ciprofibrate-6138 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the ciprofibrate-6138 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOT11 acyl-CoA thioesterase 11
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
ANG angiogenin, ribonuclease, RNase A family, 5
APOE apolipoprotein E
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARHGAP26 Rho GTPase activating protein 26
ARL2BP ADP-ribosylation factor-like 2 binding protein
C21ORF2 chromosome 21 open reading frame 2
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCDC81 coiled-coil domain containing 81
CCL8 chemokine (C-C motif) ligand 8
CCND1 cyclin D1
CD80 CD80 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLTA clathrin, light chain A
COL8A2 collagen, type VIII, alpha 2
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CRYGC crystallin, gamma C
CXXC4 CXXC finger protein 4
CYLD cylindromatosis (turban tumor syndrome)
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1
DCAF4 DDB1 and CUL4 associated factor 4
DOC2A double C2-like domains, alpha
DSTYK dual serine/threonine and tyrosine protein kinase
DUSP4 dual specificity phosphatase 4
EFNA5 ephrin-A5
EFR3B EFR3 homolog B (S. cerevisiae)
ERBB4 erb-b2 receptor tyrosine kinase 4
EXTL3 exostosin-like glycosyltransferase 3
FBXO31 F-box protein 31
FOXG1 forkhead box G1
FOXI1 forkhead box I1
FRS2 fibroblast growth factor receptor substrate 2
FST follistatin
GP2 glycoprotein 2 (zymogen granule membrane)
GPATCH4 G patch domain containing 4
GSTT1 glutathione S-transferase theta 1
HIST1H1D histone cluster 1, H1d
HIST1H2AL histone cluster 1, H2al
HLA-DOA major histocompatibility complex, class II, DO alpha
HPR haptoglobin-related protein
HS6ST1 heparan sulfate 6-O-sulfotransferase 1
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
IL11 interleukin 11
IQSEC1 IQ motif and Sec7 domain 1
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
LPAR1 lysophosphatidic acid receptor 1
LRRC37BP1 leucine rich repeat containing 37B pseudogene 1
MAOA monoamine oxidase A
MBP myelin basic protein
MFSD6 major facilitator superfamily domain containing 6
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
MLH3 mutL homolog 3
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MYL10 myosin, light chain 10, regulatory
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYRF myelin regulatory factor
NCAN neurocan
NEBL nebulette
NF2 neurofibromin 2 (merlin)
NLRP1 NLR family, pyrin domain containing 1
NOV nephroblastoma overexpressed
NTF3 neurotrophin 3
OR2H2 olfactory receptor, family 2, subfamily H, member 2
PCSK6 proprotein convertase subtilisin/kexin type 6
PDE4DIP phosphodiesterase 4D interacting protein
PER3 period circadian clock 3
PKP3 plakophilin 3
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RFX2 regulatory factor X, 2 (influences HLA class II expression)
RUNDC3A RUN domain containing 3A
RXRB retinoid X receptor, beta
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLIT2 slit homolog 2 (Drosophila)
SP1 Sp1 transcription factor
STEAP4 STEAP family member 4
SYNJ2 synaptojanin 2
TAPT1 transmembrane anterior posterior transformation 1
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TCF20 transcription factor 20 (AR1)
TESPA1 thymocyte expressed, positive selection associated 1
TMEM176A transmembrane protein 176A
TPM3 tropomyosin 3
TRD T cell receptor delta locus
TROVE2 TROVE domain family, member 2
TRPC2 transient receptor potential cation channel, subfamily C, member 2, pseudogene
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TRPV5 transient receptor potential cation channel, subfamily V, member 5
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
VGF VGF nerve growth factor inducible
WNT16 wingless-type MMTV integration site family, member 16
ZFAND5 zinc finger, AN1-type domain 5
ZNF76 zinc finger protein 76
ZSCAN12 zinc finger and SCAN domain containing 12

decreased expression

Symbol Name
AGBL5 ATP/GTP binding protein-like 5
ALPK1 alpha-kinase 1
AMIGO2 adhesion molecule with Ig-like domain 2
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ARMC4 armadillo repeat containing 4
C11ORF63 chromosome 11 open reading frame 63
CDHR2 cadherin-related family member 2
CDR2L cerebellar degeneration-related protein 2-like
CEP97 centrosomal protein 97kDa
CHM choroideremia (Rab escort protein 1)
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLCF1 cardiotrophin-like cytokine factor 1
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
CRMP1 collapsin response mediator protein 1
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DHRS3 dehydrogenase/reductase (SDR family) member 3
ENO3 enolase 3 (beta, muscle)
EYA3 EYA transcriptional coactivator and phosphatase 3
FAM53B family with sequence similarity 53, member B
FBXL7 F-box and leucine-rich repeat protein 7
FGFBP1 fibroblast growth factor binding protein 1
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FURIN furin (paired basic amino acid cleaving enzyme)
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GID4 GID complex subunit 4
GLCE glucuronic acid epimerase
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GP6 glycoprotein VI (platelet)
GPC3 glypican 3
GSPT2 G1 to S phase transition 2
HDAC7 histone deacetylase 7
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3
HIST1H1T histone cluster 1, H1t
HIST1H2AG histone cluster 1, H2ag
HIST1H2AJ histone cluster 1, H2aj
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOOK2 hook microtubule-tethering protein 2
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
IGLV1-44 immunoglobulin lambda variable 1-44
KDM8 lysine (K)-specific demethylase 8
LIG4 ligase IV, DNA, ATP-dependent
LIME1 Lck interacting transmembrane adaptor 1
LIN7A lin-7 homolog A (C. elegans)
LLGL2 lethal giant larvae homolog 2 (Drosophila)
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
MAGEF1 melanoma antigen family F1
MAP6D1 MAP6 domain containing 1
MED9 mediator complex subunit 9
MEGF8 multiple EGF-like-domains 8
MMRN2 multimerin 2
MVD mevalonate (diphospho) decarboxylase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYL5 myosin, light chain 5, regulatory
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NAT6 N-acetyltransferase 6 (GCN5-related)
NINJ2 ninjurin 2
OR1G1 olfactory receptor, family 1, subfamily G, member 1
P2RY11 purinergic receptor P2Y, G-protein coupled, 11
PENK proenkephalin
PODNL1 podocan-like 1
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PPP1R26 protein phosphatase 1, regulatory subunit 26
PROL1 proline rich, lacrimal 1
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RAP1GAP2 RAP1 GTPase activating protein 2
RHOB ras homolog family member B
RNF122 ring finger protein 122
RPL23AP7 ribosomal protein L23a pseudogene 7
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SHPK sedoheptulokinase
SLITRK5 SLIT and NTRK-like family, member 5
SPATA20 spermatogenesis associated 20
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPINT1 serine peptidase inhibitor, Kunitz type 1
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
TGFBR1 transforming growth factor, beta receptor 1
THBS3 thrombospondin 3
TMEM53 transmembrane protein 53
TNS2 tensin 2
TRIM45 tripartite motif containing 45
TSPAN13 tetraspanin 13
TTLL1 tubulin tyrosine ligase-like family member 1
TUBA4B tubulin, alpha 4b
UNC119 unc-119 homolog (C. elegans)
WFDC2 WAP four-disulfide core domain 2
XYLT2 xylosyltransferase II
ZBTB22 zinc finger and BTB domain containing 22
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZIC3 Zic family member 3
ZNF223 zinc finger protein 223
ZNF250 zinc finger protein 250
ZNF276 zinc finger protein 276
ZNF428 zinc finger protein 428
ZNF862 zinc finger protein 862