clozapine-2689 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the clozapine-2689 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACRV1 acrosomal vesicle protein 1
ADAM22 ADAM metallopeptidase domain 22
ADGRF5 adhesion G protein-coupled receptor F5
BMP8B bone morphogenetic protein 8b
BTF3P11 basic transcription factor 3 pseudogene 11
C1ORF105 chromosome 1 open reading frame 105
C5AR1 complement component 5a receptor 1
CABP1 calcium binding protein 1
CALD1 caldesmon 1
CASR calcium-sensing receptor
CD59 CD59 molecule, complement regulatory protein
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CLDN1 claudin 1
CPN2 carboxypeptidase N, polypeptide 2
DGCR8 DGCR8 microprocessor complex subunit
DGKE diacylglycerol kinase, epsilon 64kDa
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
E2F2 E2F transcription factor 2
EBF2 early B-cell factor 2
EDA ectodysplasin A
EPHB2 EPH receptor B2
FABP6 fatty acid binding protein 6, ileal
FBXO40 F-box protein 40
FUBP1 far upstream element (FUSE) binding protein 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GC group-specific component (vitamin D binding protein)
GPR37L1 G protein-coupled receptor 37 like 1
GUCA2B guanylate cyclase activator 2B (uroguanylin)
HDAC7 histone deacetylase 7
HIST1H2BJ histone cluster 1, H2bj
HOXD13 homeobox D13
HTR7P1 5-hydroxytryptamine (serotonin) receptor 7 pseudogene 1
HUS1 HUS1 checkpoint homolog (S. pombe)
ICOS inducible T-cell co-stimulator
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IL36RN interleukin 36 receptor antagonist
INCENP inner centromere protein antigens 135/155kDa
ISG20 interferon stimulated exonuclease gene 20kDa
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KCNH6 potassium channel, voltage gated eag related subfamily H, member 6
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KIAA0125 KIAA0125
KIAA1045 KIAA1045
KMT2A lysine (K)-specific methyltransferase 2A
KRT14 keratin 14, type I
LLGL1 lethal giant larvae homolog 1 (Drosophila)
MAU2 MAU2 sister chromatid cohesion factor
MTUS1 microtubule associated tumor suppressor 1
MUC6 mucin 6, oligomeric mucus/gel-forming
NEFM neurofilament, medium polypeptide
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NUDC nudC nuclear distribution protein
ONECUT1 one cut homeobox 1
PADI4 peptidyl arginine deiminase, type IV
PARP3 poly (ADP-ribose) polymerase family, member 3
PDE4DIP phosphodiesterase 4D interacting protein
PHKG1 phosphorylase kinase, gamma 1 (muscle)
PKP3 plakophilin 3
PPIA peptidylprolyl isomerase A (cyclophilin A)
PRSS21 protease, serine, 21 (testisin)
RFC1 replication factor C (activator 1) 1, 145kDa
RLN1 relaxin 1
SCUBE3 signal peptide, CUB domain, EGF-like 3
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SMG7-AS1 SMG7 antisense RNA 1
SNAP25 synaptosomal-associated protein, 25kDa
SPRR2B small proline-rich protein 2B
SRPK3 SRSF protein kinase 3
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
STMN4 stathmin-like 4
STX11 syntaxin 11
STX5 syntaxin 5
STX7 syntaxin 7
SUGCT succinyl-CoA:glutarate-CoA transferase
SUSD5 sushi domain containing 5
SYT13 synaptotagmin XIII
SYT5 synaptotagmin V
TESK1 testis-specific kinase 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TLX3 T-cell leukemia homeobox 3
TMEM63A transmembrane protein 63A
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TPMT thiopurine S-methyltransferase
TRD T cell receptor delta locus
TSPAN2 tetraspanin 2
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
ZFHX3 zinc finger homeobox 3
ZNF259P1 zinc finger protein 259 pseudogene 1
ZNF385D zinc finger protein 385D

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADGRE3 adhesion G protein-coupled receptor E3
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
BNC2 basonuclin 2
C16ORF59 chromosome 16 open reading frame 59
C7ORF43 chromosome 7 open reading frame 43
CCL27 chemokine (C-C motif) ligand 27
CD160 CD160 molecule
CD79B CD79b molecule, immunoglobulin-associated beta
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CGA glycoprotein hormones, alpha polypeptide
CLGN calmegin
CLIP2 CAP-GLY domain containing linker protein 2
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DNM3 dynamin 3
DSCAM Down syndrome cell adhesion molecule
EGR3 early growth response 3
EHD3 EH-domain containing 3
ENO3 enolase 3 (beta, muscle)
EXO5 exonuclease 5
FAM131A family with sequence similarity 131, member A
FAM53B family with sequence similarity 53, member B
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FBXL2 F-box and leucine-rich repeat protein 2
FGF6 fibroblast growth factor 6
G0S2 G0/G1 switch 2
GID4 GID complex subunit 4
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GPATCH2L G patch domain containing 2-like
GPC1 glypican 1
GPR3 G protein-coupled receptor 3
GTF2IRD1 GTF2I repeat domain containing 1
GUCA2A guanylate cyclase activator 2A (guanylin)
HIST1H2AJ histone cluster 1, H2aj
HOXB9 homeobox B9
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
IBSP integrin-binding sialoprotein
IDI2-AS1 IDI2 antisense RNA 1
INA internexin neuronal intermediate filament protein, alpha
LIG4 ligase IV, DNA, ATP-dependent
LY6E lymphocyte antigen 6 complex, locus E
MARC1 mitochondrial amidoxime reducing component 1
MDM4 MDM4, p53 regulator
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MLPH melanophilin
MRAS muscle RAS oncogene homolog
MTERF4 mitochondrial transcription termination factor 4
MTHFSD methenyltetrahydrofolate synthetase domain containing
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NFE2L3 nuclear factor, erythroid 2-like 3
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
P2RY11 purinergic receptor P2Y, G-protein coupled, 11
PGP phosphoglycolate phosphatase
PLA2G15 phospholipase A2, group XV
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRDM12 PR domain containing 12
PRKCZ protein kinase C, zeta
PYGB phosphorylase, glycogen; brain
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RNF122 ring finger protein 122
RNF25 ring finger protein 25
RPL13P5 ribosomal protein L13 pseudogene 5
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SALL2 spalt-like transcription factor 2
SCRN3 secernin 3
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SH3BGR SH3 domain binding glutamate-rich protein
SLC22A14 solute carrier family 22, member 14
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SPATA2L spermatogenesis associated 2-like
TAOK1 TAO kinase 1
TBKBP1 TBK1 binding protein 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TMEM180 transmembrane protein 180
TMEM53 transmembrane protein 53
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TPM3 tropomyosin 3
TRAF2 TNF receptor-associated factor 2
TTC26 tetratricopeptide repeat domain 26
TUBA3C tubulin, alpha 3c
TXLNG taxilin gamma
UNC13A unc-13 homolog A (C. elegans)
USP32 ubiquitin specific peptidase 32
VEZT vezatin, adherens junctions transmembrane protein
ZBTB6 zinc finger and BTB domain containing 6
ZNF276 zinc finger protein 276
ZNF528 zinc finger protein 528
ZNF711 zinc finger protein 711
ZNF768 zinc finger protein 768