congestive heart failure Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body. (Human Disease Ontology, DOID_6000)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:6000
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Genes

233 genes associated with the disease congestive heart failure in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
KLKB1 kallikrein B, plasma (Fletcher factor) 1 3.1728
IL1RL1 interleukin 1 receptor-like 1 3.00967
IL18RAP interleukin 18 receptor accessory protein 2.42027
IL18R1 interleukin 18 receptor 1 2.36124
SLC9A4 solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4 2.34245
EDN1 endothelin 1 2.21414
NAT8 N-acetyltransferase 8 (GCN5-related, putative) 2.10422
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 2.07725
IL1R1 interleukin 1 receptor, type I 1.99917
IL1RL2 interleukin 1 receptor-like 2 1.91983
SLC35F1 solute carrier family 35, member F1 1.50906
CTNNA3 catenin (cadherin-associated protein), alpha 3 1.34719
TNNT2 troponin T type 2 (cardiac) 1.34719
DENND1B DENN/MADD domain containing 1B 1.28906
TPD52 tumor protein D52 1.28906
CMTM7 CKLF-like MARVEL transmembrane domain containing 7 1.26953
CCL28 chemokine (C-C motif) ligand 28 1.25477
GRID1 glutamate receptor, ionotropic, delta 1 1.21996
BNC2 basonuclin 2 1.21996
CDH15 cadherin 15, type 1, M-cadherin (myotubule) 1.21156
TMEM232 transmembrane protein 232 1.20161
C15ORF54 chromosome 15 open reading frame 54 1.19386
OTUD7A OTU deubiquitinase 7A 1.19386
NTM neurotrimin 1.19386
ICA1 islet cell autoantigen 1, 69kDa 1.19386
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 1.14463
MYO5A myosin VA (heavy chain 12, myoxin) 1.14463
SLCO5A1 solute carrier organic anion transporter family, member 5A1 1.14463
ATP6V1C2 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 1.14463
CADPS Ca++-dependent secretion activator 1.14463
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1 1.14463
WWOX WW domain containing oxidoreductase 1.10764
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa 1.10764
NRG1 neuregulin 1 1.10764
FAM155A family with sequence similarity 155, member A 1.10764
GAS8 growth arrest-specific 8 1.0908
EGFLAM EGF-like, fibronectin type III and laminin G domains 1.08338
SLC44A3 solute carrier family 44, member 3 1.07599
ANKRD6 ankyrin repeat domain 6 1.07599
CNTN1 contactin 1 1.07599
NUGGC nuclear GTPase, germinal center associated 1.07599
PRTFDC1 phosphoribosyl transferase domain containing 1 1.07599
COMMD10 COMM domain containing 10 1.07599
GPM6A glycoprotein M6A 1.07599
DAP death-associated protein 1.04846
LOC100507053 uncharacterized LOC100507053 1.04846
SHB Src homology 2 domain containing adaptor protein B 1.04846
ADGRL2 adhesion G protein-coupled receptor L2 1.02476
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 1.02476
AAK1 AP2 associated kinase 1 1.02476
KIF13B kinesin family member 13B 1.02476
PARVA parvin, alpha 1.00407
BCL2 B-cell CLL/lymphoma 2 1.00407
SORCS1 sortilin-related VPS10 domain containing receptor 1 1.00407
NUP98 nucleoporin 98kDa 1.00407
ISM1 isthmin 1, angiogenesis inhibitor 1.00407
TUBGCP3 tubulin, gamma complex associated protein 3 1.0024
RANBP17 RAN binding protein 17 0.99985
GABRP gamma-aminobutyric acid (GABA) A receptor, pi 0.993169
EYS eyes shut homolog (Drosophila) 0.986376
RELN reelin 0.986376
PRKCE protein kinase C, epsilon 0.986376
IFRD1 interferon-related developmental regulator 1 0.971169
ZNF213 zinc finger protein 213 0.971169
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.971169
CCDC178 coiled-coil domain containing 178 0.971169
USP47 ubiquitin specific peptidase 47 0.962251
TRIM33 tripartite motif containing 33 0.930169
CPM carboxypeptidase M 0.926808
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 0.918934
CNGB3 cyclic nucleotide gated channel beta 3 0.831584
CNOT2 CCR4-NOT transcription complex, subunit 2 0.830304
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.814557
GPR137C G protein-coupled receptor 137C 0.812342
SMAD9 SMAD family member 9 0.804621
CPNE7 copine VII 0.789217
DBN1 drebrin 1 0.78104
SULF2 sulfatase 2 0.728218
CCNJL cyclin J-like 0.725521
GPR39 G protein-coupled receptor 39 0.701544
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.699101
FOXN3 forkhead box N3 0.692585
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.684944
SCIN scinderin 0.684794
BMP6 bone morphogenetic protein 6 0.681401
VSTM1 V-set and transmembrane domain containing 1 0.676587
ATF6 activating transcription factor 6 0.67239
TENM2 teneurin transmembrane protein 2 0.67173
TTC6 tetratricopeptide repeat domain 6 0.660239
SFSWAP splicing factor, suppressor of white-apricot family 0.659337
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.657565
PTPRD protein tyrosine phosphatase, receptor type, D 0.656693
SYNJ2 synaptojanin 2 0.653298
ARNTL aryl hydrocarbon receptor nuclear translocator-like 0.642063
LOC100129620 uncharacterized LOC100129620 0.639985
MTUS2 microtubule associated tumor suppressor candidate 2 0.638972
HIBADH 3-hydroxyisobutyrate dehydrogenase 0.633685
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.632771
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.627273
FOCAD focadhesin 0.627273
KIAA1468 KIAA1468 0.626482
CAMTA1 calmodulin binding transcription activator 1 0.626482
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.622315
KCNU1 potassium channel, subfamily U, member 1 0.62159
LAMC3 laminin, gamma 3 0.61577
STXBP5 syntaxin binding protein 5 (tomosyn) 0.611686
MECOM MDS1 and EVI1 complex locus 0.60781
UPB1 ureidopropionase, beta 0.60781
NCOA7 nuclear receptor coactivator 7 0.606266
GPATCH2 G patch domain containing 2 0.60074
CNTN5 contactin 5 0.599097
ADCY9 adenylate cyclase 9 0.596524
CELF2 CUGBP, Elav-like family member 2 0.594024
DOCK2 dedicator of cytokinesis 2 0.592677
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 0.590838
C9ORF171 chromosome 9 open reading frame 171 0.590323
PIGN phosphatidylinositol glycan anchor biosynthesis, class N 0.589052
C7 complement component 7 0.585627
ANKRD11 ankyrin repeat domain 11 0.584682
ETAA1 Ewing tumor-associated antigen 1 0.584682
FBXL7 F-box and leucine-rich repeat protein 7 0.581481
HS3ST4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 0.58076
ATE1 arginyltransferase 1 0.57934
TGFBR3 transforming growth factor, beta receptor III 0.578411
TNS1 tensin 1 0.577495
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.576816
GLI3 GLI family zinc finger 3 0.575259
CLU clusterin 0.574821
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome 0.573097
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.572043
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19 0.571211
POU2AF1 POU class 2 associating factor 1 0.571211
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.57039
KIRREL3 kin of IRRE like 3 (Drosophila) 0.56878
ARSG arylsulfatase G 0.566821
LRRC69 leucine rich repeat containing 69 0.564921
ANO4 anoctamin 4 0.563808
DOCK8 dedicator of cytokinesis 8 0.563624
STRN3 striatin, calmodulin binding protein 3 0.563041
HCFC2 host cell factor C2 0.559975
ACO1 aconitase 1, soluble 0.559045
ANPEP alanyl (membrane) aminopeptidase 0.558676
E2F3 E2F transcription factor 3 0.558127
SERPINE3 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 0.55355
BIVM basic, immunoglobulin-like variable motif containing 0.552872
CASC15 cancer susceptibility candidate 15 (non-protein coding) 0.552035
BMPER BMP binding endothelial regulator 0.551374
NLRP4 NLR family, pyrin domain containing 4 0.551045
SPEN spen family transcriptional repressor 0.54879
ATXN1 ataxin 1 0.546152
CRNKL1 crooked neck pre-mRNA splicing factor 1 0.545546
NALCN sodium leak channel, non selective 0.545396
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.541821
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 0.541213
ERICH3 glutamate-rich 3 0.539863
LMNTD1 lamin tail domain containing 1 0.539863
STXBP6 syntaxin binding protein 6 (amisyn) 0.539124
PLCL2 phospholipase C-like 2 0.537815
LOC100652894 uncharacterized LOC100652894 0.536813
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa 0.536671
DOCK9 dedicator of cytokinesis 9 0.53653
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 0.535408
KDM4C lysine (K)-specific demethylase 4C 0.534853
ADAM19 ADAM metallopeptidase domain 19 0.534715
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.533894
CDH13 cadherin 13 0.533758
SMYD3 SET and MYND domain containing 3 0.533623
NIPAL4 NIPA-like domain containing 4 0.532414
USP22 ubiquitin specific peptidase 22 0.532016
SDK1 sidekick cell adhesion molecule 1 0.53162
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 0.531226
KIAA1217 KIAA1217 0.530705
AK5 adenylate kinase 5 0.529931
TRAPPC11 trafficking protein particle complex 11 0.529931
PPP1R9B protein phosphatase 1, regulatory subunit 9B 0.528535
ADGRE1 adhesion G protein-coupled receptor E1 0.527166
LARGE like-glycosyltransferase 0.526189
STAMBPL1 STAM binding protein-like 1 0.525946
PRDM7 PR domain containing 7 0.525223
ROR1 receptor tyrosine kinase-like orphan receptor 1 0.523916
FGF14 fibroblast growth factor 14 0.523916
ARHGAP15 Rho GTPase activating protein 15 0.523916
FHIT fragile histidine triad 0.522174
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.520588
MPPED2 metallophosphoesterase domain containing 2 0.520364
SERAC1 serine active site containing 1 0.51992
RGS5 regulator of G-protein signaling 5 0.519588
PLXDC2 plexin domain containing 2 0.519258
NXPH2 neurexophilin 2 0.51817
FRMD6 FERM domain containing 6 0.516782
AHCYL2 adenosylhomocysteinase-like 2 0.516466
PTHLH parathyroid hormone-like hormone 0.51563
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium) 0.515216
LIFR leukemia inhibitory factor receptor alpha 0.513889
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.511996
LYST lysosomal trafficking regulator 0.511702
RHBDL1 rhomboid, veinlet-like 1 (Drosophila) 0.510925
DCLK2 doublecortin-like kinase 2 0.510732
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.510348
ZNF451 zinc finger protein 451 0.509586
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) 0.509397
RASGEF1C RasGEF domain family, member 1C 0.50809
AKAP7 A kinase (PRKA) anchor protein 7 0.507466
TRAPPC9 trafficking protein particle complex 9 0.506176
OSM oncostatin M 0.505613
MOB3B MOB kinase activator 3B 0.504848
GRID2 glutamate receptor, ionotropic, delta 2 0.50471
GAP43 growth associated protein 43 0.504367
SRFBP1 serum response factor binding protein 1 0.50335
NLRP9 NLR family, pyrin domain containing 9 0.502816
STK32A serine/threonine kinase 32A 0.502353
DCBLD1 discoidin, CUB and LCCL domain containing 1 0.502156
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 0.502091
SYCP1 synaptonemal complex protein 1 0.502025
NVL nuclear VCP-like 0.501829
AATK apoptosis-associated tyrosine kinase 0.501375
JADE2 jade family PHD finger 2 0.501375
SDF2L1 stromal cell-derived factor 2-like 1 0.50131
RCL1 RNA terminal phosphate cyclase-like 1 0.50131
DLG2 discs, large homolog 2 (Drosophila) 0.500098
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.499973
ANK2 ankyrin 2, neuronal 0.499847
CCDC108 coiled-coil domain containing 108 0.499597
IQSEC3 IQ motif and Sec7 domain 3 0.499534
MYO16 myosin XVI 0.499472
FAM135B family with sequence similarity 135, member B 0.49941
MUC16 mucin 16, cell surface associated 0.498424
SHC4 SHC (Src homology 2 domain containing) family, member 4 0.497998
TBC1D5 TBC1 domain family, member 5 0.497998
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 0.497877
VWA3B von Willebrand factor A domain containing 3B 0.497817
CDH10 cadherin 10, type 2 (T2-cadherin) 0.496624
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.496447