cushing's syndrome Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description An adrenal gland hyperfunction that is caused by overactivity of the adrenal cortex caused by a tumor of the pituitary gland. (Human Disease Ontology, DOID_12252)
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Genes

126 genes co-occuring with the disease cushing's syndrome in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
POMC proopiomelanocortin 3.97632
CRH corticotropin releasing hormone 2.7917
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.89545
SST somatostatin 1.86689
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 1.78444
PRL prolactin 1.68091
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 1.66285
PDE11A phosphodiesterase 11A 1.59519
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 1.58805
TRH thyrotropin-releasing hormone 1.50798
REN renin 1.47945
GHRH growth hormone releasing hormone 1.43552
INS insulin 1.43244
GIPR gastric inhibitory polypeptide receptor 1.42323
ARMC5 armadillo repeat containing 5 1.40176
GIP gastric inhibitory polypeptide 1.33676
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 1.31319
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1 1.29527
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 1.2765
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 1.26647
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 1.26298
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 1.24211
PDE8B phosphodiesterase 8B 1.22475
SSTR5 somatostatin receptor 5 1.19402
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 1.18066
MEN1 multiple endocrine neoplasia I 1.12572
IGF1 insulin-like growth factor 1 (somatomedin C) 1.11435
AVPR1B arginine vasopressin receptor 1B 1.08999
SSTR2 somatostatin receptor 2 1.06816
AVP arginine vasopressin 1.06564
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 1.05429
MC2R melanocortin 2 receptor (adrenocorticotropic hormone) 1.04756
PRKCA protein kinase C, alpha 1.03198
CALCA calcitonin-related polypeptide alpha 0.980952
SSTR1 somatostatin receptor 1 0.974642
GNAS GNAS complex locus 0.97212
BGLAP bone gamma-carboxyglutamate (gla) protein 0.965405
CHGA chromogranin A 0.937874
LEP leptin 0.925452
SYP synaptophysin 0.910199
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6 0.909376
CRHBP corticotropin releasing hormone binding protein 0.906498
NR3C2 nuclear receptor subfamily 3, group C, member 2 0.894589
GCG glucagon 0.86714
GHRL ghrelin/obestatin prepropeptide 0.86018
GAST gastrin 0.799513
GH1 growth hormone 1 0.781888
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 0.771661
ENO2 enolase 2 (gamma, neuronal) 0.764718
CORT cortistatin 0.748424
GHSR growth hormone secretagogue receptor 0.745578
AVPR1A arginine vasopressin receptor 1A 0.707961
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 0.697911
SCG5 secretogranin V 0.682294
SHBG sex hormone-binding globulin 0.632777
VWF von Willebrand factor 0.610448
GHR growth hormone receptor 0.575772
SSTR4 somatostatin receptor 4 0.572662
PTH parathyroid hormone 0.555568
LRRC75A-AS1 LRRC75A antisense RNA 1 0.554791
CRHR1 corticotropin releasing hormone receptor 1 0.546256
ALPPL2 alkaline phosphatase, placental-like 2 0.529608
ALPP alkaline phosphatase, placental 0.529222
ALPL alkaline phosphatase, liver/bone/kidney 0.528835
F8 coagulation factor VIII, procoagulant component 0.516879
MC4R melanocortin 4 receptor 0.514956
LHCGR luteinizing hormone/choriogonadotropin receptor 0.505356
IGF2 insulin-like growth factor 2 0.494648
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 0.484364
SNED1 sushi, nidogen and EGF-like domains 1 0.476014
MC3R melanocortin 3 receptor 0.451078
UFC1 ubiquitin-fold modifier conjugating enzyme 1 0.448064
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 0.44129
TP53 tumor protein p53 0.437154
CYB5A cytochrome b5 type A (microsomal) 0.435275
FDX1 ferredoxin 1 0.431894
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.413527
NPS neuropeptide S 0.411283
PGR progesterone receptor 0.401199
NPPA natriuretic peptide A 0.390025
VIP vasoactive intestinal peptide 0.389653
PPARG peroxisome proliferator-activated receptor gamma 0.385565
TSC22D3 TSC22 domain family, member 3 0.350084
NPY neuropeptide Y 0.342372
BMP4 bone morphogenetic protein 4 0.340173
MGP matrix Gla protein 0.337242
AGRP agouti related neuropeptide 0.335412
CLASP2 cytoplasmic linker associated protein 2 0.334315
INHA inhibin, alpha 0.33066
MRGPRX2 MAS-related GPR, member X2 0.3292
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta 0.326281
F10 coagulation factor X 0.317909
PCSK2 proprotein convertase subtilisin/kexin type 2 0.313915
TXN2 thioredoxin 2 0.300173
GAL galanin/GMAP prepropeptide 0.293694
PCSK1 proprotein convertase subtilisin/kexin type 1 0.291539
IL6 interleukin 6 0.267977
ALB albumin 0.265494
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.249608
DRD2 dopamine receptor D2 0.246448
TXNIP thioredoxin interacting protein 0.240847
HDAC2 histone deacetylase 2 0.240497
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta 0.237357
PGK1 phosphoglycerate kinase 1 0.232142
RET ret proto-oncogene 0.221793
FOXRED1 FAD-dependent oxidoreductase domain containing 1 0.218715
INSR insulin receptor 0.217693
PLG plasminogen 0.214636
SSR2 signal sequence receptor, beta (translocon-associated protein beta) 0.212271
LPL lipoprotein lipase 0.211597
NR5A1 nuclear receptor subfamily 5, group A, member 1 0.210589
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 0.203933
LIFR leukemia inhibitory factor receptor alpha 0.199681
POR P450 (cytochrome) oxidoreductase 0.190786
TM4SF5 transmembrane 4 L six family member 5 0.188938
MKI67 marker of proliferation Ki-67 0.180367
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae) 0.175146
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 0.175146
COL1A2 collagen, type I, alpha 2 0.174881
MLANA melan-A 0.173571
F3 coagulation factor III (thromboplastin, tissue factor) 0.173314
SSTR3 somatostatin receptor 3 0.170789
CREB1 cAMP responsive element binding protein 1 0.166544
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.162908
CEL carboxyl ester lipase 0.160948
LRRC25 leucine rich repeat containing 25 0.160948