clozapine-2644 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the clozapine-2644 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A1CF APOBEC1 complementation factor
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACAA2 acetyl-CoA acyltransferase 2
AGFG2 ArfGAP with FG repeats 2
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BEND5 BEN domain containing 5
BIN1 bridging integrator 1
C10ORF95 chromosome 10 open reading frame 95
C1QL1 complement component 1, q subcomponent-like 1
C22ORF46 chromosome 22 open reading frame 46
CASP5 caspase 5, apoptosis-related cysteine peptidase
CD300A CD300a molecule
CD6 CD6 molecule
CDHR2 cadherin-related family member 2
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
COL1A1 collagen, type I, alpha 1
COL4A1 collagen, type IV, alpha 1
CPNE7 copine VII
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
CYTH4 cytohesin 4
DMTN dematin actin binding protein
DOK2 docking protein 2, 56kDa
DUSP1 dual specificity phosphatase 1
ELL elongation factor RNA polymerase II
ELL2 elongation factor, RNA polymerase II, 2
ELOVL5 ELOVL fatty acid elongase 5
FAM155A family with sequence similarity 155, member A
FAM184A family with sequence similarity 184, member A
FGF6 fibroblast growth factor 6
FH fumarate hydratase
FLOT2 flotillin 2
FOXN2 forkhead box N2
FRMPD1 FERM and PDZ domain containing 1
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GNA14 guanine nucleotide binding protein (G protein), alpha 14
HES2 hes family bHLH transcription factor 2
HR hair growth associated
IGLJ3 immunoglobulin lambda joining 3
INHBC inhibin, beta C
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
IQSEC2 IQ motif and Sec7 domain 2
JUN jun proto-oncogene
KLK7 kallikrein-related peptidase 7
KRT83 keratin 83, type II
LAMA4 laminin, alpha 4
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LRRC48 leucine rich repeat containing 48
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARK4 MAP/microtubule affinity-regulating kinase 4
METTL7A methyltransferase like 7A
MOCS1 molybdenum cofactor synthesis 1
NEB nebulin
NOL12 nucleolar protein 12
NPTX1 neuronal pentraxin I
NR2F6 nuclear receptor subfamily 2, group F, member 6
NR4A2 nuclear receptor subfamily 4, group A, member 2
ONECUT2 one cut homeobox 2
PARVB parvin, beta
PAX8 paired box 8
PHF7 PHD finger protein 7
PIN1P1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 pseudogene 1
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
POFUT1 protein O-fucosyltransferase 1
PPARD peroxisome proliferator-activated receptor delta
PRB3 proline-rich protein BstNI subfamily 3
PRKCA protein kinase C, alpha
PRKCE protein kinase C, epsilon
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RABGAP1L RAB GTPase activating protein 1-like
RNF43 ring finger protein 43
RPL23AP32 ribosomal protein L23a pseudogene 32
RPS4Y1 ribosomal protein S4, Y-linked 1
RUNX1 runt-related transcription factor 1
SENP7 SUMO1/sentrin specific peptidase 7
SH2D1A SH2 domain containing 1A
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLIT1 slit homolog 1 (Drosophila)
SPAG8 sperm associated antigen 8
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPTBN1 spectrin, beta, non-erythrocytic 1
STMN3 stathmin-like 3
TAS2R9 taste receptor, type 2, member 9
TDRKH tudor and KH domain containing
TGFB1 transforming growth factor, beta 1
TMCC2 transmembrane and coiled-coil domain family 2
TRAC T cell receptor alpha constant
UBXN1 UBX domain protein 1
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
VWA5A von Willebrand factor A domain containing 5A
XYLB xylulokinase homolog (H. influenzae)
ZFP37 ZFP37 zinc finger protein
ZNF37BP zinc finger protein 37B, pseudogene
ZNF771 zinc finger protein 771

decreased expression

Symbol Name
ADCY6 adenylate cyclase 6
ADORA2B adenosine A2b receptor
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANKRD40 ankyrin repeat domain 40
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ARRB1 arrestin, beta 1
ATAD3A ATPase family, AAA domain containing 3A
AXIN1 axin 1
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BTBD2 BTB (POZ) domain containing 2
C11ORF30 chromosome 11 open reading frame 30
CBX7 chromobox homolog 7
CCDC85C coiled-coil domain containing 85C
CD79B CD79b molecule, immunoglobulin-associated beta
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHKB choline kinase beta
CLASP1 cytoplasmic linker associated protein 1
CLCN5 chloride channel, voltage-sensitive 5
CLDN15 claudin 15
CLK1 CDC-like kinase 1
CTNNBIP1 catenin, beta interacting protein 1
CXORF56 chromosome X open reading frame 56
DNA2 DNA replication helicase/nuclease 2
EFNA3 ephrin-A3
EHMT1 euchromatic histone-lysine N-methyltransferase 1
FBRS fibrosin
FILIP1L filamin A interacting protein 1-like
GID4 GID complex subunit 4
GLCE glucuronic acid epimerase
GMEB1 glucocorticoid modulatory element binding protein 1
GRPR gastrin-releasing peptide receptor
HOOK1 hook microtubule-tethering protein 1
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
KIF13B kinesin family member 13B
KIFAP3 kinesin-associated protein 3
KLF3 Kruppel-like factor 3 (basic)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG4 ligase IV, DNA, ATP-dependent
LINC00115 long intergenic non-protein coding RNA 115
LINC00339 long intergenic non-protein coding RNA 339
LRRC20 leucine rich repeat containing 20
LY6G6C lymphocyte antigen 6 complex, locus G6C
LYPD1 LY6/PLAUR domain containing 1
MANEA mannosidase, endo-alpha
MAP1S microtubule-associated protein 1S
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MED24 mediator complex subunit 24
MEIS1 Meis homeobox 1
MTRF1 mitochondrial translational release factor 1
MVD mevalonate (diphospho) decarboxylase
NKX3-2 NK3 homeobox 2
NPFFR1 neuropeptide FF receptor 1
NPM3 nucleophosmin/nucleoplasmin 3
NUBPL nucleotide binding protein-like
OLFML2A olfactomedin-like 2A
PADI2 peptidyl arginine deiminase, type II
PEX26 peroxisomal biogenesis factor 26
PHEX phosphate regulating endopeptidase homolog, X-linked
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
PMCH pro-melanin-concentrating hormone
POLE polymerase (DNA directed), epsilon, catalytic subunit
POLL polymerase (DNA directed), lambda
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
QTRT1 queuine tRNA-ribosyltransferase 1
RARS arginyl-tRNA synthetase
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF121 ring finger protein 121
RNF141 ring finger protein 141
RPAIN RPA interacting protein
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC12A9 solute carrier family 12, member 9
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SPG11 spastic paraplegia 11 (autosomal recessive)
SPINK5 serine peptidase inhibitor, Kazal type 5
SSFA2 sperm specific antigen 2
STX1A syntaxin 1A (brain)
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TCTN2 tectonic family member 2
TFB1M transcription factor B1, mitochondrial
TICAM1 toll-like receptor adaptor molecule 1
TMEM180 transmembrane protein 180
TMEM62 transmembrane protein 62
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)
UBXN8 UBX domain protein 8
ZBTB22 zinc finger and BTB domain containing 22
ZBTB25 zinc finger and BTB domain containing 25
ZMAT5 zinc finger, matrin-type 5
ZNF329 zinc finger protein 329
ZNF573 zinc finger protein 573
ZNF74 zinc finger protein 74
ZNF770 zinc finger protein 770
ZNRD1-AS1 ZNRD1 antisense RNA 1