clomipramine-6825 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the clomipramine-6825 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM23 ADAM metallopeptidase domain 23
ADRBK1 adrenergic, beta, receptor kinase 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BMP2K BMP2 inducible kinase
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CALCR calcitonin receptor
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDHR2 cadherin-related family member 2
CLGN calmegin
CXCR4 chemokine (C-X-C motif) receptor 4
DDIT3 DNA-damage-inducible transcript 3
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DRICH1 aspartate-rich 1
DUSP8 dual specificity phosphatase 8
EFNB3 ephrin-B3
EFS embryonal Fyn-associated substrate
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EHBP1L1 EH domain binding protein 1-like 1
FAM155A family with sequence similarity 155, member A
FCMR Fc fragment of IgM receptor
FGF18 fibroblast growth factor 18
FLOT1 flotillin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FRMD1 FERM domain containing 1
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
FZD10 frizzled class receptor 10
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GNG3 guanine nucleotide binding protein (G protein), gamma 3
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HPX hemopexin
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HYAL3 hyaluronoglucosaminidase 3
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IL22 interleukin 22
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNK12 potassium channel, two pore domain subfamily K, member 12
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KLF13 Kruppel-like factor 13
KLF2 Kruppel-like factor 2
KLHL24 kelch-like family member 24
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEC1 melanoma antigen family C1
MALL mal, T-cell differentiation protein-like
MAPK10 mitogen-activated protein kinase 10
MAPK14 mitogen-activated protein kinase 14
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MCF2L MCF.2 cell line derived transforming sequence-like
MPL MPL proto-oncogene, thrombopoietin receptor
MPZ myelin protein zero
MUC3B mucin 3B, cell surface associated
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NUDT7 nudix (nucleoside diphosphate linked moiety X)-type motif 7
OASL 2'-5'-oligoadenylate synthetase-like
OR1D2 olfactory receptor, family 1, subfamily D, member 2
OSGIN1 oxidative stress induced growth inhibitor 1
PCNX pecanex homolog (Drosophila)
PGAP1 post-GPI attachment to proteins 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PPARD peroxisome proliferator-activated receptor delta
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHCG Rh family, C glycoprotein
RND1 Rho family GTPase 1
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RUSC2 RUN and SH3 domain containing 2
SAMD9 sterile alpha motif domain containing 9
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLCO2B1 solute carrier organic anion transporter family, member 2B1
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TBL1Y transducin (beta)-like 1, Y-linked
TEX15 testis expressed 15
TMEM63A transmembrane protein 63A
TNF tumor necrosis factor
TUBA4B tubulin, alpha 4b
VIPR1 vasoactive intestinal peptide receptor 1
WSCD1 WSC domain containing 1
ZCCHC24 zinc finger, CCHC domain containing 24
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ACOT8 acyl-CoA thioesterase 8
ADGRG2 adhesion G protein-coupled receptor G2
ALPK1 alpha-kinase 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARRB2 arrestin, beta 2
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATAD5 ATPase family, AAA domain containing 5
BAHD1 bromo adjacent homology domain containing 1
BRAF B-Raf proto-oncogene, serine/threonine kinase
C19ORF73 chromosome 19 open reading frame 73
C1ORF35 chromosome 1 open reading frame 35
CAMK1 calcium/calmodulin-dependent protein kinase I
CAMK1D calcium/calmodulin-dependent protein kinase ID
CCDC85C coiled-coil domain containing 85C
CCNO cyclin O
CDK3 cyclin-dependent kinase 3
CHKB choline kinase beta
CLIP4 CAP-GLY domain containing linker protein family, member 4
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
CORT cortistatin
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DEAF1 DEAF1 transcription factor
DGAT1 diacylglycerol O-acyltransferase 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOC2A double C2-like domains, alpha
EGFL7 EGF-like-domain, multiple 7
EIF5A2 eukaryotic translation initiation factor 5A2
F2R coagulation factor II (thrombin) receptor
FAM169A family with sequence similarity 169, member A
FAM184A family with sequence similarity 184, member A
FOCAD focadhesin
GLB1L2 galactosidase, beta 1-like 2
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GSTTP1 glutathione S-transferase theta pseudogene 1
HEATR3 HEAT repeat containing 3
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IL20RA interleukin 20 receptor, alpha
IQSEC2 IQ motif and Sec7 domain 2
KCTD20 potassium channel tetramerization domain containing 20
KLHL25 kelch-like family member 25
KREMEN2 kringle containing transmembrane protein 2
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LMNB1 lamin B1
LOC100287590 uncharacterized LOC100287590
MOCS3 molybdenum cofactor synthesis 3
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
NABP2 nucleic acid binding protein 2
NPIPB3 nuclear pore complex interacting protein family, member B3
NR1H3 nuclear receptor subfamily 1, group H, member 3
NRGN neurogranin (protein kinase C substrate, RC3)
NUBPL nucleotide binding protein-like
PADI3 peptidyl arginine deiminase, type III
PC pyruvate carboxylase
PCSK7 proprotein convertase subtilisin/kexin type 7
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PODXL2 podocalyxin-like 2
POLR1B polymerase (RNA) I polypeptide B, 128kDa
POMT2 protein-O-mannosyltransferase 2
PP14571 uncharacterized LOC100130449
PRF1 perforin 1 (pore forming protein)
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PRODH proline dehydrogenase (oxidase) 1
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1
RCOR3 REST corepressor 3
RIN1 Ras and Rab interactor 1
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
S100A9 S100 calcium binding protein A9
SAV1 salvador family WW domain containing protein 1
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SMIM14 small integral membrane protein 14
SSBP3 single stranded DNA binding protein 3
SSFA2 sperm specific antigen 2
STAG3L4 stromal antigen 3-like 4 (pseudogene)
TBC1D19 TBC1 domain family, member 19
TCTN1 tectonic family member 1
TMEM120B transmembrane protein 120B
TMEM121 transmembrane protein 121
TMEM209 transmembrane protein 209
TOM1 target of myb1 (chicken)
TTC33 tetratricopeptide repeat domain 33
TUBGCP5 tubulin, gamma complex associated protein 5
USB1 U6 snRNA biogenesis 1
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VAX2 ventral anterior homeobox 2
VWA1 von Willebrand factor A domain containing 1
ZBTB25 zinc finger and BTB domain containing 25
ZBTB39 zinc finger and BTB domain containing 39
ZBTB6 zinc finger and BTB domain containing 6
ZNF408 zinc finger protein 408
ZNF606 zinc finger protein 606
ZNF747 zinc finger protein 747