coronary disease Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles. (Human Disease Ontology, DOID_3393)
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Genes

196 genes associated with the disease coronary disease in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8
ACE angiotensin I converting enzyme
ACTN1 actinin, alpha 1
AGTR1 angiotensin II receptor, type 1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ALX4 ALX homeobox 4
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
APOA4 apolipoprotein A-IV
APOA5 apolipoprotein A-V
APOB apolipoprotein B
APOC1 apolipoprotein C-I
APOC2 apolipoprotein C-II
APOC3 apolipoprotein C-III
APOC4 apolipoprotein C-IV
APOE apolipoprotein E
APOM apolipoprotein M
ASB2 ankyrin repeat and SOCS box containing 2
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
ATP8B4 ATPase, class I, type 8B, member 4
AUTS2 autism susceptibility candidate 2
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
C2 complement component 2
C3 complement component 3
CAMTA1 calmodulin binding transcription activator 1
CAPN10 calpain 10
CAT catalase
CDH13 cadherin 13
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CETP cholesteryl ester transfer protein, plasma
CFB complement factor B
CFD complement factor D (adipsin)
CFH complement factor H
CLASP1 cytoplasmic linker associated protein 1
CLMN calmin (calponin-like, transmembrane)
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2
CPB2 carboxypeptidase B2 (plasma)
CRP C-reactive protein, pentraxin-related
CSMD1 CUB and Sushi multiple domains 1
CTR9 CTR9, Paf1/RNA polymerase II complex component
CTSS cathepsin S
CWC27 CWC27 spliceosome-associated protein homolog (S. cerevisiae)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
CYBA cytochrome b-245, alpha polypeptide
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
DENND1A DENN/MADD domain containing 1A
DNM2 dynamin 2
DOCK6 dedicator of cytokinesis 6
DTNB dystrobrevin, beta
E2F4 E2F transcription factor 4, p107/p130-binding
EBF2 early B-cell factor 2
EDC4 enhancer of mRNA decapping 4
EXOC3L1 exocyst complex component 3-like 1
EXT2 exostosin glycosyltransferase 2
F2 coagulation factor II (thrombin)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FGB fibrinogen beta chain
FMN2 formin 2
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FTO fat mass and obesity associated
G6PD glucose-6-phosphate dehydrogenase
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GCOM1 GRINL1A complex locus 1
GHRL ghrelin/obestatin prepropeptide
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GSK3A glycogen synthase kinase 3 alpha
GSTM1 glutathione S-transferase mu 1
GSTM3 glutathione S-transferase mu 3 (brain)
GSTM4 glutathione S-transferase mu 4
GSTM5 glutathione S-transferase mu 5
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HHEX hematopoietically expressed homeobox
HMOX1 heme oxygenase 1
HNF1A HNF1 homeobox A
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ICAM1 intercellular adhesion molecule 1
IFNG interferon, gamma
IGSF5 immunoglobulin superfamily, member 5
IL10 interleukin 10
IL18RAP interleukin 18 receptor accessory protein
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL6 interleukin 6
IL6R interleukin 6 receptor
IL6ST interleukin 6 signal transducer
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KAZN kazrin, periplakin interacting protein
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KCTD12 potassium channel tetramerization domain containing 12
KIF26B kinesin family member 26B
KLHL29 kelch-like family member 29
LAMC2 laminin, gamma 2
LDLR low density lipoprotein receptor
LEPR leptin receptor
LGI2 leucine-rich repeat LGI family, member 2
LIPC lipase, hepatic
LIPE lipase, hormone-sensitive
LITAF lipopolysaccharide-induced TNF factor
LPA lipoprotein, Lp(a)
LPAR3 lysophosphatidic acid receptor 3
LPL lipoprotein lipase
LRP1 low density lipoprotein receptor-related protein 1
LRP5 low density lipoprotein receptor-related protein 5
LTA lymphotoxin alpha
MAOA monoamine oxidase A
MCTP2 multiple C2 domains, transmembrane 2
MIA3 melanoma inhibitory activity family, member 3
MMP26 matrix metallopeptidase 26
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MYD88 myeloid differentiation primary response 88
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NES nestin
NEUROG3 neurogenin 3
NLRC5 NLR family, CARD domain containing 5
NOS3 nitric oxide synthase 3 (endothelial cell)
NRXN3 neurexin 3
OPRM1 opioid receptor, mu 1
OR51A7 olfactory receptor, family 51, subfamily A, member 7
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PARVB parvin, beta
PCNXL2 pecanex-like 2 (Drosophila)
PCSK9 proprotein convertase subtilisin/kexin type 9
PDE10A phosphodiesterase 10A
PDE4A phosphodiesterase 4A, cAMP-specific
PDGFD platelet derived growth factor D
PHACTR1 phosphatase and actin regulator 1
PLA2G10 phospholipase A2, group X
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLEKHO2 pleckstrin homology domain containing, family O member 2
PON1 paraoxonase 1
PRDX5 peroxiredoxin 5
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSRC1 proline/serine-rich coiled-coil 1
PTPRD protein tyrosine phosphatase, receptor type, D
PTPRE protein tyrosine phosphatase, receptor type, E
RALYL RALY RNA binding protein-like
RASSF3 Ras association (RalGDS/AF-6) domain family member 3
RBBP4 retinoblastoma binding protein 4
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RNF130 ring finger protein 130
RPA1 replication protein A1, 70kDa
SAMM50 SAMM50 sorting and assembly machinery component
SELE selectin E
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SEZ6L seizure related 6 homolog (mouse)-like
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SIK2 salt-inducible kinase 2
SLC12A9 solute carrier family 12, member 9
SLC30A8 solute carrier family 30 (zinc transporter), member 8
SMAD3 SMAD family member 3
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SOD2 superoxide dismutase 2, mitochondrial
SORCS3 sortilin-related VPS10 domain containing receptor 3
SREBF1 sterol regulatory element binding transcription factor 1
STAB2 stabilin 2
TBL1Y transducin (beta)-like 1, Y-linked
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFEB transcription factor EB
TGFB1 transforming growth factor, beta 1
TGFB3 transforming growth factor, beta 3
TIMP1 TIMP metallopeptidase inhibitor 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TMEM169 transmembrane protein 169
TNF tumor necrosis factor
TNIK TRAF2 and NCK interacting kinase
TPRG1 tumor protein p63 regulated 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
USP9Y ubiquitin specific peptidase 9, Y-linked
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
VIMP VCP-interacting membrane selenoprotein
VWF von Willebrand factor
WWOX WW domain containing oxidoreductase
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
ZBP1 Z-DNA binding protein 1
ZFHX3 zinc finger homeobox 3
ZNF202 zinc finger protein 202
ZNF580 zinc finger protein 580
ZNF581 zinc finger protein 581