clozapine-1009 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the clozapine-1009 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACVR1B activin A receptor, type IB
ALOX15 arachidonate 15-lipoxygenase
ALS2CL ALS2 C-terminal like
ARHGAP33 Rho GTPase activating protein 33
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ARRB1 arrestin, beta 1
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BCL6 B-cell CLL/lymphoma 6
BICD1 bicaudal D homolog 1 (Drosophila)
BMP2K BMP2 inducible kinase
BMP5 bone morphogenetic protein 5
CD6 CD6 molecule
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CNGA1 cyclic nucleotide gated channel alpha 1
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CUL9 cullin 9
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOHH deoxyhypusine hydroxylase/monooxygenase
DTX2P1-UPK3BP1-PMS2P11 DTX2P1-UPK3BP1-PMS2P11 readthrough transcribed pseudogene
ETNK2 ethanolamine kinase 2
F11R F11 receptor
FADS3 fatty acid desaturase 3
FAM214B family with sequence similarity 214, member B
FGD1 FYVE, RhoGEF and PH domain containing 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GBP2 guanylate binding protein 2, interferon-inducible
GJA9 gap junction protein, alpha 9, 59kDa
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GPC4 glypican 4
HIST1H2BC histone cluster 1, H2bc
HMGN5 high mobility group nucleosome binding domain 5
HOXC10 homeobox C10
HRASLS2 HRAS-like suppressor 2
IFT140 intraflagellar transport 140
JAG1 jagged 1
JAK2 Janus kinase 2
JMJD6 jumonji domain containing 6
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LUZP1 leucine zipper protein 1
LYRM9 LYR motif containing 9
MAN2C1 mannosidase, alpha, class 2C, member 1
MGC12488
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MSR1 macrophage scavenger receptor 1
NME5 NME/NM23 family member 5
NUP214 nucleoporin 214kDa
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PADI1 peptidyl arginine deiminase, type I
PDE12 phosphodiesterase 12
PDE4DIP phosphodiesterase 4D interacting protein
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PLSCR3 phospholipid scramblase 3
PNMAL1 paraneoplastic Ma antigen family-like 1
PPARD peroxisome proliferator-activated receptor delta
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTCRA pre T-cell antigen receptor alpha
PTK6 protein tyrosine kinase 6
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAB40AL RAB40A, member RAS oncogene family-like
RAD51B RAD51 paralog B
RAD51D RAD51 paralog D
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RIMS3 regulating synaptic membrane exocytosis 3
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SAPCD1 suppressor APC domain containing 1
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SFTPB surfactant protein B
SGSM2 small G protein signaling modulator 2
SH3BP2 SH3-domain binding protein 2
SIDT2 SID1 transmembrane family, member 2
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SOAT2 sterol O-acyltransferase 2
STC1 stanniocalcin 1
STMN3 stathmin-like 3
SUGP1 SURP and G patch domain containing 1
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TARP TCR gamma alternate reading frame protein
TCP11L1 t-complex 11, testis-specific-like 1
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TSPYL2 TSPY-like 2
TTC28 tetratricopeptide repeat domain 28
TTLL3 tubulin tyrosine ligase-like family member 3
VEGFA vascular endothelial growth factor A
WDR25 WD repeat domain 25
ZFP36L2 ZFP36 ring finger protein-like 2
ZHX3 zinc fingers and homeoboxes 3
ZNF589 zinc finger protein 589
ZNF76 zinc finger protein 76
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
ACSL4 acyl-CoA synthetase long-chain family member 4
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARID3B AT rich interactive domain 3B (BRIGHT-like)
BAHD1 bromo adjacent homology domain containing 1
BBS7 Bardet-Biedl syndrome 7
BMP4 bone morphogenetic protein 4
C11ORF73 chromosome 11 open reading frame 73
C11ORF95 chromosome 11 open reading frame 95
C21ORF91 chromosome 21 open reading frame 91
C7ORF43 chromosome 7 open reading frame 43
CAPG capping protein (actin filament), gelsolin-like
CAPN15 calpain 15
CD302 CD302 molecule
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CORO2A coronin, actin binding protein, 2A
CRABP1 cellular retinoic acid binding protein 1
CRYBB2P1 crystallin, beta B2 pseudogene 1
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CUEDC1 CUE domain containing 1
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DGKE diacylglycerol kinase, epsilon 64kDa
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
EIF5A2 eukaryotic translation initiation factor 5A2
FBXL6 F-box and leucine-rich repeat protein 6
FKBP8 FK506 binding protein 8, 38kDa
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FUZ fuzzy planar cell polarity protein
GALK1 galactokinase 1
GCHFR GTP cyclohydrolase I feedback regulator
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GDAP1 ganglioside induced differentiation associated protein 1
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GUSBP3 glucuronidase, beta pseudogene 3
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HOOK1 hook microtubule-tethering protein 1
HYI hydroxypyruvate isomerase (putative)
IRF7 interferon regulatory factor 7
ITPKB inositol-trisphosphate 3-kinase B
ITPKC inositol-trisphosphate 3-kinase C
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRRC61 leucine rich repeat containing 61
LYPLA2P1 lysophospholipase II pseudogene 1
MAGOHB mago-nashi homolog B (Drosophila)
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MDM4 MDM4, p53 regulator
MFSD11 major facilitator superfamily domain containing 11
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MT1H metallothionein 1H
MTG1 mitochondrial ribosome-associated GTPase 1
MTMR12 myotubularin related protein 12
MVD mevalonate (diphospho) decarboxylase
MXD3 MAX dimerization protein 3
MYBBP1A MYB binding protein (P160) 1a
NDE1 nudE neurodevelopment protein 1
NRGN neurogranin (protein kinase C substrate, RC3)
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
PAQR3 progestin and adipoQ receptor family member III
PDZRN3 PDZ domain containing ring finger 3
PIBF1 progesterone immunomodulatory binding factor 1
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PNPLA6 patatin-like phospholipase domain containing 6
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RFTN1 raftlin, lipid raft linker 1
RNF2 ring finger protein 2
RPAP2 RNA polymerase II associated protein 2
RPH3AL rabphilin 3A-like (without C2 domains)
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SNORA21 small nucleolar RNA, H/ACA box 21
SPRYD7 SPRY domain containing 7
STBD1 starch binding domain 1
STK25 serine/threonine kinase 25
STRN striatin, calmodulin binding protein
SYT17 synaptotagmin XVII
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative)
TEX264 testis expressed 264
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMOD3 tropomodulin 3 (ubiquitous)
TMUB2 transmembrane and ubiquitin-like domain containing 2
TNS2 tensin 2
TRAIP TRAF interacting protein
TSPAN1 tetraspanin 1
UBQLN4 ubiquilin 4
ULBP2 UL16 binding protein 2
USP6NL USP6 N-terminal like
VEGFC vascular endothelial growth factor C
WDR4 WD repeat domain 4
XYLT2 xylosyltransferase II
ZFAND3 zinc finger, AN1-type domain 3
ZNF668 zinc finger protein 668
ZNRD1-AS1 ZNRD1 antisense RNA 1