clozapine-6188 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the clozapine-6188 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7
ADCY9 adenylate cyclase 9
ADORA1 adenosine A1 receptor
ALX4 ALX homeobox 4
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARHGAP24 Rho GTPase activating protein 24
ARSA arylsulfatase A
BCL6 B-cell CLL/lymphoma 6
BMP7 bone morphogenetic protein 7
C1ORF105 chromosome 1 open reading frame 105
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CARD10 caspase recruitment domain family, member 10
CCR8 chemokine (C-C motif) receptor 8
CDK10 cyclin-dependent kinase 10
CFAP45 cilia and flagella associated protein 45
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
COL10A1 collagen, type X, alpha 1
COL4A6 collagen, type IV, alpha 6
CSF1 colony stimulating factor 1 (macrophage)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTNNBIP1 catenin, beta interacting protein 1
CYLD cylindromatosis (turban tumor syndrome)
DAPK3 death-associated protein kinase 3
DCAF17 DDB1 and CUL4 associated factor 17
DDR1 discoidin domain receptor tyrosine kinase 1
DLG3 discs, large homolog 3 (Drosophila)
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOCK1 dedicator of cytokinesis 1
DVL2 dishevelled segment polarity protein 2
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2
EPS8L1 EPS8-like 1
ERC2-IT1 ERC2 intronic transcript 1
EXT1 exostosin glycosyltransferase 1
EXTL3 exostosin-like glycosyltransferase 3
FAM50B family with sequence similarity 50, member B
FUT2 fucosyltransferase 2 (secretor status included)
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GK3P glycerol kinase 3 pseudogene
GPR135 G protein-coupled receptor 135
GPX2 glutathione peroxidase 2
GRK5 G protein-coupled receptor kinase 5
GTPBP1 GTP binding protein 1
HNMT histamine N-methyltransferase
HSF2BP heat shock transcription factor 2 binding protein
HSPA1L heat shock 70kDa protein 1-like
IFNW1 interferon, omega 1
KHK ketohexokinase (fructokinase)
KIAA0226L KIAA0226-like
KIF1C kinesin family member 1C
KLHL36 kelch-like family member 36
KRT6B keratin 6B, type II
KRT75 keratin 75, type II
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LTBP2 latent transforming growth factor beta binding protein 2
MAL mal, T-cell differentiation protein
MED25 mediator complex subunit 25
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MOGAT2 monoacylglycerol O-acyltransferase 2
MR1 major histocompatibility complex, class I-related
MYBPC1 myosin binding protein C, slow type
NEBL nebulette
NF2 neurofibromin 2 (merlin)
NLRP1 NLR family, pyrin domain containing 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OLFML2B olfactomedin-like 2B
OXCT2 3-oxoacid CoA transferase 2
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PART1 prostate androgen-regulated transcript 1 (non-protein coding)
PCNXL2 pecanex-like 2 (Drosophila)
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PHC3 polyhomeotic homolog 3 (Drosophila)
PLD2 phospholipase D2
PNMAL1 paraneoplastic Ma antigen family-like 1
PRLR prolactin receptor
PVR poliovirus receptor
REC8 REC8 meiotic recombination protein
REM1 RAS (RAD and GEM)-like GTP-binding 1
RUFY3 RUN and FYVE domain containing 3
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
SH2D3A SH2 domain containing 3A
SH3BP2 SH3-domain binding protein 2
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SS18 synovial sarcoma translocation, chromosome 18
TGFBR1 transforming growth factor, beta receptor 1
TIMELESS timeless circadian clock
TLK1 tousled-like kinase 1
TMEM53 transmembrane protein 53
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TSC22D2 TSC22 domain family, member 2
UBOX5 U-box domain containing 5
VPS13B vacuolar protein sorting 13 homolog B (yeast)
ZER1 zyg-11 related, cell cycle regulator
ZFX zinc finger protein, X-linked
ZNF24 zinc finger protein 24
ZNF41 zinc finger protein 41

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACPP acid phosphatase, prostate
ANKRD36 ankyrin repeat domain 36
ANXA3 annexin A3
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BAG4 BCL2-associated athanogene 4
BCAS3 breast carcinoma amplified sequence 3
BTBD18 BTB (POZ) domain containing 18
C1ORF56 chromosome 1 open reading frame 56
CALCOCO1 calcium binding and coiled-coil domain 1
CAPN5 calpain 5
CCDC85C coiled-coil domain containing 85C
CD69 CD69 molecule
CDIP1 cell death-inducing p53 target 1
CDKL3 cyclin-dependent kinase-like 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDR2L cerebellar degeneration-related protein 2-like
CRY2 cryptochrome circadian clock 2
CXCL2 chemokine (C-X-C motif) ligand 2
CXORF56 chromosome X open reading frame 56
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DFNA5 deafness, autosomal dominant 5
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
ECHDC2 enoyl CoA hydratase domain containing 2
EDAR ectodysplasin A receptor
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
FAM127B family with sequence similarity 127, member B
FAM131A family with sequence similarity 131, member A
FKBP14 FK506 binding protein 14, 22 kDa
GID4 GID complex subunit 4
GLTP glycolipid transfer protein
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GNL1 guanine nucleotide binding protein-like 1
GPATCH2L G patch domain containing 2-like
GPR35 G protein-coupled receptor 35
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRAMD1B GRAM domain containing 1B
GSDMD gasdermin D
HHLA3 HERV-H LTR-associating 3
HIST1H3H histone cluster 1, H3h
HIST2H2AA3 histone cluster 2, H2aa3
IL11RA interleukin 11 receptor, alpha
INF2 inverted formin, FH2 and WH2 domain containing
IRF7 interferon regulatory factor 7
KIAA0319L KIAA0319-like
KIAA1024 KIAA1024
KLF1 Kruppel-like factor 1 (erythroid)
LAMB3 laminin, beta 3
LIN7B lin-7 homolog B (C. elegans)
LINC00597 long intergenic non-protein coding RNA 597
LOC157562 uncharacterized LOC157562
LPPR2 lipid phosphate phosphatase-related protein type 2
LRRK1 leucine-rich repeat kinase 1
MAGEF1 melanoma antigen family F1
MED15 mediator complex subunit 15
MEGF8 multiple EGF-like-domains 8
MFSD11 major facilitator superfamily domain containing 11
MLYCD malonyl-CoA decarboxylase
MRAS muscle RAS oncogene homolog
MYO15A myosin XVA
OMG oligodendrocyte myelin glycoprotein
OVGP1 oviductal glycoprotein 1, 120kDa
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PCBP4 poly(rC) binding protein 4
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PHC1 polyhomeotic homolog 1 (Drosophila)
PNOC prepronociceptin
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
PRY PTPN13-like, Y-linked
PYGB phosphorylase, glycogen; brain
RAB3A RAB3A, member RAS oncogene family
RANBP17 RAN binding protein 17
REPS2 RALBP1 associated Eps domain containing 2
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SLC16A6 solute carrier family 16, member 6
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
STBD1 starch binding domain 1
TBC1D17 TBC1 domain family, member 17
TEX40 testis expressed 40
THBS4 thrombospondin 4
TSPYL2 TSPY-like 2
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
TXNDC15 thioredoxin domain containing 15
UBE2O ubiquitin-conjugating enzyme E2O
USP18 ubiquitin specific peptidase 18
USP32 ubiquitin specific peptidase 32
WDR62 WD repeat domain 62
ZBTB25 zinc finger and BTB domain containing 25
ZC3H12A zinc finger CCCH-type containing 12A
ZNF137P zinc finger protein 137, pseudogene
ZNF14 zinc finger protein 14
ZNF219 zinc finger protein 219
ZNF552 zinc finger protein 552