clozapine-4670 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the clozapine-4670 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADGB androglobin
AOC3 amine oxidase, copper containing 3
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
ATP9A ATPase, class II, type 9A
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CADM4 cell adhesion molecule 4
CASQ2 calsequestrin 2 (cardiac muscle)
CCR7 chemokine (C-C motif) receptor 7
CEP295 centrosomal protein 295kDa
CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
CNGB3 cyclic nucleotide gated channel beta 3
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL4A6 collagen, type IV, alpha 6
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
CXORF21 chromosome X open reading frame 21
DGKA diacylglycerol kinase, alpha 80kDa
DST dystonin
E2F4 E2F transcription factor 4, p107/p130-binding
ECEL1 endothelin converting enzyme-like 1
EIF3F eukaryotic translation initiation factor 3, subunit F
EMC3 ER membrane protein complex subunit 3
ENOX1 ecto-NOX disulfide-thiol exchanger 1
EXOC7 exocyst complex component 7
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
FAM134B family with sequence similarity 134, member B
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FN1 fibronectin 1
FRMD4A FERM domain containing 4A
FRS3 fibroblast growth factor receptor substrate 3
GAB1 GRB2-associated binding protein 1
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3
GOLGA8A golgin A8 family, member A
GRB7 growth factor receptor-bound protein 7
GYPB glycophorin B (MNS blood group)
HEMK1 HemK methyltransferase family member 1
HIST1H4A histone cluster 1, H4a
HRASLS2 HRAS-like suppressor 2
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IL5RA interleukin 5 receptor, alpha
INSR insulin receptor
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
LIMD2 LIM domain containing 2
LIPG lipase, endothelial
LOC440895 two pore channel 3 pseudogene
LRRC15 leucine rich repeat containing 15
LTB4R leukotriene B4 receptor
MST1 macrophage stimulating 1
MYBPC3 myosin binding protein C, cardiac
NCR2 natural cytotoxicity triggering receptor 2
OVOL2 ovo-like zinc finger 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PCDH1 protocadherin 1
PCDHB3 protocadherin beta 3
PCNX pecanex homolog (Drosophila)
PDE10A phosphodiesterase 10A
PELI2 pellino E3 ubiquitin protein ligase family member 2
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PLK3 polo-like kinase 3
PLXNB3 plexin B3
PTBP3 polypyrimidine tract binding protein 3
SIGLEC8 sialic acid binding Ig-like lectin 8
SIT1 signaling threshold regulating transmembrane adaptor 1
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SNRK SNF related kinase
SOCS3 suppressor of cytokine signaling 3
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPTB spectrin, beta, erythrocytic
SRSF7 serine/arginine-rich splicing factor 7
STX7 syntaxin 7
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1
TAOK1 TAO kinase 1
TBC1D2B TBC1 domain family, member 2B
TBL2 transducin (beta)-like 2
TBX6 T-box 6
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFEB transcription factor EB
THBD thrombomodulin
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TPP1 tripeptidyl peptidase I
TRIM29 tripartite motif containing 29
USF2 upstream transcription factor 2, c-fos interacting
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VASH1 vasohibin 1
WSB1 WD repeat and SOCS box containing 1
ZFHX2 zinc finger homeobox 2
ZNF174 zinc finger protein 174
ZNF343 zinc finger protein 343
ZNF444 zinc finger protein 444

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ADAM2 ADAM metallopeptidase domain 2
ADGRG2 adhesion G protein-coupled receptor G2
ASB13 ankyrin repeat and SOCS box containing 13
BCORL1 BCL6 corepressor-like 1
C14ORF79 chromosome 14 open reading frame 79
C9ORF40 chromosome 9 open reading frame 40
CASP5 caspase 5, apoptosis-related cysteine peptidase
CD79A CD79a molecule, immunoglobulin-associated alpha
CDC37L1 cell division cycle 37-like 1
CDHR2 cadherin-related family member 2
CDK6 cyclin-dependent kinase 6
CENPO centromere protein O
CLCN6 chloride channel, voltage-sensitive 6
CRYBA2 crystallin, beta A2
CRYGC crystallin, gamma C
CYSLTR1 cysteinyl leukotriene receptor 1
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
EDN1 endothelin 1
EGLN3 egl-9 family hypoxia-inducible factor 3
ELOVL4 ELOVL fatty acid elongase 4
ELSPBP1 epididymal sperm binding protein 1
EYA4 EYA transcriptional coactivator and phosphatase 4
F3 coagulation factor III (thromboplastin, tissue factor)
FAM186A family with sequence similarity 186, member A
FGF23 fibroblast growth factor 23
GAREM GRB2 associated, regulator of MAPK1
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GPC3 glypican 3
HDAC11 histone deacetylase 11
HIST1H2AK histone cluster 1, H2ak
HIST1H2BN histone cluster 1, H2bn
HIST1H3C histone cluster 1, H3c
HOXA1 homeobox A1
IFT140 intraflagellar transport 140
IL12RB1 interleukin 12 receptor, beta 1
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDM8 lysine (K)-specific demethylase 8
KIAA1462 KIAA1462
KRT34 keratin 34, type I
LY6D lymphocyte antigen 6 complex, locus D
LY96 lymphocyte antigen 96
LYPLA2P1 lysophospholipase II pseudogene 1
MCC mutated in colorectal cancers
MCMBP minichromosome maintenance complex binding protein
MEIS1 Meis homeobox 1
METTL16 methyltransferase like 16
MGP matrix Gla protein
MRPL41 mitochondrial ribosomal protein L41
MYH15 myosin, heavy chain 15
MYOZ1 myozenin 1
MYOZ3 myozenin 3
NABP1 nucleic acid binding protein 1
NAG18 NAG18 mRNA
NOL10 nucleolar protein 10
NPFFR1 neuropeptide FF receptor 1
OCA2 oculocutaneous albinism II
OLFM4 olfactomedin 4
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PLA2G1B phospholipase A2, group IB (pancreas)
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PRSS8 protease, serine, 8
PTK6 protein tyrosine kinase 6
PTPRS protein tyrosine phosphatase, receptor type, S
PWAR5 Prader Willi/Angelman region RNA 5
ROM1 retinal outer segment membrane protein 1
RUNDC3B RUN domain containing 3B
SCN1B sodium channel, voltage gated, type I beta subunit
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC25A40 solute carrier family 25, member 40
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SNHG3 small nucleolar RNA host gene 3
SPIDR scaffolding protein involved in DNA repair
STEAP4 STEAP family member 4
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TMEM53 transmembrane protein 53
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TSNAXIP1 translin-associated factor X interacting protein 1
WNT10B wingless-type MMTV integration site family, member 10B
ZBTB33 zinc finger and BTB domain containing 33
ZFP30 ZFP30 zinc finger protein
ZNF10 zinc finger protein 10
ZNF124 zinc finger protein 124
ZNF254 zinc finger protein 254
ZNF428 zinc finger protein 428
ZNF528 zinc finger protein 528
ZNF671 zinc finger protein 671
ZNF76 zinc finger protein 76
ZSCAN2 zinc finger and SCAN domain containing 2