congenital hypothyroidism Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A hypothyroidism that is present at birth. (Human Disease Ontology, DOID_0050328)
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Genes

114 genes co-occuring with the disease congenital hypothyroidism in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
PAX8 paired box 8 2.30811
DUOXA2 dual oxidase maturation factor 2 2.22926
TG thyroglobulin 2.22019
FOXE1 forkhead box E1 2.13921
TPO thyroid peroxidase 2.10376
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 2.0554
TSHB thyroid stimulating hormone, beta 2.05405
DUOX2 dual oxidase 2 2.05315
TSHR thyroid stimulating hormone receptor 2.00378
IYD iodotyrosine deiodinase 1.84136
NKX2-1 NK2 homeobox 1 1.83863
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 1.82775
TRH thyrotropin-releasing hormone 1.48121
CKAP2 cytoskeleton associated protein 2 1.36422
DUOXA1 dual oxidase maturation factor 1 1.3603
CLTC clathrin, heavy chain (Hc) 1.32279
NKX2-5 NK2 homeobox 5 1.28523
GLIS3 GLIS family zinc finger 3 1.24906
SLC26A4 solute carrier family 26 (anion exchanger), member 4 1.21435
DUOX1 dual oxidase 1 1.18755
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 1.17593
POU1F1 POU class 1 homeobox 1 1.17164
ZNF252P zinc finger protein 252, pseudogene 1.15624
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa 1.13585
TPST2 tyrosylprotein sulfotransferase 2 1.10258
GNAS GNAS complex locus 1.01385
IGSF1 immunoglobulin superfamily, member 1 1.00794
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17 0.962053
SFTA3 surfactant associated 3 0.952438
STAMBP STAM binding protein 0.903621
DIO2 deiodinase, iodothyronine, type II 0.864684
PROP1 PROP paired-like homeobox 1 0.855268
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10 0.818385
TRHR thyrotropin-releasing hormone receptor 0.813462
HESX1 HESX homeobox 1 0.773296
ARPC5L actin related protein 2/3 complex, subunit 5-like 0.768393
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter) 0.754527
TRIM37 tripartite motif containing 37 0.746391
THRB thyroid hormone receptor, beta 0.714005
GLIS1 GLIS family zinc finger 1 0.708767
HHEX hematopoietically expressed homeobox 0.697911
NLGN3 neuroligin 3 0.684292
IGF1 insulin-like growth factor 1 (somatomedin C) 0.672324
LHX3 LIM homeobox 3 0.66596
VIMP VCP-interacting membrane selenoprotein 0.663578
RASD2 RASD family, member 2 0.646165
G6PD glucose-6-phosphate dehydrogenase 0.642221
SERINC5 serine incorporator 5 0.617486
GLIS2 GLIS family zinc finger 2 0.608494
NTNG1 netrin G1 0.578494
GPX5 glutathione peroxidase 5 0.557897
GPX4 glutathione peroxidase 4 0.554403
PAX2 paired box 2 0.552463
NEUROD2 neuronal differentiation 2 0.550134
NTNG2 netrin G2 0.547807
GPX1 glutathione peroxidase 1 0.538893
SAR1A secretion associated, Ras related GTPase 1A 0.531928
RAP2B RAP2B, member of RAS oncogene family 0.528449
RAB1B RAB1B, member RAS oncogene family 0.524974
SFTPB surfactant protein B 0.52343
IGFBP3 insulin-like growth factor binding protein 3 0.514186
ARF3 ADP-ribosylation factor 3 0.511496
SFTPC surfactant protein C 0.508424
NKX6-1 NK6 homeobox 1 0.491597
PRDX5 peroxiredoxin 5 0.468441
TXNRD2 thioredoxin reductase 2 0.447687
PRL prolactin 0.445805
THRA thyroid hormone receptor, alpha 0.430017
BTD biotinidase 0.41727
CALCA calcitonin-related polypeptide alpha 0.415398
FRG1 FSHD region gene 1 0.405678
SHFM1 split hand/foot malformation (ectrodactyly) type 1 0.393374
ERP29 endoplasmic reticulum protein 29 0.377402
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 0.370737
WDHD1 WD repeat and HMG-box DNA binding protein 1 0.356341
EPHA5 EPH receptor A5 0.352659
FBN2 fibrillin 2 0.35082
TAS1R1 taste receptor, type 1, member 1 0.348981
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.341639
DIO1 deiodinase, iodothyronine, type I 0.335046
MEMO1 mediator of cell motility 1 0.32993
THOP1 thimet oligopeptidase 1 0.329565
AFP alpha-fetoprotein 0.32701
WWTR1 WW domain containing transcription regulator 1 0.323002
SLCO1C1 solute carrier organic anion transporter family, member 1C1 0.313915
TGM1 transglutaminase 1 0.309204
CA10 carbonic anhydrase X 0.298011
HOXB4 homeobox B4 0.295132
SGPL1 sphingosine-1-phosphate lyase 1 0.289027
SALL1 spalt-like transcription factor 1 0.268687
ANXA6 annexin A6 0.267267
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.254536
NGDN neuroguidin, EIF4E binding protein 0.252422
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 0.245747
TBX1 T-box 1 0.244345
HLA-A major histocompatibility complex, class I, A 0.243295
THEM5 thioesterase superfamily member 5 0.240497
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.228333
SEPT2 septin 2 0.219057
ADCY2 adenylate cyclase 2 (brain) 0.211597
ACHE acetylcholinesterase (Yt blood group) 0.209918
GH1 growth hormone 1 0.206248
POMC proopiomelanocortin 0.202946
NRGN neurogranin (protein kinase C substrate, RC3) 0.201962
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 0.192971
CRYBB2 crystallin, beta B2 0.190168
NME4 NME/NM23 nucleoside diphosphate kinase 4 0.188326
NME3 NME/NM23 nucleoside diphosphate kinase 3 0.187415
PRDM16 PR domain containing 16 0.182375
FIGF c-fos induced growth factor (vascular endothelial growth factor D) 0.177301
PTH parathyroid hormone 0.165874
GCDH glutaryl-CoA dehydrogenase 0.159658
APOB apolipoprotein B 0.15948
PVALB parvalbumin 0.158605