clioquinol-4663 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

192 genes differentially expressed following the clioquinol-4663 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ADTRP androgen-dependent TFPI-regulating protein
AIM2 absent in melanoma 2
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ALOXE3 arachidonate lipoxygenase 3
ANGPT4 angiopoietin 4
ARC activity-regulated cytoskeleton-associated protein
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CACYBP calcyclin binding protein
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFAP43 cilia and flagella associated protein 43
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL1A1 collagen, type I, alpha 1
COL9A3 collagen, type IX, alpha 3
CSF1 colony stimulating factor 1 (macrophage)
CXCL2 chemokine (C-X-C motif) ligand 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DHRS9 dehydrogenase/reductase (SDR family) member 9
DLX5 distal-less homeobox 5
DNAI2 dynein, axonemal, intermediate chain 2
EGR1 early growth response 1
EPB41L5 erythrocyte membrane protein band 4.1 like 5
GABARAPL3 GABA(A) receptors associated protein like 3, pseudogene
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HMOX1 heme oxygenase 1
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFITM1 interferon induced transmembrane protein 1
IGHM immunoglobulin heavy constant mu
IL24 interleukin 24
IRF5 interferon regulatory factor 5
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KRT17 keratin 17, type I
KRTAP1-3 keratin associated protein 1-3
LAG3 lymphocyte-activation gene 3
LARP7 La ribonucleoprotein domain family, member 7
LIMD2 LIM domain containing 2
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LTB4R leukotriene B4 receptor
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MX1 MX dynamin-like GTPase 1
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NR4A1 nuclear receptor subfamily 4, group A, member 1
NTN1 netrin 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OASL 2'-5'-oligoadenylate synthetase-like
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PKLR pyruvate kinase, liver and RBC
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POU6F1 POU class 6 homeobox 1
PPP1R2P9 protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 9
PRDM2 PR domain containing 2, with ZNF domain
PROX1 prospero homeobox 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAG2 recombination activating gene 2
REG1A regenerating islet-derived 1 alpha
RND1 Rho family GTPase 1
RUNX1 runt-related transcription factor 1
SCGB2A1 secretoglobin, family 2A, member 1
SCN11A sodium channel, voltage gated, type XI alpha subunit
SLA Src-like-adaptor
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SOX21 SRY (sex determining region Y)-box 21
SPX spexin hormone
STC2 stanniocalcin 2
SULF1 sulfatase 1
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TAS2R1 taste receptor, type 2, member 1
TAS2R3 taste receptor, type 2, member 3
TBX6 T-box 6
TET3 tet methylcytosine dioxygenase 3
TEX14 testis expressed 14
THEMIS2 thymocyte selection associated family member 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE4 transducin-like enhancer of split 4
TRIM29 tripartite motif containing 29
TRIM48 tripartite motif containing 48
TTLL4 tubulin tyrosine ligase-like family member 4
USP22 ubiquitin specific peptidase 22
ZC3HAV1 zinc finger CCCH-type, antiviral 1
ZNF771 zinc finger protein 771

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABT1 activator of basal transcription 1
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
AFAP1 actin filament associated protein 1
AGO4 argonaute RISC catalytic component 4
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AMT aminomethyltransferase
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANKRD40 ankyrin repeat domain 40
ANXA2P3 annexin A2 pseudogene 3
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
AXIN1 axin 1
BCORL1 BCL6 corepressor-like 1
BHLHB9 basic helix-loop-helix domain containing, class B, 9
C11ORF30 chromosome 11 open reading frame 30
CAND2 cullin-associated and neddylation-dissociated 2 (putative)
CCDC85C coiled-coil domain containing 85C
CCP110 centriolar coiled coil protein 110kDa
CHML choroideremia-like (Rab escort protein 2)
CHPF chondroitin polymerizing factor
CISH cytokine inducible SH2-containing protein
CLDN1 claudin 1
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CORO1A coronin, actin binding protein, 1A
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DCAF4 DDB1 and CUL4 associated factor 4
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DEPTOR DEP domain containing MTOR-interacting protein
ERCC2 excision repair cross-complementation group 2
ETNK2 ethanolamine kinase 2
EYA3 EYA transcriptional coactivator and phosphatase 3
EYA4 EYA transcriptional coactivator and phosphatase 4
FBXW12 F-box and WD repeat domain containing 12
FSD1 fibronectin type III and SPRY domain containing 1
GAS8 growth arrest-specific 8
GPALPP1 GPALPP motifs containing 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HOXA6 homeobox A6
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
HSPA1L heat shock 70kDa protein 1-like
IFT140 intraflagellar transport 140
INCENP inner centromere protein antigens 135/155kDa
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KIAA0895 KIAA0895
KLF13 Kruppel-like factor 13
KRT6A keratin 6A, type II
LIG4 ligase IV, DNA, ATP-dependent
LTC4S leukotriene C4 synthase
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAGEH1 melanoma antigen family H1
MAP6D1 MAP6 domain containing 1
MAST3 microtubule associated serine/threonine kinase 3
METTL16 methyltransferase like 16
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MTMR12 myotubularin related protein 12
MYLIP myosin regulatory light chain interacting protein
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NOL12 nucleolar protein 12
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
OCA2 oculocutaneous albinism II
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PADI1 peptidyl arginine deiminase, type I
PALMD palmdelphin
PAN2 PAN2 poly(A) specific ribonuclease subunit
PARM1 prostate androgen-regulated mucin-like protein 1
PHKG2 phosphorylase kinase, gamma 2 (testis)
PLCG1 phospholipase C, gamma 1
POLL polymerase (DNA directed), lambda
PPT2 palmitoyl-protein thioesterase 2
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PSKH1 protein serine kinase H1
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SDC3 syndecan 3
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SIX1 SIX homeobox 1
SMAD5 SMAD family member 5
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SPRYD7 SPRY domain containing 7
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TTLL1 tubulin tyrosine ligase-like family member 1
TXLNG taxilin gamma
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VEZT vezatin, adherens junctions transmembrane protein
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZNF141 zinc finger protein 141
ZNF219 zinc finger protein 219
ZNF528 zinc finger protein 528
ZNF529 zinc finger protein 529
ZNF76 zinc finger protein 76