clorgiline-6659 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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194 genes differentially expressed following the clorgiline-6659 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ACSS3 acyl-CoA synthetase short-chain family member 3
ADAM7 ADAM metallopeptidase domain 7
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7
ANGPT4 angiopoietin 4
AOC3 amine oxidase, copper containing 3
APOB apolipoprotein B
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATP9B ATPase, class II, type 9B
AURKC aurora kinase C
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BGN biglycan
BMP8A bone morphogenetic protein 8a
C17ORF53 chromosome 17 open reading frame 53
C2CD2L C2CD2-like
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CADM4 cell adhesion molecule 4
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
COL10A1 collagen, type X, alpha 1
CPB2 carboxypeptidase B2 (plasma)
CTAG2 cancer/testis antigen 2
CWH43 cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)
CXCL14 chemokine (C-X-C motif) ligand 14
DCN decorin
DGKG diacylglycerol kinase, gamma 90kDa
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DSCR4 Down syndrome critical region 4
EDN1 endothelin 1
EGR1 early growth response 1
ETV6 ets variant 6
EXOSC2 exosome component 2
FASLG Fas ligand (TNF superfamily, member 6)
FRMD4B FERM domain containing 4B
FRMPD1 FERM and PDZ domain containing 1
FSHB follicle stimulating hormone, beta polypeptide
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45G growth arrest and DNA-damage-inducible, gamma
GPR75 G protein-coupled receptor 75
GREM2 gremlin 2, DAN family BMP antagonist
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
IL1RN interleukin 1 receptor antagonist
IMPG1 interphotoreceptor matrix proteoglycan 1
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA1644 KIAA1644
KRT23 keratin 23, type I
KRT83 keratin 83, type II
LECT1 leukocyte cell derived chemotaxin 1
LINC00115 long intergenic non-protein coding RNA 115
LRRC48 leucine rich repeat containing 48
MAGEC3 melanoma antigen family C3
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MME membrane metallo-endopeptidase
MST1L macrophage stimulating 1-like
MYO15A myosin XVA
NEU3 sialidase 3 (membrane sialidase)
NIPAL2 NIPA-like domain containing 2
NPR1 natriuretic peptide receptor 1
NRCAM neuronal cell adhesion molecule
OASL 2'-5'-oligoadenylate synthetase-like
PAPPA2 pappalysin 2
PAX2 paired box 2
PAX8 paired box 8
PCDH12 protocadherin 12
PCDHGA11 protocadherin gamma subfamily A, 11
PDGFB platelet-derived growth factor beta polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PER2 period circadian clock 2
PGAP3 post-GPI attachment to proteins 3
PHC3 polyhomeotic homolog 3 (Drosophila)
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
REC8 REC8 meiotic recombination protein
RIMS2 regulating synaptic membrane exocytosis 2
RPL13 ribosomal protein L13
RPL35A ribosomal protein L35a
SARM1 sterile alpha and TIR motif containing 1
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPO11 SPO11 meiotic protein covalently bound to DSB
TNK2 tyrosine kinase, non-receptor, 2
TREX1 three prime repair exonuclease 1
TRPC1 transient receptor potential cation channel, subfamily C, member 1
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UBXN1 UBX domain protein 1
ZHX3 zinc fingers and homeoboxes 3
ZNF334 zinc finger protein 334
ZNF778 zinc finger protein 778

decreased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
AFAP1 actin filament associated protein 1
AFF4 AF4/FMR2 family, member 4
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALPK1 alpha-kinase 1
ARHGAP10 Rho GTPase activating protein 10
ATAD5 ATPase family, AAA domain containing 5
BAHD1 bromo adjacent homology domain containing 1
C14ORF93 chromosome 14 open reading frame 93
C19ORF40 chromosome 19 open reading frame 40
C3 complement component 3
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CD82 CD82 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CPA4 carboxypeptidase A4
CRYGC crystallin, gamma C
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DTX2 deltex 2, E3 ubiquitin ligase
EDC3 enhancer of mRNA decapping 3
EDIL3 EGF-like repeats and discoidin I-like domains 3
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
ERAP2 endoplasmic reticulum aminopeptidase 2
FANCC Fanconi anemia, complementation group C
FER fer (fps/fes related) tyrosine kinase
FGD6 FYVE, RhoGEF and PH domain containing 6
FGF23 fibroblast growth factor 23
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GDAP1 ganglioside induced differentiation associated protein 1
GMPR guanosine monophosphate reductase
GPATCH2L G patch domain containing 2-like
GRAMD4 GRAM domain containing 4
GTF2I general transcription factor IIi
GUSBP3 glucuronidase, beta pseudogene 3
HAUS6 HAUS augmin-like complex, subunit 6
HIST1H1D histone cluster 1, H1d
HIST1H2AK histone cluster 1, H2ak
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HLX H2.0-like homeobox
HOXC10 homeobox C10
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IL13RA2 interleukin 13 receptor, alpha 2
KIAA0319L KIAA0319-like
KIAA0513 KIAA0513
KIAA0922 KIAA0922
LIPG lipase, endothelial
MB myoglobin
MCTP2 multiple C2 domains, transmembrane 2
MEFV Mediterranean fever
METTL16 methyltransferase like 16
MFSD11 major facilitator superfamily domain containing 11
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MYO1F myosin IF
NOD1 nucleotide-binding oligomerization domain containing 1
OSR2 odd-skipped related transciption factor 2
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PAX9 paired box 9
PCSK7 proprotein convertase subtilisin/kexin type 7
PID1 phosphotyrosine interaction domain containing 1
PLA1A phospholipase A1 member A
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
POMT2 protein-O-mannosyltransferase 2
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PRICKLE3 prickle homolog 3 (Drosophila)
PTK6 protein tyrosine kinase 6
RAB25 RAB25, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
RFWD3 ring finger and WD repeat domain 3
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SLC44A1 solute carrier family 44 (choline transporter), member 1
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SND1-IT1 SND1 intronic transcript 1
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TAGLN3 transgelin 3
TGFBI transforming growth factor, beta-induced, 68kDa
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM6SF1 transmembrane 6 superfamily member 1
TMEM183A transmembrane protein 183A
TMEM8B transmembrane protein 8B
TOM1 target of myb1 (chicken)
TTC30A tetratricopeptide repeat domain 30A
TUBA4B tubulin, alpha 4b
USP19 ubiquitin specific peptidase 19
WDR25 WD repeat domain 25
WDR4 WD repeat domain 4
WFDC2 WAP four-disulfide core domain 2
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
XYLT2 xylosyltransferase II
ZBTB48 zinc finger and BTB domain containing 48
ZNF16 zinc finger protein 16
ZNF286A zinc finger protein 286A
ZNF675 zinc finger protein 675
ZNF711 zinc finger protein 711
ZW10 zw10 kinetochore protein