chronic lymphocytic leukemia Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A lymphoblastic leukemia characterized by over production of B-cells and their accumulation in bone marrow and blood. (Human Disease Ontology, DOID_1040)
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Genes

723 genes co-occuring with the disease chronic lymphocytic leukemia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
CD5 CD5 molecule 2.79417
CD38 CD38 molecule 2.56776
IGH immunoglobulin heavy locus 2.56111
IGHV5-51 immunoglobulin heavy variable 5-51 2.47474
CD19 CD19 molecule 2.31432
TCL1A T-cell leukemia/lymphoma 1A 2.13769
CD52 CD52 molecule 2.0491
CD22 CD22 molecule 2.03966
TP53 tumor protein p53 1.83092
CD79B CD79b molecule, immunoglobulin-associated beta 1.77315
ATM ATM serine/threonine kinase 1.76275
SLC35B2 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2 1.75868
ACPP acid phosphatase, prostate 1.72092
IGHV3-21 immunoglobulin heavy variable 3-21 1.69769
CD40 CD40 molecule, TNF receptor superfamily member 5 1.67232
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 1.63232
CD40LG CD40 ligand 1.62918
IGHV1-69 immunoglobulin heavy variable 1-69 1.601
SYK spleen tyrosine kinase 1.59698
IGHV4-39 immunoglobulin heavy variable 4-39 1.59251
IGHV3-9 immunoglobulin heavy variable 3-9 1.59028
CLLU1 chronic lymphocytic leukemia up-regulated 1 1.58403
BCL3 B-cell CLL/lymphoma 3 1.57645
CCND1 cyclin D1 1.57556
BTK Bruton agammaglobulinemia tyrosine kinase 1.57022
IL2 interleukin 2 1.56844
CDA cytidine deaminase 1.55734
IFNA1 interferon, alpha 1 1.54009
IGHV4-34 immunoglobulin heavy variable 4-34 1.53965
CD4 CD4 molecule 1.4755
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 1.43552
CD37 CD37 molecule 1.42235
DLEU2L deleted in lymphocytic leukemia 2-like 1.38036
BCL2 B-cell CLL/lymphoma 2 1.36161
BCR breakpoint cluster region 1.35594
B2M beta-2-microglobulin 1.34766
BAX BCL2-associated X protein 1.3337
IGKV2-30 immunoglobulin kappa variable 2-30 1.3276
IGHJ6 immunoglobulin heavy joining 6 1.3062
ADA adenosine deaminase 1.30357
IL2RA interleukin 2 receptor, alpha 1.27432
ATR ATR serine/threonine kinase 1.26909
IGKV1-39 immunoglobulin kappa variable 1-39 (gene/pseudogene) 1.24776
AICDA activation-induced cytidine deaminase 1.23386
SIGLEC10 sialic acid binding Ig-like lectin 10 1.23082
NOTCH1 notch 1 1.20093
IL4 interleukin 4 1.18669
COLEC10 collectin sub-family member 10 (C-type lectin) 1.17636
CD7 CD7 molecule 1.17464
BCL2L1 BCL2-like 1 1.16649
CXCL12 chemokine (C-X-C motif) ligand 12 1.16221
ROR1 receptor tyrosine kinase-like orphan receptor 1 1.15752
B3GAT1 beta-1,3-glucuronyltransferase 1 1.14093
DCK deoxycytidine kinase 1.13839
CD27 CD27 molecule 1.13289
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 1.1253
BCL6 B-cell CLL/lymphoma 6 1.11856
ANXA5 annexin A5 1.11267
CD79A CD79a molecule, immunoglobulin-associated alpha 1.09629
CD80 CD80 molecule 1.09587
FMOD fibromodulin 1.09251
IFNA2 interferon, alpha 2 1.09251
IGHJ3 immunoglobulin heavy joining 3 1.0837
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding) 1.07866
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 1.07824
TNF tumor necrosis factor 1.07656
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.07446
ADAM29 ADAM metallopeptidase domain 29 1.07404
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 1.07362
CD200 CD200 molecule 1.05976
BIRC3 baculoviral IAP repeat containing 3 1.0585
MTCP1 mature T-cell proliferation 1 1.05639
CD34 CD34 molecule 1.05513
FCMR Fc fragment of IgM receptor 1.05261
PAX5 paired box 5 1.05219
BCL2L11 BCL2-like 11 (apoptosis facilitator) 1.04125
LYN LYN proto-oncogene, Src family tyrosine kinase 1.03493
NT5E 5'-nucleotidase, ecto (CD73) 1.03282
CD72 CD72 molecule 1.01723
NCAM1 neural cell adhesion molecule 1 1.01554
HCLS1 hematopoietic cell-specific Lyn substrate 1 1.01216
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.00246
CLEC12A C-type lectin domain family 12, member A 0.999503
PNP purine nucleoside phosphorylase 0.993596
CCR7 chemokine (C-C motif) receptor 7 0.983479
ICAM1 intercellular adhesion molecule 1 0.975482
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.967502
IRF4 interferon regulatory factor 4 0.964148
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 0.963728
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 0.948685
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.946603
CD33 CD33 molecule 0.94078
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.930828
IGHV4-59 immunoglobulin heavy variable 4-59 0.926279
CXCR5 chemokine (C-X-C motif) receptor 5 0.920911
SOX11 SRY (sex determining region Y)-box 11 0.920498
HLA-G major histocompatibility complex, class I, G 0.911845
IGHV3-7 immunoglobulin heavy variable 3-7 0.909376
LEF1 lymphoid enhancer-binding factor 1 0.909376
CD2 CD2 molecule 0.904032
PTPRC protein tyrosine phosphatase, receptor type, C 0.901978
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.890078
LCK LCK proto-oncogene, Src family tyrosine kinase 0.890078
TCL1B T-cell leukemia/lymphoma 1B 0.889258
RB1 retinoblastoma 1 0.886389
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) 0.88516
SP140 SP140 nuclear body protein 0.879833
CD86 CD86 molecule 0.878605
CCND2 cyclin D2 0.866731
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.866321
TLR9 toll-like receptor 9 0.857724
FCRL1 Fc receptor-like 1 0.855677
TK1 thymidine kinase 1, soluble 0.854859
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.850354
SPRYD7 SPRY domain containing 7 0.849945
CD44 CD44 molecule (Indian blood group) 0.840525
IGLJ2 immunoglobulin lambda joining 2 0.838885
CCL19 chemokine (C-C motif) ligand 19 0.836017
MNDA myeloid cell nuclear differentiation antigen 0.831918
IGHJ5 immunoglobulin heavy joining 5 0.827819
IGKV1-5 immunoglobulin kappa variable 1-5 0.827819
CD160 CD160 molecule 0.822897
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.821257
IPO4 importin 4 0.819206
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.817155
ARHGAP20 Rho GTPase activating protein 20 0.815104
IGKV1D-42 immunoglobulin kappa variable 1D-42 (non-functional) 0.813052
RFC1 replication factor C (activator 1) 1, 145kDa 0.81059
HRAS Harvey rat sarcoma viral oncogene homolog 0.81059
IGHV1-8 immunoglobulin heavy variable 1-8 0.807308
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.801974
TRAC T cell receptor alpha constant 0.795002
MCL1 myeloid cell leukemia 1 0.793771
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 0.787623
SLITRK1 SLIT and NTRK-like family, member 1 0.783936
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.783116
CD69 CD69 molecule 0.781888
DGUOK deoxyguanosine kinase 0.779432
PAX2 paired box 2 0.779432
CDR2 cerebellar degeneration-related protein 2, 62kDa 0.776977
DNTT DNA nucleotidylexotransferase 0.774523
CD70 CD70 molecule 0.774114
OAT ornithine aminotransferase 0.767576
C5ORF49 chromosome 5 open reading frame 49 0.763902
IGKV3-20 immunoglobulin kappa variable 3-20 0.762678
CHL1 cell adhesion molecule L1-like 0.756564
FCRL5 Fc receptor-like 5 0.753306
SEPT10 septin 10 0.748424
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 0.746798
CD58 CD58 molecule 0.745578
CD9 CD9 molecule 0.742329
PDE7B phosphodiesterase 7B 0.738271
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 0.737865
CD24 CD24 molecule 0.73746
LPL lipoprotein lipase 0.737054
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 0.733001
CXCL13 chemokine (C-X-C motif) ligand 13 0.728952
NOTCH2 notch 2 0.726929
NOTCH2NL notch 2 N-terminal like 0.724098
CD8B CD8b molecule 0.72329
IGHV3-74 immunoglobulin heavy variable 3-74 0.72127
USP32 ubiquitin specific peptidase 32 0.71925
ACOXL acyl-CoA oxidase-like 0.718846
CARS cysteinyl-tRNA synthetase 0.718443
CCND3 cyclin D3 0.716828
MIR223 microRNA 223 0.716021
TFRC transferrin receptor 0.715215
BIRC5 baculoviral IAP repeat containing 5 0.705949
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.701526
CDK9 cyclin-dependent kinase 9 0.699919
STAT1 signal transducer and activator of transcription 1, 91kDa 0.697109
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.696306
PDE3B phosphodiesterase 3B, cGMP-inhibited 0.695905
PDE4A phosphodiesterase 4A, cAMP-specific 0.693098
PDE7A phosphodiesterase 7A 0.689092
HLA-C major histocompatibility complex, class I, C 0.687091
IGHJ4 immunoglobulin heavy joining 4 0.677504
SELL selectin L 0.675112
KCNRG potassium channel regulator 0.672722
DAPK1 death-associated protein kinase 1 0.662387
WNT16 wingless-type MMTV integration site family, member 16 0.661594
MRO maestro 0.646165
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 0.644586
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.643797
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 0.641039
IL6 interleukin 6 0.640645
PARP1 poly (ADP-ribose) polymerase 1 0.640645
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.637102
FCRL2 Fc receptor-like 2 0.628457
YPEL5 yippee-like 5 (Drosophila) 0.628457
TLR7 toll-like receptor 7 0.62728
BLNK B-cell linker 0.620226
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa 0.615921
MYD88 myeloid differentiation primary response 88 0.610057
CCL4 chemokine (C-C motif) ligand 4 0.609666
IGHV1-18 immunoglobulin heavy variable 1-18 0.607323
IGKJ2 immunoglobulin kappa joining 2 0.607323
IGKJ1 immunoglobulin kappa joining 1 0.607323
IGHV2-5 immunoglobulin heavy variable 2-5 0.607323
IFNA10 interferon, alpha 10 0.606152
BST1 bone marrow stromal cell antigen 1 0.604201
POT1 protection of telomeres 1 0.60303
PRDM1 PR domain containing 1, with ZNF domain 0.60069
FMNL1 formin-like 1 0.596012
BMF Bcl2 modifying factor 0.594843
CD59 CD59 molecule, complement regulatory protein 0.592506
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D 0.592116
OCA2 oculocutaneous albinism II 0.591337
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1 0.590558
MRPL50 mitochondrial ribosomal protein L50 0.587054
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 0.587054
IGHV3-72 immunoglobulin heavy variable 3-72 0.587054
IGHV3-48 immunoglobulin heavy variable 3-48 0.587054
IGKV3-11 immunoglobulin kappa variable 3-11 0.587054
DPH7 diphthamide biosynthesis 7 0.587054
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 0.583552
BCL2A1 BCL2-related protein A1 0.580439
HLA-A major histocompatibility complex, class I, A 0.577716
AGO2 argonaute RISC catalytic component 2 0.574605
CHST9 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 0.571884
IL10 interleukin 10 0.569552
FGF2 fibroblast growth factor 2 (basic) 0.568386
HDAC9 histone deacetylase 9 0.563723
PHYH phytanoyl-CoA 2-hydroxylase 0.554403
SETDB2 SET domain, bifurcated 2 0.551686
CCL21 chemokine (C-C motif) ligand 21 0.550522
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.544705
FCRL6 Fc receptor-like 6 0.541992
PRAME preferentially expressed antigen in melanoma 0.541605
RAI2 retinoic acid induced 2 0.539667
CDK7 cyclin-dependent kinase 7 0.538506
CDR1 cerebellar degeneration-related protein 1, 34kDa 0.535796
CDKN2A cyclin-dependent kinase inhibitor 2A 0.530768
PCGF6 polycomb group ring finger 6 0.528449
EFNA4 ephrin-A4 0.527676
CCL3 chemokine (C-C motif) ligand 3 0.52536
FASLG Fas ligand (TNF superfamily, member 6) 0.521117
ANKRD34B ankyrin repeat domain 34B 0.520731
TRBV2 T cell receptor beta variable 2 0.520731
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.519961
CD6 CD6 molecule 0.51842
VCAM1 vascular cell adhesion molecule 1 0.517649
C11ORF21 chromosome 11 open reading frame 21 0.516879
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.51611
OGFOD1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 0.515725
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.51534
NT5C2 5'-nucleotidase, cytosolic II 0.512648
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.512264
USE1 unconventional SNARE in the ER 1 homolog (S. cerevisiae) 0.51188
JUN jun proto-oncogene 0.511112
FAM129C family with sequence similarity 129, member C 0.508424
HIST1H2AC histone cluster 1, H2ac 0.50689
HACD4 3-hydroxyacyl-CoA dehydratase 4 0.502292
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C 0.500761
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 0.498467
FLT3 fms-related tyrosine kinase 3 0.496939
JAK2 Janus kinase 2 0.496175
CD247 CD247 molecule 0.495793
BTG4 B-cell translocation gene 4 0.493885
IGLV7-43 immunoglobulin lambda variable 7-43 0.49274
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 0.491978
OSBPL3 oxysterol binding protein-like 3 0.491597
ZFYVE19 zinc finger, FYVE domain containing 19 0.488169
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 0.487788
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.484744
PLXNB1 plexin B1 0.484364
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.480945
GRB2 growth factor receptor-bound protein 2 0.480566
HMMR hyaluronan-mediated motility receptor (RHAMM) 0.476772
NPTXR neuronal pentraxin receptor 0.47374
TRAF1 TNF receptor-associated factor 1 0.47374
CXCR4 chemokine (C-X-C motif) receptor 4 0.471089
TYRO3 TYRO3 protein tyrosine kinase 0.471089
LSP1 lymphocyte-specific protein 1 0.467306
ALPPL2 alkaline phosphatase, placental-like 2 0.465416
ALPP alkaline phosphatase, placental 0.465038
IL3 interleukin 3 0.465038
ALPL alkaline phosphatase, liver/bone/kidney 0.46466
IPCEF1 interaction protein for cytohesin exchange factors 1 0.460129
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 0.458241
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 0.457864
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene) 0.456355
NUP155 nucleoporin 155kDa 0.453716
MIR19A microRNA 19a 0.453339
FXYD5 FXYD domain containing ion transport regulator 5 0.452962
FN1 fibronectin 1 0.452585
H2AFX H2A histone family, member X 0.451831
APAF1 apoptotic peptidase activating factor 1 0.451831
DOCK10 dedicator of cytokinesis 10 0.449947
ACP5 acid phosphatase 5, tartrate resistant 0.447687
TRAF5 TNF receptor-associated factor 5 0.443171
FSTL3 follistatin-like 3 (secreted glycoprotein) 0.44129
IGHV3-64 immunoglobulin heavy variable 3-64 0.440162
MIR17 microRNA 17 0.440162
FOXP3 forkhead box P3 0.436402
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit 0.435651
PEG10 paternally expressed 10 0.434148
PDLIM7 PDZ and LIM domain 7 (enigma) 0.433772
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 0.433397
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.433397
CRY1 cryptochrome circadian clock 1 0.432646
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 0.43227
ARHGAP27 Rho GTPase activating protein 27 0.431519
ARHGAP23 Rho GTPase activating protein 23 0.430768
JAK3 Janus kinase 3 0.430393
MARCKSL1 MARCKS-like 1 0.429642
OARD1 O-acyl-ADP-ribose deacylase 1 0.427765
CDK4 cyclin-dependent kinase 4 0.42739
PIDD1 p53-induced death domain protein 1 0.424389
CXCR3 chemokine (C-X-C motif) receptor 3 0.42364
PDE1B phosphodiesterase 1B, calmodulin-dependent 0.420641
DEK DEK proto-oncogene 0.420641
C6ORF15 chromosome 6 open reading frame 15 0.419142
N4BP2 NEDD4 binding protein 2 0.418768
GRAMD1B GRAM domain containing 1B 0.418019
C1RL complement component 1, r subcomponent-like 0.416521
ICAM2 intercellular adhesion molecule 2 0.415024
VEGFA vascular endothelial growth factor A 0.41465
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.411657
CXCL9 chemokine (C-X-C motif) ligand 9 0.411283
CD276 CD276 molecule 0.411283
WNT9A wingless-type MMTV integration site family, member 9A 0.411283
BIRC2 baculoviral IAP repeat containing 2 0.411283
IGHV3-11 immunoglobulin heavy variable 3-11 (gene/pseudogene) 0.409787
ZMAT4 zinc finger, matrin-type 4 0.406425
ZNF101 zinc finger protein 101 0.405678
DIABLO diablo, IAP-binding mitochondrial protein 0.399707
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4 0.399334
ARHGAP12 Rho GTPase activating protein 12 0.397843
TGFB1 transforming growth factor, beta 1 0.397843
IL1B interleukin 1, beta 0.397098
SBF1 SET binding factor 1 0.396725
ZAK sterile alpha motif and leucine zipper containing kinase AZK 0.396353
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.394118
BCL7C B-cell CLL/lymphoma 7C 0.392257
FOS FBJ murine osteosarcoma viral oncogene homolog 0.392257
EPO erythropoietin 0.391885
FCRL3 Fc receptor-like 3 0.391141
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.389281
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 0.384822
PIM2 Pim-2 proto-oncogene, serine/threonine kinase 0.379997
C11ORF54 chromosome 11 open reading frame 54 0.379997
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.378885
CD1D CD1d molecule 0.378885
ANGPT2 angiopoietin 2 0.377402
ALB albumin 0.37629
IGLJ3 immunoglobulin lambda joining 3 0.373328
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.372958
ANXA1 annexin A1 0.372217
PIBF1 progesterone immunomodulatory binding factor 1 0.370368
PRF1 perforin 1 (pore forming protein) 0.369628
FLT1 fms-related tyrosine kinase 1 0.369258
CARD11 caspase recruitment domain family, member 11 0.368888
PTGR2 prostaglandin reductase 2 0.365562
IGLV1-44 immunoglobulin lambda variable 1-44 0.365562
CDK2 cyclin-dependent kinase 2 0.364085
IL1A interleukin 1, alpha 0.363347
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 0.361502
TMEM176A transmembrane protein 176A 0.360395
VENTX VENT homeobox 0.360395
EEF2 eukaryotic translation elongation factor 2 0.360026
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1) 0.358551
SH2D1A SH2 domain containing 1A 0.358551
DPF3 D4, zinc and double PHD fingers, family 3 0.358183
TRAF3 TNF receptor-associated factor 3 0.356709
AKAP17A A kinase (PRKA) anchor protein 17A 0.355972
WNT3 wingless-type MMTV integration site family, member 3 0.354868
LHX1 LIM homeobox 1 0.354499
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.354499
IL2RB interleukin 2 receptor, beta 0.354499
FUCA2 fucosidase, alpha-L- 2, plasma 0.354131
TARP TCR gamma alternate reading frame protein 0.353763
FCRL4 Fc receptor-like 4 0.353027
TRIM8 tripartite motif containing 8 0.352291
IL21 interleukin 21 0.351923
TXN thioredoxin 0.35082
LAG3 lymphocyte-activation gene 3 0.350452
BRWD3 bromodomain and WD repeat domain containing 3 0.350084
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae) 0.350084
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.349349
MIR21 microRNA 21 0.349349
VAV1 vav 1 guanine nucleotide exchange factor 0.348614
IL3RA interleukin 3 receptor, alpha (low affinity) 0.347879
PTPRJ protein tyrosine phosphatase, receptor type, J 0.344574
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 0.34384
RACGAP1 Rac GTPase activating protein 1 0.343106
HBA1 hemoglobin, alpha 1 0.342739
FER1L4 fer-1-like family member 4, pseudogene (functional) 0.342372
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 0.339073
ARHGAP25 Rho GTPase activating protein 25 0.339073
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.339073
TIA1 TIA1 cytotoxic granule-associated RNA binding protein 0.336144
CCDC50 coiled-coil domain containing 50 0.335046
CMBL carboxymethylenebutenolidase homolog (Pseudomonas) 0.334681
IL7 interleukin 7 0.332487
BCL10 B-cell CLL/lymphoma 10 0.332121
TRIM13 tripartite motif containing 13 0.330295
ETV5 ets variant 5 0.329565
PRAP1 proline-rich acidic protein 1 0.329565
BIRC7 baculoviral IAP repeat containing 7 0.3292
S1PR1 sphingosine-1-phosphate receptor 1 0.328105
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.32774
CD83 CD83 molecule 0.32701
PDIA6 protein disulfide isomerase family A, member 6 0.324094
CSF3 colony stimulating factor 3 (granulocyte) 0.322273
HBA2 hemoglobin, alpha 2 0.321545
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 0.319363
SYNJ2 synaptojanin 2 0.318999
FBXW10 F-box and WD repeat domain containing 10 0.317909
SMG6 SMG6 nonsense mediated mRNA decay factor 0.315003
HIST1H2AD histone cluster 1, H2ad 0.312464
HIST1H2AJ histone cluster 1, H2aj 0.312464
KLRK1 killer cell lectin-like receptor subfamily K, member 1 0.312464
HIST1H1C histone cluster 1, H1c 0.311739
H2AFV H2A histone family, member V 0.310652
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2 0.309928
H2AFB2 H2A histone family, member B2 0.309928
H2AFB1 H2A histone family, member B1 0.308842
H2AFY2 H2A histone family, member Y2 0.308842
HIST1H2AH histone cluster 1, H2ah 0.307757
H2AFJ H2A histone family, member J 0.307757
ARHGAP19 Rho GTPase activating protein 19 0.30631
HIST1H2AM histone cluster 1, H2am 0.304503
IFNA21 interferon, alpha 21 0.304503
CD84 CD84 molecule 0.302698
IL15 interleukin 15 0.302337
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta 0.301976
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 0.299452
HIST1H2AB histone cluster 1, H2ab 0.299092
HIST1H2AE histone cluster 1, H2ae 0.299092
ATG2B autophagy related 2B 0.299092
CFLAR CASP8 and FADD-like apoptosis regulator 0.298371
FOXP1 forkhead box P1 0.298371
TUG1 taurine up-regulated 1 (non-protein coding) 0.298371
FADD Fas (TNFRSF6)-associated via death domain 0.297291
IGLV3-21 immunoglobulin lambda variable 3-21 0.297291
THRAP3 thyroid hormone receptor associated protein 3 0.295851
HIST1H2AG histone cluster 1, H2ag 0.292257
ZHX2 zinc fingers and homeoboxes 2 0.292257
PREB prolactin regulatory element binding 0.292257
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 0.291898
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.291898
HPX hemopexin 0.290821
MALT1 MALT1 paracaspase 0.290103
PCNA proliferating cell nuclear antigen 0.289386
XCL2 chemokine (C motif) ligand 2 0.288668
TBX21 T-box 21 0.287235
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 0.285086
POU3F1 POU class 3 homeobox 1 0.284371
IFNA17 interferon, alpha 17 0.284013
RPA2 replication protein A2, 32kDa 0.283655
IGHV3-30 immunoglobulin heavy variable 3-30 0.283297
SEMG1 semenogelin I 0.28294
ALK anaplastic lymphoma receptor tyrosine kinase 0.282582
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.282225
U2AF1 U2 small nuclear RNA auxiliary factor 1 0.281153
LPO lactoperoxidase 0.281153
CD81 CD81 molecule 0.279367
CD68 CD68 molecule 0.279367
PDE4B phosphodiesterase 4B, cAMP-specific 0.278297
RAD51 RAD51 recombinase 0.278297
LTA lymphotoxin alpha 0.276514
GUSB glucuronidase, beta 0.276514
SDC1 syndecan 1 0.276158
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 0.275445
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.274732
MIR222 microRNA 222 0.274376
TP53I3 tumor protein p53 inducible protein 3 0.272597
GMIP GEM interacting protein 0.272241
THPO thrombopoietin 0.271174
RCC1 regulator of chromosome condensation 1 0.270819
BCL2L12 BCL2-like 12 (proline rich) 0.270464
TMEM176B transmembrane protein 176B 0.270108
H2AFY H2A histone family, member Y 0.269043
GALNT16 polypeptide N-acetylgalactosaminyltransferase 16 0.266913
ZNF280B zinc finger protein 280B 0.265849
APRT adenine phosphoribosyltransferase 0.264785
ICK intestinal cell (MAK-like) kinase 0.263014
ABI3 ABI family, member 3 0.262306
REM1 RAS (RAD and GEM)-like GTP-binding 1 0.261952
NAAA N-acylethanolamine acid amidase 0.259124
ADK adenosine kinase 0.257358
ZBTB4 zinc finger and BTB domain containing 4 0.257358
MS4A8 membrane-spanning 4-domains, subfamily A, member 8 0.254888
IGHD3-10 immunoglobulin heavy diversity 3-10 0.254183
XBP1 X-box binding protein 1 0.254183
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 0.253831
IL2RG interleukin 2 receptor, gamma 0.253479
SUSD2 sushi domain containing 2 0.25207
LYZ lysozyme 0.25207
CD8A CD8a molecule 0.251718
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 0.251366
FOLR3 folate receptor 3 (gamma) 0.251366
STAT5B signal transducer and activator of transcription 5B 0.251015
FCRLA Fc receptor-like A 0.248203
BAG1 BCL2-associated athanogene 0.245747
FUCA1 fucosidase, alpha-L- 1, tissue 0.244696
MTERF1 mitochondrial transcription termination factor 1 0.244696
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 0.242595
ARHGAP32 Rho GTPase activating protein 32 0.242245
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 0.241196
TIGAR TP53 induced glycolysis regulatory phosphatase 0.240847
ARHGAP22 Rho GTPase activating protein 22 0.239101
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.237357
ARHGAP17 Rho GTPase activating protein 17 0.23666
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.236312
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 0.235616
CD180 CD180 molecule 0.231448
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 0.230755
TERT telomerase reverse transcriptase 0.229716
GADD45A growth arrest and DNA-damage-inducible, alpha 0.22937
CD48 CD48 molecule 0.22937
CARD6 caspase recruitment domain family, member 6 0.227297
WNT5B wingless-type MMTV integration site family, member 5B 0.226607
JAK1 Janus kinase 1 0.225917
RAB11B RAB11B, member RAS oncogene family 0.225573
GSTA3 glutathione S-transferase alpha 3 0.222822
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.222479
GSTA2 glutathione S-transferase alpha 2 0.221793
KLRC4 killer cell lectin-like receptor subfamily C, member 4 0.22145
P4HB prolyl 4-hydroxylase, beta polypeptide 0.220424
GSTA4 glutathione S-transferase alpha 4 0.220424
CARTPT CART prepropeptide 0.220424
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.220081
GADD45B growth arrest and DNA-damage-inducible, beta 0.218715
DMRT2 doublesex and mab-3 related transcription factor 2 0.218715
ARHGAP9 Rho GTPase activating protein 9 0.218374
BBC3 BCL2 binding component 3 0.218034
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4 0.216332
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 0.215992
GSTA1 glutathione S-transferase alpha 1 0.215314
MKI67 marker of proliferation Ki-67 0.214297
COBLL1 cordon-bleu WH2 repeat protein-like 1 0.212945
YARS tyrosyl-tRNA synthetase 0.212945
ULBP1 UL16 binding protein 1 0.212608
DPH5 diphthamide biosynthesis 5 0.210589
MMP9 matrix metallopeptidase 9 0.209248
MARCKS myristoylated alanine-rich protein kinase C substrate 0.205916
CD28 CD28 molecule 0.204923
CCR6 chemokine (C-C motif) receptor 6 0.204923
ACOX3 acyl-CoA oxidase 3, pristanoyl 0.204593
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 0.204593
TOP1 topoisomerase (DNA) I 0.204263
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 0.203933
CRNN cornulin 0.203604
DCTD dCMP deaminase 0.202946
WNT10A wingless-type MMTV integration site family, member 10A 0.199681
PANX3 pannexin 3 0.199033
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.198064
BIRC8 baculoviral IAP repeat containing 8 0.196139
DPP7 dipeptidyl-peptidase 7 0.19582
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.194865
ICAM3 intercellular adhesion molecule 3 0.194232
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 0.194232
CFAP20 cilia and flagella associated protein 20 0.193915
FGR FGR proto-oncogene, Src family tyrosine kinase 0.193915
IGHA1 immunoglobulin heavy constant alpha 1 0.192344
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.191719
DROSHA drosha, ribonuclease type III 0.190786
LAMP1 lysosomal-associated membrane protein 1 0.190476
PIK3IP1 phosphoinositide-3-kinase interacting protein 1 0.188326
ULBP2 UL16 binding protein 2 0.188326
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.187719
PLD1 phospholipase D1, phosphatidylcholine-specific 0.187113
MICA MHC class I polypeptide-related sequence A 0.18621
SOX14 SRY (sex determining region Y)-box 14 0.18591
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.184424
CDC42 cell division cycle 42 0.183248
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.183248
MPO myeloperoxidase 0.182957
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.182666
COX7B cytochrome c oxidase subunit VIIb 0.182666
CMC4 C-x(9)-C motif containing 4 0.182375
SESN1 sestrin 1 0.182086
SULF2 sulfatase 2 0.181798
CD244 CD244 molecule, natural killer cell receptor 2B4 0.18151
ANAPC1 anaphase promoting complex subunit 1 0.180937
IGLV1-50 immunoglobulin lambda variable 1-50 (non-functional) 0.17896
BID BH3 interacting domain death agonist 0.178403
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.178403
RAD51D RAD51 paralog D 0.177851
SERBP1 SERPINE1 mRNA binding protein 1 0.177029
DVL2 dishevelled segment polarity protein 2 0.176757
CHPT1 choline phosphotransferase 1 0.176757
SCX scleraxis basic helix-loop-helix transcription factor 0.176757
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.176215
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.175411
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.174354
IGLV1-36 immunoglobulin lambda variable 1-36 0.173314
RASSF7 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 0.172544
MAPK1 mitogen-activated protein kinase 1 0.171286
RNASEH2A ribonuclease H2, subunit A 0.170299
PLEK pleckstrin 0.168381
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 0.168381
RAB1A RAB1A, member RAS oncogene family 0.167915
IFNB1 interferon, beta 1, fibroblast 0.167915
AXL AXL receptor tyrosine kinase 0.167452
COX6C cytochrome c oxidase subunit VIc 0.167224
RASSF3 Ras association (RalGDS/AF-6) domain family member 3 0.166095
ARHGAP24 Rho GTPase activating protein 24 0.165655
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 0.165001
POU2AF1 POU class 2 associating factor 1 0.164149
ZBTB25 zinc finger and BTB domain containing 25 0.164149
CXCL8 chemokine (C-X-C motif) ligand 8 0.163729
ENC1 ectodermal-neural cortex 1 (with BTB domain) 0.163317
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.163111
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.161912
JAG2 jagged 2 0.161716
MIR107 microRNA 107 0.161523
PTEN phosphatase and tensin homolog 0.161139
RAD51AP1 RAD51 associated protein 1 0.160948
MTAP methylthioadenosine phosphorylase 0.159658
PIM3 Pim-3 proto-oncogene, serine/threonine kinase 0.159658
TRIM37 tripartite motif containing 37 0.159658
PDE8A phosphodiesterase 8A 0.15948
INSIG1 insulin induced gene 1 0.142405
FAM20C family with sequence similarity 20, member C 0.141888
CAND2 cullin-associated and neddylation-dissociated 2 (putative) 0.141446
CTRC chymotrypsin C (caldecrin) 0.141359
RIN3 Ras and Rab interactor 3 0.137629
ICOSLG inducible T-cell co-stimulator ligand 0.137569
FOXN3 forkhead box N3 0.136512
DACT3 dishevelled-binding antagonist of beta-catenin 3 0.134546
CT45A1 cancer/testis antigen family 45, member A1 0.134514
IFITM1 interferon induced transmembrane protein 1 0.134498
MSH5 mutS homolog 5 0.131285
GYPE glycophorin E (MNS blood group) 0.131228
PIAS3 protein inhibitor of activated STAT, 3 0.130717
CXCR2 chemokine (C-X-C motif) receptor 2 0.130166
TPP1 tripeptidyl peptidase I 0.129927
BTLA B and T lymphocyte associated 0.129363
IGHV1-2 immunoglobulin heavy variable 1-2 0.129256
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.128843
IPO5 importin 5 0.127745
GNG8 guanine nucleotide binding protein (G protein), gamma 8 0.127451
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 0.127248
PLIN3 perilipin 3 0.127136
INTU inturned planar cell polarity protein 0.12633
SH2B3 SH2B adaptor protein 3 0.12628
CTF1 cardiotrophin 1 0.126245
KAT6A K(lysine) acetyltransferase 6A 0.125969
ELL2 elongation factor, RNA polymerase II, 2 0.125814
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.125278
NCR1 natural cytotoxicity triggering receptor 1 0.124398
PLCG1 phospholipase C, gamma 1 0.124107
ACPT acid phosphatase, testicular 0.123988
NPAT nuclear protein, ataxia-telangiectasia locus 0.123712
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta 0.12272
MLH1 mutL homolog 1 0.121761
CHEK2 checkpoint kinase 2 0.121604
SULF1 sulfatase 1 0.121287
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.121264
CYGB cytoglobin 0.120822
IFNGR1 interferon gamma receptor 1 0.119637
ZEB2 zinc finger E-box binding homeobox 2 0.117607
CSN2 casein beta 0.117525
TAL1 T-cell acute lymphocytic leukemia 1 0.117415
GCAT glycine C-acetyltransferase 0.117142
MSMB microseminoprotein, beta- 0.116974
ETV6 ets variant 6 0.116945
PTPRT protein tyrosine phosphatase, receptor type, T 0.116917
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.116748
OSM oncostatin M 0.116208
ERVW-1 endogenous retrovirus group W, member 1 0.116178
OSTC oligosaccharyltransferase complex subunit (non-catalytic) 0.115887
HAVCR1 hepatitis A virus cellular receptor 1 0.115887
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.115858
CXXC5 CXXC finger protein 5 0.115508
PTHLH parathyroid hormone-like hormone 0.114907
GEMIN4 gem (nuclear organelle) associated protein 4 0.114667
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase 0.114418
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 0.114232
HES1 hes family bHLH transcription factor 1 0.113892
RAD52 RAD52 homolog (S. cerevisiae) 0.113798
DUOXA1 dual oxidase maturation factor 1 0.113702
MYB v-myb avian myeloblastosis viral oncogene homolog 0.11367
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) 0.11367
JAM3 junctional adhesion molecule 3 0.113638
GLI3 GLI family zinc finger 3 0.113543
SEPT9 septin 9 0.113351
SYN2 synapsin II 0.113095
CNTN1 contactin 1 0.112999
CXCL2 chemokine (C-X-C motif) ligand 2 0.112968
C1QBP complement component 1, q subcomponent binding protein 0.112805
FAS Fas cell surface death receptor 0.112541
MSH3 mutS homolog 3 0.112212
CR2 complement component (3d/Epstein Barr virus) receptor 2 0.111845
FSCN3 fascin actin-bundling protein 3, testicular 0.110368
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.110333
ACP2 acid phosphatase 2, lysosomal 0.110193
GLI2 GLI family zinc finger 2 0.110089
CXCR1 chemokine (C-X-C motif) receptor 1 0.109874
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 0.109227
ASXL1 additional sex combs like transcriptional regulator 1 0.108973
MSH2 mutS homolog 2 0.108493
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.108235
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 0.108161
PTER phosphotriesterase related 0.10805
CD1A CD1a molecule 0.10786
FSCN2 fascin actin-bundling protein 2, retinal 0.107784
GZMK granzyme K (granzyme 3; tryptase II) 0.107177
NOX5 NADPH oxidase, EF-hand calcium binding domain 5 0.106871
SEBOX SEBOX homeobox 0.106676
GPR176 G protein-coupled receptor 176 0.106169
IARS isoleucyl-tRNA synthetase 0.105975
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.105176
TET2 tet methylcytosine dioxygenase 2 0.10453
SYN3 synapsin III 0.104489
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.103955
NUPR1 nuclear protein, transcriptional regulator, 1 0.103914
SHMT1 serine hydroxymethyltransferase 1 (soluble) 0.103873
MARK2 MAP/microtubule affinity-regulating kinase 2 0.103669
MVP major vault protein 0.103627
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.102406
CIITA class II, major histocompatibility complex, transactivator 0.100933
F8 coagulation factor VIII, procoagulant component 0.100668
NPTN neuroplastin 0.100139
APEH acylaminoacyl-peptide hydrolase 0.098281
FSCN1 fascin actin-bundling protein 1 0.096932
ERBB4 erb-b2 receptor tyrosine kinase 4 0.096509
NGF nerve growth factor (beta polypeptide) 0.096179
RORA RAR-related orphan receptor A 0.095746
GRM1 glutamate receptor, metabotropic 1 0.095314