clozapine-6947 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the clozapine-6947 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD14A abhydrolase domain containing 14A
APOM apolipoprotein M
ARFRP1 ADP-ribosylation factor related protein 1
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARL4C ADP-ribosylation factor-like 4C
ASB1 ankyrin repeat and SOCS box containing 1
ASTN2 astrotactin 2
BLVRA biliverdin reductase A
C11ORF30 chromosome 11 open reading frame 30
C7ORF69 chromosome 7 open reading frame 69
CACFD1 calcium channel flower domain containing 1
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CAMSAP1 calmodulin regulated spectrin-associated protein 1
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCPG1 cell cycle progression 1
CD82 CD82 molecule
CEP290 centrosomal protein 290kDa
CLCN2 chloride channel, voltage-sensitive 2
CLEC10A C-type lectin domain family 10, member A
CNGB3 cyclic nucleotide gated channel beta 3
CREM cAMP responsive element modulator
CTNND2 catenin (cadherin-associated protein), delta 2
CYR61 cysteine-rich, angiogenic inducer, 61
DMC1 DNA meiotic recombinase 1
EDRF1 erythroid differentiation regulatory factor 1
EHBP1L1 EH domain binding protein 1-like 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FAM63A family with sequence similarity 63, member A
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FGFR2 fibroblast growth factor receptor 2
GAB2 GRB2-associated binding protein 2
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GON4L gon-4-like (C. elegans)
GOSR2 golgi SNAP receptor complex member 2
GPR137 G protein-coupled receptor 137
HGFAC HGF activator
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HSPA12A heat shock 70kDa protein 12A
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
KAZN kazrin, periplakin interacting protein
KDM4B lysine (K)-specific demethylase 4B
KIF21B kinesin family member 21B
KLF5 Kruppel-like factor 5 (intestinal)
KLF7 Kruppel-like factor 7 (ubiquitous)
LBX1 ladybird homeobox 1
LPIN1 lipin 1
MAP1A microtubule-associated protein 1A
MAPKBP1 mitogen-activated protein kinase binding protein 1
MECP2 methyl CpG binding protein 2
MFN2 mitofusin 2
MFSD11 major facilitator superfamily domain containing 11
MSI1 musashi RNA-binding protein 1
MTRF1L mitochondrial translational release factor 1-like
MYOF myoferlin
N4BP3 NEDD4 binding protein 3
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEBL nebulette
NEK9 NIMA-related kinase 9
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NKX3-2 NK3 homeobox 2
NR2E3 nuclear receptor subfamily 2, group E, member 3
OASL 2'-5'-oligoadenylate synthetase-like
PASK PAS domain containing serine/threonine kinase
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PAX4 paired box 4
PDCD6 programmed cell death 6
PLA2G5 phospholipase A2, group V
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PROSC proline synthetase co-transcribed homolog (bacterial)
PSKH1 protein serine kinase H1
RBM19 RNA binding motif protein 19
RFTN1 raftlin, lipid raft linker 1
RNF19B ring finger protein 19B
RPAP1 RNA polymerase II associated protein 1
RREB1 ras responsive element binding protein 1
S100A13 S100 calcium binding protein A13
S100A8 S100 calcium binding protein A8
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNED1 sushi, nidogen and EGF-like domains 1
SPHK2 sphingosine kinase 2
SPRYD7 SPRY domain containing 7
SPTBN1 spectrin, beta, non-erythrocytic 1
STOML1 stomatin (EPB72)-like 1
TMEM53 transmembrane protein 53
TRAK1 trafficking protein, kinesin binding 1
TSR3 TSR3, 20S rRNA accumulation, homolog (S. cerevisiae)
USB1 U6 snRNA biogenesis 1
WDR62 WD repeat domain 62
WDR91 WD repeat domain 91
WSCD1 WSC domain containing 1
ZBTB6 zinc finger and BTB domain containing 6
ZNF335 zinc finger protein 335
ZNF770 zinc finger protein 770

decreased expression

Symbol Name
ABHD4 abhydrolase domain containing 4
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
AP4M1 adaptor-related protein complex 4, mu 1 subunit
ARC activity-regulated cytoskeleton-associated protein
ARMC7 armadillo repeat containing 7
ASB6 ankyrin repeat and SOCS box containing 6
BAHD1 bromo adjacent homology domain containing 1
BBC3 BCL2 binding component 3
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BPGM 2,3-bisphosphoglycerate mutase
C22ORF29 chromosome 22 open reading frame 29
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCDC176 coiled-coil domain containing 176
CCP110 centriolar coiled coil protein 110kDa
CCS copper chaperone for superoxide dismutase
CEP131 centrosomal protein 131kDa
CEP72 centrosomal protein 72kDa
CIR1 corepressor interacting with RBPJ, 1
CRY2 cryptochrome circadian clock 2
DAGLA diacylglycerol lipase, alpha
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DHDDS dehydrodolichyl diphosphate synthase
EAF2 ELL associated factor 2
EFCAB2 EF-hand calcium binding domain 2
ETAA1 Ewing tumor-associated antigen 1
FAM160B2 family with sequence similarity 160, member B2
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLB1L2 galactosidase, beta 1-like 2
GLTSCR1 glioma tumor suppressor candidate region gene 1
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HIST1H3B histone cluster 1, H3b
IFT88 intraflagellar transport 88
IP6K2 inositol hexakisphosphate kinase 2
IRX4 iroquois homeobox 4
KAT2A K(lysine) acetyltransferase 2A
KLHL25 kelch-like family member 25
L2HGDH L-2-hydroxyglutarate dehydrogenase
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LINS lines homolog (Drosophila)
LRRC20 leucine rich repeat containing 20
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAN2C1 mannosidase, alpha, class 2C, member 1
MCOLN3 mucolipin 3
MEIS2 Meis homeobox 2
MGC12488
MTCL1 microtubule crosslinking factor 1
MTRF1 mitochondrial translational release factor 1
NCAM2 neural cell adhesion molecule 2
NPIPB15 nuclear pore complex interacting protein family, member B15
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
OTUD3 OTU deubiquitinase 3
PARD6A par-6 family cell polarity regulator alpha
PDE12 phosphodiesterase 12
PGBD5 piggyBac transposable element derived 5
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PLA2G15 phospholipase A2, group XV
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
POLL polymerase (DNA directed), lambda
RAB3A RAB3A, member RAS oncogene family
RBL1 retinoblastoma-like 1
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RIBC2 RIB43A domain with coiled-coils 2
RNF123 ring finger protein 123
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
SALL2 spalt-like transcription factor 2
SCN1B sodium channel, voltage gated, type I beta subunit
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SETD8 SET domain containing (lysine methyltransferase) 8
SLC12A9 solute carrier family 12, member 9
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SREK1IP1 SREK1-interacting protein 1
STARD5 StAR-related lipid transfer (START) domain containing 5
STK25 serine/threonine kinase 25
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TCTN2 tectonic family member 2
TH tyrosine hydroxylase
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TM7SF3 transmembrane 7 superfamily member 3
TMC5 transmembrane channel-like 5
TOLLIP toll interacting protein
TRIM5 tripartite motif containing 5
UBTD1 ubiquitin domain containing 1
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
VGF VGF nerve growth factor inducible
YEATS4 YEATS domain containing 4
ZMAT5 zinc finger, matrin-type 5
ZNF180 zinc finger protein 180
ZNF253 zinc finger protein 253
ZNF276 zinc finger protein 276
ZNF574 zinc finger protein 574
ZNF767P zinc finger family member 767, pseudogene
ZNF768 zinc finger protein 768