colitis Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER. (Experimental Factor Ontology, EFO_0003872)
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Genes

375 genes co-occuring with the biological term colitis in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACAT2 acetyl-CoA acetyltransferase 2
ACE angiotensin I converting enzyme
ACSM3 acyl-CoA synthetase medium-chain family member 3
ADAM10 ADAM metallopeptidase domain 10
ADAM17 ADAM metallopeptidase domain 17
ADAM19 ADAM metallopeptidase domain 19
ADAM9 ADAM metallopeptidase domain 9
ADIPOQ adiponectin, C1Q and collagen domain containing
AHR aryl hydrocarbon receptor
AHSG alpha-2-HS-glycoprotein
AICDA activation-induced cytidine deaminase
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDOB aldolase B, fructose-bisphosphate
ALPI alkaline phosphatase, intestinal
ANXA2 annexin A2
APC adenomatous polyposis coli
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APOA1 apolipoprotein A-I
APOA4 apolipoprotein A-IV
APOE apolipoprotein E
APOH apolipoprotein H (beta-2-glycoprotein I)
AQP8 aquaporin 8
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
BBC3 BCL2 binding component 3
BCL3 B-cell CLL/lymphoma 3
BIRC3 baculoviral IAP repeat containing 3
BIRC5 baculoviral IAP repeat containing 5
BRAF B-Raf proto-oncogene, serine/threonine kinase
BSN bassoon presynaptic cytomatrix protein
BTNL2 butyrophilin-like 2
C19ORF33 chromosome 19 open reading frame 33
CA2 carbonic anhydrase II
CALCA calcitonin-related polypeptide alpha
CARD8 caspase recruitment domain family, member 8
CARD9 caspase recruitment domain family, member 9
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCL11 chemokine (C-C motif) ligand 11
CCL2 chemokine (C-C motif) ligand 2
CCL21 chemokine (C-C motif) ligand 21
CCL24 chemokine (C-C motif) ligand 24
CCL26 chemokine (C-C motif) ligand 26
CCL3 chemokine (C-C motif) ligand 3
CCND1 cyclin D1
CCNY cyclin Y
CCR3 chemokine (C-C motif) receptor 3
CCR6 chemokine (C-C motif) receptor 6
CD14 CD14 molecule
CD209 CD209 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD80 CD80 molecule
CD86 CD86 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDX2 caudal type homeobox 2
CFLAR CASP8 and FADD-like apoptosis regulator
CHGA chromogranin A
CHGB chromogranin B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN1 claudin 1
CLDN18 claudin 18
CLDN2 claudin 2
CLDN4 claudin 4
CLDN7 claudin 7
CLEC2D C-type lectin domain family 2, member D
CLEC7A C-type lectin domain family 7, member A
CRHR1 corticotropin releasing hormone receptor 1
CRHR2 corticotropin releasing hormone receptor 2
CRP C-reactive protein, pentraxin-related
CTGF connective tissue growth factor
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSG cathepsin G
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR3 chemokine (C-X-C motif) receptor 3
CXCR4 chemokine (C-X-C motif) receptor 4
CYC1 cytochrome c-1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DAPK1 death-associated protein kinase 1
DCC DCC netrin 1 receptor
DEFB1 defensin, beta 1
DEFB4A defensin, beta 4A
DLG5 discs, large homolog 5 (Drosophila)
DMBT1 deleted in malignant brain tumors 1
DUOX2 dual oxidase 2
DUOXA2 dual oxidase maturation factor 2
ECM1 extracellular matrix protein 1
EED embryonic ectoderm development
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ESR1 estrogen receptor 1
EYA4 EYA transcriptional coactivator and phosphatase 4
F2 coagulation factor II (thrombin)
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
F2RL3 coagulation factor II (thrombin) receptor-like 3
F5 coagulation factor V (proaccelerin, labile factor)
FABP2 fatty acid binding protein 2, intestinal
FAS Fas cell surface death receptor
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FHIT fragile histidine triad
FOXP3 forkhead box P3
FUBP1 far upstream element (FUSE) binding protein 1
FUT2 fucosyltransferase 2 (secretor status included)
GATA3 GATA binding protein 3
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GPBAR1 G protein-coupled bile acid receptor 1
GPR35 G protein-coupled receptor 35
GRN granulin
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HAVCR2 hepatitis A virus cellular receptor 2
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB3 major histocompatibility complex, class II, DR beta 3
HLA-G major histocompatibility complex, class I, G
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMOX1 heme oxygenase 1
HNF4A hepatocyte nuclear factor 4, alpha
HPS4 Hermansky-Pudlak syndrome 4
HPSE heparanase
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HSF2 heat shock transcription factor 2
HSPA1B heat shock 70kDa protein 1B
HSPA4 heat shock 70kDa protein 4
IBD5 inflammatory bowel disease 5
ICAM1 intercellular adhesion molecule 1
ICOS inducible T-cell co-stimulator
IDO1 indoleamine 2,3-dioxygenase 1
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IFNG interferon, gamma
IGF2 insulin-like growth factor 2
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL10RB interleukin 10 receptor, beta
IL11 interleukin 11
IL12A interleukin 12A
IL12B interleukin 12B
IL13 interleukin 13
IL13RA2 interleukin 13 receptor, alpha 2
IL15 interleukin 15
IL17A interleukin 17A
IL17C interleukin 17C
IL17F interleukin 17F
IL17REL interleukin 17 receptor E-like
IL18 interleukin 18
IL19 interleukin 19
IL1B interleukin 1, beta
IL1RL1 interleukin 1 receptor-like 1
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL20 interleukin 20
IL21 interleukin 21
IL22 interleukin 22
IL23A interleukin 23, alpha subunit p19
IL23R interleukin 23 receptor
IL27 interleukin 27
IL33 interleukin 33
IL37 interleukin 37
IL4 interleukin 4
IL5 interleukin 5
IL6 interleukin 6
IL6R interleukin 6 receptor
IL9R interleukin 9 receptor
IRAK3 interleukin-1 receptor-associated kinase 3
IRF5 interferon regulatory factor 5
IRGM immunity-related GTPase family, M
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
JAK2 Janus kinase 2
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KLF6 Kruppel-like factor 6
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT18 keratin 18, type I
KRT20 keratin 20, type I
KRT7 keratin 7, type II
KRT8 keratin 8, type II
LAMB1 laminin, beta 1
LEP leptin
LEPR leptin receptor
LPL lipoprotein lipase
LRG1 leucine-rich alpha-2-glycoprotein 1
LTF lactotransferrin
LYZ lysozyme
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MBL2 mannose-binding lectin (protein C) 2, soluble
MDK midkine (neurite growth-promoting factor 2)
MEFV Mediterranean fever
MFGE8 milk fat globule-EGF factor 8 protein
MICA MHC class I polypeptide-related sequence A
MICB MHC class I polypeptide-related sequence B
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR124-1 microRNA 124-1
MIR143 microRNA 143
MIR145 microRNA 145
MIR155 microRNA 155
MIR196A2 microRNA 196a-2
MIR19A microRNA 19a
MIR221 microRNA 221
MIR222 microRNA 222
MIR499A microRNA 499a
MLH1 mutL homolog 1
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MMP8 matrix metallopeptidase 8
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MST1 macrophage stimulating 1
MST1R macrophage stimulating 1 receptor
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MUC17 mucin 17, cell surface associated
MUC2 mucin 2, oligomeric mucus/gel-forming
MYB v-myb avian myeloblastosis viral oncogene homolog
MYO9B myosin IXB
NAMPT nicotinamide phosphoribosyltransferase
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX2-3 NK2 homeobox 3
NOD1 nucleotide-binding oligomerization domain containing 1
NOD2 nucleotide-binding oligomerization domain containing 2
NOS2 nitric oxide synthase 2, inducible
NQO1 NAD(P)H dehydrogenase, quinone 1
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR5A2 nuclear receptor subfamily 5, group A, member 2
NTF3 neurotrophin 3
OCLN occludin
OTUD3 OTU deubiquitinase 3
OVGP1 oviductal glycoprotein 1, 120kDa
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3
PADI4 peptidyl arginine deiminase, type IV
PANX1 pannexin 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PER3 period circadian clock 3
PI3 peptidase inhibitor 3, skin-derived
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G2E phospholipase A2, group IIE
PON1 paraoxonase 1
PPARG peroxisome proliferator-activated receptor gamma
PRDM1 PR domain containing 1, with ZNF domain
PROSER1 proline and serine rich 1
PRSS1 protease, serine, 1 (trypsin 1)
PTEN phosphatase and tensin homolog
PTGDR2 prostaglandin D2 receptor 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRS protein tyrosine phosphatase, receptor type, S
PTX3 pentraxin 3, long
PYY peptide YY
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RAVER2 ribonucleoprotein, PTB-binding 2
RB1 retinoblastoma 1
RBPJ recombination signal binding protein for immunoglobulin kappa J region
REG1A regenerating islet-derived 1 alpha
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RNF186 ring finger protein 186
RUNX3 runt-related transcription factor 3
S100A1 S100 calcium binding protein A1
S100A9 S100 calcium binding protein A9
S100B S100 calcium binding protein B
SAA1 serum amyloid A1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG2 secretogranin II
SCNN1B sodium channel, non voltage gated 1 beta subunit
SCNN1G sodium channel, non voltage gated 1 gamma subunit
SDC1 syndecan 1
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
SELE selectin E
SELPLG selectin P ligand
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SFTPD surfactant protein D
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
SLIT2 slit homolog 2 (Drosophila)
SMOX spermine oxidase
SOCS1 suppressor of cytokine signaling 1
SOCS3 suppressor of cytokine signaling 3
SOD2 superoxide dismutase 2, mitochondrial
SPI1 Spi-1 proto-oncogene
SPP1 secreted phosphoprotein 1
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
STAT5A signal transducer and activator of transcription 5A
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TAC1 tachykinin, precursor 1
TACR1 tachykinin receptor 1
TCF4 transcription factor 4
TERF2 telomeric repeat binding factor 2
TERF2IP telomeric repeat binding factor 2, interacting protein
TGFB1 transforming growth factor, beta 1
TGFBR1 transforming growth factor, beta receptor 1
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP4 TIMP metallopeptidase inhibitor 4
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TLR9 toll-like receptor 9
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2
TNF tumor necrosis factor
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TP53 tumor protein p53
TRAF2 TNF receptor-associated factor 2
TRAF3IP2 TRAF3 interacting protein 2
TREM1 triggering receptor expressed on myeloid cells 1
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TWIST1 twist family bHLH transcription factor 1
TXNIP thioredoxin interacting protein
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VIPR1 vasoactive intestinal peptide receptor 1
WISP1 WNT1 inducible signaling pathway protein 1
XBP1 X-box binding protein 1
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa