citiolone-3930 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the citiolone-3930 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AGMAT agmatine ureohydrolase (agmatinase)
ALDOB aldolase B, fructose-bisphosphate
ANKH ANKH inorganic pyrophosphate transport regulator
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARHGAP1 Rho GTPase activating protein 1
BNC2 basonuclin 2
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
C1ORF95 chromosome 1 open reading frame 95
CA9 carbonic anhydrase IX
CD8A CD8a molecule
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CLDN18 claudin 18
COL16A1 collagen, type XVI, alpha 1
COL4A2 collagen, type IV, alpha 2
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor
CRHR2 corticotropin releasing hormone receptor 2
CRISP2 cysteine-rich secretory protein 2
CROCC ciliary rootlet coiled-coil, rootletin
CRP C-reactive protein, pentraxin-related
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DLX2 distal-less homeobox 2
ELN elastin
ETV7 ets variant 7
EYA4 EYA transcriptional coactivator and phosphatase 4
FAM182B family with sequence similarity 182, member B
FHL1 four and a half LIM domains 1
FRMD8 FERM domain containing 8
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GATA2 GATA binding protein 2
GIMAP5 GTPase, IMAP family member 5
GJD2 gap junction protein, delta 2, 36kDa
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GP6 glycoprotein VI (platelet)
GPR22 G protein-coupled receptor 22
IL36G interleukin 36, gamma
ING1 inhibitor of growth family, member 1
INHBE inhibin, beta E
INPP5J inositol polyphosphate-5-phosphatase J
KEL Kell blood group, metallo-endopeptidase
KIR3DX1 killer cell immunoglobulin-like receptor, three domains, X1
KLK15 kallikrein-related peptidase 15
KLRK1 killer cell lectin-like receptor subfamily K, member 1
LAT2 linker for activation of T cells family, member 2
LENEP lens epithelial protein
LOX lysyl oxidase
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MAGEA5 melanoma antigen family A5
MAPK11 mitogen-activated protein kinase 11
MRPL44 mitochondrial ribosomal protein L44
MST1 macrophage stimulating 1
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYL10 myosin, light chain 10, regulatory
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
NYNRIN NYN domain and retroviral integrase containing
OR1E1 olfactory receptor, family 1, subfamily E, member 1
OR2C1 olfactory receptor, family 2, subfamily C, member 1
ORM1 orosomucoid 1
OXCT2 3-oxoacid CoA transferase 2
P2RY11 purinergic receptor P2Y, G-protein coupled, 11
PARP3 poly (ADP-ribose) polymerase family, member 3
PART1 prostate androgen-regulated transcript 1 (non-protein coding)
PCNXL2 pecanex-like 2 (Drosophila)
PDE4D phosphodiesterase 4D, cAMP-specific
PDZD2 PDZ domain containing 2
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
POLL polymerase (DNA directed), lambda
PTGDR2 prostaglandin D2 receptor 2
PVT1 Pvt1 oncogene (non-protein coding)
RAB6B RAB6B, member RAS oncogene family
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RECQL5 RecQ protein-like 5
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
RUSC2 RUN and SH3 domain containing 2
RYR1 ryanodine receptor 1 (skeletal)
SAFB scaffold attachment factor B
SFTPB surfactant protein B
SIRPB1 signal-regulatory protein beta 1
SNCG synuclein, gamma (breast cancer-specific protein 1)
SOCS7 suppressor of cytokine signaling 7
SOGA1 suppressor of glucose, autophagy associated 1
SPINK5 serine peptidase inhibitor, Kazal type 5
SPON2 spondin 2, extracellular matrix protein
STAC SH3 and cysteine rich domain
STOML1 stomatin (EPB72)-like 1
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TBCD tubulin folding cofactor D
TEC tec protein tyrosine kinase
TEK TEK tyrosine kinase, endothelial
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSC2 tuberous sclerosis 2
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
YPEL1 yippee-like 1 (Drosophila)
ZNF154 zinc finger protein 154

decreased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ACPP acid phosphatase, prostate
ACSL5 acyl-CoA synthetase long-chain family member 5
ADAM15 ADAM metallopeptidase domain 15
AHNAK2 AHNAK nucleoprotein 2
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
C11ORF30 chromosome 11 open reading frame 30
C14ORF93 chromosome 14 open reading frame 93
C16ORF45 chromosome 16 open reading frame 45
C17ORF80 chromosome 17 open reading frame 80
C8ORF44 chromosome 8 open reading frame 44
CARTPT CART prepropeptide
CCDC71 coiled-coil domain containing 71
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CDK20 cyclin-dependent kinase 20
CDK3 cyclin-dependent kinase 3
CDK6 cyclin-dependent kinase 6
CDON cell adhesion associated, oncogene regulated
CEND1 cell cycle exit and neuronal differentiation 1
CEP295 centrosomal protein 295kDa
CHM choroideremia (Rab escort protein 1)
CIDEB cell death-inducing DFFA-like effector b
CPA4 carboxypeptidase A4
CRIP1 cysteine-rich protein 1 (intestinal)
CRMP1 collapsin response mediator protein 1
DNAH17 dynein, axonemal, heavy chain 17
ERN2 endoplasmic reticulum to nucleus signaling 2
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FLCN folliculin
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GPR1 G protein-coupled receptor 1
GPR143 G protein-coupled receptor 143
GREB1L growth regulation by estrogen in breast cancer-like
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HDAC5 histone deacetylase 5
HIST1H4A histone cluster 1, H4a
HOXA4 homeobox A4
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
IFI6 interferon, alpha-inducible protein 6
IFT81 intraflagellar transport 81
ITGA8 integrin, alpha 8
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
ITPKB inositol-trisphosphate 3-kinase B
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KDM8 lysine (K)-specific demethylase 8
KIAA0319L KIAA0319-like
KRT83 keratin 83, type II
LGALS4 lectin, galactoside-binding, soluble, 4
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAL mal, T-cell differentiation protein
MALL mal, T-cell differentiation protein-like
MDM4 MDM4, p53 regulator
MOB3B MOB kinase activator 3B
MTA2 metastasis associated 1 family, member 2
MTCP1 mature T-cell proliferation 1
MX2 MX dynamin-like GTPase 2
MXD3 MAX dimerization protein 3
NKAIN1 Na+/K+ transporting ATPase interacting 1
NPFFR1 neuropeptide FF receptor 1
NPY neuropeptide Y
NSUN6 NOP2/Sun domain family, member 6
OSMR oncostatin M receptor
PCDHB3 protocadherin beta 3
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PGLYRP4 peptidoglycan recognition protein 4
PORCN porcupine homolog (Drosophila)
PTPRM protein tyrosine phosphatase, receptor type, M
RAB40C RAB40C, member RAS oncogene family
RHBG Rh family, B glycoprotein (gene/pseudogene)
RNF39 ring finger protein 39
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC17A2 solute carrier family 17, member 2
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC46A3 solute carrier family 46, member 3
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TFF2 trefoil factor 2
TGFBR1 transforming growth factor, beta receptor 1
TM4SF4 transmembrane 4 L six family member 4
TM4SF5 transmembrane 4 L six family member 5
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TSC22D4 TSC22 domain family, member 4
TTLL1 tubulin tyrosine ligase-like family member 1
USP20 ubiquitin specific peptidase 20
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
XDH xanthine dehydrogenase
YBX2 Y box binding protein 2
YY2 YY2 transcription factor
ZBTB33 zinc finger and BTB domain containing 33
ZNF205 zinc finger protein 205
ZNF230 zinc finger protein 230
ZNF532 zinc finger protein 532