clozapine-1170 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the clozapine-1170 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOX1 acyl-CoA oxidase 1, palmitoyl
ADARB1 adenosine deaminase, RNA-specific, B1
ALS2CL ALS2 C-terminal like
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APP amyloid beta (A4) precursor protein
AREG amphiregulin
ARHGAP1 Rho GTPase activating protein 1
ARL2BP ADP-ribosylation factor-like 2 binding protein
ARMC6 armadillo repeat containing 6
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1
BTG2 BTG family, member 2
C1ORF56 chromosome 1 open reading frame 56
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CD79B CD79b molecule, immunoglobulin-associated beta
CEP290 centrosomal protein 290kDa
CLCN5 chloride channel, voltage-sensitive 5
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CTSB cathepsin B
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
DGKA diacylglycerol kinase, alpha 80kDa
DKFZP434L187 uncharacterized LOC26082
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ELL elongation factor RNA polymerase II
EPHA4 EPH receptor A4
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERAP2 endoplasmic reticulum aminopeptidase 2
EYA3 EYA transcriptional coactivator and phosphatase 3
FH fumarate hydratase
FLI1 Fli-1 proto-oncogene, ETS transcription factor
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa
HSDL2 hydroxysteroid dehydrogenase like 2
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL1RN interleukin 1 receptor antagonist
IL24 interleukin 24
INO80B INO80 complex subunit B
IQSEC2 IQ motif and Sec7 domain 2
KIAA0753 KIAA0753
KIAA1109 KIAA1109
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
MAN1C1 mannosidase, alpha, class 1C, member 1
MAP2K4 mitogen-activated protein kinase kinase 4
MAP2K5 mitogen-activated protein kinase kinase 5
MCL1 myeloid cell leukemia 1
MCOLN1 mucolipin 1
MFSD11 major facilitator superfamily domain containing 11
MSRB2 methionine sulfoxide reductase B2
MYO1B myosin IB
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NINJ2 ninjurin 2
NLK nemo-like kinase
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NOP16 NOP16 nucleolar protein
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PAM peptidylglycine alpha-amidating monooxygenase
PDIA2 protein disulfide isomerase family A, member 2
POLR2D polymerase (RNA) II (DNA directed) polypeptide D
PSEN1 presenilin 1
PSEN2 presenilin 2
PTAFR platelet-activating factor receptor
PTBP3 polypyrimidine tract binding protein 3
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
REEP4 receptor accessory protein 4
RGS14 regulator of G-protein signaling 14
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RUNX1 runt-related transcription factor 1
SEC24D SEC24 family member D
SH3GL1 SH3-domain GRB2-like 1
SHB Src homology 2 domain containing adaptor protein B
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
SOAT1 sterol O-acyltransferase 1
SOX12 SRY (sex determining region Y)-box 12
SRPK3 SRSF protein kinase 3
SRSF7 serine/arginine-rich splicing factor 7
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
STARD3 StAR-related lipid transfer (START) domain containing 3
STK17A serine/threonine kinase 17a
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TNNT1 troponin T type 1 (skeletal, slow)
TNS1 tensin 1
TRA T cell receptor alpha locus
TRAF1 TNF receptor-associated factor 1
TULP3 tubby like protein 3
UBOX5 U-box domain containing 5
VPS13B vacuolar protein sorting 13 homolog B (yeast)
WAPAL wings apart-like homolog (Drosophila)
WDR33 WD repeat domain 33
ZBTB43 zinc finger and BTB domain containing 43
ZNF224 zinc finger protein 224
ZNF552 zinc finger protein 552

decreased expression

Symbol Name
ACAD10 acyl-CoA dehydrogenase family, member 10
APOBR apolipoprotein B receptor
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
ASPN asporin
ATAD2B ATPase family, AAA domain containing 2B
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
ATXN2 ataxin 2
BAHD1 bromo adjacent homology domain containing 1
BAK1 BCL2-antagonist/killer 1
BRPF1 bromodomain and PHD finger containing, 1
C1ORF106 chromosome 1 open reading frame 106
C1ORF21 chromosome 1 open reading frame 21
C22ORF29 chromosome 22 open reading frame 29
C8ORF44 chromosome 8 open reading frame 44
CCDC109B coiled-coil domain containing 109B
CCNJ cyclin J
CD1D CD1d molecule
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CEP97 centrosomal protein 97kDa
CFAP44 cilia and flagella associated protein 44
CHMP1A charged multivesicular body protein 1A
CLEC4E C-type lectin domain family 4, member E
CLSPN claspin
COG4 component of oligomeric golgi complex 4
CRIP1 cysteine-rich protein 1 (intestinal)
CTNNBIP1 catenin, beta interacting protein 1
CYSLTR1 cysteinyl leukotriene receptor 1
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DOLK dolichol kinase
DYM dymeclin
ERCC6L excision repair cross-complementation group 6-like
FAM204A family with sequence similarity 204, member A
FAM53B family with sequence similarity 53, member B
FPGS folylpolyglutamate synthase
GLTSCR1 glioma tumor suppressor candidate region gene 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPR22 G protein-coupled receptor 22
GPR65 G protein-coupled receptor 65
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
HDAC5 histone deacetylase 5
HELZ helicase with zinc finger
HHLA3 HERV-H LTR-associating 3
IL4R interleukin 4 receptor
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
KIAA0556 KIAA0556
KLHL21 kelch-like family member 21
LIMD2 LIM domain containing 2
LRRC42 leucine rich repeat containing 42
MAPKAP1 mitogen-activated protein kinase associated protein 1
MKL2 MKL/myocardin-like 2
MPC1 mitochondrial pyruvate carrier 1
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYL5 myosin, light chain 5, regulatory
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PGM1 phosphoglucomutase 1
PGPEP1 pyroglutamyl-peptidase I
PLA2G15 phospholipase A2, group XV
PLIN3 perilipin 3
PNOC prepronociceptin
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
RECQL4 RecQ protein-like 4
RFC4 replication factor C (activator 1) 4, 37kDa
RGS19 regulator of G-protein signaling 19
SALL2 spalt-like transcription factor 2
SAMD9 sterile alpha motif domain containing 9
SCRN3 secernin 3
SETD6 SET domain containing 6
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SIPA1 signal-induced proliferation-associated 1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMAD7 SMAD family member 7
STX17 syntaxin 17
TBX19 T-box 19
TERT telomerase reverse transcriptase
THOC1 THO complex 1
TM7SF3 transmembrane 7 superfamily member 3
TMA7 translation machinery associated 7 homolog (S. cerevisiae)
TMEM127 transmembrane protein 127
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNRC6B trinucleotide repeat containing 6B
TOR3A torsin family 3, member A
TPCN1 two pore segment channel 1
TRIM45 tripartite motif containing 45
TRPV2 transient receptor potential cation channel, subfamily V, member 2
TSPAN13 tetraspanin 13
TSPYL2 TSPY-like 2
TUBGCP5 tubulin, gamma complex associated protein 5
UBXN6 UBX domain protein 6
URM1 ubiquitin related modifier 1
VANGL1 VANGL planar cell polarity protein 1
VILL villin-like
WT1-AS WT1 antisense RNA
ZNF580 zinc finger protein 580
ZNF665 zinc finger protein 665
ZNF7 zinc finger protein 7
ZNF74 zinc finger protein 74
ZNF816 zinc finger protein 816