cyclobenzaprine-4252 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the cyclobenzaprine-4252 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ANTXR1 anthrax toxin receptor 1
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ART1 ADP-ribosyltransferase 1
BAZ2A bromodomain adjacent to zinc finger domain, 2A
C1ORF105 chromosome 1 open reading frame 105
C1ORF54 chromosome 1 open reading frame 54
CA5B carbonic anhydrase VB, mitochondrial
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CACNG5 calcium channel, voltage-dependent, gamma subunit 5
CCDC121 coiled-coil domain containing 121
CCDC170 coiled-coil domain containing 170
CD226 CD226 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD79B CD79b molecule, immunoglobulin-associated beta
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CLCN6 chloride channel, voltage-sensitive 6
CLIC2 chloride intracellular channel 2
CLMN calmin (calponin-like, transmembrane)
CLTC clathrin, heavy chain (Hc)
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2
CNTFR ciliary neurotrophic factor receptor
CREB3L1 cAMP responsive element binding protein 3-like 1
CSF1R colony stimulating factor 1 receptor
CST1 cystatin SN
CST4 cystatin S
CTSS cathepsin S
CXCR4 chemokine (C-X-C motif) receptor 4
DDIT3 DNA-damage-inducible transcript 3
DHRS12 dehydrogenase/reductase (SDR family) member 12
DPF3 D4, zinc and double PHD fingers, family 3
EDA ectodysplasin A
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
EPS8L1 EPS8-like 1
ESRRG estrogen-related receptor gamma
ETV6 ets variant 6
FAM65B family with sequence similarity 65, member B
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR1 fibroblast growth factor receptor 1
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GRK4 G protein-coupled receptor kinase 4
HCG4B HLA complex group 4B (non-protein coding)
HEG1 heart development protein with EGF-like domains 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES2 hes family bHLH transcription factor 2
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
IL6 interleukin 6
INO80D INO80 complex subunit D
ITPK1 inositol-tetrakisphosphate 1-kinase
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KIF1C kinesin family member 1C
KLRB1 killer cell lectin-like receptor subfamily B, member 1
KRT34 keratin 34, type I
LAT2 linker for activation of T cells family, member 2
LIMD2 LIM domain containing 2
LMOD1 leiomodin 1 (smooth muscle)
LRRC75B leucine rich repeat containing 75B
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPK8 mitogen-activated protein kinase 8
MST1 macrophage stimulating 1
MUC3B mucin 3B, cell surface associated
MUC5B mucin 5B, oligomeric mucus/gel-forming
NCALD neurocalcin delta
NEU3 sialidase 3 (membrane sialidase)
NPFF neuropeptide FF-amide peptide precursor
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUP54 nucleoporin 54kDa
NUPR1 nuclear protein, transcriptional regulator, 1
PAX5 paired box 5
PCDH17 protocadherin 17
PDE4B phosphodiesterase 4B, cAMP-specific
PDE4DIP phosphodiesterase 4D interacting protein
PDGFA platelet-derived growth factor alpha polypeptide
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PKD1 polycystic kidney disease 1 (autosomal dominant)
PKP4 plakophilin 4
PLCG1 phospholipase C, gamma 1
PLEKHS1 pleckstrin homology domain containing, family S member 1
PP14571 uncharacterized LOC100130449
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSG4 pregnancy specific beta-1-glycoprotein 4
PTAFR platelet-activating factor receptor
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN21 protein tyrosine phosphatase, non-receptor type 21
PTPRR protein tyrosine phosphatase, receptor type, R
RAB2A RAB2A, member RAS oncogene family
RAB6A RAB6A, member RAS oncogene family
RFPL3 ret finger protein-like 3
RPL10L ribosomal protein L10-like
SBNO1 strawberry notch homolog 1 (Drosophila)
SFRP5 secreted frizzled-related protein 5
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SP4 Sp4 transcription factor
SRCAP Snf2-related CREBBP activator protein
SV2B synaptic vesicle glycoprotein 2B
SYT17 synaptotagmin XVII
VASH1 vasohibin 1
ZNF518A zinc finger protein 518A

decreased expression

Symbol Name
ADGRB2 adhesion G protein-coupled receptor B2
AFAP1 actin filament associated protein 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALOX12 arachidonate 12-lipoxygenase
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
AXIN1 axin 1
BAK1 BCL2-antagonist/killer 1
BCAS3 breast carcinoma amplified sequence 3
BTC betacellulin
C14ORF105 chromosome 14 open reading frame 105
C22ORF46 chromosome 22 open reading frame 46
C7ORF69 chromosome 7 open reading frame 69
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CD101 CD101 molecule
CLCA1 chloride channel accessory 1
CNN1 calponin 1, basic, smooth muscle
COL9A2 collagen, type IX, alpha 2
COMP cartilage oligomeric matrix protein
CXORF21 chromosome X open reading frame 21
DGCR9 DiGeorge syndrome critical region gene 9 (non-protein coding)
DNAH7 dynein, axonemal, heavy chain 7
DOK5 docking protein 5
EGOT eosinophil granule ontogeny transcript (non-protein coding)
ERCC4 excision repair cross-complementation group 4
ERMP1 endoplasmic reticulum metallopeptidase 1
FBXL15 F-box and leucine-rich repeat protein 15
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FRMPD1 FERM and PDZ domain containing 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GIF gastric intrinsic factor (vitamin B synthesis)
GPATCH2L G patch domain containing 2-like
GPR19 G protein-coupled receptor 19
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HIST1H2AK histone cluster 1, H2ak
HPR haptoglobin-related protein
IFI44L interferon-induced protein 44-like
IFNA14 interferon, alpha 14
IFT140 intraflagellar transport 140
IL36RN interleukin 36 receptor antagonist
IQCG IQ motif containing G
IRAK4 interleukin-1 receptor-associated kinase 4
KANSL3 KAT8 regulatory NSL complex subunit 3
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LENEP lens epithelial protein
LIME1 Lck interacting transmembrane adaptor 1
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LNPEP leucyl/cystinyl aminopeptidase
LOXL3 lysyl oxidase-like 3
LRRC37A4P leucine rich repeat containing 37, member A4, pseudogene
LYPD3 LY6/PLAUR domain containing 3
MAGEA6 melanoma antigen family A6
MED31 mediator complex subunit 31
MRPL41 mitochondrial ribosomal protein L41
MTA2 metastasis associated 1 family, member 2
MYO15A myosin XVA
NOTCH4 notch 4
OLFML2B olfactomedin-like 2B
OR10H1 olfactory receptor, family 10, subfamily H, member 1
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
ORAI3 ORAI calcium release-activated calcium modulator 3
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PAIP2B poly(A) binding protein interacting protein 2B
PARP6 poly (ADP-ribose) polymerase family, member 6
PDE8B phosphodiesterase 8B
PHEX phosphate regulating endopeptidase homolog, X-linked
PODNL1 podocan-like 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKG2 protein kinase, cGMP-dependent, type II
PRM2 protamine 2
PXMP4 peroxisomal membrane protein 4, 24kDa
RAB40A RAB40A, member RAS oncogene family
RBM12B-AS1 RBM12B antisense RNA 1
RFPL1 ret finger protein-like 1
RIN1 Ras and Rab interactor 1
RNF2 ring finger protein 2
SCUBE3 signal peptide, CUB domain, EGF-like 3
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SMR3A submaxillary gland androgen regulated protein 3A
STEAP4 STEAP family member 4
TEX40 testis expressed 40
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TWISTNB TWIST neighbor
USB1 U6 snRNA biogenesis 1
USP20 ubiquitin specific peptidase 20
VLDLR very low density lipoprotein receptor
WNT1 wingless-type MMTV integration site family, member 1
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZBTB6 zinc finger and BTB domain containing 6
ZFHX3 zinc finger homeobox 3
ZFP30 ZFP30 zinc finger protein
ZNF140 zinc finger protein 140
ZNF639 zinc finger protein 639
ZNF768 zinc finger protein 768