clozapine-4453 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the clozapine-4453 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACO2 aconitase 2, mitochondrial
ADAM28 ADAM metallopeptidase domain 28
ADGRL3 adhesion G protein-coupled receptor L3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AHSG alpha-2-HS-glycoprotein
ANGPTL2 angiopoietin-like 2
ARSA arylsulfatase A
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATN1 atrophin 1
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BHLHB9 basic helix-loop-helix domain containing, class B, 9
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CADM3 cell adhesion molecule 3
CALB2 calbindin 2
CAMKV CaM kinase-like vesicle-associated
CCL27 chemokine (C-C motif) ligand 27
CD52 CD52 molecule
CD6 CD6 molecule
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
CLCA1 chloride channel accessory 1
CLCN7 chloride channel, voltage-sensitive 7
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DGKE diacylglycerol kinase, epsilon 64kDa
DOK2 docking protein 2, 56kDa
EDN1 endothelin 1
EIF3F eukaryotic translation initiation factor 3, subunit F
ESR1 estrogen receptor 1
FAIM2 Fas apoptotic inhibitory molecule 2
FCAR Fc fragment of IgA receptor
FGF6 fibroblast growth factor 6
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GRM8 glutamate receptor, metabotropic 8
GSTTP1 glutathione S-transferase theta pseudogene 1
HAMP hepcidin antimicrobial peptide
HAO2 hydroxyacid oxidase 2 (long chain)
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H3F histone cluster 1, H3f
HNF4A hepatocyte nuclear factor 4, alpha
HPCA hippocalcin
IL12B interleukin 12B
IRF4 interferon regulatory factor 4
ITGB8 integrin, beta 8
KHK ketohexokinase (fructokinase)
KLF13 Kruppel-like factor 13
KLK12 kallikrein-related peptidase 12
LAX1 lymphocyte transmembrane adaptor 1
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LRP4 low density lipoprotein receptor-related protein 4
MAP2K7 mitogen-activated protein kinase kinase 7
MAP7D3 MAP7 domain containing 3
MED25 mediator complex subunit 25
MRC2 mannose receptor, C type 2
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
MSLN mesothelin
NCAPH2 non-SMC condensin II complex, subunit H2
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NRG1 neuregulin 1
ONECUT2 one cut homeobox 2
OR10J1 olfactory receptor, family 10, subfamily J, member 1
PAGE4 P antigen family, member 4 (prostate associated)
PAX5 paired box 5
PCDH12 protocadherin 12
PGLYRP4 peptidoglycan recognition protein 4
PHOX2A paired-like homeobox 2a
PIAS2 protein inhibitor of activated STAT, 2
PIGR polymeric immunoglobulin receptor
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
PYY peptide YY
RGCC regulator of cell cycle
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNF208 ring finger protein 208
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
RUNX3 runt-related transcription factor 3
SALL1 spalt-like transcription factor 1
SCNN1D sodium channel, non voltage gated 1 delta subunit
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC17A2 solute carrier family 17, member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SPAG6 sperm associated antigen 6
SPAG8 sperm associated antigen 8
SULF1 sulfatase 1
SVIL supervillin
TEF thyrotrophic embryonic factor
TOX thymocyte selection-associated high mobility group box
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
UNC93A unc-93 homolog A (C. elegans)
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
ZNF440 zinc finger protein 440

decreased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
ABHD4 abhydrolase domain containing 4
ACTG2 actin, gamma 2, smooth muscle, enteric
ADGRB2 adhesion G protein-coupled receptor B2
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ALPK1 alpha-kinase 1
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
BEX1 brain expressed, X-linked 1
BMP4 bone morphogenetic protein 4
BNC1 basonuclin 1
C14ORF93 chromosome 14 open reading frame 93
C17ORF53 chromosome 17 open reading frame 53
C17ORF80 chromosome 17 open reading frame 80
C1QTNF3 C1q and tumor necrosis factor related protein 3
C1R complement component 1, r subcomponent
C5 complement component 5
CAMKMT calmodulin-lysine N-methyltransferase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCNO cyclin O
CD70 CD70 molecule
CFAP45 cilia and flagella associated protein 45
CHMP1A charged multivesicular body protein 1A
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CIDEC cell death-inducing DFFA-like effector c
CLDN11 claudin 11
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CNTLN centlein, centrosomal protein
COBL cordon-bleu WH2 repeat protein
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
EML4 echinoderm microtubule associated protein like 4
ERCC4 excision repair cross-complementation group 4
ERF Ets2 repressor factor
GLDC glycine dehydrogenase (decarboxylating)
GPR176 G protein-coupled receptor 176
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRAMD1C GRAM domain containing 1C
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HDAC11 histone deacetylase 11
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
IFI30 interferon, gamma-inducible protein 30
IL12RB1 interleukin 12 receptor, beta 1
IL33 interleukin 33
KIAA1107 KIAA1107
LINC00597 long intergenic non-protein coding RNA 597
LRP3 low density lipoprotein receptor-related protein 3
LRRC37A4P leucine rich repeat containing 37, member A4, pseudogene
MCRS1 microspherule protein 1
MOXD1 monooxygenase, DBH-like 1
MTA2 metastasis associated 1 family, member 2
MUM1 melanoma associated antigen (mutated) 1
MXD3 MAX dimerization protein 3
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
OSMR oncostatin M receptor
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PAX9 paired box 9
PECR peroxisomal trans-2-enoyl-CoA reductase
PER3 period circadian clock 3
PHEX phosphate regulating endopeptidase homolog, X-linked
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLA1A phospholipase A1 member A
POLL polymerase (DNA directed), lambda
POLM polymerase (DNA directed), mu
PORCN porcupine homolog (Drosophila)
PSAT1 phosphoserine aminotransferase 1
QSER1 glutamine and serine rich 1
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RNF25 ring finger protein 25
S100A3 S100 calcium binding protein A3
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SETD8 SET domain containing (lysine methyltransferase) 8
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SUGCT succinyl-CoA:glutarate-CoA transferase
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TCTN1 tectonic family member 1
THOP1 thimet oligopeptidase 1
THRAP3 thyroid hormone receptor associated protein 3
TMEM209 transmembrane protein 209
TRIM25 tripartite motif containing 25
TRIM45 tripartite motif containing 45
TUBA3C tubulin, alpha 3c
TUBGCP5 tubulin, gamma complex associated protein 5
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
YY2 YY2 transcription factor
ZC2HC1C zinc finger, C2HC-type containing 1C
ZNF141 zinc finger protein 141
ZNF197 zinc finger protein 197
ZNF37BP zinc finger protein 37B, pseudogene
ZNF442 zinc finger protein 442
ZNF573 zinc finger protein 573