crohn's disease Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description An intestinal disease that involves inflammation located_in intestine. (Human Disease Ontology, DOID_8778)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:8778
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Genes

252 genes associated with the disease crohn's disease in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
NOD2 nucleotide-binding oligomerization domain containing 2 3.51446
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 2.78762
IL23R interleukin 23 receptor 2.76758
CARD9 caspase recruitment domain family, member 9 2.37834
ZMIZ1 zinc finger, MIZ-type containing 1 2.28171
SNX20 sorting nexin 20 2.24775
SBNO2 strawberry notch homolog 2 (Drosophila) 2.0635
LACC1 laccase (multicopper oxidoreductase) domain containing 1 2.05547
C5ORF56 chromosome 5 open reading frame 56 2.02959
SMAD3 SMAD family member 3 1.97455
GPR65 G protein-coupled receptor 65 1.93435
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 1.90552
MST1 macrophage stimulating 1 1.89195
KSR1 kinase suppressor of ras 1 1.88168
SP140 SP140 nuclear body protein 1.8787
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 1.86468
NKX2-3 NK2 homeobox 3 1.85801
UBE2L3 ubiquitin-conjugating enzyme E2L 3 1.84833
PTPN2 protein tyrosine phosphatase, non-receptor type 2 1.84063
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 1.83309
FUT2 fucosyltransferase 2 (secretor status included) 1.83309
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.82268
ZGPAT zinc finger, CCCH-type with G patch domain 1.81431
AMT aminomethyltransferase 1.81257
THADA thyroid adenoma associated 1.77455
LOC285626 uncharacterized LOC285626 1.75531
SCAMP3 secretory carrier membrane protein 3 1.7256
FGFR1OP FGFR1 oncogene partner 1.69467
TYK2 tyrosine kinase 2 1.69467
BANK1 B-cell scaffold protein with ankyrin repeats 1 1.68078
IL18RAP interleukin 18 receptor accessory protein 1.68078
ATG16L2 autophagy related 16-like 2 (S. cerevisiae) 1.67551
BTNL2 butyrophilin-like 2 1.67004
BSN bassoon presynaptic cytomatrix protein 1.66545
ANKRD55 ankyrin repeat domain 55 1.6622
RNASET2 ribonuclease T2 1.64426
PUS10 pseudouridylate synthase 10 1.63837
TMEM258 transmembrane protein 258 1.62029
CLN3 ceroid-lipofuscinosis, neuronal 3 1.62029
GCKR glucokinase (hexokinase 4) regulator 1.59609
ERAP2 endoplasmic reticulum aminopeptidase 2 1.57556
PPP5C protein phosphatase 5, catalytic subunit 1.55738
RSPO3 R-spondin 3 1.53704
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 1.52341
KIF21B kinesin family member 21B 1.51596
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 1.51254
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 1.51254
ITLN1 intelectin 1 (galactofuranose binding) 1.50906
RTEL1 regulator of telomere elongation helicase 1 1.50085
IL2RA interleukin 2 receptor, alpha 1.47287
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 1.46358
PLCL1 phospholipase C-like 1 1.46277
JAZF1 JAZF zinc finger 1 1.46277
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 1.45471
CPEB4 cytoplasmic polyadenylation element binding protein 4 1.45471
PER3 period circadian clock 3 1.44134
ZNF365 zinc finger protein 365 1.44134
SLC22A23 solute carrier family 22, member 23 1.44134
ELF1 E74-like factor 1 (ets domain transcription factor) 1.43537
CCNY cyclin Y 1.43513
TEX9 testis expressed 9 1.43125
DENND1B DENN/MADD domain containing 1B 1.42967
MLN motilin 1.42467
APEH acylaminoacyl-peptide hydrolase 1.41417
NKD1 naked cuticle homolog 1 (Drosophila) 1.39473
SLAIN2 SLAIN motif family, member 2 1.39396
PTRF polymerase I and transcript release factor 1.37327
SKAP2 src kinase associated phosphoprotein 2 1.37327
CYLD cylindromatosis (turban tumor syndrome) 1.37061
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 1.36436
JAK2 Janus kinase 2 1.35423
TCTA T-cell leukemia translocation altered 1.30936
LINC00284 long intergenic non-protein coding RNA 284 1.30261
C1ORF141 chromosome 1 open reading frame 141 1.28906
C1ORF106 chromosome 1 open reading frame 106 1.28906
OSBPL3 oxysterol binding protein-like 3 1.28906
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 1.28597
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 1.27567
NOTCH1 notch 1 1.274
LYRM4 LYR motif containing 4 1.26211
RHOA ras homolog family member A 1.25987
FCHSD2 FCH and double SH3 domains 2 1.25477
NICN1 nicolin 1 1.25259
BCAS3 breast carcinoma amplified sequence 3 1.24044
CD244 CD244 molecule, natural killer cell receptor 2B4 1.23034
PSORS1C3 psoriasis susceptibility 1 candidate 3 (non-protein coding) 1.21996
GRK5 G protein-coupled receptor kinase 5 1.19723
C6ORF10 chromosome 6 open reading frame 10 1.1764
USP4 ubiquitin specific peptidase 4 (proto-oncogene) 1.17539
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6 1.17002
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1 1.15017
LOC285484 uncharacterized LOC285484 1.11453
NELL1 NEL-like 1 (chicken) 1.10764
ITGA9 integrin, alpha 9 1.10659
BSN-AS2 BSN antisense RNA 2 (head to head) 1.1012
HLA-DOB major histocompatibility complex, class II, DO beta 1.10088
WDR78 WD repeat domain 78 1.08934
CDC42SE2 CDC42 small effector 2 1.08832
WDR27 WD repeat domain 27 1.08211
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 1.0793
LDLRAD3 low density lipoprotein receptor class A domain containing 3 1.0725
IL3 interleukin 3 1.07221
MYH16 myosin, heavy chain 16 pseudogene 1.06483
CARD8 caspase recruitment domain family, member 8 1.05056
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 1.02945
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 1.02476
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 1.02476
TMEM47 transmembrane protein 47 1.02407
MIER1 mesoderm induction early response 1, transcriptional regulator 1.02182
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 1.02138
IQCB1 IQ motif containing B1 1.01789
ACSL6 acyl-CoA synthetase long-chain family member 6 1.01577
ZDHHC23 zinc finger, DHHC-type containing 23 1.00407
ZBTB16 zinc finger and BTB domain containing 16 0.989716
F11 coagulation factor XI 0.989546
CAPZB capping protein (actin filament) muscle Z-line, beta 0.986376
CCDC169 coiled-coil domain containing 169 0.983144
GPSM3 G-protein signaling modulator 3 0.979244
LOC728637 0.977726
RUNX3 runt-related transcription factor 3 0.971169
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.96977
FAM92B family with sequence similarity 92, member B 0.963873
ANKRD44 ankyrin repeat domain 44 0.960778
ZNF664-FAM101A filamin-interacting protein FAM101A 0.959568
TRAIP TRAF interacting protein 0.948266
CCDC38 coiled-coil domain containing 38 0.938237
CAMKV CaM kinase-like vesicle-associated 0.926808
RALGDS ral guanine nucleotide dissociation stimulator 0.918185
IP6K1 inositol hexakisphosphate kinase 1 0.911472
AKAP13 A kinase (PRKA) anchor protein 13 0.898875
NCF4 neutrophil cytosolic factor 4, 40kDa 0.895671
SUGT1P3 SUGT1 pseudogene 3 0.895671
PRIM2 primase, DNA, polypeptide 2 (58kDa) 0.892579
FNIP1 folliculin interacting protein 1 0.891373
ZFPM2 zinc finger protein, FOG family member 2 0.886521
TTC6 tetratricopeptide repeat domain 6 0.886521
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.884624
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.882152
BATF basic leucine zipper transcription factor, ATF-like 0.866472
IL1R2 interleukin 1 receptor, type II 0.865959
BRD2 bromodomain containing 2 0.862937
MUC21 mucin 21, cell surface associated 0.856323
MST1R macrophage stimulating 1 receptor 0.850354
PRPF18 pre-mRNA processing factor 18 0.844278
RADIL Ras association and DIL domains 0.839855
FREM2 FRAS1 related extracellular matrix protein 2 0.831584
MON1A MON1 secretory trafficking family member A 0.823134
ZNF532 zinc finger protein 532 0.821119
COL11A2 collagen, type XI, alpha 2 0.812707
FDPS farnesyl diphosphate synthase 0.801304
ROR1 receptor tyrosine kinase-like orphan receptor 1 0.789873
RHOU ras homolog family member U 0.787593
NOTCH4 notch 4 0.785677
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.78442
DZIP1 DAZ interacting zinc finger protein 1 0.782256
EPHB2 EPH receptor B2 0.781342
COL23A1 collagen, type XXIII, alpha 1 0.764084
TET2 tet methylcytosine dioxygenase 2 0.763226
CHSY3 chondroitin sulfate synthase 3 0.762092
KAZN kazrin, periplakin interacting protein 0.75931
SPON1 spondin 1, extracellular matrix protein 0.756867
SORCS2 sortilin-related VPS10 domain containing receptor 2 0.756598
TNXB tenascin XB 0.752656
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 0.751885
GSDMB gasdermin B 0.751885
ATRNL1 attractin-like 1 0.748856
CCDC91 coiled-coil domain containing 91 0.747619
SCN3A sodium channel, voltage gated, type III alpha subunit 0.74567
HLA-DPB2 major histocompatibility complex, class II, DP beta 2 (pseudogene) 0.740032
CLSTN2 calsyntenin 2 0.738669
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 0.733819
VAMP3 vesicle-associated membrane protein 3 0.720109
MACROD2 MACRO domain containing 2 0.713952
RNF5 ring finger protein 5, E3 ubiquitin protein ligase 0.688304
FBXL13 F-box and leucine-rich repeat protein 13 0.687994
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 0.687839
HPSE2 heparanase 2 (inactive) 0.686001
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.681401
SORCS1 sortilin-related VPS10 domain containing receptor 1 0.676587
BCL9 B-cell CLL/lymphoma 9 0.670567
POU5F1 POU class 5 homeobox 1 0.669849
LDLRAD4 low density lipoprotein receptor class A domain containing 4 0.668836
MAML2 mastermind-like 2 (Drosophila) 0.650844
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 0.644215
TCF19 transcription factor 19 0.640498
AGER advanced glycosylation end product-specific receptor 0.636511
TAGAP T-cell activation RhoGTPase activating protein 0.632771
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 0.625701
GPC6 glypican 6 0.621951
KAT6B K(lysine) acetyltransferase 6B 0.618434
MB21D2 Mab-21 domain containing 2 0.618434
SLC9A4 solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4 0.614068
CCHCR1 coiled-coil alpha-helical rod protein 1 0.613378
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.613036
ARHGAP19 Rho GTPase activating protein 19 0.59964
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.59964
CLUL1 clusterin-like 1 (retinal) 0.59964
VSTM4 V-set and transmembrane domain containing 4 0.591358
CHD9 chromodomain helicase DNA binding protein 9 0.590323
RAB6B RAB6B, member RAS oncogene family 0.588801
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.586345
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.583982
TEX41 testis expressed 41 (non-protein coding) 0.583982
CSMD1 CUB and Sushi multiple domains 1 0.583982
ZNF311 zinc finger protein 311 0.583982
CD36 CD36 molecule (thrombospondin receptor) 0.57934
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 0.576144
SULF2 sulfatase 2 0.575922
MTMR3 myotubularin related protein 3 0.572885
QPCT glutaminyl-peptide cyclotransferase 0.570595
CFB complement factor B 0.567015
NPAS3 neuronal PAS domain protein 3 0.560918
GDPD4 glycerophosphodiester phosphodiesterase domain containing 4 0.55372
CCDC85A coiled-coil domain containing 85A 0.552035
HLA-DRA major histocompatibility complex, class II, DR alpha 0.550555
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.550393
FHIT fragile histidine triad 0.550393
MARCH11 membrane-associated ring finger (C3HC4) 11 0.549747
SRPK1 SRSF protein kinase 1 0.548003
COL19A1 collagen, type XIX, alpha 1 0.545697
SLC14A2 solute carrier family 14 (urea transporter), member 2 0.542589
TUBD1 tubulin, delta 1 0.538539
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 0.533352
MIPEP mitochondrial intermediate peptidase 0.531226
FERMT1 fermitin family member 1 0.53006
PDE8A phosphodiesterase 8A 0.529931
TEK TEK tyrosine kinase, endothelial 0.527413
HLA-C major histocompatibility complex, class I, C 0.523564
LPPR5 lipid phosphate phosphatase-related protein type 5 0.520364
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.519258
NOS2 nitric oxide synthase 2, inducible 0.516677
DNAH11 dynein, axonemal, heavy chain 11 0.516047
NPSR1 neuropeptide S receptor 1 0.516047
COL25A1 collagen, type XXV, alpha 1 0.515216
CNTNAP5 contactin associated protein-like 5 0.514498
GRM5 glutamate receptor, metabotropic 5 0.51399
SCUBE3 signal peptide, CUB domain, EGF-like 3 0.513486
ITGB6 integrin, beta 6 0.512985
AGBL4 ATP/GTP binding protein-like 4 0.508182
FAM188A family with sequence similarity 188, member A 0.508182
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 0.507322
RAB12 RAB12, member RAS oncogene family 0.506603
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 0.505894
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 0.504026
MYO5B myosin VB 0.502485
WDR46 WD repeat domain 46 0.502353
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.501829
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.500542
SIDT1 SID1 transmembrane family, member 1 0.500542
DSCAM Down syndrome cell adhesion molecule 0.499285
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.498668
SGCZ sarcoglycan, zeta 0.498668