clemastine-7443 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the clemastine-7443 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALCAM activated leukocyte cell adhesion molecule
ANKZF1 ankyrin repeat and zinc finger domain containing 1
APC adenomatous polyposis coli
ATF3 activating transcription factor 3
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BAG4 BCL2-associated athanogene 4
BBS9 Bardet-Biedl syndrome 9
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CHPF2 chondroitin polymerizing factor 2
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
CXCR4 chemokine (C-X-C motif) receptor 4
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
EED embryonic ectoderm development
EGR1 early growth response 1
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
ERAP1 endoplasmic reticulum aminopeptidase 1
FBXL2 F-box and leucine-rich repeat protein 2
FDPS farnesyl diphosphate synthase
FGFR4 fibroblast growth factor receptor 4
FOXG1 forkhead box G1
FOXN3 forkhead box N3
FRAT1 frequently rearranged in advanced T-cell lymphomas 1
FZD7 frizzled class receptor 7
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GLS2 glutaminase 2 (liver, mitochondrial)
GOSR2 golgi SNAP receptor complex member 2
GPR137 G protein-coupled receptor 137
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HDLBP high density lipoprotein binding protein
HFE hemochromatosis
HIST1H2BJ histone cluster 1, H2bj
HIST2H2AA3 histone cluster 2, H2aa3
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KHNYN KH and NYN domain containing
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
LDLR low density lipoprotein receptor
LPCAT3 lysophosphatidylcholine acyltransferase 3
LPIN1 lipin 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGOH2P mago-nashi homolog 2, pseudogene
MAP2K5 mitogen-activated protein kinase kinase 5
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MPDZ multiple PDZ domain protein
MSMO1 methylsterol monooxygenase 1
MVD mevalonate (diphospho) decarboxylase
MVK mevalonate kinase
MXD3 MAX dimerization protein 3
N4BP3 NEDD4 binding protein 3
NCAPH2 non-SMC condensin II complex, subunit H2
NF2 neurofibromin 2 (merlin)
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NNAT neuronatin
NUMA1 nuclear mitotic apparatus protein 1
ORAI2 ORAI calcium release-activated calcium modulator 2
PHTF2 putative homeodomain transcription factor 2
PLCH1 phospholipase C, eta 1
POFUT1 protein O-fucosyltransferase 1
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PSD3 pleckstrin and Sec7 domain containing 3
PSEN2 presenilin 2
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RPL23AP32 ribosomal protein L23a pseudogene 32
SAT1 spermidine/spermine N1-acetyltransferase 1
SBNO1 strawberry notch homolog 1 (Drosophila)
SGPL1 sphingosine-1-phosphate lyase 1
SH3BP2 SH3-domain binding protein 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SPATA5L1 spermatogenesis associated 5-like 1
SSPN sarcospan
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYNRG synergin, gamma
SYT17 synaptotagmin XVII
TMCO3 transmembrane and coiled-coil domains 3
TOP3A topoisomerase (DNA) III alpha
TRAIP TRAF interacting protein
TRIM2 tripartite motif containing 2
TUBG2 tubulin, gamma 2
UBE3B ubiquitin protein ligase E3B
WDR48 WD repeat domain 48
WIPI1 WD repeat domain, phosphoinositide interacting 1
YIPF4 Yip1 domain family, member 4
ZFP36L1 ZFP36 ring finger protein-like 1
ZMYM1 zinc finger, MYM-type 1

decreased expression

Symbol Name
ABLIM3 actin binding LIM protein family, member 3
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BIRC7 baculoviral IAP repeat containing 7
C10ORF88 chromosome 10 open reading frame 88
C19ORF40 chromosome 19 open reading frame 40
C1ORF35 chromosome 1 open reading frame 35
C7ORF43 chromosome 7 open reading frame 43
CARD8 caspase recruitment domain family, member 8
CASZ1 castor zinc finger 1
CBR3 carbonyl reductase 3
CCP110 centriolar coiled coil protein 110kDa
CGREF1 cell growth regulator with EF-hand domain 1
CLDN9 claudin 9
CLSPN claspin
CRY2 cryptochrome circadian clock 2
CTSV cathepsin V
DTX4 deltex 4, E3 ubiquitin ligase
EFCAB2 EF-hand calcium binding domain 2
EGLN3 egl-9 family hypoxia-inducible factor 3
ELOVL4 ELOVL fatty acid elongase 4
EPHA4 EPH receptor A4
ERCC4 excision repair cross-complementation group 4
EVPL envoplakin
FBXL6 F-box and leucine-rich repeat protein 6
FBXO2 F-box protein 2
FMO4 flavin containing monooxygenase 4
FURIN furin (paired basic amino acid cleaving enzyme)
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GDAP2 ganglioside induced differentiation associated protein 2
GJA1 gap junction protein, alpha 1, 43kDa
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GPR19 G protein-coupled receptor 19
GPR27 G protein-coupled receptor 27
GPRASP1 G protein-coupled receptor associated sorting protein 1
GRB7 growth factor receptor-bound protein 7
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
HIST1H3B histone cluster 1, H3b
HIST1H4C histone cluster 1, H4c
KIAA0125 KIAA0125
KIF15 kinesin family member 15
KREMEN2 kringle containing transmembrane protein 2
LAMA5 laminin, alpha 5
LHX1 LIM homeobox 1
LOC390998 ribosomal protein L10 pseudogene
LRRC49 leucine rich repeat containing 49
MAP1S microtubule-associated protein 1S
MBNL3 muscleblind-like splicing regulator 3
NFE2L3 nuclear factor, erythroid 2-like 3
NPY5R neuropeptide Y receptor Y5
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PCDHB13 protocadherin beta 13
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLD2 phospholipase D2
PLXNA3 plexin A3
PPT2 palmitoyl-protein thioesterase 2
PROCR protein C receptor, endothelial
PRR15L proline rich 15-like
PYCRL pyrroline-5-carboxylate reductase-like
R3HCC1L R3H domain and coiled-coil containing 1-like
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
SH2D4A SH2 domain containing 4A
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC12A9 solute carrier family 12, member 9
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SNHG20 small nucleolar RNA host gene 20
STARD13 StAR-related lipid transfer (START) domain containing 13
STBD1 starch binding domain 1
STXBP1 syntaxin binding protein 1
TDRD1 tudor domain containing 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TMEM109 transmembrane protein 109
TMEM53 transmembrane protein 53
TRAF2 TNF receptor-associated factor 2
TRIM25 tripartite motif containing 25
TUBA3C tubulin, alpha 3c
UBQLN4 ubiquilin 4
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
VPS9D1 VPS9 domain containing 1
XAB2 XPA binding protein 2
XKR8 XK, Kell blood group complex subunit-related family, member 8
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZBED1 zinc finger, BED-type containing 1
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZDHHC18 zinc finger, DHHC-type containing 18
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF205 zinc finger protein 205
ZNF23 zinc finger protein 23
ZNHIT2 zinc finger, HIT-type containing 2
ZW10 zw10 kinetochore protein