clebopride-2646 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the clebopride-2646 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCY7 adenylate cyclase 7
AKAP11 A kinase (PRKA) anchor protein 11
ANGPT4 angiopoietin 4
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
ATXN2L ataxin 2-like
AUTS2 autism susceptibility candidate 2
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BRD4 bromodomain containing 4
C2ORF68 chromosome 2 open reading frame 68
CADM3 cell adhesion molecule 3
CBX8 chromobox homolog 8
CDK13 cyclin-dependent kinase 13
CETN1 centrin, EF-hand protein, 1
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CIB2 calcium and integrin binding family member 2
CLPS colipase, pancreatic
CNPPD1 cyclin Pas1/PHO80 domain containing 1
COL9A3 collagen, type IX, alpha 3
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
EDAR ectodysplasin A receptor
EDN3 endothelin 3
ERCC2 excision repair cross-complementation group 2
ETNK2 ethanolamine kinase 2
ETV6 ets variant 6
FBXL18 F-box and leucine-rich repeat protein 18
FGF6 fibroblast growth factor 6
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GDNF glial cell derived neurotrophic factor
GSPT1 G1 to S phase transition 1
GSTP1 glutathione S-transferase pi 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HDAC5 histone deacetylase 5
HDLBP high density lipoprotein binding protein
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HFE hemochromatosis
HIRA histone cell cycle regulator
HIST1H1E histone cluster 1, H1e
HMOX1 heme oxygenase 1
HOXC5 homeobox C5
IGFBP5 insulin-like growth factor binding protein 5
IRF8 interferon regulatory factor 8
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JUN jun proto-oncogene
KHSRP KH-type splicing regulatory protein
KIAA0319L KIAA0319-like
KIAA1456 KIAA1456
KIF1C kinesin family member 1C
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KLK5 kallikrein-related peptidase 5
KRT83 keratin 83, type II
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LSP1 lymphocyte-specific protein 1
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MRC2 mannose receptor, C type 2
MST1 macrophage stimulating 1
MYL10 myosin, light chain 10, regulatory
MYO1E myosin IE
N4BP3 NEDD4 binding protein 3
NCOA2 nuclear receptor coactivator 2
NDRG1 N-myc downstream regulated 1
NOL10 nucleolar protein 10
NR4A1 nuclear receptor subfamily 4, group A, member 1
PARVA parvin, alpha
PARVB parvin, beta
PCDH17 protocadherin 17
PCSK6 proprotein convertase subtilisin/kexin type 6
PDIA3 protein disulfide isomerase family A, member 3
PLD3 phospholipase D family, member 3
PLIN2 perilipin 2
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRKG2 protein kinase, cGMP-dependent, type II
PRPH peripherin
PSAT1 phosphoserine aminotransferase 1
PSG4 pregnancy specific beta-1-glycoprotein 4
PTPRU protein tyrosine phosphatase, receptor type, U
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C)
RNF2 ring finger protein 2
RPL23AP32 ribosomal protein L23a pseudogene 32
RPL35A ribosomal protein L35a
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
SEC14L2 SEC14-like 2 (S. cerevisiae)
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SH2D3A SH2 domain containing 3A
SLCO2B1 solute carrier organic anion transporter family, member 2B1
SLIT1 slit homolog 1 (Drosophila)
SMG7 SMG7 nonsense mediated mRNA decay factor
SPTAN1 spectrin, alpha, non-erythrocytic 1
TKTL1 transketolase-like 1
TMCC2 transmembrane and coiled-coil domain family 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
TP53I11 tumor protein p53 inducible protein 11
VASH2 vasohibin 2
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WDR78 WD repeat domain 78
ZNF646 zinc finger protein 646

decreased expression

Symbol Name
ACSF2 acyl-CoA synthetase family member 2
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
AMDHD2 amidohydrolase domain containing 2
ARRB1 arrestin, beta 1
BTF3P12 basic transcription factor 3 pseudogene 12
C9ORF9 chromosome 9 open reading frame 9
CALCOCO1 calcium binding and coiled-coil domain 1
CBX7 chromobox homolog 7
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CD302 CD302 molecule
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CHKB choline kinase beta
CLCF1 cardiotrophin-like cytokine factor 1
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
DGKE diacylglycerol kinase, epsilon 64kDa
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DYSF dysferlin
EHD3 EH-domain containing 3
EMID1 EMI domain containing 1
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM169A family with sequence similarity 169, member A
FAM204A family with sequence similarity 204, member A
FAM212B family with sequence similarity 212, member B
FBXO31 F-box protein 31
FER fer (fps/fes related) tyrosine kinase
FKBP10 FK506 binding protein 10, 65 kDa
FKBP5 FK506 binding protein 5
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GALK1 galactokinase 1
GAMT guanidinoacetate N-methyltransferase
GAN gigaxonin
GMEB1 glucocorticoid modulatory element binding protein 1
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H2BO histone cluster 1, H2bo
HIST1H4D histone cluster 1, H4d
HYI hydroxypyruvate isomerase (putative)
IPO8 importin 8
IRF1 interferon regulatory factor 1
KLHL12 kelch-like family member 12
KLHL25 kelch-like family member 25
KRI1 KRI1 homolog (S. cerevisiae)
L2HGDH L-2-hydroxyglutarate dehydrogenase
LAMB3 laminin, beta 3
LARP6 La ribonucleoprotein domain family, member 6
LHX6 LIM homeobox 6
LRP5 low density lipoprotein receptor-related protein 5
LRRC61 leucine rich repeat containing 61
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MBTPS2 membrane-bound transcription factor peptidase, site 2
MED9 mediator complex subunit 9
MTMR12 myotubularin related protein 12
MVD mevalonate (diphospho) decarboxylase
MXD3 MAX dimerization protein 3
MYLIP myosin regulatory light chain interacting protein
MYO1F myosin IF
NDE1 nudE neurodevelopment protein 1
NEK11 NIMA-related kinase 11
NPM3 nucleophosmin/nucleoplasmin 3
PADI1 peptidyl arginine deiminase, type I
PCNXL4 pecanex-like 4 (Drosophila)
PHEX phosphate regulating endopeptidase homolog, X-linked
PLEKHO2 pleckstrin homology domain containing, family O member 2
POGLUT1 protein O-glucosyltransferase 1
POLL polymerase (DNA directed), lambda
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
QTRT1 queuine tRNA-ribosyltransferase 1
RAB5C RAB5C, member RAS oncogene family
RABL6 RAB, member RAS oncogene family-like 6
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RARS arginyl-tRNA synthetase
RIN2 Ras and Rab interactor 2
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF122 ring finger protein 122
RP2 retinitis pigmentosa 2 (X-linked recessive)
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SCN1B sodium channel, voltage gated, type I beta subunit
SETD8 SET domain containing (lysine methyltransferase) 8
SIRT6 sirtuin 6
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SMA4 glucuronidase, beta pseudogene
SOX3 SRY (sex determining region Y)-box 3
SPINK5 serine peptidase inhibitor, Kazal type 5
STK25 serine/threonine kinase 25
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TCTN2 tectonic family member 2
TEAD3 TEA domain family member 3
TMEM104 transmembrane protein 104
TOM1 target of myb1 (chicken)
TRABD TraB domain containing
TRIM21 tripartite motif containing 21
UBE2S ubiquitin-conjugating enzyme E2S
UBXN6 UBX domain protein 6
ULBP2 UL16 binding protein 2
WDR4 WD repeat domain 4
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZNF510 zinc finger protein 510
ZNF770 zinc finger protein 770