 to S phase transition 1
HDAC6 histone deacetylase 6
HNF4A hepatocyte nuclear factor 4, alpha
HOXB6 homeobox B6
HRH4 histamine receptor H4
ICA1 islet cell autoantigen 1, 69kDa
IL11 interleukin 11
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KIF1A kinesin family member 1A
KLHL36 kelch-like family member 36
LAMA5 laminin, alpha 5
LINC01558 long intergenic non-protein coding RNA 1558
LRRC1 leucine rich repeat containing 1
LRRC75B leucine rich repeat containing 75B
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MED25 mediator complex subunit 25
MMP7 matrix metallopeptidase 7
MPZL1 myelin protein zero-like 1
NECAB2 N-terminal EF-hand calcium binding protein 2
NEUROD1 neuronal differentiation 1
NF2 neurofibromin 2 (merlin)
NLRP1 NLR family, pyrin domain containing 1
NOS2 nitric oxide synthase 2, inducible
OLFML2B olfactomedin-like 2B
OSBP2 oxysterol binding protein 2
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PAWR PRKC, apoptosis, WT1, regulator
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE4DIP phosphodiesterase 4D interacting protein
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLD2 phospholipase D2
PMEL premelanosome protein
PON1 paraoxonase 1
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
RASAL2 RAS protein activator like 2
RET ret proto-oncogene
RGSL1 regulator of G-protein signaling like 1
SH3BP1 SH3-domain binding protein 1
SIX1 SIX homeobox 1
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC7A4 solute carrier family 7, member 4
SMAD3 SMAD family member 3
SNCG synuclein, gamma (breast cancer-specific protein 1)
SOX15 SRY (sex determining region Y)-box 15
SPPL2B signal peptide peptidase like 2B
SV2A synaptic vesicle glycoprotein 2A
SYNDIG1 synapse differentiation inducing 1
THTPA thiamine triphosphatase
TMCC1 transmembrane and coiled-coil domain family 1
TSC22D2 TSC22 domain family, member 2
TTC38 tetratricopeptide repeat domain 38
VPS9D1 VPS9 domain containing 1
WDR55 WD repeat domain 55
WSCD1 WSC domain containing 1
ZNF185 zinc finger protein 185 (LIM domain)
ZNF235 zinc finger protein 235
ZNF668 zinc finger protein 668
ZSWIM1 zinc finger, SWIM-type containing 1

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ACAD10 acyl-CoA dehydrogenase family, member 10
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARNT aryl hydrocarbon receptor nuclear translocator
ARSB arylsulfatase B
ASB7 ankyrin repeat and SOCS box containing 7
AVPI1 arginine vasopressin-induced 1
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
C11ORF30 chromosome 11 open reading frame 30
CBX4 chromobox homolog 4
CIC capicua transcriptional repressor
CLDN15 claudin 15
COQ6 coenzyme Q6 monooxygenase
CORT cortistatin
CRABP2 cellular retinoic acid binding protein 2
CRY2 cryptochrome circadian clock 2
CXCR2 chemokine (C-X-C motif) receptor 2
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DGKE diacylglycerol kinase, epsilon 64kDa
DSPP dentin sialophosphoprotein
DVL1 dishevelled segment polarity protein 1
ERMAP erythroblast membrane-associated protein (Scianna blood group)
EVA1B eva-1 homolog B (C. elegans)
FAM127B family with sequence similarity 127, member B
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FKBP5 FK506 binding protein 5
GPX2 glutathione peroxidase 2
GRAMD1B GRAM domain containing 1B
GSPT2 G1 to S phase transition 2
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GTF2IRD1 GTF2I repeat domain containing 1
HIST1H3G histone cluster 1, H3g
IGFBP4 insulin-like growth factor binding protein 4
INO80D INO80 complex subunit D
ITPKC inositol-trisphosphate 3-kinase C
KIF17 kinesin family member 17
KIF1B kinesin family member 1B
LAX1 lymphocyte transmembrane adaptor 1
LOC390998 ribosomal protein L10 pseudogene
LOC730101 uncharacterized LOC730101
MAGEF1 melanoma antigen family F1
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MBNL3 muscleblind-like splicing regulator 3
METTL2B methyltransferase like 2B
MRPL44 mitochondrial ribosomal protein L44
MTHFS 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
MXD3 MAX dimerization protein 3
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NACA2 nascent polypeptide-associated complex alpha subunit 2
NINJ2 ninjurin 2
NSUN6 NOP2/Sun domain family, member 6
NUBPL nucleotide binding protein-like
OMG oligodendrocyte myelin glycoprotein
PCYOX1 prenylcysteine oxidase 1
PELP1 proline, glutamate and leucine rich protein 1
POM121L2 POM121 transmembrane nucleoporin-like 2
PRR4 proline rich 4 (lacrimal)
PYGB phosphorylase, glycogen; brain
RAB33A RAB33A, member RAS oncogene family
RARS arginyl-tRNA synthetase
RPL13P5 ribosomal protein L13 pseudogene 5
RPP25 ribonuclease P/MRP 25kDa subunit
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SCGB2A2 secretoglobin, family 2A, member 2
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SERTAD3 SERTA domain containing 3
SGCE sarcoglycan, epsilon
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SMR3A submaxillary gland androgen regulated protein 3A
SNX15 sorting nexin 15
SOX12 SRY (sex determining region Y)-box 12
SSBP3 single stranded DNA binding protein 3
TESK1 testis-specific kinase 1
TESK2 testis-specific kinase 2
TGFBR1 transforming growth factor, beta receptor 1
TGM5 transglutaminase 5
THBS3 thrombospondin 3
TMEM53 transmembrane protein 53
TPBG trophoblast glycoprotein
TRAIP TRAF interacting protein
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
TRPS1 trichorhinophalangeal syndrome I
TTC26 tetratricopeptide repeat domain 26
TUBB2A tubulin, beta 2A class IIa
UNC119 unc-119 homolog (C. elegans)
ZFP37 ZFP37 zinc finger protein
ZFYVE16 zinc finger, FYVE domain containing 16
ZHX2 zinc fingers and homeoboxes 2
ZMYM3 zinc finger, MYM-type 3
ZNF329 zinc finger protein 329
ZNF34 zinc finger protein 34