clozapine-5265 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the clozapine-5265 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACSF2 acyl-CoA synthetase family member 2
AIPL1 aryl hydrocarbon receptor interacting protein-like 1
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARTN artemin
ATM ATM serine/threonine kinase
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CD52 CD52 molecule
CFLAR CASP8 and FADD-like apoptosis regulator
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CLCN4 chloride channel, voltage-sensitive 4
CLDN11 claudin 11
CTNS cystinosin, lysosomal cystine transporter
DCN decorin
DMXL2 Dmx-like 2
DOPEY2 dopey family member 2
DPF1 D4, zinc and double PHD fingers family 1
DRD2 dopamine receptor D2
DUSP4 dual specificity phosphatase 4
EFNB3 ephrin-B3
EHBP1L1 EH domain binding protein 1-like 1
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EXOC7 exocyst complex component 7
EYA3 EYA transcriptional coactivator and phosphatase 3
FLRT2 fibronectin leucine rich transmembrane protein 2
FOXG1 forkhead box G1
GGT1 gamma-glutamyltransferase 1
GM2A GM2 ganglioside activator
GOLGA2 golgin A2
GPR137 G protein-coupled receptor 137
GPR157 G protein-coupled receptor 157
GUSBP3 glucuronidase, beta pseudogene 3
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HDAC7 histone deacetylase 7
HFE hemochromatosis
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HSPG2 heparan sulfate proteoglycan 2
IL6ST interleukin 6 signal transducer
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
KLRD1 killer cell lectin-like receptor subfamily D, member 1
LDLR low density lipoprotein receptor
LRRC1 leucine rich repeat containing 1
LRRC37A3 leucine rich repeat containing 37, member A3
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma
MAP4 microtubule-associated protein 4
MARK4 MAP/microtubule affinity-regulating kinase 4
MIR622 microRNA 622
MR1 major histocompatibility complex, class I-related
MTSS1L metastasis suppressor 1-like
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NPR2 natriuretic peptide receptor 2
OXCT2 3-oxoacid CoA transferase 2
PCDH7 protocadherin 7
PCDHGA8 protocadherin gamma subfamily A, 8
PER2 period circadian clock 2
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PKNOX2 PBX/knotted 1 homeobox 2
PLA2G3 phospholipase A2, group III
PLTP phospholipid transfer protein
PODXL2 podocalyxin-like 2
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PVT1 Pvt1 oncogene (non-protein coding)
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RAB6B RAB6B, member RAS oncogene family
RBL2 retinoblastoma-like 2
RNF208 ring finger protein 208
RPL35A ribosomal protein L35a
S100A8 S100 calcium binding protein A8
SARM1 sterile alpha and TIR motif containing 1
SCN10A sodium channel, voltage gated, type X alpha subunit
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SHOX2 short stature homeobox 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC39A9 solute carrier family 39, member 9
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
STARD13 StAR-related lipid transfer (START) domain containing 13
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYNJ2 synaptojanin 2
TBC1D22A TBC1 domain family, member 22A
THBD thrombomodulin
TREX1 three prime repair exonuclease 1
UNC119 unc-119 homolog (C. elegans)
VN1R1 vomeronasal 1 receptor 1
XIST X inactive specific transcript (non-protein coding)
ZER1 zyg-11 related, cell cycle regulator
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ADAM2 ADAM metallopeptidase domain 2
AOC2 amine oxidase, copper containing 2 (retina-specific)
ARC activity-regulated cytoskeleton-associated protein
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARMC4 armadillo repeat containing 4
ARMC6 armadillo repeat containing 6
ATP10D ATPase, class V, type 10D
BCO1 beta-carotene oxygenase 1
C14ORF79 chromosome 14 open reading frame 79
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CDC37 cell division cycle 37
CDK20 cyclin-dependent kinase 20
CDON cell adhesion associated, oncogene regulated
CFAP69 cilia and flagella associated protein 69
CIDEC cell death-inducing DFFA-like effector c
CNGB3 cyclic nucleotide gated channel beta 3
CNR2 cannabinoid receptor 2 (macrophage)
COPZ2 coatomer protein complex, subunit zeta 2
CRLF1 cytokine receptor-like factor 1
CTAGE1 cutaneous T-cell lymphoma-associated antigen 1
CXXC4 CXXC finger protein 4
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DMTN dematin actin binding protein
DNAH17 dynein, axonemal, heavy chain 17
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
EAF2 ELL associated factor 2
EFNA3 ephrin-A3
ELSPBP1 epididymal sperm binding protein 1
EN2 engrailed homeobox 2
ERCC6 excision repair cross-complementation group 6
FBXO31 F-box protein 31
FGL1 fibrinogen-like 1
FKBP10 FK506 binding protein 10, 65 kDa
FOSL1 FOS-like antigen 1
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GSTP1 glutathione S-transferase pi 1
HDAC11 histone deacetylase 11
HIST1H2BO histone cluster 1, H2bo
HPN hepsin
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IL2 interleukin 2
IL22 interleukin 22
ITGA8 integrin, alpha 8
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KIF13B kinesin family member 13B
KIF5A kinesin family member 5A
KLF2 Kruppel-like factor 2
KLF7 Kruppel-like factor 7 (ubiquitous)
KREMEN2 kringle containing transmembrane protein 2
LGALS4 lectin, galactoside-binding, soluble, 4
LHX1 LIM homeobox 1
LOC390998 ribosomal protein L10 pseudogene
LRP2 low density lipoprotein receptor-related protein 2
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MAST3 microtubule associated serine/threonine kinase 3
MFAP2 microfibrillar-associated protein 2
MMP2 matrix metallopeptidase 2
MYOZ3 myozenin 3
NEUROD4 neuronal differentiation 4
NPM3 nucleophosmin/nucleoplasmin 3
NTF3 neurotrophin 3
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PCDHA5 protocadherin alpha 5
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PHEX phosphate regulating endopeptidase homolog, X-linked
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PRKCE protein kinase C, epsilon
RAB30 RAB30, member RAS oncogene family
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RCAN3 RCAN family member 3
RFPL3 ret finger protein-like 3
RGS20 regulator of G-protein signaling 20
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIX1 SIX homeobox 1
ST5 suppression of tumorigenicity 5
STIM1 stromal interaction molecule 1
STK25 serine/threonine kinase 25
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TCTN2 tectonic family member 2
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
TSGA10 testis specific, 10
TUBA3C tubulin, alpha 3c
TUBA4B tubulin, alpha 4b
USB1 U6 snRNA biogenesis 1
VASH1 vasohibin 1
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
YY2 YY2 transcription factor
ZBTB25 zinc finger and BTB domain containing 25
ZNF205 zinc finger protein 205
ZNF747 zinc finger protein 747