colitis Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An inflammatory bowel disease that involves inflammation located_in colon. (Human Disease Ontology, DOID_0060180)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0002583
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Genes

283 genes associated with the colitis phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
NOD2 nucleotide-binding oligomerization domain containing 2 3.03532
IL23R interleukin 23 receptor 2.54554
IL1RL1 interleukin 1 receptor-like 1 2.53558
CCHCR1 coiled-coil alpha-helical rod protein 1 2.33795
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 2.33371
CARD9 caspase recruitment domain family, member 9 2.17223
IL18RAP interleukin 18 receptor accessory protein 2.11983
SLC9A4 solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4 1.92507
IL18R1 interleukin 18 receptor 1 1.87267
ZMIZ1 zinc finger, MIZ-type containing 1 1.75033
SNX20 sorting nexin 20 1.69904
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 1.63928
PUS10 pseudouridylate synthase 10 1.58913
MST1 macrophage stimulating 1 1.58566
APEH acylaminoacyl-peptide hydrolase 1.58473
NKX2-3 NK2 homeobox 3 1.55068
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 1.49827
UBE2L3 ubiquitin-conjugating enzyme E2L 3 1.48049
SBNO2 strawberry notch homolog 2 (Drosophila) 1.47262
OTUD3 OTU deubiquitinase 3 1.47083
LACC1 laccase (multicopper oxidoreductase) domain containing 1 1.4597
C5ORF56 chromosome 5 open reading frame 56 1.43716
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 1.42949
BSN bassoon presynaptic cytomatrix protein 1.42679
C1ORF106 chromosome 1 open reading frame 106 1.41863
IL1R1 interleukin 1 receptor, type I 1.4098
RTEL1 regulator of telomere elongation helicase 1 1.37921
SMAD3 SMAD family member 3 1.37664
GPR65 G protein-coupled receptor 65 1.32793
CCNY cyclin Y 1.3195
BTNL2 butyrophilin-like 2 1.30781
IL1RL2 interleukin 1 receptor-like 2 1.30717
NR5A2 nuclear receptor subfamily 5, group A, member 2 1.2884
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 1.28233
GNA12 guanine nucleotide binding protein (G protein) alpha 12 1.26013
KSR1 kinase suppressor of ras 1 1.25001
SP140 SP140 nuclear body protein 1.24751
PLCL1 phospholipase C-like 1 1.24324
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 1.2331
PTPN2 protein tyrosine phosphatase, non-receptor type 2 1.20525
FUT2 fucosyltransferase 2 (secretor status included) 1.19719
DENND1B DENN/MADD domain containing 1B 1.18463
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.18249
ZGPAT zinc finger, CCCH-type with G patch domain 1.17513
AMT aminomethyltransferase 1.1737
THADA thyroid adenoma associated 1.14116
LOC285626 uncharacterized LOC285626 1.1241
SCAMP3 secretory carrier membrane protein 3 1.09351
FGFR1OP FGFR1 oncogene partner 1.04365
TYK2 tyrosine kinase 2 1.04365
IL10 interleukin 10 1.04365
MAML2 mastermind-like 2 (Drosophila) 1.03787
GSDMB gasdermin B 1.02828
BANK1 B-cell scaffold protein with ankyrin repeats 1 1.02229
ATG16L2 autophagy related 16-like 2 (S. cerevisiae) 1.01647
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.00059
TTL tubulin tyrosine ligase 1.00059
ANKRD55 ankyrin repeat domain 55 1.00059
DAP death-associated protein 0.98569
RNASET2 ribonuclease T2 0.974021
CLN3 ceroid-lipofuscinosis, neuronal 3 0.931243
TMEM258 transmembrane protein 258 0.931243
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.884143
GCKR glucokinase (hexokinase 4) regulator 0.881851
LSP1 lymphocyte-specific protein 1 0.844241
ERAP2 endoplasmic reticulum aminopeptidase 2 0.844241
PPP5C protein phosphatase 5, catalytic subunit 0.808951
RSPO3 R-spondin 3 0.772842
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 0.746496
KIF21B kinesin family member 21B 0.73252
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 0.726078
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.726078
ITLN1 intelectin 1 (galactofuranose binding) 0.719731
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 0.676552
GPR35 G protein-coupled receptor 35 0.676552
IL2RA interleukin 2 receptor, alpha 0.650124
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.631916
JAZF1 JAZF zinc finger 1 0.630378
PARK7 parkinson protein 7 0.615522
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.615522
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.615522
SLC22A23 solute carrier family 22, member 23 0.593319
PER3 period circadian clock 3 0.593319
ZNF365 zinc finger protein 365 0.593319
ELF1 E74-like factor 1 (ets domain transcription factor) 0.584959
TEX9 testis expressed 9 0.580295
MLN motilin 0.572823
SFMBT1 Scm-like with four mbt domains 1 0.572823
NKD1 naked cuticle homolog 1 (Drosophila) 0.543331
SLAIN2 SLAIN motif family, member 2 0.542759
DSCAM Down syndrome cell adhesion molecule 0.532072
TCF4 transcription factor 4 0.530444
SKAP2 src kinase associated phosphoprotein 2 0.530444
ZFP90 ZFP90 zinc finger protein 0.530444
PTRF polymerase I and transcript release factor 0.530444
CYLD cylindromatosis (turban tumor syndrome) 0.528902
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.525457
IL7R interleukin 7 receptor 0.522136
IL17REL interleukin 17 receptor E-like 0.522136
JAK2 Janus kinase 2 0.519826
TCTA T-cell leukemia translocation altered 0.490125
LINC00284 long intergenic non-protein coding RNA 284 0.484524
OSBPL3 oxysterol binding protein-like 3 0.474018
C1ORF141 chromosome 1 open reading frame 141 0.474018
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 0.471886
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 0.464594
NOTCH1 notch 1 0.463461
LYRM4 LYR motif containing 4 0.455432
RHOA ras homolog family member A 0.453991
FCHSD2 FCH and double SH3 domains 2 0.450694
NICN1 nicolin 1 0.449288
IL26 interleukin 26 0.443208
BCAS3 breast carcinoma amplified sequence 3 0.442355
CD244 CD244 molecule, natural killer cell receptor 2B4 0.437499
PSORS1C3 psoriasis susceptibility 1 candidate 3 (non-protein coding) 0.433116
ADAD1 adenosine deaminase domain containing 1 (testis-specific) 0.426113
GRK5 G protein-coupled receptor kinase 5 0.424991
C6ORF10 chromosome 6 open reading frame 10 0.419346
USP4 ubiquitin specific peptidase 4 (proto-oncogene) 0.419059
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6 0.417559
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1 0.414522
HDAC9 histone deacetylase 9 0.413807
LOC285484 uncharacterized LOC285484 0.410818
NELL1 NEL-like 1 (chicken) 0.410331
CIITA class II, major histocompatibility complex, transactivator 0.410331
ITGA9 integrin, alpha 9 0.410257
BSN-AS2 BSN antisense RNA 2 (head to head) 0.409874
HLA-DOB major histocompatibility complex, class II, DO beta 0.409851
WDR78 WD repeat domain 78 0.409018
CDC42SE2 CDC42 small effector 2 0.408956
WDR27 WD repeat domain 27 0.408579
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.408409
LDLRAD3 low density lipoprotein receptor class A domain containing 3 0.407992
IL3 interleukin 3 0.407974
MYH16 myosin, heavy chain 16 pseudogene 0.407514
CARD8 caspase recruitment domain family, member 8 0.406705
SATB2 SATB homeobox 2 0.406588
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 0.405515
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 0.405267
TMEM47 transmembrane protein 47 0.405229
MIER1 mesoderm induction early response 1, transcriptional regulator 0.405103
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.405078
IQCB1 IQ motif containing B1 0.404882
ACSL6 acyl-CoA synthetase long-chain family member 6 0.404762
ZDHHC23 zinc finger, DHHC-type containing 23 0.40409
LAMB1 laminin, beta 1 0.40409
ZBTB16 zinc finger and BTB domain containing 16 0.403265
F11 coagulation factor XI 0.403256
CAPZB capping protein (actin filament) muscle Z-line, beta 0.403073
CCDC169 coiled-coil domain containing 169 0.402885
GPSM3 G-protein signaling modulator 3 0.402656
LOC728637 0.402567
RUNX3 runt-related transcription factor 3 0.402177
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.402093
FAM92B family with sequence similarity 92, member B 0.401727
ANKRD44 ankyrin repeat domain 44 0.401518
ZNF664-FAM101A filamin-interacting protein FAM101A 0.401436
TRAIP TRAF interacting protein 0.40066
CCDC38 coiled-coil domain containing 38 0.399953
FOS FBJ murine osteosarcoma viral oncogene homolog 0.399886
CAMKV CaM kinase-like vesicle-associated 0.399119
RALGDS ral guanine nucleotide dissociation stimulator 0.398477
IP6K1 inositol hexakisphosphate kinase 1 0.397987
AKAP13 A kinase (PRKA) anchor protein 13 0.396981
NCF4 neutrophil cytosolic factor 4, 40kDa 0.396719
SUGT1P3 SUGT1 pseudogene 3 0.396719
PRIM2 primase, DNA, polypeptide 2 (58kDa) 0.396463
FNIP1 folliculin interacting protein 1 0.396363
ZFPM2 zinc finger protein, FOG family member 2 0.395974
TTC6 tetratricopeptide repeat domain 6 0.395974
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.395833
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.395647
BATF basic leucine zipper transcription factor, ATF-like 0.394448
IL1R2 interleukin 1 receptor, type II 0.394408
BRD2 bromodomain containing 2 0.394172
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 0.393681
MUC21 mucin 21, cell surface associated 0.393681
MST1R macrophage stimulating 1 receptor 0.393173
PRPF18 pre-mRNA processing factor 18 0.39264
RADIL Ras association and DIL domains 0.392247
FREM2 FRAS1 related extracellular matrix protein 2 0.391503
MON1A MON1 secretory trafficking family member A 0.390809
ZNF532 zinc finger protein 532 0.390642
COL11A2 collagen, type XI, alpha 2 0.389938
FDPS farnesyl diphosphate synthase 0.388964
ESRRG estrogen-related receptor gamma 0.38888
ROR1 receptor tyrosine kinase-like orphan receptor 1 0.387988
RHOU ras homolog family member U 0.387776
NOTCH4 notch 4 0.387596
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.387478
DZIP1 DAZ interacting zinc finger protein 1 0.387274
EPHB2 EPH receptor B2 0.387188
COL23A1 collagen, type XXIII, alpha 1 0.385578
TET2 tet methylcytosine dioxygenase 2 0.385502
CHSY3 chondroitin sulfate synthase 3 0.385403
KAZN kazrin, periplakin interacting protein 0.385157
SPON1 spondin 1, extracellular matrix protein 0.384941
SORCS2 sortilin-related VPS10 domain containing receptor 2 0.384917
TNXB tenascin XB 0.384565
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 0.384495
ATRNL1 attractin-like 1 0.384222
CCDC91 coiled-coil domain containing 91 0.38411
SCN3A sodium channel, voltage gated, type III alpha subunit 0.383933
HLA-DPB2 major histocompatibility complex, class II, DP beta 2 (pseudogene) 0.383417
CLSTN2 calsyntenin 2 0.383291
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 0.382861
VAMP3 vesicle-associated membrane protein 3 0.381625
MACROD2 MACRO domain containing 2 0.381049
RNF5 ring finger protein 5, E3 ubiquitin protein ligase 0.37856
FBXL13 F-box and leucine-rich repeat protein 13 0.378529
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 0.378514
HPSE2 heparanase 2 (inactive) 0.37833
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.377866
SORCS1 sortilin-related VPS10 domain containing receptor 1 0.377376
BCL9 B-cell CLL/lymphoma 9 0.376755
POU5F1 POU class 5 homeobox 1 0.376661
LDLRAD4 low density lipoprotein receptor class A domain containing 4 0.376528
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 0.373119
TCF19 transcription factor 19 0.372441
AGER advanced glycosylation end product-specific receptor 0.371709
TAGAP T-cell activation RhoGTPase activating protein 0.371018
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 0.369661
GPC6 glypican 6 0.368924
KAT6B K(lysine) acetyltransferase 6B 0.368228
MB21D2 Mab-21 domain containing 2 0.368228
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.367189
CLUL1 clusterin-like 1 (retinal) 0.364711
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.364711
ARHGAP19 Rho GTPase activating protein 19 0.364711
VSTM4 V-set and transmembrane domain containing 4 0.363202
CHD9 chromodomain helicase DNA binding protein 9 0.363007
RAB6B RAB6B, member RAS oncogene family 0.36272
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.362254
ZNF311 zinc finger protein 311 0.361805
CSMD1 CUB and Sushi multiple domains 1 0.361805
TEX41 testis expressed 41 (non-protein coding) 0.361805
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.361805
CD36 CD36 molecule (thrombospondin receptor) 0.360949
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 0.360381
SULF2 sulfatase 2 0.360341
MTMR3 myotubularin related protein 3 0.359798
QPCT glutaminyl-peptide cyclotransferase 0.359386
CFB complement factor B 0.358739
NPAS3 neuronal PAS domain protein 3 0.357662
GDPD4 glycerophosphodiester phosphodiesterase domain containing 4 0.356312
CCDC85A coiled-coil domain containing 85A 0.355992
HLA-DRA major histocompatibility complex, class II, DR alpha 0.35571
FHIT fragile histidine triad 0.355679
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.355679
MARCH11 membrane-associated ring finger (C3HC4) 11 0.355555
SRPK1 SRSF protein kinase 1 0.355221
COL19A1 collagen, type XIX, alpha 1 0.354778
SLC14A2 solute carrier family 14 (urea transporter), member 2 0.354207
TUBD1 tubulin, delta 1 0.353471
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 0.352521
MIPEP mitochondrial intermediate peptidase 0.352129
FERMT1 fermitin family member 1 0.351913
PDE8A phosphodiesterase 8A 0.351889
TEK TEK tyrosine kinase, endothelial 0.351421
HLA-C major histocompatibility complex, class I, C 0.350703
LPPR5 lipid phosphate phosphatase-related protein type 5 0.350059
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.349831
NOS2 nitric oxide synthase 2, inducible 0.349298
NPSR1 neuropeptide S receptor 1 0.349168
DNAH11 dynein, axonemal, heavy chain 11 0.349168
COL25A1 collagen, type XXV, alpha 1 0.348995
CNTNAP5 contactin associated protein-like 5 0.348846
GRM5 glutamate receptor, metabotropic 5 0.348741
SCUBE3 signal peptide, CUB domain, EGF-like 3 0.348636
ITGB6 integrin, beta 6 0.348531
AGBL4 ATP/GTP binding protein-like 4 0.347526
FAM188A family with sequence similarity 188, member A 0.347526
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 0.347333
RAB12 RAB12, member RAS oncogene family 0.347142
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 0.346953
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 0.346455
MYO5B myosin VB 0.346043
WDR46 WD repeat domain 46 0.346007
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.345867
SIDT1 SID1 transmembrane family, member 1 0.345522
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.345522
SGCZ sarcoglycan, zeta 0.345017
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.345017