cirrhosis Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.|A disorder characterized by replacement of the liver parenchyma with fibrous tissue and regenerative nodules. It is usually caused by alcoholisms, hepatitis B, and hepatitis C. Complications include the development of ascites, esophageal varices, bleeding, and hepatic encephalopathy. (Experimental Factor Ontology, EFO_0001422)
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Genes

335 genes co-occuring with the biological term cirrhosis in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABHD5 abhydrolase domain containing 5
ACE angiotensin I converting enzyme
ADA adenosine deaminase
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADIPOR2 adiponectin receptor 2
ADRB3 adrenoceptor beta 3
AFP alpha-fetoprotein
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALPL alkaline phosphatase, liver/bone/kidney
ALPP alkaline phosphatase, placental
ANXA2 annexin A2
APLN apelin
APOE apolipoprotein E
APOH apolipoprotein H (beta-2-glycoprotein I)
APOM apolipoprotein M
AQP1 aquaporin 1 (Colton blood group)
AQP2 aquaporin 2 (collecting duct)
ARRB1 arrestin, beta 1
ASGR1 asialoglycoprotein receptor 1
ATM ATM serine/threonine kinase
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
ATP7B ATPase, Cu++ transporting, beta polypeptide
AZIN1 antizyme inhibitor 1
B2M beta-2-microglobulin
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BGLAP bone gamma-carboxyglutamate (gla) protein
BLVRA biliverdin reductase A
BMI1 BMI1 proto-oncogene, polycomb ring finger
CALCA calcitonin-related polypeptide alpha
CASP3 caspase 3, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCND1 cyclin D1
CCNE1 cyclin E1
CCR1 chemokine (C-C motif) receptor 1
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD14 CD14 molecule
CD27 CD27 molecule
CD38 CD38 molecule
CD4 CD4 molecule
CD40LG CD40 ligand
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK4 cyclin-dependent kinase 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHUK conserved helix-loop-helix ubiquitous kinase
CIITA class II, major histocompatibility complex, transactivator
CIRH1A cirrhosis, autosomal recessive 1A (cirhin)
CLDN1 claudin 1
CLDN7 claudin 7
CLEC16A C-type lectin domain family 16, member A
CNR1 cannabinoid receptor 1 (brain)
CNR2 cannabinoid receptor 2 (macrophage)
CNTNAP2 contactin associated protein-like 2
CPB2 carboxypeptidase B2 (plasma)
CRP C-reactive protein, pentraxin-related
CST3 cystatin C
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR3 chemokine (C-X-C motif) receptor 3
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP3A cytochrome P450, family 3, subfamily A
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1
DBT dihydrolipoamide branched chain transacylase E2
DDR1 discoidin domain receptor tyrosine kinase 1
DGUOK deoxyguanosine kinase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLAT dihydrolipoamide S-acetyltransferase
DPYD dihydropyrimidine dehydrogenase
EDN1 endothelin 1
EDNRA endothelin receptor type A
EDNRB endothelin receptor type B
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
ENG endoglin
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2
ESR1 estrogen receptor 1
ESRRG estrogen-related receptor gamma
F2 coagulation factor II (thrombin)
F3 coagulation factor III (thromboplastin, tissue factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
F8 coagulation factor VIII, procoagulant component
FAS Fas cell surface death receptor
FCAR Fc fragment of IgA receptor
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FCRL3 Fc receptor-like 3
FGF19 fibroblast growth factor 19
FGF2 fibroblast growth factor 2 (basic)
FGFR4 fibroblast growth factor receptor 4
FIBP fibroblast growth factor (acidic) intracellular binding protein
FLT1 fms-related tyrosine kinase 1
FN1 fibronectin 1
FOXO1 forkhead box O1
FOXP3 forkhead box P3
GC group-specific component (vitamin D binding protein)
GCG glucagon
GFER growth factor, augmenter of liver regeneration
GGPS1 geranylgeranyl diphosphate synthase 1
GH1 growth hormone 1
GHRL ghrelin/obestatin prepropeptide
GLS glutaminase
GMNN geminin, DNA replication inhibitor
GNLY granulysin
GOLM1 golgi membrane protein 1
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GPC3 glypican 3
GREM1 gremlin 1, DAN family BMP antagonist
GSK3B glycogen synthase kinase 3 beta
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HABP2 hyaluronan binding protein 2
HAVCR2 hepatitis A virus cellular receptor 2
HFE hemochromatosis
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-C major histocompatibility complex, class I, C
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB4 major histocompatibility complex, class II, DR beta 4
HLA-G major histocompatibility complex, class I, G
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPK heterogeneous nuclear ribonucleoprotein K
HP haptoglobin
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
ICAM1 intercellular adhesion molecule 1
ICOS inducible T-cell co-stimulator
IFNG interferon, gamma
IFNL3 interferon, lambda 3
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2 insulin-like growth factor 2
IGFBP1 insulin-like growth factor binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
IL10 interleukin 10
IL12A interleukin 12A
IL12RB2 interleukin 12 receptor, beta 2
IL17A interleukin 17A
IL18 interleukin 18
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL23A interleukin 23, alpha subunit p19
IL2RA interleukin 2 receptor, alpha
IL4 interleukin 4
IL6 interleukin 6
IL7R interleukin 7 receptor
ILK integrin-linked kinase
IRF7 interferon regulatory factor 7
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KDR kinase insert domain receptor
KLF2 Kruppel-like factor 2
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT7 keratin 7, type II
KRT8 keratin 8, type II
LAMP2 lysosomal-associated membrane protein 2
LEP leptin
LGALS3 lectin, galactoside-binding, soluble, 3
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae)
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAT2A methionine adenosyltransferase II, alpha
MATN2 matrilin 2
MBL2 mannose-binding lectin (protein C) 2, soluble
MCM2 minichromosome maintenance complex component 2
MGMT O-6-methylguanine-DNA methyltransferase
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR122 microRNA 122
MIR126 microRNA 126
MIR129-2 microRNA 129-2
MIR133A1 microRNA 133a-1
MIR196A2 microRNA 196a-2
MIR506 microRNA 506
MIR571 microRNA 571
MIR652 microRNA 652
MKI67 marker of proliferation Ki-67
MMP13 matrix metallopeptidase 13
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MSTN myostatin
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC16 mucin 16, cell surface associated
NAMPT nicotinamide phosphoribosyltransferase
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOD2 nucleotide-binding oligomerization domain containing 2
NOL11 nucleolar protein 11
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NPPB natriuretic peptide B
NUP210 nucleoporin 210kDa
ORM1 orosomucoid 1
PCNA proliferating cell nuclear antigen
PCSK7 proprotein convertase subtilisin/kexin type 7
PDCD1 programmed cell death 1
PDHX pyruvate dehydrogenase complex, component X
PGF placental growth factor
PHKA2 phosphorylase kinase, alpha 2 (liver)
PHKG2 phosphorylase kinase, gamma 2 (testis)
PIAS3 protein inhibitor of activated STAT, 3
PLAUR plasminogen activator, urokinase receptor
PNPLA3 patatin-like phospholipase domain containing 3
PON1 paraoxonase 1
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRF1 perforin 1 (pore forming protein)
PRLR prolactin receptor
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PROCR protein C receptor, endothelial
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RBP4 retinol binding protein 4, plasma
RCOR3 REST corepressor 3
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RELN reelin
RETN resistin
RGN regucalcin
RRAS related RAS viral (r-ras) oncogene homolog
RTN4 reticulon 4
S100A9 S100 calcium binding protein A9
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
SFRP2 secreted frizzled-related protein 2
SHH sonic hedgehog
SIAE sialic acid acetylesterase
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SOCS1 suppressor of cytokine signaling 1
SOCS3 suppressor of cytokine signaling 3
SOD2 superoxide dismutase 2, mitochondrial
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
STEAP3 STEAP family member 3, metalloreductase
STMN1 stathmin 1
SYVN1 synovial apoptosis inhibitor 1, synoviolin
TALDO1 transaldolase 1
TANK TRAF family member-associated NFKB activator
TERT telomerase reverse transcriptase
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFA transforming growth factor, alpha
TGFB1 transforming growth factor, beta 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBD thrombomodulin
THPO thrombopoietin
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TNF tumor necrosis factor
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TP53 tumor protein p53
TP73 tumor protein p73
TRAF1 TNF receptor-associated factor 1
TRPM5 transient receptor potential cation channel, subfamily M, member 5
TYK2 tyrosine kinase 2
TYMP thymidine phosphorylase
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7
UTS2 urotensin 2
UTS2R urotensin 2 receptor
VASH1 vasohibin 1
VCAM1 vascular cell adhesion molecule 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VIPR1 vasoactive intestinal peptide receptor 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WEE1 WEE1 G2 checkpoint kinase
WT1 Wilms tumor 1
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)