cinchonine-4107 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the cinchonine-4107 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAA2 acetyl-CoA acyltransferase 2
ACYP1 acylphosphatase 1, erythrocyte (common) type
ADRA1A adrenoceptor alpha 1A
AKAP8L A kinase (PRKA) anchor protein 8-like
AQP4 aquaporin 4
BCL6 B-cell CLL/lymphoma 6
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCZ1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
CD163 CD163 molecule
CD1A CD1a molecule
CD47 CD47 molecule
CDH10 cadherin 10, type 2 (T2-cadherin)
CELF2 CUGBP, Elav-like family member 2
CEP112 centrosomal protein 112kDa
CLCA2 chloride channel accessory 2
CPB1 carboxypeptidase B1 (tissue)
DLC1 DLC1 Rho GTPase activating protein
DPF1 D4, zinc and double PHD fingers family 1
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EFNB3 ephrin-B3
ELAC2 elaC ribonuclease Z 2
ELSPBP1 epididymal sperm binding protein 1
FAM171A1 family with sequence similarity 171, member A1
FBLN1 fibulin 1
FBXO11 F-box protein 11
FSCN3 fascin actin-bundling protein 3, testicular
FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase)
FXYD5 FXYD domain containing ion transport regulator 5
GAB1 GRB2-associated binding protein 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GFER growth factor, augmenter of liver regeneration
GK glycerol kinase
GPR85 G protein-coupled receptor 85
GSPT1 G1 to S phase transition 1
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
HFE hemochromatosis
HNF4A hepatocyte nuclear factor 4, alpha
HPX hemopexin
HRH2 histamine receptor H2
HSPG2 heparan sulfate proteoglycan 2
ICA1 islet cell autoantigen 1, 69kDa
IL2 interleukin 2
IL7 interleukin 7
ING2 inhibitor of growth family, member 2
IRS4 insulin receptor substrate 4
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
JPH3 junctophilin 3
KIAA1107 KIAA1107
KIAA1109 KIAA1109
KIAA1456 KIAA1456
KLF12 Kruppel-like factor 12
MAL mal, T-cell differentiation protein
MAPK7 mitogen-activated protein kinase 7
MEFV Mediterranean fever
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MRPL41 mitochondrial ribosomal protein L41
MYBPC3 myosin binding protein C, cardiac
MYLK myosin light chain kinase
NEUROD6 neuronal differentiation 6
NOL10 nucleolar protein 10
NOVA1 neuro-oncological ventral antigen 1
NOX1 NADPH oxidase 1
OXCT2 3-oxoacid CoA transferase 2
PADI3 peptidyl arginine deiminase, type III
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PLCL2 phospholipase C-like 2
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PRKG2 protein kinase, cGMP-dependent, type II
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RBBP9 retinoblastoma binding protein 9
RNF6 ring finger protein (C3H2C3 type) 6
RPL14 ribosomal protein L14
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
RUNX1 runt-related transcription factor 1
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SAYSD1 SAYSVFN motif domain containing 1
SH3BP2 SH3-domain binding protein 2
SKI SKI proto-oncogene
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC35E2 solute carrier family 35, member E2
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SNCG synuclein, gamma (breast cancer-specific protein 1)
SORBS2 sorbin and SH3 domain containing 2
SP4 Sp4 transcription factor
STS steroid sulfatase (microsomal), isozyme S
TBX5 T-box 5
TCF3 transcription factor 3
TDRD12 tudor domain containing 12
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS1 thrombospondin 1
TRIM38 tripartite motif containing 38
UBXN1 UBX domain protein 1
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae)
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
ZMYND8 zinc finger, MYND-type containing 8
ZNF222 zinc finger protein 222

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ALAS1 5'-aminolevulinate synthase 1
ALPK1 alpha-kinase 1
ALS2CL ALS2 C-terminal like
ARID3B AT rich interactive domain 3B (BRIGHT-like)
C11ORF30 chromosome 11 open reading frame 30
C14ORF79 chromosome 14 open reading frame 79
C2ORF27A chromosome 2 open reading frame 27A
C7ORF43 chromosome 7 open reading frame 43
C9ORF9 chromosome 9 open reading frame 9
CBX8 chromobox homolog 8
CCDC85C coiled-coil domain containing 85C
CCDC9 coiled-coil domain containing 9
CD3D CD3d molecule, delta (CD3-TCR complex)
CLCF1 cardiotrophin-like cytokine factor 1
CLEC16A C-type lectin domain family 16, member A
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CRYBB2P1 crystallin, beta B2 pseudogene 1
CTRL chymotrypsin-like
DGAT1 diacylglycerol O-acyltransferase 1
DIXDC1 DIX domain containing 1
DNAL4 dynein, axonemal, light chain 4
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFNA3 ephrin-A3
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ELP6 elongator acetyltransferase complex subunit 6
ETNK2 ethanolamine kinase 2
EVPL envoplakin
FBXL6 F-box and leucine-rich repeat protein 6
FBXL7 F-box and leucine-rich repeat protein 7
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FSD1 fibronectin type III and SPRY domain containing 1
FURIN furin (paired basic amino acid cleaving enzyme)
GCHFR GTP cyclohydrolase I feedback regulator
GINS4 GINS complex subunit 4 (Sld5 homolog)
GLS2 glutaminase 2 (liver, mitochondrial)
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H3E histone cluster 1, H3e
HOXA4 homeobox A4
HPS6 Hermansky-Pudlak syndrome 6
IFI6 interferon, alpha-inducible protein 6
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KDM5C lysine (K)-specific demethylase 5C
KDM8 lysine (K)-specific demethylase 8
LAMA3 laminin, alpha 3
LAX1 lymphocyte transmembrane adaptor 1
LRP2 low density lipoprotein receptor-related protein 2
MATK megakaryocyte-associated tyrosine kinase
MED15 mediator complex subunit 15
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MVD mevalonate (diphospho) decarboxylase
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NAT6 N-acetyltransferase 6 (GCN5-related)
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NOD1 nucleotide-binding oligomerization domain containing 1
NPY4R neuropeptide Y receptor Y4
ORAI3 ORAI calcium release-activated calcium modulator 3
PCDHGB5 protocadherin gamma subfamily B, 5
PDE12 phosphodiesterase 12
PLCD1 phospholipase C, delta 1
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PRAMEF11 PRAME family member 11
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
QTRT1 queuine tRNA-ribosyltransferase 1
RAB30 RAB30, member RAS oncogene family
RAB3D RAB3D, member RAS oncogene family
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RNF122 ring finger protein 122
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RNF126P1 ring finger protein 126 pseudogene 1
ROM1 retinal outer segment membrane protein 1
RPGRIP1L RPGRIP1-like
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SGK2 serum/glucocorticoid regulated kinase 2
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SMR3A submaxillary gland androgen regulated protein 3A
SNTA1 syntrophin, alpha 1
STRA6 stimulated by retinoic acid 6
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TBC1D17 TBC1 domain family, member 17
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TEP1 telomerase-associated protein 1
TIPRL TOR signaling pathway regulator
TRIM25 tripartite motif containing 25
TTLL1 tubulin tyrosine ligase-like family member 1
TUBA3C tubulin, alpha 3c
UBIAD1 UbiA prenyltransferase domain containing 1
UBQLN4 ubiquilin 4
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZNF280A zinc finger protein 280A
ZNF551 zinc finger protein 551
ZNF574 zinc finger protein 574
ZNF652 zinc finger protein 652
ZNF692 zinc finger protein 692