ciclopirox-2456 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the ciclopirox-2456 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADM adrenomedullin
AGRN agrin
ARC activity-regulated cytoskeleton-associated protein
ATF3 activating transcription factor 3
BIRC3 baculoviral IAP repeat containing 3
BTG2 BTG family, member 2
CD59 CD59 molecule, complement regulatory protein
CD69 CD69 molecule
CD83 CD83 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
DUSP8 dual specificity phosphatase 8
EGR1 early growth response 1
EGR3 early growth response 3
EGR4 early growth response 4
EIF1 eukaryotic translation initiation factor 1
EIF5 eukaryotic translation initiation factor 5
FADS3 fatty acid desaturase 3
FAM53C family with sequence similarity 53, member C
FCAR Fc fragment of IgA receptor
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FLT1 fms-related tyrosine kinase 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GEM GTP binding protein overexpressed in skeletal muscle
HBEGF heparin-binding EGF-like growth factor
HCAR3 hydroxycarboxylic acid receptor 3
HEXIM1 hexamethylene bis-acetamide inducible 1
HILPDA hypoxia inducible lipid droplet-associated
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IL1B interleukin 1, beta
JUN jun proto-oncogene
JUNB jun B proto-oncogene
LDLR low density lipoprotein receptor
LRRC23 leucine rich repeat containing 23
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MT2A metallothionein 2A
NAMPT nicotinamide phosphoribosyltransferase
NFIL3 nuclear factor, interleukin 3 regulated
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFYA nuclear transcription factor Y, alpha
NR4A3 nuclear receptor subfamily 4, group A, member 3
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLIN2 perilipin 2
PLK3 polo-like kinase 3
PNRC1 proline-rich nuclear receptor coactivator 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAB13 RAB13, member RAS oncogene family
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS16 regulator of G-protein signaling 16
RHOB ras homolog family member B
RND1 Rho family GTPase 1
RPL13P5 ribosomal protein L13 pseudogene 5
SAT1 spermidine/spermine N1-acetyltransferase 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOCS1 suppressor of cytokine signaling 1
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SQSTM1 sequestosome 1
TAT tyrosine aminotransferase
TESPA1 thymocyte expressed, positive selection associated 1
TEX14 testis expressed 14
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRIB1 tribbles pseudokinase 1
TUBB2A tubulin, beta 2A class IIa
UBE2I ubiquitin-conjugating enzyme E2I
ZFP36 ZFP36 ring finger protein
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF10 zinc finger protein 10

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADRB2 adrenoceptor beta 2, surface
AIM1 absent in melanoma 1
AMIGO2 adhesion molecule with Ig-like domain 2
AMT aminomethyltransferase
ANKRD55 ankyrin repeat domain 55
ANXA2P2 annexin A2 pseudogene 2
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
APOLD1 apolipoprotein L domain containing 1
B3GNT1
BAHCC1 BAH domain and coiled-coil containing 1
BCCIP BRCA2 and CDKN1A interacting protein
BSPRY B-box and SPRY domain containing
BZRAP1 benzodiazepine receptor (peripheral) associated protein 1
C5 complement component 5
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CBX7 chromobox homolog 7
CDC20 cell division cycle 20
CDC7 cell division cycle 7
CES3 carboxylesterase 3
CX3CR1 chemokine (C-X3-C motif) receptor 1
DEPDC1 DEP domain containing 1
DIXDC1 DIX domain containing 1
DKK2 dickkopf WNT signaling pathway inhibitor 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
ELMO1 engulfment and cell motility 1
EMILIN2 elastin microfibril interfacer 2
ERI2 ERI1 exoribonuclease family member 2
ETAA1 Ewing tumor-associated antigen 1
FANCF Fanconi anemia, complementation group F
FCHO1 FCH domain only 1
FSTL3 follistatin-like 3 (secreted glycoprotein)
GBAP1 glucosidase, beta, acid pseudogene 1
GFI1 growth factor independent 1 transcription repressor
GIMAP6 GTPase, IMAP family member 6
GIPC1 GIPC PDZ domain containing family, member 1
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3
HIST1H1E histone cluster 1, H1e
HIST1H4C histone cluster 1, H4c
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HPS4 Hermansky-Pudlak syndrome 4
HSPA1L heat shock 70kDa protein 1-like
HSPA4L heat shock 70kDa protein 4-like
IFI6 interferon, alpha-inducible protein 6
IRF8 interferon regulatory factor 8
KIAA0319L KIAA0319-like
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
KLF7 Kruppel-like factor 7 (ubiquitous)
LAMP5 lysosomal-associated membrane protein family, member 5
LIMD2 LIM domain containing 2
MANSC1 MANSC domain containing 1
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MXD3 MAX dimerization protein 3
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NFE2 nuclear factor, erythroid 2
NINJ2 ninjurin 2
NIPAL2 NIPA-like domain containing 2
NPM3 nucleophosmin/nucleoplasmin 3
NRGN neurogranin (protein kinase C substrate, RC3)
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLK1 polo-like kinase 1
PMFBP1 polyamine modulated factor 1 binding protein 1
POLL polymerase (DNA directed), lambda
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E
PRAF2 PRA1 domain family, member 2
PSRC1 proline/serine-rich coiled-coil 1
QTRT1 queuine tRNA-ribosyltransferase 1
RAD9A RAD9 homolog A (S. pombe)
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RNF144A ring finger protein 144A
RWDD2A RWD domain containing 2A
SKI SKI proto-oncogene
SLA Src-like-adaptor
SLITRK5 SLIT and NTRK-like family, member 5
STK16 serine/threonine kinase 16
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TFEC transcription factor EC
THBS4 thrombospondin 4
TJP2 tight junction protein 2
TMEM187 transmembrane protein 187
TOP2A topoisomerase (DNA) II alpha 170kDa
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TTLL1 tubulin tyrosine ligase-like family member 1
TUBA4B tubulin, alpha 4b
VANGL1 VANGL planar cell polarity protein 1
WDR62 WD repeat domain 62
WNT16 wingless-type MMTV integration site family, member 16
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF528 zinc finger protein 528
ZNF606 zinc finger protein 606