core mediator complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. (Gene Ontology, GO_0070847)
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20 proteins co-occuring with the core mediator complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
CDK8 cyclin-dependent kinase 8 1.78452
MED12 mediator complex subunit 12 1.60185
SUPT7L suppressor of Ty 7 (S. cerevisiae)-like 1.52766
CCNC cyclin C 1.43331
CDK19 cyclin-dependent kinase 19 1.32275
MED13 mediator complex subunit 13 1.30551
MED17 mediator complex subunit 17 1.23766
MED16 mediator complex subunit 16 1.1803
TRRAP transformation/transcription domain-associated protein 1.10307
MED15 mediator complex subunit 15 1.06903
BAZ1A bromodomain adjacent to zinc finger domain, 1A 1.03479
CDK11A cyclin-dependent kinase 11A 0.785986
DHDH dihydrodiol dehydrogenase (dimeric) 0.6638
TPH1 tryptophan hydroxylase 1 0.452427
KAT2B K(lysine) acetyltransferase 2B 0.39471
PF4 platelet factor 4 0.355183
SOX2 SRY (sex determining region Y)-box 2 0.336619
CCL3 chemokine (C-C motif) ligand 3 0.314839
NANOG Nanog homeobox 0.291787
TERT telomerase reverse transcriptase 0.269701