cicloheximide-2723 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the cicloheximide-2723 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AREG amphiregulin
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF7IP activating transcription factor 7 interacting protein
BCL3 B-cell CLL/lymphoma 3
BDNF brain-derived neurotrophic factor
BIRC3 baculoviral IAP repeat containing 3
C14ORF1 chromosome 14 open reading frame 1
C18ORF25 chromosome 18 open reading frame 25
CCR1 chemokine (C-C motif) receptor 1
CDK12 cyclin-dependent kinase 12
CREM cAMP responsive element modulator
DNAH17 dynein, axonemal, heavy chain 17
DUSP4 dual specificity phosphatase 4
EGR2 early growth response 2
FCAR Fc fragment of IgA receptor
FGFR2 fibroblast growth factor receptor 2
FILIP1L filamin A interacting protein 1-like
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45B growth arrest and DNA-damage-inducible, beta
GBP2 guanylate binding protein 2, interferon-inducible
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H1D histone cluster 1, H1d
HIST1H2AC histone cluster 1, H2ac
HIST1H2AG histone cluster 1, H2ag
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BI histone cluster 1, H2bi
HIST1H2BJ histone cluster 1, H2bj
HIST1H2BK histone cluster 1, H2bk
HIST1H4C histone cluster 1, H4c
HIST2H2BE histone cluster 2, H2be
HRH1 histamine receptor H1
HUS1 HUS1 checkpoint homolog (S. pombe)
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFT22 intraflagellar transport 22
IL1B interleukin 1, beta
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IL1RN interleukin 1 receptor antagonist
IL24 interleukin 24
ISG20 interferon stimulated exonuclease gene 20kDa
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KLF10 Kruppel-like factor 10
KLF12 Kruppel-like factor 12
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KYNU kynureninase
LAX1 lymphocyte transmembrane adaptor 1
LILRP2 leukocyte immunoglobulin-like receptor pseudogene 2
LMF1 lipase maturation factor 1
MAP7 microtubule-associated protein 7
MARC1 mitochondrial amidoxime reducing component 1
MR1 major histocompatibility complex, class I-related
MYO5C myosin VC
N4BP2L2 NEDD4 binding protein 2-like 2
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NLRP1 NLR family, pyrin domain containing 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PCLO piccolo presynaptic cytomatrix protein
PDE4B phosphodiesterase 4B, cAMP-specific
PHLDA1 pleckstrin homology-like domain, family A, member 1
PICALM phosphatidylinositol binding clathrin assembly protein
PLSCR1 phospholipid scramblase 1
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTX3 pentraxin 3, long
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBP4 retinol binding protein 4, plasma
RBPMS RNA binding protein with multiple splicing
RGS2 regulator of G-protein signaling 2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SIPA1L1 signal-induced proliferation-associated 1 like 1
SIRPB1 signal-regulatory protein beta 1
SIX3 SIX homeobox 3
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SPRY4 sprouty homolog 4 (Drosophila)
SPTBN5 spectrin, beta, non-erythrocytic 5
ST7L suppression of tumorigenicity 7 like
STAP1 signal transducing adaptor family member 1
SYNJ1 synaptojanin 1
THBS1 thrombospondin 1
THPO thrombopoietin
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRAF3IP2 TRAF3 interacting protein 2
TRAF3IP3 TRAF3 interacting protein 3
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like
TXNIP thioredoxin interacting protein
UBE2H ubiquitin-conjugating enzyme E2H
ZNF44 zinc finger protein 44

decreased expression

Symbol Name
ACVR2B activin A receptor, type IIB
ADAM23 ADAM metallopeptidase domain 23
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRA3 adhesion G protein-coupled receptor A3
ADM adrenomedullin
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AMT aminomethyltransferase
AP2M1 adaptor-related protein complex 2, mu 1 subunit
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BTBD18 BTB (POZ) domain containing 18
C10ORF2 chromosome 10 open reading frame 2
C5ORF30 chromosome 5 open reading frame 30
C8ORF44 chromosome 8 open reading frame 44
CAMKMT calmodulin-lysine N-methyltransferase
CCNI cyclin I
CD9 CD9 molecule
CDT1 chromatin licensing and DNA replication factor 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CSK c-src tyrosine kinase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDN dendrin
DEAF1 DEAF1 transcription factor
DPY19L2P2 DPY19L2 pseudogene 2
DUSP2 dual specificity phosphatase 2
FAM114A1 family with sequence similarity 114, member A1
FAM57A family with sequence similarity 57, member A
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FJX1 four jointed box 1 (Drosophila)
FOXD1 forkhead box D1
GPR22 G protein-coupled receptor 22
GRB10 growth factor receptor-bound protein 10
HIRA histone cell cycle regulator
HMGA2 high mobility group AT-hook 2
HSPA8 heat shock 70kDa protein 8
INHBE inhibin, beta E
INSIG1 insulin induced gene 1
JADE3 jade family PHD finger 3
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KLF11 Kruppel-like factor 11
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRP3 low density lipoprotein receptor-related protein 3
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MAN1C1 mannosidase, alpha, class 1C, member 1
MAT2A methionine adenosyltransferase II, alpha
MCM3AP-AS1 MCM3AP antisense RNA 1
MCRS1 microspherule protein 1
METTL1 methyltransferase like 1
MSMO1 methylsterol monooxygenase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCS1 neuronal calcium sensor 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFE2L3 nuclear factor, erythroid 2-like 3
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NLK nemo-like kinase
NPIPB3 nuclear pore complex interacting protein family, member B3
NR1H2 nuclear receptor subfamily 1, group H, member 2
NTSR1 neurotensin receptor 1 (high affinity)
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PDIA5 protein disulfide isomerase family A, member 5
PGP phosphoglycolate phosphatase
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PPAN peter pan homolog (Drosophila)
PRDM13 PR domain containing 13
PRKX protein kinase, X-linked
RAD54L RAD54-like (S. cerevisiae)
RFTN1 raftlin, lipid raft linker 1
RGS16 regulator of G-protein signaling 16
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RNF44 ring finger protein 44
SCML1 sex comb on midleg-like 1 (Drosophila)
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SERINC5 serine incorporator 5
SETD1A SET domain containing 1A
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SQLE squalene epoxidase
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STC2 stanniocalcin 2
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TEC tec protein tyrosine kinase
TERT telomerase reverse transcriptase
TMEM120B transmembrane protein 120B
TRIB3 tribbles pseudokinase 3
TXLNG taxilin gamma
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UNC13B unc-13 homolog B (C. elegans)
WT1-AS WT1 antisense RNA
XBP1 X-box binding protein 1
YY2 YY2 transcription factor
ZMAT3 zinc finger, matrin-type 3
ZNF667 zinc finger protein 667