citiolone-2176 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the citiolone-2176 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
AGTR1 angiotensin II receptor, type 1
ANKRD40 ankyrin repeat domain 40
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
BEST1 bestrophin 1
BIN1 bridging integrator 1
BMP7 bone morphogenetic protein 7
C16ORF70 chromosome 16 open reading frame 70
C21ORF2 chromosome 21 open reading frame 2
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CCDC33 coiled-coil domain containing 33
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CDRT1 CMT1A duplicated region transcript 1
CLTB clathrin, light chain B
CNOT4 CCR4-NOT transcription complex, subunit 4
CSNK1E casein kinase 1, epsilon
CTIF CBP80/20-dependent translation initiation factor
CYLD cylindromatosis (turban tumor syndrome)
DMRT1 doublesex and mab-3 related transcription factor 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOPEY2 dopey family member 2
DZIP3 DAZ interacting zinc finger protein 3
EDRF1 erythroid differentiation regulatory factor 1
ELL2 elongation factor, RNA polymerase II, 2
EML2 echinoderm microtubule associated protein like 2
EPHB2 EPH receptor B2
EXOSC2 exosome component 2
FBXL2 F-box and leucine-rich repeat protein 2
FCAR Fc fragment of IgA receptor
FGB fibrinogen beta chain
FGF23 fibroblast growth factor 23
FKBP5 FK506 binding protein 5
FXYD3 FXYD domain containing ion transport regulator 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLDC glycine dehydrogenase (decarboxylating)
GLP1R glucagon-like peptide 1 receptor
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GRIP2 glutamate receptor interacting protein 2
GRM7 glutamate receptor, metabotropic 7
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HNF1B HNF1 homeobox B
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IL1R2 interleukin 1 receptor, type II
IL6ST interleukin 6 signal transducer
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
JAK3 Janus kinase 3
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KLF3 Kruppel-like factor 3 (basic)
LAMC3 laminin, gamma 3
LMO7 LIM domain 7
LRP3 low density lipoprotein receptor-related protein 3
MAP4 microtubule-associated protein 4
MAPK7 mitogen-activated protein kinase 7
MBNL2 muscleblind-like splicing regulator 2
MIR22HG MIR22 host gene
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NKX2-5 NK2 homeobox 5
OPCML opioid binding protein/cell adhesion molecule-like
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDE4DIP phosphodiesterase 4D interacting protein
PERP PERP, TP53 apoptosis effector
RAB40B RAB40B, member RAS oncogene family
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RASAL2 RAS protein activator like 2
RB1 retinoblastoma 1
RBMS3 RNA binding motif, single stranded interacting protein 3
RDH16 retinol dehydrogenase 16 (all-trans)
SARM1 sterile alpha and TIR motif containing 1
SLAMF7 SLAM family member 7
SLAMF8 SLAM family member 8
SLC17A2 solute carrier family 17, member 2
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLN sarcolipin
SPAG8 sperm associated antigen 8
SPRR2B small proline-rich protein 2B
SSX3 synovial sarcoma, X breakpoint 3
STOM stomatin
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
SYCE1L synaptonemal complex central element protein 1-like
SYN2 synapsin II
TACSTD2 tumor-associated calcium signal transducer 2
TAOK2 TAO kinase 2
THBS1 thrombospondin 1
TM4SF5 transmembrane 4 L six family member 5
TMPRSS15 transmembrane protease, serine 15
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TRAPPC9 trafficking protein particle complex 9
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TTC30A tetratricopeptide repeat domain 30A
VASH1 vasohibin 1
YOD1 YOD1 deubiquitinase
ZBTB16 zinc finger and BTB domain containing 16
ZBTB38 zinc finger and BTB domain containing 38

decreased expression

Symbol Name
ADAM15 ADAM metallopeptidase domain 15
ADGRG2 adhesion G protein-coupled receptor G2
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4
ARMC7 armadillo repeat containing 7
ASCC1 activating signal cointegrator 1 complex subunit 1
BGLAP bone gamma-carboxyglutamate (gla) protein
BIK BCL2-interacting killer (apoptosis-inducing)
BTF3P12 basic transcription factor 3 pseudogene 12
CCDC106 coiled-coil domain containing 106
CCDC71 coiled-coil domain containing 71
CCRL2 chemokine (C-C motif) receptor-like 2
CDR2L cerebellar degeneration-related protein 2-like
CEP170B centrosomal protein 170B
CPTP ceramide-1-phosphate transfer protein
CRELD1 cysteine-rich with EGF-like domains 1
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1
CYSLTR1 cysteinyl leukotriene receptor 1
DBR1 debranching RNA lariats 1
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
EPHA4 EPH receptor A4
ERCC6L excision repair cross-complementation group 6-like
ERN2 endoplasmic reticulum to nucleus signaling 2
EXOSC1 exosome component 1
FAM127B family with sequence similarity 127, member B
FGL1 fibrinogen-like 1
FHL3 four and a half LIM domains 3
FOXN2 forkhead box N2
FSTL3 follistatin-like 3 (secreted glycoprotein)
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HIST1H2AI histone cluster 1, H2ai
INF2 inverted formin, FH2 and WH2 domain containing
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KCTD20 potassium channel tetramerization domain containing 20
KIAA0754 KIAA0754
KLHL28 kelch-like family member 28
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAK male germ cell-associated kinase
MAPK12 mitogen-activated protein kinase 12
MBD5 methyl-CpG binding domain protein 5
MDM4 MDM4, p53 regulator
MKL2 MKL/myocardin-like 2
MKRN3 makorin ring finger protein 3
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NBEA neurobeachin
NDE1 nudE neurodevelopment protein 1
NHEJ1 nonhomologous end-joining factor 1
NKX3-2 NK3 homeobox 2
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PARG poly (ADP-ribose) glycohydrolase
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLCD1 phospholipase C, delta 1
PLP1 proteolipid protein 1
PMFBP1 polyamine modulated factor 1 binding protein 1
PNOC prepronociceptin
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RAB23 RAB23, member RAS oncogene family
RAB3A RAB3A, member RAS oncogene family
RECQL4 RecQ protein-like 4
RNF126P1 ring finger protein 126 pseudogene 1
SIL1 SIL1 nucleotide exchange factor
SLC12A8 solute carrier family 12, member 8
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3
SLC35F6 solute carrier family 35, member F6
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SPAG1 sperm associated antigen 1
SPI1 Spi-1 proto-oncogene
STRN striatin, calmodulin binding protein
SUSD6 sushi domain containing 6
SYCP2 synaptonemal complex protein 2
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TAS2R10 taste receptor, type 2, member 10
TCTN2 tectonic family member 2
TESK1 testis-specific kinase 1
TGFBR3 transforming growth factor, beta receptor III
TMEM183A transmembrane protein 183A
TMEM242 transmembrane protein 242
TPM3 tropomyosin 3
TSPAN5 tetraspanin 5
TTLL1 tubulin tyrosine ligase-like family member 1
TUBB2A tubulin, beta 2A class IIa
USB1 U6 snRNA biogenesis 1
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
ZBTB22 zinc finger and BTB domain containing 22
ZMAT5 zinc finger, matrin-type 5
ZNF134 zinc finger protein 134
ZNF37BP zinc finger protein 37B, pseudogene
ZNF493 zinc finger protein 493
ZNF747 zinc finger protein 747