clozapine-1654 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the clozapine-1654 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM17 ADAM metallopeptidase domain 17
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AK1 adenylate kinase 1
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C9ORF156 chromosome 9 open reading frame 156
CCDC121 coiled-coil domain containing 121
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDK3 cyclin-dependent kinase 3
CHKB choline kinase beta
CLUAP1 clusterin associated protein 1
COPZ2 coatomer protein complex, subunit zeta 2
DSCR3 Down syndrome critical region 3
EDRF1 erythroid differentiation regulatory factor 1
EGFL7 EGF-like-domain, multiple 7
ENPEP glutamyl aminopeptidase (aminopeptidase A)
ERAP1 endoplasmic reticulum aminopeptidase 1
EXOC7 exocyst complex component 7
F3 coagulation factor III (thromboplastin, tissue factor)
FAM174B family with sequence similarity 174, member B
FAM46C family with sequence similarity 46, member C
FILIP1L filamin A interacting protein 1-like
FSCN1 fascin actin-bundling protein 1
GAMT guanidinoacetate N-methyltransferase
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GPR1 G protein-coupled receptor 1
GSK3A glycogen synthase kinase 3 alpha
GSPT1 G1 to S phase transition 1
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HIP1 huntingtin interacting protein 1
HIST1H2AI histone cluster 1, H2ai
HSDL2 hydroxysteroid dehydrogenase like 2
ICOSLG inducible T-cell co-stimulator ligand
IL11 interleukin 11
IL4R interleukin 4 receptor
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
KAT6A K(lysine) acetyltransferase 6A
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KIAA0040 KIAA0040
KRI1 KRI1 homolog (S. cerevisiae)
LEPR leptin receptor
LINC00339 long intergenic non-protein coding RNA 339
LUC7L3 LUC7-like 3 (S. cerevisiae)
LUZP1 leucine zipper protein 1
LUZP4 leucine zipper protein 4
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MARK4 MAP/microtubule affinity-regulating kinase 4
MEIS2 Meis homeobox 2
METTL5 methyltransferase like 5
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MMP2 matrix metallopeptidase 2
MSL3 male-specific lethal 3 homolog (Drosophila)
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NEK1 NIMA-related kinase 1
NEK3 NIMA-related kinase 3
NOX1 NADPH oxidase 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NYNRIN NYN domain and retroviral integrase containing
PCDHGB5 protocadherin gamma subfamily B, 5
PEX3 peroxisomal biogenesis factor 3
PIDD1 p53-induced death domain protein 1
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLD2 phospholipase D2
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
PRR4 proline rich 4 (lacrimal)
RAB2A RAB2A, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAD51B RAD51 paralog B
RAP2B RAP2B, member of RAS oncogene family
RBM19 RNA binding motif protein 19
RNF39 ring finger protein 39
RPL35A ribosomal protein L35a
RPS4Y1 ribosomal protein S4, Y-linked 1
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SIPA1L3 signal-induced proliferation-associated 1 like 3
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SRPR signal recognition particle receptor (docking protein)
SRSF8 serine/arginine-rich splicing factor 8
STRN3 striatin, calmodulin binding protein 3
TFG TRK-fused gene
TIAM1 T-cell lymphoma invasion and metastasis 1
TK2 thymidine kinase 2, mitochondrial
TLR5 toll-like receptor 5
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TRIM25 tripartite motif containing 25
TSPAN9 tetraspanin 9
TTBK2 tau tubulin kinase 2
TWF1 twinfilin actin binding protein 1
VGF VGF nerve growth factor inducible
XK X-linked Kx blood group
ZCCHC24 zinc finger, CCHC domain containing 24
ZER1 zyg-11 related, cell cycle regulator
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZNF75D zinc finger protein 75D
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
ABLIM3 actin binding LIM protein family, member 3
ACAD10 acyl-CoA dehydrogenase family, member 10
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ACVR2A activin A receptor, type IIA
ADCY6 adenylate cyclase 6
ADGRE5 adhesion G protein-coupled receptor E5
APOD apolipoprotein D
BATF basic leucine zipper transcription factor, ATF-like
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2L2 BCL2-like 2
C11ORF80 chromosome 11 open reading frame 80
C1ORF56 chromosome 1 open reading frame 56
C7ORF43 chromosome 7 open reading frame 43
CAMTA2 calmodulin binding transcription activator 2
CASZ1 castor zinc finger 1
CCNO cyclin O
CCNT1 cyclin T1
CCP110 centriolar coiled coil protein 110kDa
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CD302 CD302 molecule
CDC73 cell division cycle 73
CDKL3 cyclin-dependent kinase-like 3
CGA glycoprotein hormones, alpha polypeptide
CHPF chondroitin polymerizing factor
CLDN15 claudin 15
CLEC16A C-type lectin domain family 16, member A
COG4 component of oligomeric golgi complex 4
CORO1A coronin, actin binding protein, 1A
CORO2A coronin, actin binding protein, 2A
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CTSK cathepsin K
DENND4A DENN/MADD domain containing 4A
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
EFHD2 EF-hand domain family, member D2
EFNA3 ephrin-A3
ELOVL4 ELOVL fatty acid elongase 4
FBXO22 F-box protein 22
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GLS2 glutaminase 2 (liver, mitochondrial)
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HIST1H2AM histone cluster 1, H2am
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase
IDI2-AS1 IDI2 antisense RNA 1
IL15RA interleukin 15 receptor, alpha
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KCTD20 potassium channel tetramerization domain containing 20
LNPEP leucyl/cystinyl aminopeptidase
LOC730101 uncharacterized LOC730101
MAST3 microtubule associated serine/threonine kinase 3
MECR mitochondrial trans-2-enoyl-CoA reductase
METTL16 methyltransferase like 16
MITF microphthalmia-associated transcription factor
MUM1 melanoma associated antigen (mutated) 1
MYO1D myosin ID
NABP2 nucleic acid binding protein 2
NCAM2 neural cell adhesion molecule 2
NFE2L3 nuclear factor, erythroid 2-like 3
NKAIN1 Na+/K+ transporting ATPase interacting 1
NPM3 nucleophosmin/nucleoplasmin 3
NRGN neurogranin (protein kinase C substrate, RC3)
OTUD3 OTU deubiquitinase 3
PARG poly (ADP-ribose) glycohydrolase
PCSK7 proprotein convertase subtilisin/kexin type 7
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLD3 phospholipase D family, member 3
PLEKHO1 pleckstrin homology domain containing, family O member 1
RABL3 RAB, member of RAS oncogene family-like 3
RECQL4 RecQ protein-like 4
RFTN1 raftlin, lipid raft linker 1
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SH2D4A SH2 domain containing 4A
SIDT1 SID1 transmembrane family, member 1
SKA1 spindle and kinetochore associated complex subunit 1
SLC16A6 solute carrier family 16, member 6
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC2A4RG SLC2A4 regulator
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SPAG4 sperm associated antigen 4
SPATA2L spermatogenesis associated 2-like
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
TCTN2 tectonic family member 2
THBS3 thrombospondin 3
TMEM177 transmembrane protein 177
TPRA1 transmembrane protein, adipocyte asscociated 1
TTC23 tetratricopeptide repeat domain 23
TUBG2 tubulin, gamma 2
UBQLN4 ubiquilin 4
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZBTB48 zinc finger and BTB domain containing 48
ZC3H3 zinc finger CCCH-type containing 3
ZNF324 zinc finger protein 324
ZNF787 zinc finger protein 787
ZNHIT2 zinc finger, HIT-type containing 2