cortical actin cytoskeleton Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane. (Gene Ontology, GO_0030864)
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Genes

282 proteins co-occuring with the cortical actin cytoskeleton cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
EPB41 erythrocyte membrane protein band 4.1 3.03686
ANK1 ankyrin 1, erythrocytic 3.00073
SPTB spectrin, beta, erythrocytic 2.82271
SPTA1 spectrin, alpha, erythrocytic 1 1.99262
SPTAN1 spectrin, alpha, non-erythrocytic 1 1.95091
DMD dystrophin 1.91048
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 1.84497
DNM2 dynamin 2 1.7187
CAST calpastatin 1.5972
GYPE glycophorin E (MNS blood group) 1.51864
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 1.50961
SPTBN1 spectrin, beta, non-erythrocytic 1 1.49944
ANK2 ankyrin 2, neuronal 1.48984
CALM3 calmodulin 3 (phosphorylase kinase, delta) 1.4198
CALM2 calmodulin 2 (phosphorylase kinase, delta) 1.4198
CALM1 calmodulin 1 (phosphorylase kinase, delta) 1.41923
PLS1 plastin 1 1.30604
DMTN dematin actin binding protein 1.27133
UTRN utrophin 1.25495
SPTBN2 spectrin, beta, non-erythrocytic 2 1.24602
EPB41L1 erythrocyte membrane protein band 4.1-like 1 1.24079
ADD2 adducin 2 (beta) 1.22153
EPB41L2 erythrocyte membrane protein band 4.1-like 2 1.18646
TPM1 tropomyosin 1 (alpha) 1.18338
SYNE1 spectrin repeat containing, nuclear envelope 1 1.17927
SPTBN4 spectrin, beta, non-erythrocytic 4 1.16184
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.14239
ADD1 adducin 1 (alpha) 1.12756
VCL vinculin 1.11429
GYPC glycophorin C (Gerbich blood group) 1.10613
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.05539
PLEK pleckstrin 0.999068
EZR ezrin 0.986342
CAPN2 calpain 2, (m/II) large subunit 0.970814
MACF1 microtubule-actin crosslinking factor 1 0.961187
RDX radixin 0.924197
MSN moesin 0.923259
ACTN2 actinin, alpha 2 0.922322
CSN1S1 casein alpha s1 0.90739
NFASC neurofascin 0.90321
TMOD1 tropomodulin 1 0.894406
EPB42 erythrocyte membrane protein band 4.2 0.890707
SYN1 synapsin I 0.881016
KALRN kalirin, RhoGEF kinase 0.825877
SPTBN5 spectrin, beta, non-erythrocytic 5 0.783698
PFN4 profilin family, member 4 0.778212
DNAH8 dynein, axonemal, heavy chain 8 0.774101
PFN2 profilin 2 0.761342
SLC4A3 solute carrier family 4 (anion exchanger), member 3 0.753623
PFN1 profilin 1 0.741416
ADD3 adducin 3 (gamma) 0.739614
MARCKS myristoylated alanine-rich protein kinase C substrate 0.73018
ACTN4 actinin, alpha 4 0.729732
MCF2 MCF.2 cell line derived transforming sequence 0.713682
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.712351
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.707039
GSN gelsolin 0.691202
CDC42 cell division cycle 42 0.67463
TTN titin 0.643572
WAS Wiskott-Aldrich syndrome 0.643144
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.642715
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.640573
MAP2 microtubule-associated protein 2 0.640573
CDK5 cyclin-dependent kinase 5 0.632024
CTTN cortactin 0.620529
SYNE3 spectrin repeat containing, nuclear envelope family member 3 0.61968
ACTG1 actin gamma 1 0.617982
NRCAM neuronal cell adhesion molecule 0.606973
ACTN1 actinin, alpha 1 0.604017
DST dystonin 0.578416
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.577999
SESTD1 SEC14 and spectrin domains 1 0.575495
AMPH amphiphysin 0.565092
UBC ubiquitin C 0.553078
RHAG Rh-associated glycoprotein 0.552664
DCTN1 dynactin 1 0.548122
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.533309
RPS27A ribosomal protein S27a 0.528388
TMOD4 tropomodulin 4 (muscle) 0.527569
FLNA filamin A, alpha 0.524294
UBB ubiquitin B 0.512047
MYO7A myosin VIIA 0.508383
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.499447
GAS2 growth arrest-specific 2 0.492966
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3 0.490944
ANXA2 annexin A2 0.478038
CAMSAP1 calmodulin regulated spectrin-associated protein 1 0.476831
TRPC4 transient receptor potential cation channel, subfamily C, member 4 0.476429
IQGAP1 IQ motif containing GTPase activating protein 1 0.474018
PDLIM3 PDZ and LIM domain 3 0.472813
ZNF251 zinc finger protein 251 0.472011
PAM peptidylglycine alpha-amidating monooxygenase 0.466399
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.450836
ARHGAP44 Rho GTPase activating protein 44 0.449643
STOM stomatin 0.448451
FMN1 formin 1 0.448451
ZNF333 zinc finger protein 333 0.447656
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.445275
ALB albumin 0.438146
GSTA3 glutathione S-transferase alpha 3 0.434196
GSTA2 glutathione S-transferase alpha 2 0.432618
GSTA4 glutathione S-transferase alpha 4 0.432224
FCHSD1 FCH and double SH3 domains 1 0.431041
GSTA1 glutathione S-transferase alpha 1 0.430253
AHNAK AHNAK nucleoprotein 0.429859
DSP desmoplakin 0.429465
TUBA1A tubulin, alpha 1a 0.421212
RHBG Rh family, B glycoprotein (gene/pseudogene) 0.417685
ACHE acetylcholinesterase (Yt blood group) 0.415337
ACTB actin, beta 0.414946
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 0.414555
L1CAM L1 cell adhesion molecule 0.413382
POU3F4 POU class 3 homeobox 4 0.413382
FLOT2 flotillin 2 0.412992
PCDH15 protocadherin-related 15 0.403637
PKLR pyruvate kinase, liver and RBC 0.401693
PRDX2 peroxiredoxin 2 0.393162
FYN FYN proto-oncogene, Src family tyrosine kinase 0.391615
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.391615
G6PD glucose-6-phosphate dehydrogenase 0.389296
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 0.386593
PTBP3 polypyrimidine tract binding protein 3 0.386208
IPCEF1 interaction protein for cytohesin exchange factors 1 0.384665
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit 0.383895
MAPT microtubule-associated protein tau 0.383509
KNCN kinocilin 0.381969
EMD emerin 0.378891
FN1 fibronectin 1 0.363567
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.360896
LDB3 LIM domain binding 3 0.356324
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 0.355944
FSCN1 fascin actin-bundling protein 1 0.355563
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 0.350622
INA internexin neuronal intermediate filament protein, alpha 0.348346
BCAM basal cell adhesion molecule (Lutheran blood group) 0.333225
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 0.333225
VASP vasodilator-stimulated phosphoprotein 0.329084
ATP11A ATPase, class VI, type 11A 0.329084
MAP1B microtubule-associated protein 1B 0.328332
ARF6 ADP-ribosylation factor 6 0.327205
PRX periaxin 0.327205
LMNA lamin A/C 0.326453
C6ORF15 chromosome 6 open reading frame 15 0.325702
PKM pyruvate kinase, muscle 0.324951
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.324576
SORBS3 sorbin and SH3 domain containing 3 0.324201
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 0.322325
JUP junction plakoglobin 0.317082
FANCA Fanconi anemia, complementation group A 0.31596
MYLK myosin light chain kinase 0.309613
TMOD3 tropomodulin 3 (ubiquitous) 0.308867
MYH1 myosin, heavy chain 1, skeletal muscle, adult 0.308122
TJP1 tight junction protein 1 0.307377
CPAMD8 C3 and PZP-like, alpha-2-macroglobulin domain containing 8 0.307004
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.302168
MYO5A myosin VA (heavy chain 12, myoxin) 0.29994
SH3PXD2A SH3 and PX domains 2A 0.298084
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 0.297713
COBL cordon-bleu WH2 repeat protein 0.296972
PYHIN1 pyrin and HIN domain family, member 1 0.289569
DPYSL2 dihydropyrimidinase-like 2 0.283663
ARL14 ADP-ribosylation factor-like 14 0.281085
PLA2G1B phospholipase A2, group IB (pancreas) 0.281085
CAPNS1 calpain, small subunit 1 0.280349
GLDN gliomedin 0.278141
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.276671
MAP4 microtubule-associated protein 4 0.273734
CNTNAP1 contactin associated protein 1 0.273367
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 0.2708
HBE1 hemoglobin, epsilon 1 0.269701
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) 0.269335
LDHD lactate dehydrogenase D 0.267871
JMY junction mediating and regulatory protein, p53 cofactor 0.267871
PPL periplakin 0.267505
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 0.265311
FRMD3 FERM domain containing 3 0.26166
NPTXR neuronal pentraxin receptor 0.261296
PCDH19 protocadherin 19 0.260931
SSH3 slingshot protein phosphatase 3 0.259837
CALD1 caldesmon 1 0.258381
LIN52 lin-52 DREAM MuvB core complex component 0.256561
MYO1C myosin IC 0.256561
VAV1 vav 1 guanine nucleotide exchange factor 0.255107
ARHGAP5 Rho GTPase activating protein 5 0.252927
ANKRD26 ankyrin repeat domain 26 0.252564
EXOC1 exocyst complex component 1 0.251839
ARHGAP24 Rho GTPase activating protein 24 0.246769
ANXA1 annexin A1 0.245685
CALB1 calbindin 1, 28kDa 0.245685
MGAM maltase-glucoamylase 0.244962
SCN1A sodium channel, voltage gated, type I alpha subunit 0.244601
NCKAP1L NCK-associated protein 1-like 0.241356
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 0.240636
THAP3 THAP domain containing, apoptosis associated protein 3 0.238478
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.237042
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.236683
ARX aristaless related homeobox 0.234533
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.234174
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.233817
NEXN nexilin (F actin binding protein) 0.233101
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome 0.229532
EPB41L4A erythrocyte membrane protein band 4.1 like 4A 0.227752
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 0.226331
HSPA4 heat shock 70kDa protein 4 0.221378
ANXA6 annexin A6 0.219969
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.218914
SPIRE1 spire-type actin nucleation factor 1 0.215761
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma 0.215761
XK X-linked Kx blood group 0.214366
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 0.213322
DAND5 DAN domain family member 5, BMP antagonist 0.211933
AQP1 aquaporin 1 (Colton blood group) 0.211587
FCHSD2 FCH and double SH3 domains 2 0.210203
MCF2L MCF.2 cell line derived transforming sequence-like 0.210203
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 0.209513
GBP1 guanylate binding protein 1, interferon-inducible 0.209169
BAX BCL2-associated X protein 0.207108
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3 0.205059
LYN LYN proto-oncogene, Src family tyrosine kinase 0.201672
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.201335
WDR1 WD repeat domain 1 0.200328
PKP4 plakophilin 4 0.200328
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 0.199325
WIPF1 WAS/WASL interacting protein family, member 1 0.199325
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 0.198658
MYO1H myosin IH 0.197662
NGF nerve growth factor (beta polypeptide) 0.195681
ACT actin-like protein (ACT) gene 0.195353
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.195353
GFAP glial fibrillary acidic protein 0.195025
PLEK2 pleckstrin 2 0.194698
TRPC5 transient receptor potential cation channel, subfamily C, member 5 0.194371
DBN1 drebrin 1 0.194045
LST1 leukocyte specific transcript 1 0.193719
POTEF POTE ankyrin domain family, member F 0.19307
LAMA2 laminin, alpha 2 0.19307
FANCC Fanconi anemia, complementation group C 0.192746
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.189857
FLNC filamin C, gamma 0.187333
TMEM53 transmembrane protein 53 0.184853
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22 0.183935
OAF OAF homolog (Drosophila) 0.183631
MYO1B myosin IB 0.183631
SCN8A sodium channel, voltage gated, type VIII alpha subunit 0.182422
CLIC4 chloride intracellular channel 4 0.182422
CLMN calmin (calponin-like, transmembrane) 0.181823
FLOT1 flotillin 1 0.178877
PXN paxillin 0.178588
FSCN3 fascin actin-bundling protein 3, testicular 0.17687
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase 0.176305
COX7B cytochrome c oxidase subunit VIIb 0.174911
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.174911
ZFYVE1 zinc finger, FYVE domain containing 1 0.173814
RAI14 retinoic acid induced 14 0.172201
CAPN10 calpain 10 0.171673
FTL ferritin, light polypeptide 0.171673
CD47 CD47 molecule 0.17141
WASL Wiskott-Aldrich syndrome-like 0.170888
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 0.170371
FTH1 ferritin, heavy polypeptide 1 0.170371
TENM2 teneurin transmembrane protein 2 0.170114
EVL Enah/Vasp-like 0.170114
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.169859
TMOD2 tropomodulin 2 (neuronal) 0.168847
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 0.167856
FSCN2 fascin actin-bundling protein 2, retinal 0.167366
EVPL envoplakin 0.165932
TJP2 tight junction protein 2 0.165
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.1632
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 0.162763
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived) 0.161693
PLEKHG4 pleckstrin homology domain containing, family G (with RhoGef domain) member 4 0.160863
PLEC plectin 0.160658
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10 0.160053
MST1 macrophage stimulating 1 0.159462
NUMA1 nuclear mitotic apparatus protein 1 0.159268
TSPAN2 tetraspanin 2 0.158692
HBB hemoglobin, beta 0.158692
NF2 neurofibromin 2 (merlin) 0.158502
CADM4 cell adhesion molecule 4 0.158502
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.157578
NEFL neurofilament, light polypeptide 0.156513