ciprofloxacin-2022 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the ciprofloxacin-2022 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2
ACAN aggrecan
ACOX1 acyl-CoA oxidase 1, palmitoyl
ADAM8 ADAM metallopeptidase domain 8
AHI1 Abelson helper integration site 1
ARRB2 arrestin, beta 2
ATAD2B ATPase family, AAA domain containing 2B
ATG9A autophagy related 9A
BMP15 bone morphogenetic protein 15
C2CD2L C2CD2-like
C3 complement component 3
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CEP68 centrosomal protein 68kDa
CHKA choline kinase alpha
CIDEC cell death-inducing DFFA-like effector c
CLCN6 chloride channel, voltage-sensitive 6
CMC4 C-x(9)-C motif containing 4
COG5 component of oligomeric golgi complex 5
COL4A2 collagen, type IV, alpha 2
CSN2 casein beta
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
DEDD death effector domain containing
E2F4 E2F transcription factor 4, p107/p130-binding
ELMO2 engulfment and cell motility 2
EML2 echinoderm microtubule associated protein like 2
FAM188A family with sequence similarity 188, member A
FAS Fas cell surface death receptor
FYB FYN binding protein
GDF3 growth differentiation factor 3
GDF5 growth differentiation factor 5
GLTSCR1 glioma tumor suppressor candidate region gene 1
HBB hemoglobin, beta
HIRA histone cell cycle regulator
HTT huntingtin
INPP5K inositol polyphosphate-5-phosphatase K
KIFC1 kinesin family member C1
KIZ kizuna centrosomal protein
LIMD2 LIM domain containing 2
LPP LIM domain containing preferred translocation partner in lipoma
LTB4R leukotriene B4 receptor
LTBP2 latent transforming growth factor beta binding protein 2
LY6E lymphocyte antigen 6 complex, locus E
MAGED2 melanoma antigen family D2
MAML3 mastermind-like 3 (Drosophila)
MAPKBP1 mitogen-activated protein kinase binding protein 1
MAST3 microtubule associated serine/threonine kinase 3
MAZ MYC-associated zinc finger protein (purine-binding transcription factor)
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta)
MECP2 methyl CpG binding protein 2
MED15 mediator complex subunit 15
MED7 mediator complex subunit 7
MSH3 mutS homolog 3
NBEAL2 neurobeachin-like 2
NCOA3 nuclear receptor coactivator 3
NCR2 natural cytotoxicity triggering receptor 2
PAK1IP1 PAK1 interacting protein 1
PARD3 par-3 family cell polarity regulator
PAX1 paired box 1
PCTP phosphatidylcholine transfer protein
PDE8A phosphodiesterase 8A
PHTF1 putative homeodomain transcription factor 1
PIDD1 p53-induced death domain protein 1
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PPP1R7 protein phosphatase 1, regulatory subunit 7
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PSG6 pregnancy specific beta-1-glycoprotein 6
PTCRA pre T-cell antigen receptor alpha
RAD23B RAD23 homolog B (S. cerevisiae)
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RARA retinoic acid receptor, alpha
RBBP5 retinoblastoma binding protein 5
RBM34 RNA binding motif protein 34
RBM48 RNA binding motif protein 48
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
SH3BP2 SH3-domain binding protein 2
SIK2 salt-inducible kinase 2
SIPA1 signal-induced proliferation-associated 1
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SOD3 superoxide dismutase 3, extracellular
SSH3 slingshot protein phosphatase 3
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein
STAB2 stabilin 2
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae)
TBC1D29 TBC1 domain family, member 29
TESK1 testis-specific kinase 1
TGM5 transglutaminase 5
THY1 Thy-1 cell surface antigen
TM2D1 TM2 domain containing 1
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TRIP11 thyroid hormone receptor interactor 11
TSPYL2 TSPY-like 2
TTLL4 tubulin tyrosine ligase-like family member 4
TULP3 tubby like protein 3
UBE3A ubiquitin protein ligase E3A
UBOX5 U-box domain containing 5
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
WDR48 WD repeat domain 48

decreased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACTL6A actin-like 6A
ADAM23 ADAM metallopeptidase domain 23
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3
ARFRP1 ADP-ribosylation factor related protein 1
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ATAD2 ATPase family, AAA domain containing 2
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BCORL1 BCL6 corepressor-like 1
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CTSK cathepsin K
DBF4B DBF4 zinc finger B
DIXDC1 DIX domain containing 1
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
EPM2AIP1 EPM2A (laforin) interacting protein 1
ERBB2IP erbb2 interacting protein
FAM50B family with sequence similarity 50, member B
FAM63A family with sequence similarity 63, member A
FANCC Fanconi anemia, complementation group C
FANCF Fanconi anemia, complementation group F
FBXO5 F-box protein 5
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
GRM6 glutamate receptor, metabotropic 6
GRPR gastrin-releasing peptide receptor
GSTM5 glutathione S-transferase mu 5
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
HINFP histone H4 transcription factor
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HSPA4L heat shock 70kDa protein 4-like
IL4R interleukin 4 receptor
IMPACT impact RWD domain protein
INPP1 inositol polyphosphate-1-phosphatase
KIFAP3 kinesin-associated protein 3
LHFPL2 lipoma HMGIC fusion partner-like 2
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LOC642236 FSHD region gene 1 pseudogene
LONRF3 LON peptidase N-terminal domain and ring finger 3
LRP5L low density lipoprotein receptor-related protein 5-like
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
MBIP MAP3K12 binding inhibitory protein 1
METTL21B methyltransferase like 21B
METTL22 methyltransferase like 22
MPDU1 mannose-P-dolichol utilization defect 1
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
NIP7 NIP7, nucleolar pre-rRNA processing protein
NPPA natriuretic peptide A
NRBP1 nuclear receptor binding protein 1
NT5DC3 5'-nucleotidase domain containing 3
NTAN1 N-terminal asparagine amidase
OR1F1 olfactory receptor, family 1, subfamily F, member 1
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
OSTF1 osteoclast stimulating factor 1
OVGP1 oviductal glycoprotein 1, 120kDa
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PAGR1 PAXIP1 associated glutamate-rich protein 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PDZD8 PDZ domain containing 8
PGRMC2 progesterone receptor membrane component 2
PLCD1 phospholipase C, delta 1
PODNL1 podocan-like 1
PRDM13 PR domain containing 13
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
RHOH ras homolog family member H
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SETD1B SET domain containing 1B
SIAH2 siah E3 ubiquitin protein ligase 2
SMAP1 small ArfGAP 1
SNX10 sorting nexin 10
SP140L SP140 nuclear body protein-like
SPON2 spondin 2, extracellular matrix protein
STXBP3 syntaxin binding protein 3
TBCCD1 TBCC domain containing 1
TMA7 translation machinery associated 7 homolog (S. cerevisiae)
TMEM14A transmembrane protein 14A
TMPRSS6 transmembrane protease, serine 6
TSPYL4 TSPY-like 4
TTF2 transcription termination factor, RNA polymerase II
TVP23B trans-golgi network vesicle protein 23 homolog B (S. cerevisiae)
TXNDC15 thioredoxin domain containing 15
UNC93B1 unc-93 homolog B1 (C. elegans)
VASP vasodilator-stimulated phosphoprotein
WDR76 WD repeat domain 76
YEATS4 YEATS domain containing 4
YPEL5 yippee-like 5 (Drosophila)
ZFAND1 zinc finger, AN1-type domain 1
ZNF32 zinc finger protein 32
ZNF443 zinc finger protein 443
ZNF529 zinc finger protein 529
ZNF671 zinc finger protein 671
ZNF804A zinc finger protein 804A