clomifene-4994 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the clomifene-4994 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ARG1 arginase 1
ASIC1 acid sensing (proton gated) ion channel 1
ATF3 activating transcription factor 3
BAIAP3 BAI1-associated protein 3
BAZ2A bromodomain adjacent to zinc finger domain, 2A
C3ORF18 chromosome 3 open reading frame 18
CAPN9 calpain 9
CARF calcium responsive transcription factor
CARTPT CART prepropeptide
CCDC134 coiled-coil domain containing 134
CDC14B cell division cycle 14B
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CNTNAP2 contactin associated protein-like 2
CPED1 cadherin-like and PC-esterase domain containing 1
CRP C-reactive protein, pentraxin-related
DCT dopachrome tautomerase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EGR1 early growth response 1
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
ETV5 ets variant 5
EXOC6B exocyst complex component 6B
FAM129A family with sequence similarity 129, member A
FGF18 fibroblast growth factor 18
FGF6 fibroblast growth factor 6
GADD45A growth arrest and DNA-damage-inducible, alpha
GFI1 growth factor independent 1 transcription repressor
GK glycerol kinase
GNAS GNAS complex locus
GPC3 glypican 3
GRPR gastrin-releasing peptide receptor
HDLBP high density lipoprotein binding protein
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H2BJ histone cluster 1, H2bj
HIST1H2BO histone cluster 1, H2bo
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IFIH1 interferon induced with helicase C domain 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL1B interleukin 1, beta
IL2RG interleukin 2 receptor, gamma
IL4R interleukin 4 receptor
INHBE inhibin, beta E
INPP5J inositol polyphosphate-5-phosphatase J
IRF1 interferon regulatory factor 1
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KLK13 kallikrein-related peptidase 13
KRT6B keratin 6B, type II
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MED16 mediator complex subunit 16
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1X metallothionein 1X
MT2A metallothionein 2A
MTRF1L mitochondrial translational release factor 1-like
NEFM neurofilament, medium polypeptide
NOP16 NOP16 nucleolar protein
OASL 2'-5'-oligoadenylate synthetase-like
OSBPL3 oxysterol binding protein-like 3
PHF8 PHD finger protein 8
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLLP plasmolipin
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRELP proline/arginine-rich end leucine-rich repeat protein
PTGIS prostaglandin I2 (prostacyclin) synthase
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN21 protein tyrosine phosphatase, non-receptor type 21
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RND1 Rho family GTPase 1
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
SCN2B sodium channel, voltage gated, type II beta subunit
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
SRCAP Snf2-related CREBBP activator protein
TLE4 transducin-like enhancer of split 4
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TRD T cell receptor delta locus
TRIB3 tribbles pseudokinase 3
TRIO trio Rho guanine nucleotide exchange factor
WNT10B wingless-type MMTV integration site family, member 10B
WNT16 wingless-type MMTV integration site family, member 16
ZBTB22 zinc finger and BTB domain containing 22
ZNF175 zinc finger protein 175
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ADGRA3 adhesion G protein-coupled receptor A3
AGBL5 ATP/GTP binding protein-like 5
ANXA2P3 annexin A2 pseudogene 3
ARHGAP11A Rho GTPase activating protein 11A
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
BAG4 BCL2-associated athanogene 4
BCCIP BRCA2 and CDKN1A interacting protein
BYSL bystin-like
C9ORF40 chromosome 9 open reading frame 40
CAPN15 calpain 15
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCDC121 coiled-coil domain containing 121
CCDC25 coiled-coil domain containing 25
CDK3 cyclin-dependent kinase 3
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CENPT centromere protein T
CEP97 centrosomal protein 97kDa
CFD complement factor D (adipsin)
CIDEC cell death-inducing DFFA-like effector c
CTC1 CTS telomere maintenance complex component 1
CTPS1 CTP synthase 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DDB1 damage-specific DNA binding protein 1, 127kDa
DEAF1 DEAF1 transcription factor
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
ERCC4 excision repair cross-complementation group 4
FAM118A family with sequence similarity 118, member A
FAM169A family with sequence similarity 169, member A
FCF1 FCF1 rRNA-processing protein
FKBPL FK506 binding protein like
FOXC1 forkhead box C1
FSD1 fibronectin type III and SPRY domain containing 1
GLB1L2 galactosidase, beta 1-like 2
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GPRASP1 G protein-coupled receptor associated sorting protein 1
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa
HP1BP3 heterochromatin protein 1, binding protein 3
HYAL2 hyaluronoglucosaminidase 2
IFI27 interferon, alpha-inducible protein 27
INCENP inner centromere protein antigens 135/155kDa
INO80D INO80 complex subunit D
INTS9 integrator complex subunit 9
IPO8 importin 8
KLC2 kinesin light chain 2
KLHL28 kelch-like family member 28
LIG4 ligase IV, DNA, ATP-dependent
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRRC61 leucine rich repeat containing 61
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LZTR1 leucine-zipper-like transcription regulator 1
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MBTPS2 membrane-bound transcription factor peptidase, site 2
MPPED2 metallophosphoesterase domain containing 2
NCS1 neuronal calcium sensor 1
NFE2L3 nuclear factor, erythroid 2-like 3
NINJ1 ninjurin 1
NME5 NME/NM23 family member 5
NPM3 nucleophosmin/nucleoplasmin 3
NPY1R neuropeptide Y receptor Y1
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PARD6A par-6 family cell polarity regulator alpha
PCDHB3 protocadherin beta 3
POMT2 protein-O-mannosyltransferase 2
PTPN14 protein tyrosine phosphatase, non-receptor type 14
PUS3 pseudouridylate synthase 3
PYCRL pyrroline-5-carboxylate reductase-like
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB3A RAB3A, member RAS oncogene family
RCL1 RNA terminal phosphate cyclase-like 1
RPH3AL rabphilin 3A-like (without C2 domains)
RPL23AP32 ribosomal protein L23a pseudogene 32
SGK1 serum/glucocorticoid regulated kinase 1
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SNORA21 small nucleolar RNA, H/ACA box 21
SPIDR scaffolding protein involved in DNA repair
SSFA2 sperm specific antigen 2
STK16 serine/threonine kinase 16
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SUSD4 sushi domain containing 4
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TMEM180 transmembrane protein 180
TMEM183A transmembrane protein 183A
TPST2 tyrosylprotein sulfotransferase 2
TRIM25 tripartite motif containing 25
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
USP18 ubiquitin specific peptidase 18
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
WDR3 WD repeat domain 3
WDR4 WD repeat domain 4
ZW10 zw10 kinetochore protein