chronic fatigue syndrome Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A syndrome that involves prolonged and severe tiredness or weariness that is unrelated to exertion, is not relieved by rest and for a minimum of six months and is not directly caused by other conditions. (Human Disease Ontology, DOID_8544)
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Genes

267 genes co-occuring with the disease chronic fatigue syndrome in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 1.92811
CSHL1 chorionic somatomammotropin hormone-like 1 1.82595
LVRN laeverin 1.57957
GRID2 glutamate receptor, ionotropic, delta 2 1.30095
HSF4 heat shock transcription factor 4 1.19229
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 1.15709
XPR1 xenotropic and polytropic retrovirus receptor 1 1.12066
GRM1 glutamate receptor, metabotropic 1 1.11687
CRH corticotropin releasing hormone 1.09335
ATP5J2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2 1.07992
POMC proopiomelanocortin 1.07446
TOB1 transducer of ERBB2, 1 1.07236
WWOX WW domain containing oxidoreductase 1.06228
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 0.992752
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.955779
FHIT fragile histidine triad 0.955361
CBLN1 cerebellin 1 precursor 0.954943
PDXP pyridoxal (pyridoxine, vitamin B6) phosphatase 0.932898
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.908965
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 0.904032
CD4 CD4 molecule 0.892538
SPIDR scaffolding protein involved in DNA repair 0.885569
MGAM maltase-glucoamylase 0.883521
MRPL23 mitochondrial ribosomal protein L23 0.879014
SOCS7 suppressor of cytokine signaling 7 0.86714
PDCD2 programmed cell death 2 0.863456
NHLH1 nescient helix loop helix 1 0.848716
MACF1 microtubule-actin crosslinking factor 1 0.846259
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 0.840525
NBEA neurobeachin 0.838476
SMAD2 SMAD family member 2 0.829049
NPS neuropeptide S 0.822077
GOLGA6A golgin A6 family, member A 0.781888
GOLGA6B golgin A6 family, member B 0.781888
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.773296
CD79A CD79a molecule, immunoglobulin-associated alpha 0.77207
ANAPC11 anaphase promoting complex subunit 11 0.75412
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 0.74883
AVP arginine vasopressin 0.74761
NCAM1 neural cell adhesion molecule 1 0.746798
IL1B interleukin 1, beta 0.741111
TSPAN3 tetraspanin 3 0.733406
RORA RAR-related orphan receptor A 0.728952
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.716021
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 0.714811
SLC25A40 solute carrier family 25, member 40 0.707559
VIPR2 vasoactive intestinal peptide receptor 2 0.707559
CTPS1 CTP synthase 1 0.699517
TNF tumor necrosis factor 0.694702
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa 0.692697
BST2 bone marrow stromal cell antigen 2 0.681894
SH3KBP1 SH3-domain kinase binding protein 1 0.675112
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 0.673917
EFS embryonal Fyn-associated substrate 0.67312
IGF1 insulin-like growth factor 1 (somatomedin C) 0.662387
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 0.658818
TGFB1 transforming growth factor, beta 1 0.656837
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 0.649718
RPLP0 ribosomal protein, large, P0 0.645375
TOLLIP toll interacting protein 0.644192
FN1 fibronectin 1 0.639857
IL6 interleukin 6 0.624927
POLR2G polymerase (RNA) II (DNA directed) polypeptide G 0.622575
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 0.620226
SESN1 sestrin 1 0.617094
ASNA1 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) 0.613965
LDHD lactate dehydrogenase D 0.612401
TSKU tsukushi, small leucine rich proteoglycan 0.605372
RNASEH1 ribonuclease H1 0.605372
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.60342
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 0.59874
GABPA GA binding protein transcription factor, alpha subunit 60kDa 0.589001
ATP5J ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6 0.587054
CENPV centromere protein V 0.585887
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 0.580828
CD69 CD69 molecule 0.571107
TPH2 tryptophan hydroxylase 2 0.568775
COX5B cytochrome c oxidase subunit Vb 0.557509
TIMP1 TIMP metallopeptidase inhibitor 1 0.554403
SOD2 superoxide dismutase 2, mitochondrial 0.550911
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 0.541992
IL2 interleukin 2 0.541605
KPNB1 karyopherin (importin) beta 1 0.540055
MAOA monoamine oxidase A 0.535022
VIP vasoactive intestinal peptide 0.526904
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 0.52343
CAT catalase 0.521117
CFB complement factor B 0.520731
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G 0.519961
SP6 Sp6 transcription factor 0.519575
FNTA farnesyltransferase, CAAX box, alpha 0.519575
NPR3 natriuretic peptide receptor 3 0.50689
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 0.50689
SUGP1 SURP and G patch domain containing 1 0.506123
COL3A1 collagen, type III, alpha 1 0.505356
GLUD2 glutamate dehydrogenase 2 0.501144
CD19 CD19 molecule 0.498849
C4A complement component 4A (Rodgers blood group) 0.484364
VAC14 Vac14 homolog (S. cerevisiae) 0.476393
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 0.470711
DUT deoxyuridine triphosphatase 0.469576
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.469197
TLR4 toll-like receptor 4 0.468819
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 0.468063
ETV6 ets variant 6 0.468063
PTPRK protein tyrosine phosphatase, receptor type, K 0.463905
GABARAPL1 GABA(A) receptor-associated protein like 1 0.462394
NOTCH1 notch 1 0.462016
IL1A interleukin 1, alpha 0.457864
PEX16 peroxisomal biogenesis factor 16 0.457864
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.455601
SCG2 secretogranin II 0.455601
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.45447
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 0.451078
COMT catechol-O-methyltransferase 0.448441
ABCD4 ATP-binding cassette, sub-family D (ALD), member 4 0.447687
RNASEH2A ribonuclease H2, subunit A 0.443171
CRP C-reactive protein, pentraxin-related 0.442418
BMP2K BMP2 inducible kinase 0.442042
ARPP21 cAMP-regulated phosphoprotein, 21kDa 0.435651
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.434148
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 0.430393
CNTNAP2 contactin associated protein-like 2 0.428891
ZNF350 zinc finger protein 350 0.42589
NLGN2 neuroligin 2 0.424014
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 0.421016
ORM2 orosomucoid 2 0.413901
FCN1 ficolin (collagen/fibrinogen domain containing) 1 0.412405
TK2 thymidine kinase 2, mitochondrial 0.410909
ASIC3 acid sensing (proton gated) ion channel 3 0.408292
RASSF3 Ras association (RalGDS/AF-6) domain family member 3 0.407172
FOSL2 FOS-like antigen 2 0.403811
HSPA2 heat shock 70kDa protein 2 0.402692
MMP2 matrix metallopeptidase 2 0.399707
DNER delta/notch-like EGF repeat containing 0.399334
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 0.395608
ZNF423 zinc finger protein 423 0.395608
P2RY1 purinergic receptor P2Y, G-protein coupled, 1 0.393001
COL1A1 collagen, type I, alpha 1 0.391513
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 0.382966
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.382223
CTGF connective tissue growth factor 0.38111
ALB albumin 0.373698
GZMK granzyme K (granzyme 3; tryptase II) 0.367779
IFNA1 interferon, alpha 1 0.361502
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 0.359657
HMCN1 hemicentin 1 0.354131
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 0.352659
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 0.352291
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 0.351555
RAD51B RAD51 paralog B 0.349349
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.348246
CD38 CD38 molecule 0.344574
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B 0.342372
IGFBP3 insulin-like growth factor binding protein 3 0.341272
TSPO translocator protein (18kDa) 0.338707
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4 0.337608
AK6 adenylate kinase 6 0.332121
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 0.328469
F2 coagulation factor II (thrombin) 0.323002
LMNB1 lamin B1 0.322637
MMP1 matrix metallopeptidase 1 0.321909
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.318272
KHSRP KH-type splicing regulatory protein 0.317545
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.316092
KIAA1109 KIAA1109 0.311377
SYN1 synapsin I 0.31029
PARK2 parkin RBR E3 ubiquitin protein ligase 0.31029
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.308118
APEH acylaminoacyl-peptide hydrolase 0.304864
PKN1 protein kinase N1 0.300894
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.299452
TRIM5 tripartite motif containing 5 0.296571
NPAS2 neuronal PAS domain protein 2 0.293334
LRP1B low density lipoprotein receptor-related protein 1B 0.291539
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1 0.290821
DGAT2 diacylglycerol O-acyltransferase 2 0.289027
SLC1A7 solute carrier family 1 (glutamate transporter), member 7 0.286877
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 0.285086
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.283655
CD109 CD109 molecule 0.283297
CD2BP2 CD2 (cytoplasmic tail) binding protein 2 0.281868
LRP5 low density lipoprotein receptor-related protein 5 0.277584
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 0.275445
FBLN2 fibulin 2 0.268332
GJA1 gap junction protein, alpha 1, 43kDa 0.267267
CHRM1 cholinergic receptor, muscarinic 1 0.266913
AHRR aryl-hydrocarbon receptor repressor 0.265849
CTSC cathepsin C 0.259124
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 0.258064
INS insulin 0.257358
INSIG1 insulin induced gene 1 0.253127
MIR191 microRNA 191 0.251718
JUN jun proto-oncogene 0.249257
SPAG7 sperm associated antigen 7 0.247501
ELANE elastase, neutrophil expressed 0.244345
THRSP thyroid hormone responsive 0.241895
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 0.241196
PHF12 PHD finger protein 12 0.240497
AMD1 adenosylmethionine decarboxylase 1 0.238752
CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family) 0.237706
RAMP3 receptor (G protein-coupled) activity modifying protein 3 0.237357
MIR10A microRNA 10a 0.235268
TOP3A topoisomerase (DNA) III alpha 0.235268
IL10 interleukin 10 0.229024
MAPK1 mitogen-activated protein kinase 1 0.228333
COIL coilin 0.227297
MMP9 matrix metallopeptidase 9 0.226607
TRPV2 transient receptor potential cation channel, subfamily V, member 2 0.225573
HSPA4 heat shock 70kDa protein 4 0.224196
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.222136
IL17C interleukin 17C 0.221793
CD34 CD34 molecule 0.219398
GPX5 glutathione peroxidase 5 0.216672
ICAM1 intercellular adhesion molecule 1 0.214975
DCPS decapping enzyme, scavenger 0.214636
GPX4 glutathione peroxidase 4 0.213959
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 0.208579
WAPAL wings apart-like homolog (Drosophila) 0.208579
NCAN neurocan 0.206248
PPARG peroxisome proliferator-activated receptor gamma 0.205585
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.204923
VGF VGF nerve growth factor inducible 0.201635
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.201308
GPX1 glutathione peroxidase 1 0.200331
PTCH2 patched 2 0.199681
GCH1 GTP cyclohydrolase 1 0.199033
LPAR2 lysophosphatidic acid receptor 2 0.197099
HOPX HOP homeobox 0.196779
RGMB repulsive guidance molecule family member b 0.1936
FBXO7 F-box protein 7 0.192971
PTK2 protein tyrosine kinase 2 0.192657
BDNF brain-derived neurotrophic factor 0.190786
IGFBP1 insulin-like growth factor binding protein 1 0.190786
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.190476
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase 0.190168
NOS2 nitric oxide synthase 2, inducible 0.188326
ADCY6 adenylate cyclase 6 0.188326
S100A1 S100 calcium binding protein A1 0.188022
WASF3 WAS protein family, member 3 0.18591
NTS neurotensin 0.184128
ADM adrenomedullin 0.182666
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 0.182086
MMP16 matrix metallopeptidase 16 (membrane-inserted) 0.180652
PXN paxillin 0.177029
NCF4 neutrophil cytosolic factor 4, 40kDa 0.175146
FRY furry homolog (Drosophila) 0.174617
RAMP2 receptor (G protein-coupled) activity modifying protein 2 0.171036
TF transferrin 0.170789
NPPA natriuretic peptide A 0.168854
GJC1 gap junction protein, gamma 1, 45kDa 0.168381
RAB3A RAB3A, member RAS oncogene family 0.167915
CCNG1 cyclin G1 0.167682
IL1R2 interleukin 1 receptor, type II 0.166995
ACAP3 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 0.166768
LYZ lysozyme 0.166544
KCNK2 potassium channel, two pore domain subfamily K, member 2 0.166544
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.166095
IGLV3-10 immunoglobulin lambda variable 3-10 0.164571
C5AR1 complement component 5a receptor 1 0.162707
RAMP1 receptor (G protein-coupled) activity modifying protein 1 0.162707
ACTA2 actin, alpha 2, smooth muscle, aorta 0.161331
IL10RA interleukin 10 receptor, alpha 0.160948
SEMG1 semenogelin I 0.159302
MAPK3 mitogen-activated protein kinase 3 0.158605
SLC45A2 solute carrier family 45, member 2 0.158434
PGK1 phosphoglycerate kinase 1 0.158097