clozapine-1229 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the clozapine-1229 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACVR2B activin A receptor, type IIB
AKAP7 A kinase (PRKA) anchor protein 7
AMDHD2 amidohydrolase domain containing 2
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9
ATAD5 ATPase family, AAA domain containing 5
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7
BBC3 BCL2 binding component 3
C10ORF10 chromosome 10 open reading frame 10
CA5BP1 carbonic anhydrase VB pseudogene 1
CARTPT CART prepropeptide
CD40 CD40 molecule, TNF receptor superfamily member 5
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEP250 centrosomal protein 250kDa
CLEC4E C-type lectin domain family 4, member E
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DLK2 delta-like 2 homolog (Drosophila)
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EDRF1 erythroid differentiation regulatory factor 1
EGLN3 egl-9 family hypoxia-inducible factor 3
EML3 echinoderm microtubule associated protein like 3
EPHA1 EPH receptor A1
FADS3 fatty acid desaturase 3
FCMR Fc fragment of IgM receptor
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GHRHR growth hormone releasing hormone receptor
GJA4 gap junction protein, alpha 4, 37kDa
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GRTP1 growth hormone regulated TBC protein 1
GSK3A glycogen synthase kinase 3 alpha
HPS1 Hermansky-Pudlak syndrome 1
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KRT24 keratin 24, type I
KYNU kynureninase
LAMA4 laminin, alpha 4
LPCAT3 lysophosphatidylcholine acyltransferase 3
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LYZ lysozyme
MDFI MyoD family inhibitor
MEFV Mediterranean fever
METTL5 methyltransferase like 5
MMP14 matrix metallopeptidase 14 (membrane-inserted)
NDE1 nudE neurodevelopment protein 1
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NOS1 nitric oxide synthase 1 (neuronal)
NPAS2 neuronal PAS domain protein 2
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDIA2 protein disulfide isomerase family A, member 2
PER3 period circadian clock 3
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCH1 phospholipase C, eta 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLEKHO1 pleckstrin homology domain containing, family O member 1
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PPP1R7 protein phosphatase 1, regulatory subunit 7
PTAFR platelet-activating factor receptor
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
RAB11FIP3 RAB11 family interacting protein 3 (class II)
RGS4 regulator of G-protein signaling 4
RHOBTB2 Rho-related BTB domain containing 2
RPLP2 ribosomal protein, large, P2
RTEL1 regulator of telomere elongation helicase 1
SFTPB surfactant protein B
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SIX1 SIX homeobox 1
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SLN sarcolipin
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMG5 SMG5 nonsense mediated mRNA decay factor
SOD3 superoxide dismutase 3, extracellular
SPTB spectrin, beta, erythrocytic
SPTBN1 spectrin, beta, non-erythrocytic 1
SSX1 synovial sarcoma, X breakpoint 1
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae)
SYNGR4 synaptogyrin 4
TADA2A transcriptional adaptor 2A
TBL2 transducin (beta)-like 2
TJAP1 tight junction associated protein 1 (peripheral)
TLE2 transducin-like enhancer of split 2
TMEM209 transmembrane protein 209
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TP53I11 tumor protein p53 inducible protein 11
TRABD TraB domain containing
TRIM25 tripartite motif containing 25
TRPM4 transient receptor potential cation channel, subfamily M, member 4
USB1 U6 snRNA biogenesis 1
WIPI2 WD repeat domain, phosphoinositide interacting 2
ZBTB6 zinc finger and BTB domain containing 6
ZNF197 zinc finger protein 197
ZNF606 zinc finger protein 606
ZNF74 zinc finger protein 74
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
ABHD8 abhydrolase domain containing 8
ACAD10 acyl-CoA dehydrogenase family, member 10
ACBD4 acyl-CoA binding domain containing 4
AEN apoptosis enhancing nuclease
ALPK1 alpha-kinase 1
ANKEF1 ankyrin repeat and EF-hand domain containing 1
APLP1 amyloid beta (A4) precursor-like protein 1
ARRB2 arrestin, beta 2
ARSJ arylsulfatase family, member J
ASB7 ankyrin repeat and SOCS box containing 7
BAG4 BCL2-associated athanogene 4
BCL9 B-cell CLL/lymphoma 9
BCOR BCL6 corepressor
BRIP1 BRCA1 interacting protein C-terminal helicase 1
BRIX1 BRX1, biogenesis of ribosomes
C4ORF19 chromosome 4 open reading frame 19
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCP110 centriolar coiled coil protein 110kDa
CDC37L1 cell division cycle 37-like 1
CHML choroideremia-like (Rab escort protein 2)
CLCN5 chloride channel, voltage-sensitive 5
CNTNAP3B contactin associated protein-like 3B
CTSF cathepsin F
DCAF13 DDB1 and CUL4 associated factor 13
DEPTOR DEP domain containing MTOR-interacting protein
DLEU2 deleted in lymphocytic leukemia 2 (non-protein coding)
DMTN dematin actin binding protein
EML4 echinoderm microtubule associated protein like 4
EYA4 EYA transcriptional coactivator and phosphatase 4
FBXL6 F-box and leucine-rich repeat protein 6
FBXL7 F-box and leucine-rich repeat protein 7
FUZ fuzzy planar cell polarity protein
GID4 GID complex subunit 4
GLS2 glutaminase 2 (liver, mitochondrial)
GRAMD1C GRAM domain containing 1C
HDAC5 histone deacetylase 5
HSPA4L heat shock 70kDa protein 4-like
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IREB2 iron-responsive element binding protein 2
KDM5C lysine (K)-specific demethylase 5C
LPAR3 lysophosphatidic acid receptor 3
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3
LYPD1 LY6/PLAUR domain containing 1
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAGEA6 melanoma antigen family A6
MAGEH1 melanoma antigen family H1
MAP6D1 MAP6 domain containing 1
METTL8 methyltransferase like 8
MFSD6 major facilitator superfamily domain containing 6
MRPL44 mitochondrial ribosomal protein L44
MUM1 melanoma associated antigen (mutated) 1
MYLIP myosin regulatory light chain interacting protein
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
NOL12 nucleolar protein 12
NOTCH1 notch 1
NRSN2 neurensin 2
NYNRIN NYN domain and retroviral integrase containing
OSMR oncostatin M receptor
PARP3 poly (ADP-ribose) polymerase family, member 3
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PEX26 peroxisomal biogenesis factor 26
PGM1 phosphoglucomutase 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PRR14L proline rich 14-like
PSKH1 protein serine kinase H1
PTGFR prostaglandin F receptor (FP)
RARS arginyl-tRNA synthetase
RBBP5 retinoblastoma binding protein 5
SCYL2 SCY1-like 2 (S. cerevisiae)
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SNPH syntaphilin
SPATA7 spermatogenesis associated 7
SPEG SPEG complex locus
SPIDR scaffolding protein involved in DNA repair
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae)
SYTL2 synaptotagmin-like 2
TGS1 trimethylguanosine synthase 1
TINAGL1 tubulointerstitial nephritis antigen-like 1
TMEM104 transmembrane protein 104
TMEM177 transmembrane protein 177
TRAIP TRAF interacting protein
TSPAN8 tetraspanin 8
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
ZHX2 zinc fingers and homeoboxes 2
ZMYM3 zinc finger, MYM-type 3
ZNF177 zinc finger protein 177
ZNF230 zinc finger protein 230
ZNF253 zinc finger protein 253
ZNF37BP zinc finger protein 37B, pseudogene
ZNF574 zinc finger protein 574
ZNF623 zinc finger protein 623
ZNF667 zinc finger protein 667
ZSCAN5A zinc finger and SCAN domain containing 5A