cyclobenzaprine-4834 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the cyclobenzaprine-4834 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
ACRV1 acrosomal vesicle protein 1
ACSL4 acyl-CoA synthetase long-chain family member 4
ACVR1B activin A receptor, type IB
AFF2 AF4/FMR2 family, member 2
AGFG1 ArfGAP with FG repeats 1
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ATF7IP activating transcription factor 7 interacting protein
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BCL2L2 BCL2-like 2
BMP2 bone morphogenetic protein 2
C11ORF21 chromosome 11 open reading frame 21
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CELA2A chymotrypsin-like elastase family, member 2A
CEMIP cell migration inducing protein, hyaluronan binding
CEP112 centrosomal protein 112kDa
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DOCK5 dedicator of cytokinesis 5
DSTYK dual serine/threonine and tyrosine protein kinase
DUSP4 dual specificity phosphatase 4
EMP1 epithelial membrane protein 1
ETAA1 Ewing tumor-associated antigen 1
ETV5 ets variant 5
FABP3 fatty acid binding protein 3, muscle and heart
FOXG1 forkhead box G1
FXYD5 FXYD domain containing ion transport regulator 5
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
H2AFX H2A histone family, member X
HAMP hepcidin antimicrobial peptide
HLA-DOA major histocompatibility complex, class II, DO alpha
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXA10 homeobox A10
HSPA13 heat shock protein 70kDa family, member 13
IDS iduronate 2-sulfatase
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
INHBE inhibin, beta E
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
ITGA6 integrin, alpha 6
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNK1 potassium channel, two pore domain subfamily K, member 1
KCTD7 potassium channel tetramerization domain containing 7
LAMC2 laminin, gamma 2
LAMP1 lysosomal-associated membrane protein 1
LPIN1 lipin 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
MAN1A2 mannosidase, alpha, class 1A, member 2
MAN1C1 mannosidase, alpha, class 1C, member 1
MAN2A2 mannosidase, alpha, class 2A, member 2
MBD2 methyl-CpG binding domain protein 2
MED25 mediator complex subunit 25
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NMT2 N-myristoyltransferase 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NXPE3 neurexophilin and PC-esterase domain family, member 3
PEX5L peroxisomal biogenesis factor 5-like
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAU plasminogen activator, urokinase
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
POMT2 protein-O-mannosyltransferase 2
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTHLH parathyroid hormone-like hormone
PURG purine-rich element binding protein G
RAB6A RAB6A, member RAS oncogene family
RGSL1 regulator of G-protein signaling like 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGMS1 sphingomyelin synthase 1
SH3GL3 SH3-domain GRB2-like 3
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SNAI2 snail family zinc finger 2
SP1 Sp1 transcription factor
SRF serum response factor (c-fos serum response element-binding transcription factor)
TAGLN3 transgelin 3
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBL2 transducin (beta)-like 2
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
WSB1 WD repeat and SOCS box containing 1
ZNF287 zinc finger protein 287
ZNF442 zinc finger protein 442
ZNF646 zinc finger protein 646
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ADCY6 adenylate cyclase 6
BAK1 BCL2-antagonist/killer 1
C8ORF60 chromosome 8 open reading frame 60
CAPN1 calpain 1, (mu/I) large subunit
CASZ1 castor zinc finger 1
CBX4 chromobox homolog 4
CDK3 cyclin-dependent kinase 3
CEP85 centrosomal protein 85kDa
CHPF chondroitin polymerizing factor
COPZ2 coatomer protein complex, subunit zeta 2
CPNE1 copine I
CRABP1 cellular retinoic acid binding protein 1
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CUL9 cullin 9
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DDB1 damage-specific DNA binding protein 1, 127kDa
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DOCK4 dedicator of cytokinesis 4
DUSP2 dual specificity phosphatase 2
EDC4 enhancer of mRNA decapping 4
EGFL7 EGF-like-domain, multiple 7
ERAL1 Era-like 12S mitochondrial rRNA chaperone 1
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ERN2 endoplasmic reticulum to nucleus signaling 2
ETNK2 ethanolamine kinase 2
FADS2 fatty acid desaturase 2
FAM63A family with sequence similarity 63, member A
FAM86C1 family with sequence similarity 86, member C1
FBRS fibrosin
FPGS folylpolyglutamate synthase
FUZ fuzzy planar cell polarity protein
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B
GCHFR GTP cyclohydrolase I feedback regulator
GMPR guanosine monophosphate reductase
GPRASP1 G protein-coupled receptor associated sorting protein 1
GRB7 growth factor receptor-bound protein 7
GSTA4 glutathione S-transferase alpha 4
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HLA-J major histocompatibility complex, class I, J (pseudogene)
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
LIME1 Lck interacting transmembrane adaptor 1
LMNB2 lamin B2
LRP3 low density lipoprotein receptor-related protein 3
LY6D lymphocyte antigen 6 complex, locus D
MEIS1 Meis homeobox 1
MFAP2 microfibrillar-associated protein 2
MOCS3 molybdenum cofactor synthesis 3
MORC4 MORC family CW-type zinc finger 4
MPDU1 mannose-P-dolichol utilization defect 1
MTMR12 myotubularin related protein 12
MVP major vault protein
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
NRSN2 neurensin 2
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2
OVGP1 oviductal glycoprotein 1, 120kDa
PCBP4 poly(rC) binding protein 4
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PITX2 paired-like homeodomain 2
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLIN3 perilipin 3
PNPLA6 patatin-like phospholipase domain containing 6
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
RAD54L2 RAD54-like 2 (S. cerevisiae)
RHBG Rh family, B glycoprotein (gene/pseudogene)
RNH1 ribonuclease/angiogenin inhibitor 1
RNMTL1 RNA methyltransferase like 1
SCAMP4 secretory carrier membrane protein 4
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SETD8 SET domain containing (lysine methyltransferase) 8
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5)
STRA6 stimulated by retinoic acid 6
STX1A syntaxin 1A (brain)
TCTN1 tectonic family member 1
TFF2 trefoil factor 2
TICAM1 toll-like receptor adaptor molecule 1
TLN1 talin 1
TMEM104 transmembrane protein 104
TMEM183A transmembrane protein 183A
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TSSC4 tumor suppressing subtransferable candidate 4
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2
UNC93B1 unc-93 homolog B1 (C. elegans)
UPK2 uroplakin 2
URM1 ubiquitin related modifier 1
VGF VGF nerve growth factor inducible
WLS wntless Wnt ligand secretion mediator
XAB2 XPA binding protein 2
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF16 zinc finger protein 16
ZNF324 zinc finger protein 324
ZNF611 zinc finger protein 611
ZNF701 zinc finger protein 701