clozapine-5226 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the clozapine-5226 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACRV1 acrosomal vesicle protein 1
ACTA1 actin, alpha 1, skeletal muscle
ADAM22 ADAM metallopeptidase domain 22
ADAP2 ArfGAP with dual PH domains 2
ANK2 ankyrin 2, neuronal
APP amyloid beta (A4) precursor protein
ARMC4 armadillo repeat containing 4
ASPH aspartate beta-hydroxylase
C21ORF2 chromosome 21 open reading frame 2
C7ORF69 chromosome 7 open reading frame 69
CASKIN2 CASK interacting protein 2
CCPG1 cell cycle progression 1
CD52 CD52 molecule
CD6 CD6 molecule
CD83 CD83 molecule
CDH8 cadherin 8, type 2
CDHR2 cadherin-related family member 2
CDON cell adhesion associated, oncogene regulated
CFAP69 cilia and flagella associated protein 69
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLCN7 chloride channel, voltage-sensitive 7
CXORF21 chromosome X open reading frame 21
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DOK4 docking protein 4
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DSC3 desmocollin 3
EFNB3 ephrin-B3
EPHA3 EPH receptor A3
FLJ21369 uncharacterized protein FLJ21369
FSCN1 fascin actin-bundling protein 1
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GFI1 growth factor independent 1 transcription repressor
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GRIK5 glutamate receptor, ionotropic, kainate 5
HCAR3 hydroxycarboxylic acid receptor 3
HOXA10 homeobox A10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGLJ3 immunoglobulin lambda joining 3
IL12RB1 interleukin 12 receptor, beta 1
IRF9 interferon regulatory factor 9
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA8 integrin, alpha 8
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
KALRN kalirin, RhoGEF kinase
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
LEPR leptin receptor
LIN7A lin-7 homolog A (C. elegans)
LMF2 lipase maturation factor 2
MAN1A2 mannosidase, alpha, class 1A, member 2
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MIOS missing oocyte, meiosis regulator, homolog (Drosophila)
MMRN2 multimerin 2
MSL3 male-specific lethal 3 homolog (Drosophila)
NDOR1 NADPH dependent diflavin oxidoreductase 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NME5 NME/NM23 family member 5
NTF3 neurotrophin 3
OXCT2 3-oxoacid CoA transferase 2
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PBX2 pre-B-cell leukemia homeobox 2
PCDHA5 protocadherin alpha 5
PDAP1 PDGFA associated protein 1
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRKCE protein kinase C, epsilon
PTGDS prostaglandin D2 synthase 21kDa (brain)
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RBM26 RNA binding motif protein 26
RERE arginine-glutamic acid dipeptide (RE) repeats
RPS3A ribosomal protein S3A
RUNX1 runt-related transcription factor 1
RUSC2 RUN and SH3 domain containing 2
S100A7 S100 calcium binding protein A7
SDC3 syndecan 3
SFRP4 secreted frizzled-related protein 4
SGK2 serum/glucocorticoid regulated kinase 2
SH3D21 SH3 domain containing 21
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SOCS3 suppressor of cytokine signaling 3
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
SSX1 synovial sarcoma, X breakpoint 1
SULT4A1 sulfotransferase family 4A, member 1
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TFEB transcription factor EB
TIGD6 tigger transposable element derived 6
TMLHE trimethyllysine hydroxylase, epsilon
TRAK1 trafficking protein, kinesin binding 1
TRPC1 transient receptor potential cation channel, subfamily C, member 1
USP2 ubiquitin specific peptidase 2
ZNF37BP zinc finger protein 37B, pseudogene
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ARSB arylsulfatase B
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
C1ORF105 chromosome 1 open reading frame 105
C1ORF35 chromosome 1 open reading frame 35
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CEP85 centrosomal protein 85kDa
CGA glycoprotein hormones, alpha polypeptide
CHKB choline kinase beta
CLDN15 claudin 15
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa
CRYBB2P1 crystallin, beta B2 pseudogene 1
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CUL9 cullin 9
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DCAF13 DDB1 and CUL4 associated factor 13
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ELOVL4 ELOVL fatty acid elongase 4
FLCN folliculin
FMO4 flavin containing monooxygenase 4
FSTL3 follistatin-like 3 (secreted glycoprotein)
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GCHFR GTP cyclohydrolase I feedback regulator
GPR1 G protein-coupled receptor 1
GPR19 G protein-coupled receptor 19
GSTTP1 glutathione S-transferase theta pseudogene 1
GUSBP3 glucuronidase, beta pseudogene 3
HDAC4 histone deacetylase 4
HIST1H2AI histone cluster 1, H2ai
HIST1H2BO histone cluster 1, H2bo
HIST2H2AA3 histone cluster 2, H2aa3
HOXA4 homeobox A4
IGFLR1 IGF-like family receptor 1
INPP1 inositol polyphosphate-1-phosphatase
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KDM5C lysine (K)-specific demethylase 5C
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRRC37A3 leucine rich repeat containing 37, member A3
LY6D lymphocyte antigen 6 complex, locus D
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAPKBP1 mitogen-activated protein kinase binding protein 1
MAST3 microtubule associated serine/threonine kinase 3
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MMP3 matrix metallopeptidase 3
MRPL41 mitochondrial ribosomal protein L41
MTA2 metastasis associated 1 family, member 2
NARFL nuclear prelamin A recognition factor-like
NIPAL2 NIPA-like domain containing 2
NR1H3 nuclear receptor subfamily 1, group H, member 3
NRSN2 neurensin 2
NXPH4 neurexophilin 4
PCDHA6 protocadherin alpha 6
PCDHB3 protocadherin beta 3
PCDHGB5 protocadherin gamma subfamily B, 5
PHACTR4 phosphatase and actin regulator 4
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PLEKHA6 pleckstrin homology domain containing, family A member 6
PTPRE protein tyrosine phosphatase, receptor type, E
QSER1 glutamine and serine rich 1
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB36 RAB36, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
RIBC2 RIB43A domain with coiled-coils 2
RIN1 Ras and Rab interactor 1
RNF2 ring finger protein 2
RNF43 ring finger protein 43
SECTM1 secreted and transmembrane 1
SLC12A9 solute carrier family 12, member 9
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC16A6 solute carrier family 16, member 6
SLC46A3 solute carrier family 46, member 3
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SP1 Sp1 transcription factor
STON1 stonin 1
STRA6 stimulated by retinoic acid 6
SYTL2 synaptotagmin-like 2
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TARP TCR gamma alternate reading frame protein
TMEM212 transmembrane protein 212
TMEM45A transmembrane protein 45A
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRIM36 tripartite motif containing 36
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae)
WDR91 WD repeat domain 91
WFDC2 WAP four-disulfide core domain 2
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZBTB39 zinc finger and BTB domain containing 39
ZNF34 zinc finger protein 34
ZNF446 zinc finger protein 446
ZNF750 zinc finger protein 750
ZNF767P zinc finger family member 767, pseudogene