chronic kidney failure Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:784
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Genes

271 genes associated with the disease chronic kidney failure in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16 2.0618
SHROOM3 shroom family member 3 2.05772
UBE2Q2 ubiquitin-conjugating enzyme E2Q family member 2 1.90321
CPS1 carbamoyl-phosphate synthase 1, mitochondrial 1.83309
BCAS3 breast carcinoma amplified sequence 3 1.83309
ALMS1P Alstrom syndrome 1 pseudogene 1.83309
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 1.81431
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 1.78856
GCKR glucokinase (hexokinase 4) regulator 1.76581
NAT8 N-acetyltransferase 8 (GCN5-related, putative) 1.75531
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta 1.74508
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 1.71975
WDR72 WD repeat domain 72 1.71806
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 1.70803
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 1.65151
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 1.60875
DACH1 dachshund family transcription factor 1 1.60875
ATXN2 ataxin 2 1.60174
CEP89 centrosomal protein 89kDa 1.59609
ADCY5 adenylate cyclase 5 1.55134
TBX2 T-box 2 1.54533
HMGA2 high mobility group AT-hook 2 1.54381
UMOD uromodulin 1.53704
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 1.50906
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 1.49837
CDK12 cyclin-dependent kinase 12 1.47206
WDR37 WD repeat domain 37 1.42467
ALMS1 Alstrom syndrome protein 1 1.36864
INO80 INO80 complex subunit 1.35784
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1 1.3457
PDE4D phosphodiesterase 4D, cAMP-specific 1.30135
GRIP1 glutamate receptor interacting protein 1 1.28041
SGK1 serum/glucocorticoid regulated kinase 1 1.27621
HSDL2 hydroxysteroid dehydrogenase like 2 1.24242
DOK6 docking protein 6 1.2382
FBXL20 F-box and leucine-rich repeat protein 20 1.20693
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 1.18698
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 1.1662
KIRREL3 kin of IRRE like 3 (Drosophila) 1.16174
KIAA1958 KIAA1958 1.10906
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 1.08832
SPATS2L spermatogenesis associated, serine-rich 2-like 1.07336
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 1.04096
MAP3K15 mitogen-activated protein kinase kinase kinase 15 1.00737
LCORL ligand dependent nuclear receptor corepressor-like 1.00275
PRR5L proline rich 5 like 0.986212
SFI1 Sfi1 homolog, spindle assembly associated (yeast) 0.985258
SMYD3 SET and MYND domain containing 3 0.970467
TENM4 teneurin transmembrane protein 4 0.963246
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.951514
NTNG2 netrin G2 0.930169
WDR20 WD repeat domain 20 0.905653
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.879744
MXRA7 matrix-remodelling associated 7 0.87015
MYH9 myosin, heavy chain 9, non-muscle 0.869934
GRM4 glutamate receptor, metabotropic 4 0.866989
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.862937
SMYD2 SET and MYND domain containing 2 0.839855
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.819144
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.787593
CNTN1 contactin 1 0.785994
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.784108
ILDR1 immunoglobulin-like domain containing receptor 1 0.781342
COL11A2 collagen, type XI, alpha 2 0.780738
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.773189
MSRA methionine sulfoxide reductase A 0.77125
MRPL48 mitochondrial ribosomal protein L48 0.756064
PHACTR1 phosphatase and actin regulator 1 0.752142
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 0.749355
SYT1 synaptotagmin I 0.74567
NTM neurotrimin 0.743283
BEND5 BEN domain containing 5 0.743283
ADRB1 adrenoceptor beta 1 0.73111
STK3 serine/threonine kinase 3 0.729592
RXRB retinoid X receptor, beta 0.718849
FOXO3 forkhead box O3 0.714954
ELAVL4 ELAV like neuron-specific RNA binding protein 4 0.70297
ESRRG estrogen-related receptor gamma 0.702253
FRMD4A FERM domain containing 4A 0.701544
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.699446
CA10 carbonic anhydrase X 0.689868
KIAA1549L KIAA1549-like 0.689711
UBE2J1 ubiquitin-conjugating enzyme E2, J1 0.687994
IL21R interleukin 21 receptor 0.685698
GOLGA1 golgin A1 0.685245
GRID2 glutamate receptor, ionotropic, delta 2 0.683305
IPO11 importin 11 0.683009
SH3GL2 SH3-domain GRB2-like 2 0.679107
SAR1A secretion associated, Ras related GTPase 1A 0.679107
TNRC6B trinucleotide repeat containing 6B 0.678541
PCDH9 protocadherin 9 0.678259
FAM217A family with sequence similarity 217, member A 0.676173
OPCML opioid binding protein/cell adhesion molecule-like 0.67239
ISG20 interferon stimulated exonuclease gene 20kDa 0.670567
RNF185 ring finger protein 185 0.630637
LIMK2 LIM domain kinase 2 0.624037
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.571124
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.568166
LARGE like-glycosyltransferase 0.555938
PDZRN3 PDZ domain containing ring finger 3 0.512529
CHN2 chimerin 2 0.50947
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.506842
NRG4 neuregulin 4 0.502485
PRUNE prune exopolyphosphatase 0.502485
GRIK2 glutamate receptor, ionotropic, kainate 2 0.487202
PVT1 Pvt1 oncogene (non-protein coding) 0.484681
GAS2 growth arrest-specific 2 0.484681
ZBTB20 zinc finger and BTB domain containing 20 0.484191
CENPM centromere protein M 0.481016
CARS cysteinyl-tRNA synthetase 0.480846
PTPRM protein tyrosine phosphatase, receptor type, M 0.478563
STEAP1B STEAP family member 1B 0.478563
SORBS1 sorbin and SH3 domain containing 1 0.477563
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 0.476572
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 0.476572
PCSK2 proprotein convertase subtilisin/kexin type 2 0.476572
NRG1 neuregulin 1 0.473391
ELMO1 engulfment and cell motility 1 0.472092
SH3BP4 SH3-domain binding protein 4 0.470932
UNC5C unc-5 homolog C (C. elegans) 0.468874
CDC6 cell division cycle 6 0.468527
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 0.466252
C6ORF10 chromosome 6 open reading frame 10 0.465839
LOC100132891 0.465187
LOC100294145 uncharacterized LOC100294145 0.465187
TBC1D22A TBC1 domain family, member 22A 0.463669
TBC1D14 TBC1 domain family, member 14 0.463255
PDE5A phosphodiesterase 5A, cGMP-specific 0.462274
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 0.462274
PRRC2A proline-rich coiled-coil 2A 0.460727
FAM134B family with sequence similarity 134, member B 0.460255
KAZN kazrin, periplakin interacting protein 0.457648
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 0.456019
MARCH11 membrane-associated ring finger (C3HC4) 11 0.454009
NCALD neurocalcin delta 0.454009
MACF1 microtubule-actin crosslinking factor 1 0.45341
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.452835
FAM189A1 family with sequence similarity 189, member A1 0.452032
ISM1 isthmin 1, angiogenesis inhibitor 0.452001
IL12RB1 interleukin 12 receptor, beta 1 0.451723
DNAH11 dynein, axonemal, heavy chain 11 0.451692
TBC1D31 TBC1 domain family, member 31 0.451541
NTN1 netrin 1 0.450917
FGF12 fibroblast growth factor 12 0.44946
MTUS1 microtubule associated tumor suppressor 1 0.449266
OR2L13 olfactory receptor, family 2, subfamily L, member 13 0.448948
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.448729
MYO5B myosin VB 0.447329
TMEM63C transmembrane protein 63C 0.446411
NRXN1 neurexin 1 0.446357
SCOC short coiled-coil protein 0.446143
SH2D4A SH2 domain containing 4A 0.446117
LOC645513 uncharacterized LOC645513 0.445879
ZNF202 zinc finger protein 202 0.445111
RNF17 ring finger protein 17 0.445111
GAP43 growth associated protein 43 0.444618
LOC284661 uncharacterized LOC284661 0.444377
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 0.444234
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.443743
NRXN3 neurexin 3 0.443652
NEGR1 neuronal growth regulator 1 0.443402
FABP2 fatty acid binding protein 2, intestinal 0.442536
ZMIZ1 zinc finger, MIZ-type containing 1 0.44231
NBN nibrin 0.441456
DNAH5 dynein, axonemal, heavy chain 5 0.44097
PPFIA2 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 0.440539
PEX7 peroxisomal biogenesis factor 7 0.44
CERS6 ceramide synthase 6 0.43923
VWDE von Willebrand factor D and EGF domains 0.439137
ADD1 adducin 1 (alpha) 0.438913
SIK3 SIK family kinase 3 0.438314
CTIF CBP80/20-dependent translation initiation factor 0.438137
CADM4 cell adhesion molecule 4 0.437787
LOC63930 uncharacterized LOC63930 0.437275
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) 0.437108
ZNF714 zinc finger protein 714 0.436942
MAPRE2 microtubule-associated protein, RP/EB family, member 2 0.436455
ACSS3 acyl-CoA synthetase short-chain family member 3 0.436455
PKD1L2 polycystic kidney disease 1-like 2 (gene/pseudogene) 0.435519
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 0.435218
MACROD2 MACRO domain containing 2 0.43507
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.43507
KRT35 keratin 35, type I 0.434923
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.434777
KRT2 keratin 2, type II 0.434632
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 0.433532
ALPK1 alpha-kinase 1 0.432502
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.432378
CFAP61 cilia and flagella associated protein 61 0.432254
SDK1 sidekick cell adhesion molecule 1 0.432254
SH2D4B SH2 domain containing 4B 0.432131
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 0.431066
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.431066
CDH8 cadherin 8, type 2 0.430952
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.430838
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) 0.429533
NEB nebulin 0.429533
CDH13 cadherin 13 0.429222
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.42912
GRAMD3 GRAM domain containing 3 0.428033
EPB41 erythrocyte membrane protein band 4.1 0.427938
RGS6 regulator of G-protein signaling 6 0.427562
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2 0.427562
LRP1B low density lipoprotein receptor-related protein 1B 0.426834
BID BH3 interacting domain death agonist 0.426309
TLE3 transducin-like enhancer of split 3 0.426309
MUC4 mucin 4, cell surface associated 0.426219
RAI14 retinoic acid induced 14 0.426127
NELL1 NEL-like 1 (chicken) 0.426036
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.425855
ZNF697 zinc finger protein 697 0.425497
EYA1 EYA transcriptional coactivator and phosphatase 1 0.425409
CRBN cereblon 0.424719
KRT33B keratin 33B, type I 0.424054
CTNND2 catenin (cadherin-associated protein), delta 2 0.423811
FMN2 formin 2 0.423414
GNG4 guanine nucleotide binding protein (G protein), gamma 4 0.423025
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.422872
AGBL1 ATP/GTP binding protein-like 1 0.422796
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 0.422796
SIDT2 SID1 transmembrane family, member 2 0.42272
MMS22L MMS22-like, DNA repair protein 0.42272
MGC27382 uncharacterized MGC27382 0.42257
KRTAP16-1 keratin associated protein 16-1 0.422273
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.42141
RABGAP1L RAB GTPase activating protein 1-like 0.42127
WDR1 WD repeat domain 1 0.421132
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) 0.42079
PLCD3 phospholipase C, delta 3 0.420454
SCG3 secretogranin III 0.42006
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 0.42006
DNAH12 dynein, axonemal, heavy chain 12 0.419738
ABCC13 ATP-binding cassette, sub-family C (CFTR/MRP), member 13, pseudogene 0.419675
RRBP1 ribosome binding protein 1 0.419548
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 0.418868
WWOX WW domain containing oxidoreductase 0.418567
EXOSC3 exosome component 3 0.418507
PARD6B par-6 family cell polarity regulator beta 0.418507
SV2C synaptic vesicle glycoprotein 2C 0.418271
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 0.418096
WDR17 WD repeat domain 17 0.41758
ANK2 ankyrin 2, neuronal 0.41758
UNC13C unc-13 homolog C (C. elegans) 0.417452
ACOX3 acyl-CoA oxidase 3, pristanoyl 0.417452
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 0.417325
C3ORF67 chromosome 3 open reading frame 67 0.416825
PQBP1 polyglutamine binding protein 1 0.415629
FAM107B family with sequence similarity 107, member B 0.414889
PTN pleiotrophin 0.414833
ADD3 adducin 3 (gamma) 0.414778
YPEL1 yippee-like 1 (Drosophila) 0.414722
F9 coagulation factor IX 0.414557
FHOD3 formin homology 2 domain containing 3 0.413178
BAG1 BCL2-associated athanogene 0.412823
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 0.412823
THBS4 thrombospondin 4 0.409845
TELO2 telomere maintenance 2 0.408634
TMPO thymopoietin 0.408593
BMPR1B bone morphogenetic protein receptor, type IB 0.40778
ZNF180 zinc finger protein 180 0.404368
ITGA1 integrin, alpha 1 0.403314
IGDCC4 immunoglobulin superfamily, DCC subclass, member 4 0.402949
VWF von Willebrand factor 0.398992
SGK223 homolog of rat pragma of Rnd2 0.396781
C4ORF33 chromosome 4 open reading frame 33 0.396494
ALS2CL ALS2 C-terminal like 0.395592
COL4A1 collagen, type IV, alpha 1 0.395108
COL5A1 collagen, type V, alpha 1 0.395108
GRHL2 grainyhead-like 2 (Drosophila) 0.39481
BMP5 bone morphogenetic protein 5 0.393372
CHD9 chromodomain helicase DNA binding protein 9 0.392956