cyclin-dependent protein kinase holoenzyme complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner. (Gene Ontology, GO_0000307)
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Genes

140 proteins co-occuring with the cyclin-dependent protein kinase holoenzyme complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
CDK4 cyclin-dependent kinase 4 2.43844
CDK2 cyclin-dependent kinase 2 2.02855
CCND1 cyclin D1 1.98408
CDK6 cyclin-dependent kinase 6 1.80039
CCND3 cyclin D3 1.79773
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.52992
CCNB1 cyclin B1 1.44968
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.42993
CDK1 cyclin-dependent kinase 1 1.38017
CDKN2A cyclin-dependent kinase inhibitor 2A 1.20344
CDK7 cyclin-dependent kinase 7 1.14239
CCNA2 cyclin A2 1.10256
RB1 retinoblastoma 1 1.05842
PROCA1 protein interacting with cyclin A1 1.00103
CCND2 cyclin D2 0.991714
MPHOSPH8 M-phase phosphoprotein 8 0.918579
CCNE2 cyclin E2 0.858014
AK6 adenylate kinase 6 0.851583
CDC25A cell division cycle 25A 0.846991
CCNE1 cyclin E1 0.785986
WEE1 WEE1 G2 checkpoint kinase 0.783241
E2F4 E2F transcription factor 4, p107/p130-binding 0.765438
CCNA1 cyclin A1 0.761342
AUNIP aurora kinase A and ninein interacting protein 0.756799
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.681591
MASTL microtubule associated serine/threonine kinase-like 0.616709
CCNB2 cyclin B2 0.60444
CHEK1 checkpoint kinase 1 0.595593
TRIM3 tripartite motif containing 3 0.58134
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 0.558042
SERTAD1 SERTA domain containing 1 0.538238
CCDC151 coiled-coil domain containing 151 0.537005
CDK12 cyclin-dependent kinase 12 0.52675
CDC25C cell division cycle 25C 0.519798
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.511233
TP53 tumor protein p53 0.509197
CELF1 CUGBP, Elav-like family member 1 0.507163
ZC3HC1 zinc finger, C3HC-type containing 1 0.49499
PCNA proliferating cell nuclear antigen 0.487307
TSPYL2 TSPY-like 2 0.47442
CDC20 cell division cycle 20 0.448848
E2F1 E2F transcription factor 1 0.428284
HRAS Harvey rat sarcoma viral oncogene homolog 0.406361
PLK1 polo-like kinase 1 0.405193
CHD8 chromodomain helicase DNA binding protein 8 0.404415
CDK13 cyclin-dependent kinase 13 0.400527
CKS2 CDC28 protein kinase regulatory subunit 2 0.393549
TGFB1 transforming growth factor, beta 1 0.381584
CDC25B cell division cycle 25B 0.37697
CC2D1A coiled-coil and C2 domain containing 1A 0.347208
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.341907
CDC27 cell division cycle 27 0.312224
GPS2 G protein pathway suppressor 2 0.311851
FBXO43 F-box protein 43 0.300311
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.290678
CCNK cyclin K 0.286983
CIB1 calcium and integrin binding 1 (calmyrin) 0.281821
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.272633
CIRBP cold inducible RNA binding protein 0.258016
AKAP8 A kinase (PRKA) anchor protein 8 0.252564
ATM ATM serine/threonine kinase 0.252564
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 0.233101
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.229176
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 0.217511
PTTG1 pituitary tumor-transforming 1 0.203699
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae) 0.201335
AJUBA ajuba LIM protein 0.200328
CCNH cyclin H 0.198658
BTG2 BTG family, member 2 0.195681
CYFIP2 cytoplasmic FMR1 interacting protein 2 0.194698
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.192746
POLDIP3 polymerase (DNA-directed), delta interacting protein 3 0.184547
HMP19 HMP19 protein 0.184241
KAT2A K(lysine) acetyltransferase 2A 0.179752
GSK3B glycogen synthase kinase 3 beta 0.176024
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase 0.170629
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.167125
ERBB2 erb-b2 receptor tyrosine kinase 2 0.165697
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) 0.1632
HDAC7 histone deacetylase 7 0.160658
CDK11A cyclin-dependent kinase 11A 0.158315
FANCI Fanconi anemia, complementation group I 0.129692
JAG2 jagged 2 0.125781
FBXO5 F-box protein 5 0.125636
FANCD2 Fanconi anemia, complementation group D2 0.123043
ERCC2 excision repair cross-complementation group 2 0.122689
ATR ATR serine/threonine kinase 0.12118
GMNN geminin, DNA replication inhibitor 0.120859
CDT1 chromatin licensing and DNA replication factor 1 0.119945
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa 0.118574
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa 0.118309
CDC6 cell division cycle 6 0.116432
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.116388
PRDX6 peroxiredoxin 6 0.11606
BRCA1 breast cancer 1, early onset 0.11407
GTF2H5 general transcription factor IIH, polypeptide 5 0.109449
KLF9 Kruppel-like factor 9 0.098694
RARG retinoic acid receptor, gamma 0.093715
FGFR3 fibroblast growth factor receptor 3 0.093427
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 0.092324
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 0.091933
CCNC cyclin C 0.0911
CLCN3 chloride channel, voltage-sensitive 3 0.088722
HIST3H2BB histone cluster 3, H2bb 0.086362
HIST1H2BH histone cluster 1, H2bh 0.086362
HIST2H2BF histone cluster 2, H2bf 0.086362
HIST1H2BD histone cluster 1, H2bd 0.086341
HIST1H2BC histone cluster 1, H2bc 0.086276
HIST1H2BF histone cluster 1, H2bf 0.086276
HIST1H2BA histone cluster 1, H2ba 0.086212
CDK8 cyclin-dependent kinase 8 0.085762
FOXM1 forkhead box M1 0.083465
PDPK1 3-phosphoinositide dependent protein kinase 1 0.083041
MTA1 metastasis associated 1 0.083019
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.082729
PKN1 protein kinase N1 0.082596
HDAC5 histone deacetylase 5 0.081447
APC adenomatous polyposis coli 0.080924
PDIA3 protein disulfide isomerase family A, member 3 0.080354
NCL nucleolin 0.079779
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.079433
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.077711
JUND jun D proto-oncogene 0.077617
NR5A1 nuclear receptor subfamily 5, group A, member 1 0.076035
IMMT inner membrane protein, mitochondrial 0.075417
HDAC2 histone deacetylase 2 0.07376
DLG1 discs, large homolog 1 (Drosophila) 0.073447
ACAN aggrecan 0.072671
CNTLN centlein, centrosomal protein 0.071869
RPTOR regulatory associated protein of MTOR, complex 1 0.071478
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.069144
GLI1 GLI family zinc finger 1 0.068649
RARS arginyl-tRNA synthetase 0.068452
MCM7 minichromosome maintenance complex component 7 0.067806
FYN FYN proto-oncogene, Src family tyrosine kinase 0.067583
CD40LG CD40 ligand 0.067483
DNM1L dynamin 1-like 0.067434
IL10 interleukin 10 0.06721
PDHX pyruvate dehydrogenase complex, component X 0.066637
LCK LCK proto-oncogene, Src family tyrosine kinase 0.066238