complete lethality throughout fetal growth and development Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5) (Mammalian Phenotype Ontology, MP_0011099)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0011099
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Genes

185 gene mutations causing the complete lethality throughout fetal growth and development phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADGRA2 adhesion G protein-coupled receptor A2
ADGRL2 adhesion G protein-coupled receptor L2
ADM adrenomedullin
ADRBK1 adrenergic, beta, receptor kinase 1
AMBRA1 autophagy/beclin-1 regulator 1
APAF1 apoptotic peptidase activating factor 1
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
ASXL1 additional sex combs like transcriptional regulator 1
ATE1 arginyltransferase 1
ATMIN ATM interactor
B9D1 B9 protein domain 1
BLM Bloom syndrome, RecQ helicase-like
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BRD1 bromodomain containing 1
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CALCRL calcitonin receptor-like
CALR calreticulin
CBFB core-binding factor, beta subunit
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLUAP1 clusterin associated protein 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CR1L complement component (3b/4b) receptor 1-like
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CTBP2 C-terminal binding protein 2
CUL7 cullin 7
DICER1 dicer 1, ribonuclease type III
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
E2F3 E2F transcription factor 3
ELAVL1 ELAV like RNA binding protein 1
EPAS1 endothelial PAS domain protein 1
EPO erythropoietin
EPOR erythropoietin receptor
FES FES proto-oncogene, tyrosine kinase
FGFR1 fibroblast growth factor receptor 1
FLNA filamin A, alpha
FLVCR1 feline leukemia virus subgroup C cellular receptor 1
FOXF1 forkhead box F1
FOXM1 forkhead box M1
FOXP1 forkhead box P1
FRAS1 Fraser extracellular matrix complex subunit 1
FUZ fuzzy planar cell polarity protein
GAB1 GRB2-associated binding protein 1
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GATA1 GATA binding protein 1 (globin transcription factor 1)
GATA4 GATA binding protein 4
GBE1 glucan (1,4-alpha-), branching enzyme 1
GFI1B growth factor independent 1B transcription repressor
GJB2 gap junction protein, beta 2, 26kDa
GLRX3 glutaredoxin 3
GRHL2 grainyhead-like 2 (Drosophila)
GSK3B glycogen synthase kinase 3 beta
GSN gelsolin
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HHEX hematopoietically expressed homeobox
HOXA13 homeobox A13
HS6ST1 heparan sulfate 6-O-sulfotransferase 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL6ST interleukin 6 signal transducer
INSM1 insulinoma-associated 1
INTU inturned planar cell polarity protein
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JAK2 Janus kinase 2
JARID2 jumonji, AT rich interactive domain 2
JUN jun proto-oncogene
JUP junction plakoglobin
KAT6A K(lysine) acetyltransferase 6A
KIDINS220 kinase D-interacting substrate, 220kDa
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
KLF1 Kruppel-like factor 1 (erythroid)
KLF2 Kruppel-like factor 2
KLF3 Kruppel-like factor 3 (basic)
KMT2A lysine (K)-specific methyltransferase 2A
LAMA5 laminin, alpha 5
LHX2 LIM homeobox 2
LIG1 ligase I, DNA, ATP-dependent
LIG4 ligase IV, DNA, ATP-dependent
LSR lipolysis stimulated lipoprotein receptor
LY6E lymphocyte antigen 6 complex, locus E
MAB21L2 mab-21-like 2 (C. elegans)
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK14 mitogen-activated protein kinase 14
MCM4 minichromosome maintenance complex component 4
MECOM MDS1 and EVI1 complex locus
MED31 mediator complex subunit 31
MEGF8 multiple EGF-like-domains 8
MEIS1 Meis homeobox 1
MEN1 multiple endocrine neoplasia I
MET MET proto-oncogene, receptor tyrosine kinase
MFN2 mitofusin 2
MKL2 MKL/myocardin-like 2
MKS1 Meckel syndrome, type 1
MORF4L1 mortality factor 4 like 1
MTF1 metal-regulatory transcription factor 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYB v-myb avian myeloblastosis viral oncogene homolog
MYH10 myosin, heavy chain 10, non-muscle
MYL2 myosin, light chain 2, regulatory, cardiac, slow
NCOA6 nuclear receptor coactivator 6
NCOR1 nuclear receptor corepressor 1
NCOR2 nuclear receptor corepressor 2
NF1 neurofibromin 1
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NOG noggin
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae)
OSR1 odd-skipped related transciption factor 1
PAK1IP1 PAK1 interacting protein 1
PALLD palladin, cytoskeletal associated protein
PAM peptidylglycine alpha-amidating monooxygenase
PARVA parvin, alpha
PAX3 paired box 3
PBRM1 polybromo 1
PBX1 pre-B-cell leukemia homeobox 1
PDE2A phosphodiesterase 2A, cGMP-stimulated
PHOX2B paired-like homeobox 2b
PITX2 paired-like homeodomain 2
PKD1 polycystic kidney disease 1 (autosomal dominant)
PKD1L1 polycystic kidney disease 1 like 1
PKD2 polycystic kidney disease 2 (autosomal dominant)
PKNOX1 PBX/knotted 1 homeobox 1
PLVAP plasmalemma vesicle associated protein
POU2F1 POU class 2 homeobox 1
PROS1 protein S (alpha)
PROX1 prospero homeobox 1
PSEN1 presenilin 1
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAMP2 receptor (G protein-coupled) activity modifying protein 2
RASA3 RAS p21 protein activator 3
RB1 retinoblastoma 1
RB1CC1 RB1-inducible coiled-coil 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RICTOR RPTOR independent companion of MTOR, complex 2
RNF4 ring finger protein 4
RUNX1 runt-related transcription factor 1
RUNX2 runt-related transcription factor 2
RXRA retinoid X receptor, alpha
RYR1 ryanodine receptor 1 (skeletal)
S1PR1 sphingosine-1-phosphate receptor 1
SEC24B SEC24 family member B
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SENP1 SUMO1/sentrin specific peptidase 1
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1
SHOX2 short stature homeobox 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMN1 survival of motor neuron 1, telomeric
SOX18 SRY (sex determining region Y)-box 18
SOX4 SRY (sex determining region Y)-box 4
SPEN spen family transcriptional repressor
SPI1 Spi-1 proto-oncogene
SPTAN1 spectrin, alpha, non-erythrocytic 1
SPTBN1 spectrin, beta, non-erythrocytic 1
STAG1 stromal antigen 1
STIM1 stromal interaction molecule 1
STK11 serine/threonine kinase 11
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TACC3 transforming, acidic coiled-coil containing protein 3
TBK1 TANK-binding kinase 1
TBX2 T-box 2
TBX3 T-box 3
TCEA1 transcription elongation factor A (SII), 1
TCTN1 tectonic family member 1
TGFBR3 transforming growth factor, beta receptor III
THOC1 THO complex 1
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1
TMEM231 transmembrane protein 231
TMOD3 tropomodulin 3 (ubiquitous)
TRIM71 tripartite motif containing 71, E3 ubiquitin protein ligase
TSC2 tuberous sclerosis 2
TULP3 tubby like protein 3
UBC ubiquitin C
UBE4B ubiquitination factor E4B
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
VEZF1 vascular endothelial zinc finger 1
WDR19 WD repeat domain 19
WT1 Wilms tumor 1
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
YBX1 Y box binding protein 1
ZBTB7A zinc finger and BTB domain containing 7A
ZFPM2 zinc finger protein, FOG family member 2