colorectal cancer Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A large intestine cancer that is located_in the colon and/or located_in the rectum. (Human Disease Ontology, DOID_9256)
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Genes

397 genes associated with the disease colorectal cancer in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACE angiotensin I converting enzyme
ADA adenosine deaminase
ADAR adenosine deaminase, RNA-specific
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AHCY adenosylhomocysteinase
AHR aryl hydrocarbon receptor
AKAP10 A kinase (PRKA) anchor protein 10
AKAP9 A kinase (PRKA) anchor protein 9
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALOX12 arachidonate 12-lipoxygenase
ALOX5 arachidonate 5-lipoxygenase
AMD1 adenosylmethionine decarboxylase 1
AMPD1 adenosine monophosphate deaminase 1
APC adenomatous polyposis coli
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APOE apolipoprotein E
ARL11 ADP-ribosylation factor-like 11
ASCC3 activating signal cointegrator 1 complex subunit 3
ATG12 autophagy related 12
ATG2B autophagy related 2B
ATG5 autophagy related 5
ATG9B autophagy related 9B
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
ATM ATM serine/threonine kinase
AURKA aurora kinase A
AXIN1 axin 1
AXIN2 axin 2
BAMBI BMP and activin membrane-bound inhibitor
BCL2L1 BCL2-like 1
BHMT betaine--homocysteine S-methyltransferase
BID BH3 interacting domain death agonist
BIRC5 baculoviral IAP repeat containing 5
BLM Bloom syndrome, RecQ helicase-like
BMP1 bone morphogenetic protein 1
BMP2 bone morphogenetic protein 2
BMP4 bone morphogenetic protein 4
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C11ORF53 chromosome 11 open reading frame 53
CA6 carbonic anhydrase VI
CAPN10 calpain 10
CARD8 caspase recruitment domain family, member 8
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CASR calcium-sensing receptor
CAT catalase
CBS cystathionine-beta-synthase
CCL1 chemokine (C-C motif) ligand 1
CCND1 cyclin D1
CD28 CD28 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD3EAP CD3e molecule, epsilon associated protein
CD86 CD86 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDX2 caudal type homeobox 2
CELF4 CUGBP, Elav-like family member 4
CES2 carboxylesterase 2
CHEK2 checkpoint kinase 2
CIITA class II, major histocompatibility complex, transactivator
CNR1 cannabinoid receptor 1 (brain)
COL11A1 collagen, type XI, alpha 1
COMT catechol-O-methyltransferase
COX1
COX2
COX3
CPA4 carboxypeptidase A4
CRP C-reactive protein, pentraxin-related
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSB cathepsin B
CUBN cubilin (intrinsic factor-cobalamin receptor)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1
DACT1 dishevelled-binding antagonist of beta-catenin 1
DAPK1 death-associated protein kinase 1
DCC DCC netrin 1 receptor
DFNA5 deafness, autosomal dominant 5
DHFR dihydrofolate reductase
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLG5 discs, large homolog 5 (Drosophila)
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DPYD dihydropyrimidine dehydrogenase
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
E2F2 E2F transcription factor 2
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EHMT2 euchromatic histone-lysine N-methyltransferase 2
EIF3H eukaryotic translation initiation factor 3, subunit H
EPHB2 EPH receptor B2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPHX2 epoxide hydrolase 2, cytoplasmic
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
ERCC3 excision repair cross-complementation group 3
ERCC4 excision repair cross-complementation group 4
ERCC5 excision repair cross-complementation group 5
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
ESRRG estrogen-related receptor gamma
EXO1 exonuclease 1
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
FABP2 fatty acid binding protein 2, intestinal
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FGF4 fibroblast growth factor 4
FMO3 flavin containing monooxygenase 3
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOLR1 folate receptor 1 (adult)
FPGS folylpolyglutamate synthase
FURIN furin (paired basic amino acid cleaving enzyme)
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GDF15 growth differentiation factor 15
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GH1 growth hormone 1
GHRL ghrelin/obestatin prepropeptide
GHSR growth hormone secretagogue receptor
GIF gastric intrinsic factor (vitamin B synthesis)
GLI3 GLI family zinc finger 3
GNAS GNAS complex locus
GPX1 glutathione peroxidase 1
GPX4 glutathione peroxidase 4
GREM1 gremlin 1, DAN family BMP antagonist
GSTA1 glutathione S-transferase alpha 1
GSTA2 glutathione S-transferase alpha 2
GSTA4 glutathione S-transferase alpha 4
GSTM1 glutathione S-transferase mu 1
GSTM2 glutathione S-transferase mu 2 (muscle)
GSTM3 glutathione S-transferase mu 3 (brain)
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene)
HDAC9 histone deacetylase 9
HFE hemochromatosis
HIC1 hypermethylated in cancer 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HRAS Harvey rat sarcoma viral oncogene homolog
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3
ICAM1 intercellular adhesion molecule 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGFBP1 insulin-like growth factor binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL10 interleukin 10
IL12B interleukin 12B
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL4 interleukin 4
IL4R interleukin 4 receptor
IL6 interleukin 6
ING1 inhibitor of growth family, member 1
INHBA inhibin, beta A
INS insulin
INSR insulin receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KDR kinase insert domain receptor
KLRK1 killer cell lectin-like receptor subfamily K, member 1
KRAS Kirsten rat sarcoma viral oncogene homolog
LCT lactase
LEP leptin
LEPR leptin receptor
LIPC lipase, hepatic
LTBP1 latent transforming growth factor beta binding protein 1
LTBP4 latent transforming growth factor beta binding protein 4
MANBA mannosidase, beta A, lysosomal
MAP2K4 mitogen-activated protein kinase kinase 4
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MASP2 mannan-binding lectin serine peptidase 2
MAT2A methionine adenosyltransferase II, alpha
MBL2 mannose-binding lectin (protein C) 2, soluble
MC4R melanocortin 4 receptor
MDK midkine (neurite growth-promoting factor 2)
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MGMT O-6-methylguanine-DNA methyltransferase
MICA MHC class I polypeptide-related sequence A
MLH1 mutL homolog 1
MLH3 mutL homolog 3
MMP1 matrix metallopeptidase 1
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MMRN1 multimerin 1
MPO myeloperoxidase
MRC1 mannose receptor, C type 1
MSH2 mutS homolog 2
MSH3 mutS homolog 3
MSH6 mutS homolog 6
MT-ATP6 ATP synthase F0 subunit 6
MT-CYB cytochrome b
MT-ND2 MTND2
MT-ND3 NADH dehydrogenase, subunit 3 (complex I)
MT-ND4 NADH dehydrogenase, subunit 4 (complex I)
MT-ND4L NADH dehydrogenase, subunit 4L (complex I)
MT-ND5 NADH dehydrogenase, subunit 5 (complex I)
MT-ND6 NADH dehydrogenase, subunit 6 (complex I)
MT-TD tRNA
MT-TG tRNA
MT-TL2 tRNA
MT-TN tRNA
MT-TQ tRNA
MT-TR tRNA
MT-TT tRNA
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTHFS 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MUTYH mutY homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
MYH1 myosin, heavy chain 1, skeletal muscle, adult
MYO3A myosin IIIA
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NBN nibrin
ND1
NDRG1 N-myc downstream regulated 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NLK nemo-like kinase
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOD1 nucleotide-binding oligomerization domain containing 1
NOD2 nucleotide-binding oligomerization domain containing 2
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NQO1 NAD(P)H dehydrogenase, quinone 1
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
ODC1 ornithine decarboxylase 1
OGG1 8-oxoguanine DNA glycosylase
PARP1 poly (ADP-ribose) polymerase 1
PDCD1LG2 programmed cell death 1 ligand 2
PGR progesterone receptor
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAU plasminogen activator, urokinase
PLD2 phospholipase D2
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
POU2AF1 POU class 2 associating factor 1
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
PPP1R3A protein phosphatase 1, regulatory subunit 3A
PRDM2 PR domain containing 2, with ZNF domain
PRNP prion protein
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTEN phosphatase and tensin homolog
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRJ protein tyrosine phosphatase, receptor type, J
PYGO1 pygopus family PHD finger 1
RAD18 RAD18 E3 ubiquitin protein ligase
RAD51 RAD51 recombinase
RB1 retinoblastoma 1
RETN resistin
RFC1 replication factor C (activator 1) 1, 145kDa
RHPN2 rhophilin, Rho GTPase binding protein 2
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RMI1 RecQ mediated genome instability 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNR1 RNA, ribosomal cluster 1
RNR2 RNA, ribosomal cluster 2
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
RXRA retinoid X receptor, alpha
SECISBP2 SECIS binding protein 2
SELE selectin E
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SEP15 15 kDa selenoprotein
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP2 secreted frizzled-related protein 2
SFRP4 secreted frizzled-related protein 4
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SMAD7 SMAD family member 7
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SOD2 superoxide dismutase 2, mitochondrial
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TAS2R14 taste receptor, type 2, member 14
TBR1 T-box, brain, 1
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TCN2 transcobalamin II
TFRC transferrin receptor
TGFB1 transforming growth factor, beta 1
TGFBR1 transforming growth factor, beta receptor 1
THBS1 thrombospondin 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TP53 tumor protein p53
TP73 tumor protein p73
TPMT thiopurine S-methyltransferase
TS13 Temperature sensitivity complementation, ts13
TTK TTK protein kinase
TXNRD2 thioredoxin reductase 2
TYMS thymidylate synthetase
UGT1A UDP glucuronosyltransferase 1 family, polypeptide A complex locus
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9
UMPS uridine monophosphate synthetase
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VIMP VCP-interacting membrane selenoprotein
WIF1 WNT inhibitory factor 1
WISP1 WNT1 inducible signaling pathway protein 1
WISP3 WNT1 inducible signaling pathway protein 3
WNT2B wingless-type MMTV integration site family, member 2B
WRN Werner syndrome, RecQ helicase-like
XK X-linked Kx blood group
XPA xeroderma pigmentosum, complementation group A
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)