coronary artery disease Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles. (Human Disease Ontology, DOID_3393)
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Genes

365 genes associated with the disease coronary artery disease in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8
ABI3BP ABI family, member 3 (NESH) binding protein
ABLIM2 actin binding LIM protein family, member 2
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ACE angiotensin I converting enzyme
ACO1 aconitase 1, soluble
ACOT11 acyl-CoA thioesterase 11
ACSL3 acyl-CoA synthetase long-chain family member 3
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7
ADD1 adducin 1 (alpha)
ADGRV1 adhesion G protein-coupled receptor V1
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AFF1 AF4/FMR2 family, member 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AKAP6 A kinase (PRKA) anchor protein 6
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALK anaplastic lymphoma receptor tyrosine kinase
ALOX15 arachidonate 15-lipoxygenase
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMPD1 adenosine monophosphate deaminase 1
ANGPTL4 angiopoietin-like 4
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ANO3 anoctamin 3
APH1B APH1B gamma secretase subunit
APLNR apelin receptor
APOA1 apolipoprotein A-I
APOA5 apolipoprotein A-V
APOB apolipoprotein B
APOC1 apolipoprotein C-I
APOC2 apolipoprotein C-II
APOC3 apolipoprotein C-III
APOC4 apolipoprotein C-IV
APOE apolipoprotein E
APOF apolipoprotein F
APOM apolipoprotein M
AQP5 aquaporin 5
AR androgen receptor
ARHGAP31 Rho GTPase activating protein 31
ARHGAP42 Rho GTPase activating protein 42
ARL3 ADP-ribosylation factor-like 3
ARSB arylsulfatase B
ASIC2 acid sensing (proton gated) ion channel 2
ASTN2 astrotactin 2
ASZ1 ankyrin repeat, SAM and basic leucine zipper domain containing 1
ATP10D ATPase, class V, type 10D
AURKC aurora kinase C
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BARD1 BRCA1 associated RING domain 1
BCAP29 B-cell receptor-associated protein 29
BCAS1 breast carcinoma amplified sequence 1
BCAS4 breast carcinoma amplified sequence 4
BCCIP BRCA2 and CDKN1A interacting protein
BCHE butyrylcholinesterase
BHMT betaine--homocysteine S-methyltransferase
BTD biotinidase
C10ORF11 chromosome 10 open reading frame 11
C10ORF90 chromosome 10 open reading frame 90
C12ORF43 chromosome 12 open reading frame 43
C12ORF50 chromosome 12 open reading frame 50
C20ORF27 chromosome 20 open reading frame 27
C4ORF33 chromosome 4 open reading frame 33
C5ORF34 chromosome 5 open reading frame 34
C9ORF72 chromosome 9 open reading frame 72
CAMTA1 calmodulin binding transcription activator 1
CARD10 caspase recruitment domain family, member 10
CBS cystathionine-beta-synthase
CCDC60 coiled-coil domain containing 60
CCDC68 coiled-coil domain containing 68
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD86 CD86 molecule
CDH13 cadherin 13
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CELF2 CUGBP, Elav-like family member 2
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CENPQ centromere protein Q
CEP128 centrosomal protein 128kDa
CEP162 centrosomal protein 162kDa
CETP cholesteryl ester transfer protein, plasma
CFH complement factor H
CHDH choline dehydrogenase
CHIT1 chitinase 1 (chitotriosidase)
CHRDL1 chordin-like 1
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2
CNRIP1 cannabinoid receptor interacting protein 1
CNTN3 contactin 3 (plasmacytoma associated)
COL14A1 collagen, type XIV, alpha 1
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CORIN corin, serine peptidase
CRP C-reactive protein, pentraxin-related
CTNNA2 catenin (cadherin-associated protein), alpha 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL16 chemokine (C-X-C motif) ligand 16
CYBA cytochrome b-245, alpha polypeptide
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1
DCAF5 DDB1 and CUL4 associated factor 5
DCHS1 dachsous cadherin-related 1
DDAH2 dimethylarginine dimethylaminohydrolase 2
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DENND1B DENN/MADD domain containing 1B
DHX32 DEAH (Asp-Glu-Ala-His) box polypeptide 32
DIRAS2 DIRAS family, GTP-binding RAS-like 2
DLC1 DLC1 Rho GTPase activating protein
DLGAP1 discs, large (Drosophila) homolog-associated protein 1
DMGDH dimethylglycine dehydrogenase
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13
DOCK9 dedicator of cytokinesis 9
EBF1 early B-cell factor 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHA6 EPH receptor A6
EPHB1 EPH receptor B1
ERCC2 excision repair cross-complementation group 2
ESR1 estrogen receptor 1
F13A1 coagulation factor XIII, A1 polypeptide
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FAM187B family with sequence similarity 187, member B
FAM83B family with sequence similarity 83, member B
FANK1 fibronectin type III and ankyrin repeat domains 1
FBN2 fibrillin 2
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FEN1 flap structure-specific endonuclease 1
FGD6 FYVE, RhoGEF and PH domain containing 6
FGFR1 fibroblast growth factor receptor 1
FHIT fragile histidine triad
FMN2 formin 2
FN1 fibronectin 1
FNDC1 fibronectin type III domain containing 1
FNDC3B fibronectin type III domain containing 3B
FRRS1L ferric-chelate reductase 1-like
FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase)
FYN FYN proto-oncogene, Src family tyrosine kinase
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GATA2 GATA binding protein 2
GCH1 GTP cyclohydrolase 1
GCKR glucokinase (hexokinase 4) regulator
GDNF glial cell derived neurotrophic factor
GHRL ghrelin/obestatin prepropeptide
GJA4 gap junction protein, alpha 4, 37kDa
GMPR guanosine monophosphate reductase
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GOLGA3 golgin A3
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GP6 glycoprotein VI (platelet)
GPC5 glypican 5
GPR158 G protein-coupled receptor 158
GPX1 glutathione peroxidase 1
GSR glutathione reductase
GSTM1 glutathione S-transferase mu 1
GSTT1 glutathione S-transferase theta 1
HACD4 3-hydroxyacyl-CoA dehydratase 4
HDAC9 histone deacetylase 9
HHIPL1 HHIP-like 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMOX1 heme oxygenase 1
HNF1A HNF1 homeobox A
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IL10 interleukin 10
IL16 interleukin 16
IL17A interleukin 17A
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RAP interleukin 1 receptor accessory protein
IL1RN interleukin 1 receptor antagonist
IL4 interleukin 4
IL4R interleukin 4 receptor
IL6 interleukin 6
IL6R interleukin 6 receptor
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRS1 insulin receptor substrate 1
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KALRN kalirin, RhoGEF kinase
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3
KIAA0825 KIAA0825
KIAA1456 KIAA1456
KIAA1462 KIAA1462
KIRREL kin of IRRE like (Drosophila)
LDLR low density lipoprotein receptor
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LHFP lipoma HMGIC fusion partner
LINC01600 long intergenic non-protein coding RNA 1600
LIPA lipase A, lysosomal acid, cholesterol esterase
LIPC lipase, hepatic
LIPG lipase, endothelial
LMAN1 lectin, mannose-binding, 1
LOC400499 uncharacterized LOC400499
LPA lipoprotein, Lp(a)
LPAL2 lipoprotein, Lp(a)-like 2, pseudogene
LPL lipoprotein lipase
LRRC20 leucine rich repeat containing 20
LRRC74A leucine rich repeat containing 74A
LTA lymphotoxin alpha
LY86 lymphocyte antigen 86
MACROD2 MACRO domain containing 2
MARK2 MAP/microtubule affinity-regulating kinase 2
MBL2 mannose-binding lectin (protein C) 2, soluble
MCTP2 multiple C2 domains, transmembrane 2
MEF2A myocyte enhancer factor 2A
MEGF11 multiple EGF-like-domains 11
MEOX2 mesenchyme homeobox 2
MIA3 melanoma inhibitory activity family, member 3
MKL1 megakaryoblastic leukemia (translocation) 1
MLXIPL MLX interacting protein-like
MMP12 matrix metallopeptidase 12
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MRAP2 melanocortin 2 receptor accessory protein 2
MRAS muscle RAS oncogene homolog
MRPL13 mitochondrial ribosomal protein L13
MRPS6 mitochondrial ribosomal protein S6
MTBP MDM2 binding protein
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUT methylmalonyl CoA mutase
MYLIP myosin regulatory light chain interacting protein
MYLK myosin light chain kinase
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle
MYO16 myosin XVI
NAMPT nicotinamide phosphoribosyltransferase
NNT nicotinamide nucleotide transhydrogenase
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NPC1 Niemann-Pick disease, type C1
NPC1L1 NPC1-like 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRXN3 neurexin 3
NUP50 nucleoporin 50kDa
OGG1 8-oxoguanine DNA glycosylase
OLFM4 olfactomedin 4
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
P2RY12 purinergic receptor P2Y, G-protein coupled, 12
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PARK2 parkin RBR E3 ubiquitin protein ligase
PCCA propionyl CoA carboxylase, alpha polypeptide
PCSK9 proprotein convertase subtilisin/kexin type 9
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEBP4 phosphatidylethanolamine-binding protein 4
PECAM1 platelet/endothelial cell adhesion molecule 1
PHACTR1 phosphatase and actin regulator 1
PHLDB2 pleckstrin homology-like domain, family B, member 2
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLAT plasminogen activator, tissue
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1
PLXDC2 plexin domain containing 2
PON1 paraoxonase 1
PON2 paraoxonase 2
PPAP2B phosphatidic acid phosphatase type 2B
PPARA peroxisome proliferator-activated receptor alpha
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPP1R3B protein phosphatase 1, regulatory subunit 3B
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma
PREP prolyl endopeptidase
PRIM2 primase, DNA, polypeptide 2 (58kDa)
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSRC1 proline/serine-rich coiled-coil 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
PTPRG protein tyrosine phosphatase, receptor type, G
RASGRP4 RAS guanyl releasing protein 4
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RBM47 RNA binding motif protein 47
RETN resistin
RGS7 regulator of G-protein signaling 7
RIMS1 regulating synaptic membrane exocytosis 1
SCARB1 scavenger receptor class B, member 1
SCN2A sodium channel, voltage gated, type II alpha subunit
SELE selectin E
SELL selectin L
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SEZ6L seizure related 6 homolog (mouse)-like
SGCZ sarcoglycan, zeta
SH2B3 SH2B adaptor protein 3
SH2D4A SH2 domain containing 4A
SH3RF3 SH3 domain containing ring finger 3
SHBG sex hormone-binding globulin
SHROOM3 shroom family member 3
SLC22A3 solute carrier family 22 (organic cation transporter), member 3
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9
SMAD3 SMAD family member 3
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMG6 SMG6 nonsense mediated mRNA decay factor
SMYD4 SET and MYND domain containing 4
SORBS2 sorbin and SH3 domain containing 2
SORCS2 sortilin-related VPS10 domain containing receptor 2
SORT1 sortilin 1
SPTLC1 serine palmitoyltransferase, long chain base subunit 1
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
ST2 suppression of tumorigenicity 2
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
STK35 serine/threonine kinase 35
SUGCT succinyl-CoA:glutarate-CoA transferase
SVOP SV2 related protein homolog (rat)
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
TCF21 transcription factor 21
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TCTN3 tectonic family member 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THAP2 THAP domain containing, apoptosis associated protein 2
TLR8 toll-like receptor 8
TMEM233 transmembrane protein 233
TMEM245 transmembrane protein 245
TNF tumor necrosis factor
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TOR1A torsin family 1, member A (torsin A)
TOR1B torsin family 1, member B (torsin B)
TRIM9 tripartite motif containing 9
TTC39B tetratricopeptide repeat domain 39B
UBE2Z ubiquitin-conjugating enzyme E2Z
UGT1A12P UDP glucuronosyltransferase 1 family, polypeptide A12 pseudogene
UST uronyl-2-sulfotransferase
VEGFA vascular endothelial growth factor A
VGLL4 vestigial-like family member 4
WDR12 WD repeat domain 12
WDR49 WD repeat domain 49
WWOX WW domain containing oxidoreductase
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZBTB16 zinc finger and BTB domain containing 16
ZC3HC1 zinc finger, C3HC-type containing 1
ZFC3H1 zinc finger, C3H1-type containing
ZNF264 zinc finger protein 264
ZNF334 zinc finger protein 334
ZNF813 zinc finger protein 813
ZPR1 ZPR1 zinc finger