clozapine-6988 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the clozapine-6988 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADCK2 aarF domain containing kinase 2
ADRBK1 adrenergic, beta, receptor kinase 1
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
AMPD3 adenosine monophosphate deaminase 3
AMT aminomethyltransferase
AQR aquarius intron-binding spliceosomal factor
AUTS2 autism susceptibility candidate 2
CALML3 calmodulin-like 3
CCDC93 coiled-coil domain containing 93
CD4 CD4 molecule
CD79B CD79b molecule, immunoglobulin-associated beta
CFLAR CASP8 and FADD-like apoptosis regulator
COL7A1 collagen, type VII, alpha 1
CXORF21 chromosome X open reading frame 21
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DOK4 docking protein 4
DOK5 docking protein 5
DPYSL4 dihydropyrimidinase-like 4
DRD2 dopamine receptor D2
EFNA3 ephrin-A3
EMC1 ER membrane protein complex subunit 1
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
ESR1 estrogen receptor 1
FGF4 fibroblast growth factor 4
FHL1 four and a half LIM domains 1
FLJ42627 uncharacterized LOC645644
FXYD2 FXYD domain containing ion transport regulator 2
GADD45G growth arrest and DNA-damage-inducible, gamma
GLS glutaminase
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GPR137 G protein-coupled receptor 137
GRM1 glutamate receptor, metabotropic 1
HFE hemochromatosis
HIST1H3B histone cluster 1, H3b
HLA-DRB6 major histocompatibility complex, class II, DR beta 6 (pseudogene)
HNMT histamine N-methyltransferase
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
INADL InaD-like (Drosophila)
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITGA10 integrin, alpha 10
JADE2 jade family PHD finger 2
JRK Jrk homolog (mouse)
KDM5A lysine (K)-specific demethylase 5A
LEPR leptin receptor
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK10 mitogen-activated protein kinase 10
MED6 mediator complex subunit 6
MED9 mediator complex subunit 9
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MYL10 myosin, light chain 10, regulatory
NKTR natural killer cell triggering receptor
NMT2 N-myristoyltransferase 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
PAQR6 progestin and adipoQ receptor family member VI
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PER1 period circadian clock 1
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PLEKHO2 pleckstrin homology domain containing, family O member 2
PTCRA pre T-cell antigen receptor alpha
QKI QKI, KH domain containing, RNA binding
RAD51B RAD51 paralog B
RASAL2 RAS protein activator like 2
RGS12 regulator of G-protein signaling 12
RIMS3 regulating synaptic membrane exocytosis 3
RRBP1 ribosome binding protein 1
RSU1 Ras suppressor protein 1
RYR2 ryanodine receptor 2 (cardiac)
SCAPER S-phase cyclin A-associated protein in the ER
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SETD8 SET domain containing (lysine methyltransferase) 8
SKIL SKI-like proto-oncogene
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SNAI2 snail family zinc finger 2
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein
STAG3L1 stromal antigen 3-like 1 (pseudogene)
SYBU syntabulin (syntaxin-interacting)
SYNC syncoilin, intermediate filament protein
TADA2A transcriptional adaptor 2A
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TAGLN3 transgelin 3
TAZ tafazzin
TCHH trichohyalin
TMEM63A transmembrane protein 63A
TRAIP TRAF interacting protein
VIPR1 vasoactive intestinal peptide receptor 1
WNT6 wingless-type MMTV integration site family, member 6
WWP2 WW domain containing E3 ubiquitin protein ligase 2
ZFP36L2 ZFP36 ring finger protein-like 2
ZFX zinc finger protein, X-linked
ZNF423 zinc finger protein 423
ZNF639 zinc finger protein 639
ZNF701 zinc finger protein 701
ZNF79 zinc finger protein 79

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ANKRD36 ankyrin repeat domain 36
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
AP1B1 adaptor-related protein complex 1, beta 1 subunit
ARHGAP5 Rho GTPase activating protein 5
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATAD5 ATPase family, AAA domain containing 5
BRD1 bromodomain containing 1
C2ORF44 chromosome 2 open reading frame 44
C4ORF29 chromosome 4 open reading frame 29
CAPG capping protein (actin filament), gelsolin-like
CCDC88C coiled-coil domain containing 88C
CDK3 cyclin-dependent kinase 3
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CEP131 centrosomal protein 131kDa
CEP72 centrosomal protein 72kDa
CHKB choline kinase beta
CISH cytokine inducible SH2-containing protein
CLASP1 cytoplasmic linker associated protein 1
CLEC16A C-type lectin domain family 16, member A
CLSPN claspin
CPPED1 calcineurin-like phosphoesterase domain containing 1
DNM1 dynamin 1
DSE dermatan sulfate epimerase
ECHDC3 enoyl CoA hydratase domain containing 3
EVPL envoplakin
FAM189B family with sequence similarity 189, member B
FAM57A family with sequence similarity 57, member A
FAM63A family with sequence similarity 63, member A
FBXO31 F-box protein 31
FBXO46 F-box protein 46
FCHSD2 FCH and double SH3 domains 2
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GALK1 galactokinase 1
GCHFR GTP cyclohydrolase I feedback regulator
GLB1L2 galactosidase, beta 1-like 2
GMIP GEM interacting protein
GPRC5C G protein-coupled receptor, class C, group 5, member C
HINFP histone H4 transcription factor
HIST1H2AJ histone cluster 1, H2aj
IGFLR1 IGF-like family receptor 1
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
IRX4 iroquois homeobox 4
JMJD4 jumonji domain containing 4
KATNBL1 katanin p80 subunit B-like 1
KIAA0232 KIAA0232
KLF3 Kruppel-like factor 3 (basic)
LNPEP leucyl/cystinyl aminopeptidase
LRRC37A2 leucine rich repeat containing 37, member A2
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LY6D lymphocyte antigen 6 complex, locus D
LZTR1 leucine-zipper-like transcription regulator 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MEIS2 Meis homeobox 2
MITF microphthalmia-associated transcription factor
MMP9 matrix metallopeptidase 9
MRPL2 mitochondrial ribosomal protein L2
MXD3 MAX dimerization protein 3
MYH9 myosin, heavy chain 9, non-muscle
NDRG1 N-myc downstream regulated 1
NDRG4 NDRG family member 4
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NES nestin
OTUD3 OTU deubiquitinase 3
OXTR oxytocin receptor
PARP16 poly (ADP-ribose) polymerase family, member 16
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PGP phosphoglycolate phosphatase
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PNRC1 proline-rich nuclear receptor coactivator 1
PRODH proline dehydrogenase (oxidase) 1
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RNF123 ring finger protein 123
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SCAMP4 secretory carrier membrane protein 4
SH2B3 SH2B adaptor protein 3
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SP140L SP140 nuclear body protein-like
SPIDR scaffolding protein involved in DNA repair
SPRYD7 SPRY domain containing 7
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
STARD13 StAR-related lipid transfer (START) domain containing 13
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM260 transmembrane protein 260
UBQLN4 ubiquilin 4
UNC119 unc-119 homolog (C. elegans)
VAV1 vav 1 guanine nucleotide exchange factor
WDR62 WD repeat domain 62
WDR91 WD repeat domain 91
ZNF282 zinc finger protein 282
ZNF324 zinc finger protein 324
ZNF510 zinc finger protein 510
ZNF710 zinc finger protein 710
ZNF8 zinc finger protein 8
ZSCAN31 zinc finger and SCAN domain containing 31